HRP940481A2 - Iontophoretic delivery of an antimigrene drug - Google Patents

Iontophoretic delivery of an antimigrene drug Download PDF

Info

Publication number: HRP940481A2
Authority: HR; Croatia
Prior art keywords: formula; hydrogen; drug; bivalent; radical
Prior art date: 1993-08-27

Application number

HR93.202.523.2A

Other languages

English (en)

Croatian (hr)

Inventor

Jean Louis Mesens

Gustaaf Van Reet

Frank Maria Jozef De Beukelaar

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-27

Filing date

1994-08-26

Publication date

1997-08-31

1994-08-26 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1997-08-31 Publication of HRP940481A2 publication Critical patent/HRP940481A2/hr

Links

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239000001257 hydrogen Substances 0.000 claims abstract description 24
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 24
150000003839 salts Chemical class 0.000 claims abstract description 18
239000002253 acid Substances 0.000 claims abstract description 14
150000002431 hydrogen Chemical group 0.000 claims abstract description 10
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239000004480 active ingredient Substances 0.000 claims description 18
239000000463 material Substances 0.000 claims description 9
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239000004332 silver Substances 0.000 claims description 8
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235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
229910002804 graphite Inorganic materials 0.000 description 1
239000010439 graphite Substances 0.000 description 1
159000000011 group IA salts Chemical class 0.000 description 1
231100000869 headache Toxicity 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
229910000271 hectorite Inorganic materials 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
239000003906 humectant Substances 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
239000011630 iodine Chemical group 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
239000011133 lead Substances 0.000 description 1
239000003446 ligand Substances 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
239000000391 magnesium silicate Substances 0.000 description 1
229910052919 magnesium silicate Inorganic materials 0.000 description 1
235000019792 magnesium silicate Nutrition 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
VLCAYQIMSMPEBW-UHFFFAOYSA-N methyl 3-hydroxy-2-methylidenebutanoate Chemical compound COC(=O)C(=C)C(C)O VLCAYQIMSMPEBW-UHFFFAOYSA-N 0.000 description 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
QVSXOXCYXPQXMF-OAHLLOKOSA-N n-[[(2r)-3,4-dihydro-2h-chromen-2-yl]methyl]-n'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine Chemical compound C([C@@H]1OC2=CC=CC=C2CC1)NCCCNC1=NCCCN1 QVSXOXCYXPQXMF-OAHLLOKOSA-N 0.000 description 1
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230000008693 nausea Effects 0.000 description 1
229920001220 nitrocellulos Polymers 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
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238000007911 parenteral administration Methods 0.000 description 1
239000001814 pectin Substances 0.000 description 1
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229920001277 pectin Polymers 0.000 description 1
230000035515 penetration Effects 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
150000003016 phosphoric acids Chemical class 0.000 description 1
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229920001195 polyisoprene Polymers 0.000 description 1
239000002861 polymer material Substances 0.000 description 1
239000011496 polyurethane foam Substances 0.000 description 1
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239000011118 polyvinyl acetate Substances 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
239000011148 porous material Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000008569 process Effects 0.000 description 1
239000001294 propane Substances 0.000 description 1
235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
239000000770 propane-1,2-diol alginate Substances 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229940070687 psyllium Drugs 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000003542 rubefacient Substances 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
230000036556 skin irritation Effects 0.000 description 1
231100000475 skin irritation Toxicity 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
229940080236 sodium cetyl sulfate Drugs 0.000 description 1
229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 description 1
GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
229940032147 starch Drugs 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000008719 thickening Effects 0.000 description 1
239000011135 tin Substances 0.000 description 1
229910052718 tin Inorganic materials 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
230000008673 vomiting Effects 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1
239000005019 zein Substances 0.000 description 1
229940093612 zein Drugs 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Electrotherapy Devices (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

HR93.202.523.2A 1993-08-27 1994-08-26 Iontophoretic delivery of an antimigrene drug HRP940481A2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP93202523		1993-08-27

Publications (1)

Publication Number	Publication Date
HRP940481A2 true HRP940481A2 (en)	1997-08-31

Family

ID=8214068

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR93.202.523.2A HRP940481A2 (en)	1993-08-27	1994-08-26	Iontophoretic delivery of an antimigrene drug

Country Status (28)

Country	Link
US (1)	US5674871A (de)
EP (1)	EP0719138B1 (de)
JP (1)	JP2921987B2 (de)
KR (1)	KR100187632B1 (de)
CN (1)	CN1096857C (de)
AT (1)	ATE176591T1 (de)
AU (1)	AU687876B2 (de)
BR (1)	BR9407522A (de)
CA (1)	CA2168449A1 (de)
CZ (1)	CZ290473B6 (de)
DE (1)	DE69416522T2 (de)
DK (1)	DK0719138T3 (de)
ES (1)	ES2129668T3 (de)
FI (1)	FI960887A0 (de)
GR (1)	GR3029920T3 (de)
HR (1)	HRP940481A2 (de)
HU (1)	HUT75062A (de)
IL (1)	IL110784A (de)
MY (1)	MY111022A (de)
NO (1)	NO317628B1 (de)
NZ (1)	NZ273304A (de)
PH (1)	PH31437A (de)
PL (1)	PL176290B1 (de)
RU (1)	RU2166315C2 (de)
SG (1)	SG50469A1 (de)
SI (1)	SI9400333B (de)
WO (1)	WO1995005815A1 (de)
ZA (1)	ZA946533B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5853383A (en) *	1995-05-03	1998-12-29	Alza Corporation	Preparation for formulations for electrotransport drug delivery
US7137975B2 (en) *	2001-02-13	2006-11-21	Aciont, Inc.	Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent
DE60227938D1 (de) *	2001-04-04	2008-09-11	Alza Corp	Transdermales verabreichungsgerät mittels elektrotransport mit einer kompatiblen antimikrobiellen reservoir-lösung
WO2002089803A1 (fr) *	2001-05-07	2002-11-14	Sankyo Company, Limited	Composition d'ionophorese
ATE419897T1 (de) *	2001-10-24	2009-01-15	Power Paper Ltd	Vorrichtung für die kontrollierte abgabe eines wirkstoffes in die haut
ITMI20021200A1 (it) *	2002-06-03	2003-12-03	Gafitex S R L	Tessuto atto ad esplicare un effetto barriera contro campi magnetici ed elettromagnetici e/o effetti di metalloterapia
US8016811B2 (en) *	2003-10-24	2011-09-13	Altea Therapeutics Corporation	Method for transdermal delivery of permeant substances
US20050220439A1 (en) *	2004-03-19	2005-10-06	Carton Owen A	Interactive multimedia system and method
WO2007009462A2 (en) *	2005-07-15	2007-01-25	Region Hovedstaden V/Glostrup Hospital	Treatment of migraine and headaches
GB2430364A (en) *	2005-09-22	2007-03-28	Carl Ernest Alexander	Soft agar bolus for oral drug delivery
NZ596498A (en) *	2006-04-13	2013-05-31	Nupathe Inc	Transdermal methods and systems for the delivery of anti-migraine compounds
RU2352359C1 (ru) *	2007-10-24	2009-04-20	Общество с ограниченнной ответственностью "НПО Текстильпрогресс Инженерной Академии " (ООО "НПО Текстильпрогресс ИА")	Способ создания композиции для доставки лекарственного препарата в полости организма при заболеваниях

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4028125A1 (de) *	1990-01-17	1991-07-18	Klimke Markus	Applikationsvorrichtung fuer die geregelte dosierung verschiedener pharmakons mittels elektrischem strom zum perkutanen transport zur lokalen und systemischen therapie
JP3740549B2 (ja) *	1990-03-30	2006-02-01	アルザ・コーポレーション	イオン侵透療法による薬剤投与の装置と方法
SI9300097B (en) *	1992-02-27	2001-12-31	Janssen Pharmaceutica Nv	(benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines

1994
- 1994-07-15 PH PH48643A patent/PH31437A/en unknown
- 1994-08-19 KR KR1019960700410A patent/KR100187632B1/ko not_active Expired - Fee Related
- 1994-08-19 DK DK94926855T patent/DK0719138T3/da active
- 1994-08-19 NZ NZ273304A patent/NZ273304A/en unknown
- 1994-08-19 US US08/586,700 patent/US5674871A/en not_active Expired - Fee Related
- 1994-08-19 CN CN94193196A patent/CN1096857C/zh not_active Expired - Fee Related
- 1994-08-19 BR BR9407522A patent/BR9407522A/pt not_active Application Discontinuation
- 1994-08-19 RU RU96105930/14A patent/RU2166315C2/ru not_active IP Right Cessation
- 1994-08-19 CA CA002168449A patent/CA2168449A1/en not_active Abandoned
- 1994-08-19 AT AT94926855T patent/ATE176591T1/de not_active IP Right Cessation
- 1994-08-19 PL PL94313255A patent/PL176290B1/pl not_active IP Right Cessation
- 1994-08-19 CZ CZ1996570A patent/CZ290473B6/cs not_active IP Right Cessation
- 1994-08-19 HU HU9600471A patent/HUT75062A/hu unknown
- 1994-08-19 WO PCT/EP1994/002764 patent/WO1995005815A1/en not_active Ceased
- 1994-08-19 DE DE69416522T patent/DE69416522T2/de not_active Expired - Fee Related
- 1994-08-19 AU AU76542/94A patent/AU687876B2/en not_active Ceased
- 1994-08-19 SG SG1996002184A patent/SG50469A1/en unknown
- 1994-08-19 EP EP94926855A patent/EP0719138B1/de not_active Expired - Lifetime
- 1994-08-19 JP JP7507338A patent/JP2921987B2/ja not_active Expired - Fee Related
- 1994-08-19 ES ES94926855T patent/ES2129668T3/es not_active Expired - Lifetime
- 1994-08-25 IL IL11078494A patent/IL110784A/xx not_active IP Right Cessation
- 1994-08-25 MY MYPI94002234A patent/MY111022A/en unknown
- 1994-08-26 HR HR93.202.523.2A patent/HRP940481A2/hr not_active Application Discontinuation
- 1994-08-26 SI SI9400333A patent/SI9400333B/sl not_active IP Right Cessation
- 1994-08-26 ZA ZA946533A patent/ZA946533B/xx unknown
1996
- 1996-02-26 NO NO19960769A patent/NO317628B1/no unknown
- 1996-02-26 FI FI960887A patent/FI960887A0/fi not_active Application Discontinuation
1999
- 1999-04-07 GR GR990401012T patent/GR3029920T3/el unknown

Also Published As

Publication number	Publication date
JPH09501180A (ja)	1997-02-04
NO317628B1 (no)	2004-11-29
CA2168449A1 (en)	1995-03-02
ES2129668T3 (es)	1999-06-16
FI960887A7 (fi)	1996-02-26
PL176290B1 (pl)	1999-05-31
DK0719138T3 (da)	1999-09-20
US5674871A (en)	1997-10-07
CN1096857C (zh)	2002-12-25
NZ273304A (en)	1997-02-24
WO1995005815A1 (en)	1995-03-02
ZA946533B (en)	1996-02-26
CZ57096A3 (en)	1996-08-14
CN1129905A (zh)	1996-08-28
BR9407522A (pt)	1997-01-07
EP0719138A1 (de)	1996-07-03
IL110784A (en)	1999-05-09
DE69416522T2 (de)	1999-09-23
JP2921987B2 (ja)	1999-07-19
AU7654294A (en)	1995-03-21
GR3029920T3 (en)	1999-07-30
HU9600471D0 (en)	1996-04-29
PH31437A (en)	1998-11-03
FI960887A0 (fi)	1996-02-26
SG50469A1 (en)	1998-07-20
SI9400333B (sl)	2002-02-28
EP0719138B1 (de)	1999-02-10
SI9400333A (en)	1995-04-30
DE69416522D1 (de)	1999-03-25
KR100187632B1 (ko)	1999-06-01
AU687876B2 (en)	1998-03-05
ATE176591T1 (de)	1999-02-15
NO960769L (no)	1996-04-23
MY111022A (en)	1999-07-31
HUT75062A (en)	1997-03-28
RU2166315C2 (ru)	2001-05-10
NO960769D0 (no)	1996-02-26
CZ290473B6 (cs)	2002-07-17
IL110784A0 (en)	1994-11-11
PL313255A1 (en)	1996-06-24

Legal Events

Date	Code	Title	Description
1997-08-31	A1OB	Publication of a patent application
1998-04-15	ODBC	Application rejected

Publication	Publication Date	Title
EP0435436B1 (de)	1994-01-12	Verstärker des transdermalen Flusses in Kombination mit Iontophorese für die topische Verabreichung von Arzneimitteln
EP2281559A1 (de)	2011-02-09	Pharmazeutische Zusammensetzung enthaltend Rotigotin (Salze oder Na), insbesondere für Iontophorese
HRP940481A2 (en)	1997-08-31	Iontophoretic delivery of an antimigrene drug
HU184575B (en)	1984-09-28	Method for producing preparations fixable on skin generating locally electrolytic and bio currents
US20050234389A1 (en)	2005-10-20	Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds
EP2874693A1 (de)	2015-05-27	Durch ein elektrisches feld unterstützte verabreichung von tapentadol
RU2371179C2 (ru)	2009-10-27	Чрескожное введение соединений пиперазинил-2 (3н)-бензоксазолона посредством электрофореза
US20250360156A1 (en)	2025-11-27	Synergistic combination of nad+ and therapeutic peptides delivered via iontophoresis for enhanced and prolonged regenerative effects
JPH0572890B2 (de)	1993-10-13
ROUTE	0	Pharmacy Review & Research
Madhulatha et al.	2012	Pharmaceutical and Nano Sciences
Kotur	2006	Development Of Atenolol Gels For Transdermal Application By Iontophoresis
KR20070012432A (ko)	2007-01-25	피페라지닐-2(3ｈ)-벤즈옥사졸론 화합물의 경피이온삼투요법적 전달
WO2005020967A1 (ja)	2005-03-10	電気的薬物移送製剤
MXPA06011018A (en)	2007-04-20	Transdermal iontophoretic delivery of piperazinyl-2(3h)-benzoxazolone compounds