HRP920817A2 - New imidazol-5-carbon acid derivatives acylales, process for the preparation and application thereof - Google Patents

New imidazol-5-carbon acid derivatives acylales, process for the preparation and application thereof Download PDF

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Publication number
HRP920817A2
HRP920817A2 HRA1987/91A HRP920817A HRP920817A2 HR P920817 A2 HRP920817 A2 HR P920817A2 HR P920817 A HRP920817 A HR P920817A HR P920817 A2 HRP920817 A2 HR P920817A2
Authority
HR
Croatia
Prior art keywords
image
formula
compound
salts
carboxylic acid
Prior art date
Application number
HRA1987/91A
Other languages
English (en)
Croatian (hr)
Inventor
Dieter Binder
Josef Weinberger
Original Assignee
Chem Pharm Forsch Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Pharm Forsch Gmbh filed Critical Chem Pharm Forsch Gmbh
Publication of HRP920817A2 publication Critical patent/HRP920817A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HRA1987/91A 1991-10-04 1992-10-02 New imidazol-5-carbon acid derivatives acylales, process for the preparation and application thereof HRP920817A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0198791A AT398202B (de) 1991-10-04 1991-10-04 Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
HRP920817A2 true HRP920817A2 (en) 1996-08-31

Family

ID=3525398

Family Applications (1)

Application Number Title Priority Date Filing Date
HRA1987/91A HRP920817A2 (en) 1991-10-04 1992-10-02 New imidazol-5-carbon acid derivatives acylales, process for the preparation and application thereof

Country Status (22)

Country Link
US (1) US5298519A (cs)
EP (1) EP0535420A1 (cs)
JP (1) JP2544565B2 (cs)
CN (1) CN1032856C (cs)
AT (1) AT398202B (cs)
AU (1) AU649357B2 (cs)
CA (1) CA2079735A1 (cs)
CZ (1) CZ301992A3 (cs)
FI (1) FI924353L (cs)
HR (1) HRP920817A2 (cs)
HU (1) HUT62291A (cs)
IL (1) IL103329A (cs)
LV (1) LV10256B (cs)
MY (1) MY108350A (cs)
NO (1) NO923798L (cs)
NZ (1) NZ244320A (cs)
RU (1) RU2105764C1 (cs)
SI (1) SI9200240A (cs)
SK (1) SK301992A3 (cs)
TW (1) TW223073B (cs)
YU (1) YU48290B (cs)
ZA (1) ZA927205B (cs)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2105939B1 (es) * 1994-08-02 1998-07-01 Uriach & Cia Sa J Nuevos pirazoles con actividad antagonista de la angiotensina ii.
DK1653950T3 (da) * 2003-07-31 2008-05-26 Nicox Sa Nitrooxyderivater af Losartan, Valsatan, Candesartan, Telmisartan, Eprosartan og Olmesartan som angiotensin II-receptorblokkere til behandling af cardiovaskulære sygdomme
CN101024643A (zh) 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
CN101195615B (zh) * 2006-12-06 2013-03-27 深圳市信立泰资产管理有限公司 咪唑-5-羧酸衍生物的盐、制备方法及其药物组合物
EP2103610B1 (en) * 2006-12-06 2011-09-21 Shanghai Allist Pharmaceutical., Inc. Salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof
CN101214242A (zh) * 2007-01-05 2008-07-09 上海艾力斯医药科技有限公司 新的药用组合物
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CN101317842A (zh) * 2007-06-07 2008-12-10 上海艾力斯医药科技有限公司 一种咪唑-5-羧酸衍生物的治疗用途
CN101367795B (zh) * 2007-08-17 2012-05-02 上海艾力斯生物医药有限公司 一种咪唑-5-羧酸衍生物及其制备方法
CN101407511B (zh) * 2007-10-11 2013-01-09 上海艾力斯生物医药有限公司 一种结晶型的咪唑-5-羧酸衍生物
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103012377A (zh) * 2011-09-27 2013-04-03 江苏艾力斯生物医药有限公司 一种咪唑-5-羧酸酯的重结晶方法
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
KR950009860B1 (ko) * 1989-06-30 1995-08-29 이. 아이. 듀퐁 드 네모아 앤드 캄파니 융합된 환 아릴 치환된 이미다졸과 약제학적으로 허용되는 이의 염, 이들의 제조방법 및 이들을 함유하는 약제학적 조성물
ATE113281T1 (de) * 1989-08-02 1994-11-15 Takeda Chemical Industries Ltd Pyrazol-derivate, verfahren zu deren herstellung und anwendung.
DE4132631A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Imidazolyl-propensaeurederivate
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate
ES2155827T3 (es) * 1992-06-02 2001-06-01 Sankyo Co 4-carboxiimidazoles como antagonistas de la angiotensina ii y su uso terapeutico.

Also Published As

Publication number Publication date
FI924353A0 (fi) 1992-09-29
RU2105764C1 (ru) 1998-02-27
JP2544565B2 (ja) 1996-10-16
CZ301992A3 (en) 1993-08-11
AU649357B2 (en) 1994-05-19
US5298519A (en) 1994-03-29
LV10256A (lv) 1994-10-20
CN1032856C (zh) 1996-09-25
ZA927205B (en) 1993-03-23
CA2079735A1 (en) 1993-04-05
MY108350A (en) 1996-09-30
NO923798L (no) 1993-04-05
YU87592A (sh) 1995-10-03
NZ244320A (en) 1995-01-27
LV10256B (en) 1995-04-20
IL103329A0 (en) 1993-03-15
FI924353A7 (fi) 1993-04-05
EP0535420A1 (de) 1993-04-07
NO923798D0 (no) 1992-09-30
JPH05310731A (ja) 1993-11-22
YU48290B (sh) 1998-05-15
ATA198791A (de) 1994-02-15
AT398202B (de) 1994-10-25
SI9200240A (en) 1993-06-30
SK301992A3 (en) 1995-10-11
HU9203149D0 (en) 1992-12-28
TW223073B (cs) 1994-05-01
CN1071426A (zh) 1993-04-28
IL103329A (en) 1996-10-31
AU2617692A (en) 1993-04-08
FI924353L (fi) 1993-04-05
HUT62291A (en) 1993-04-28

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A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
PPPP Transfer of rights

Owner name: DIETER BINDER, AT

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