HRP940695B1 - Oxalyl-aminoacid derivatives, process for their preparration and use as drug for inhibiting the prolyl-hydroxylase - Google Patents

Oxalyl-aminoacid derivatives, process for their preparration and use as drug for inhibiting the prolyl-hydroxylase

Info

Publication number: HRP940695B1
Authority: HR; Croatia
Prior art keywords: hydroxylase; alkyl; prolyl; preparration; oxalyl
Prior art date: 1990-05-12

Application number

HRP-809/91A

Other languages

English (en)

Inventor

Volkmar Guenzler-Pukall

Original Assignee

Volkmar Guenzler-Pukall

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-12

Filing date

1994-10-19

Publication date

1999-04-30

1994-10-19 Application filed by Volkmar Guenzler-Pukall filed Critical Volkmar Guenzler-Pukall

1997-02-28 Publication of HRP940695A2 publication Critical patent/HRP940695A2/xx

1999-04-30 Publication of HRP940695B1 publication Critical patent/HRP940695B1/xx

Links

102000004079 Prolyl Hydroxylases Human genes 0.000 title abstract 2
108010043005 Prolyl Hydroxylases Proteins 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
102000008490 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Human genes 0.000 abstract 1
108010020504 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Transplantation (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pyrrole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)

HRP-809/91A 1990-05-12 1994-10-19 Oxalyl-aminoacid derivatives, process for their preparration and use as drug for inhibiting the prolyl-hydroxylase HRP940695B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4015255A DE4015255A1 (de)	1990-05-12	1990-05-12	Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase
YU80991		1991-05-09

Publications (2)

Publication Number	Publication Date
HRP940695A2 HRP940695A2 (en)	1997-02-28
HRP940695B1 true HRP940695B1 (en)	1999-04-30

Family

ID=6406245

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HRP-809/91A HRP940695B1 (en)	1990-05-12	1994-10-19	Oxalyl-aminoacid derivatives, process for their preparration and use as drug for inhibiting the prolyl-hydroxylase

Country Status (28)

Country	Link
US (1)	US5204338A (cs)
EP (1)	EP0457163B1 (cs)
JP (1)	JP2504874B2 (cs)
KR (1)	KR910019612A (cs)
CN (1)	CN1032253C (cs)
AT (1)	ATE108177T1 (cs)
AU (1)	AU641760B2 (cs)
BR (1)	BR9101927A (cs)
CA (1)	CA2042282A1 (cs)
CZ (1)	CZ279939B6 (cs)
DE (2)	DE4015255A1 (cs)
DK (1)	DK0457163T3 (cs)
EG (1)	EG19762A (cs)
ES (1)	ES2057655T3 (cs)
HR (1)	HRP940695B1 (cs)
HU (1)	HU217974B (cs)
IE (1)	IE65298B1 (cs)
IL (1)	IL98109A (cs)
LT (1)	LT3953B (cs)
LV (1)	LV10387B (cs)
MA (1)	MA22152A1 (cs)
MX (1)	MX25723A (cs)
MY (1)	MY108608A (cs)
NZ (1)	NZ238112A (cs)
PT (1)	PT97642B (cs)
RU (1)	RU2025123C1 (cs)
TW (1)	TW225988B (cs)
ZA (1)	ZA913538B (cs)

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US5192773A (en) *	1990-07-02	1993-03-09	Vertex Pharmaceuticals, Inc.	Immunosuppressive compounds
ES2137186T3 (es) *	1991-05-09	1999-12-16	Vertex Pharma	Nuevos compuestos inmunosupresores.
US5620971A (en) *	1991-05-09	1997-04-15	Vertex Pharmaceuticals Incorporated	Biologically active acylated amino acid derivatives
US5723459A (en) *	1991-05-09	1998-03-03	Vertex Pharmaceuticals Incorporated	Biologically active acylated amino acid derivatives
ES2101420T3 (es) *	1993-11-02	1997-07-01	Hoechst Ag	Esteres-amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos.
EP0650961B1 (de)	1993-11-02	1997-03-05	Hoechst Aktiengesellschaft	Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
NZ270267A (en) *	1993-12-30	1997-03-24	Hoechst Ag	3-hydroxypyridin-2yl (and -quinolin-2-yl) carboxamide derivatives and pharmaceutical compositions
US5543423A (en) *	1994-11-16	1996-08-06	Vertex Pharmaceuticals, Incorporated	Amino acid derivatives with improved multi-drug resistance activity
US6046219A (en) *	1995-01-20	2000-04-04	Cornell Research Foundation, Inc.	Method for the treatment of conditions mediated by collagen formation together with cell proliferation by application of inhibitors of protein hydroxylation
US5789426A (en) *	1995-01-20	1998-08-04	Cornell Research Foundation, Inc.	Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation
US7056935B2 (en)	1995-06-07	2006-06-06	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US5859031A (en) *	1995-06-07	1999-01-12	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
IL135495A (en) *	1995-09-28	2002-12-01	Hoechst Ag	Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid
US5801197A (en) *	1995-10-31	1998-09-01	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US5717092A (en) *	1996-03-29	1998-02-10	Vertex Pharmaceuticals Inc.	Compounds with improved multi-drug resistance activity
US5786378A (en) *	1996-09-25	1998-07-28	Gpi Nil Holdings, Inc.	Heterocyclic thioesters
US5801187A (en)	1996-09-25	1998-09-01	Gpi-Nil Holdings, Inc.	Heterocyclic esters and amides
US6218424B1 (en)	1996-09-25	2001-04-17	Gpi Nil Holdings, Inc.	Heterocyclic ketone and thioester compounds and uses
DE19650215A1 (de) *	1996-12-04	1998-06-10	Hoechst Ag	3-Hydroxypyridin-2-carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel
US6274602B1 (en)	1998-06-03	2001-08-14	Gpi Nil Holdings, Inc.	Heterocyclic thioester and ketone hair growth compositions and uses
US20010049381A1 (en)	1997-06-04	2001-12-06	Gpl Nil Holdings, Inc.,	Pyrrolidine derivative hair growth compositions and uses
US6271244B1 (en)	1998-06-03	2001-08-07	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6187784B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Pipecolic acid derivative hair growth compositions and uses
US6187796B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Sulfone hair growth compositions and uses
US5945441A (en) *	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
DE19746287A1 (de) *	1997-10-20	1999-04-22	Hoechst Marion Roussel De Gmbh	Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
US6172087B1 (en)	1998-06-03	2001-01-09	Gpi Nil Holding, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
EP1085853A1 (en)	1998-06-03	2001-03-28	GPI NIL Holdings, Inc.	Heterocyclic ester and amide hair growth compositions and uses
US6429215B1 (en)	1998-06-03	2002-08-06	Gpi Nil Holdings, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6331537B1 (en)	1998-06-03	2001-12-18	Gpi Nil Holdings, Inc.	Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6333340B1 (en)	1998-08-14	2001-12-25	Gpi Nil Holdings, Inc.	Small molecule sulfonamides for vision and memory disorders
US7338976B1 (en)	1998-08-14	2008-03-04	Gpi Nil Holdings, Inc.	Heterocyclic esters or amides for vision and memory disorders
US6335348B1 (en)	1998-08-14	2002-01-01	Gpi Nil Holdings, Inc.	Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6506788B1 (en)	1998-08-14	2003-01-14	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6384056B1 (en)	1998-08-14	2002-05-07	Gpi Nil Holdings, Inc.	Heterocyclic thioesters or ketones for vision and memory disorders
US6462072B1 (en)	1998-09-21	2002-10-08	Gpi Nil Holdings, Inc.	Cyclic ester or amide derivatives
CN102552263A (zh) *	2001-12-06	2012-07-11	法布罗根股份有限公司	提高内源性红细胞生成素(epo)的方法
RU2214596C1 (ru) *	2002-05-21	2003-10-20	Подковкин Владимир Георгиевич	Способ оценки метаболизма коллагена
WO2006134963A1 (ja) *	2005-06-15	2006-12-21	Nippon Zoki Pharmaceutical Co., Ltd.	オキサルル酸誘導体を含有する線維性疾患用剤

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GB1195854A (en) *	1966-08-08	1970-06-24	Ajinomoto Kk	Oxazole Derivatives and process of producing the same
DE1645987A1 (de) *	1966-08-08	1971-01-21	Ajinomoto Kk	Oxalzolderivate und Verfahren zu deren Herstellung
US3646061A (en) *	1968-06-10	1972-02-29	Ajinomoto Kk	Method of preparing n-alkoxalyl and n-formyl derivatives of alpha-amino acid esters

1990
- 1990-05-12 DE DE4015255A patent/DE4015255A1/de not_active Withdrawn
1991
- 1991-01-25 TW TW080100597A patent/TW225988B/zh active
- 1991-04-26 AU AU76221/91A patent/AU641760B2/en not_active Ceased
- 1991-05-07 AT AT91107424T patent/ATE108177T1/de active
- 1991-05-07 DE DE59102102T patent/DE59102102D1/de not_active Expired - Fee Related
- 1991-05-07 DK DK91107424.3T patent/DK0457163T3/da active
- 1991-05-07 EP EP91107424A patent/EP0457163B1/de not_active Expired - Lifetime
- 1991-05-07 ES ES91107424T patent/ES2057655T3/es not_active Expired - Lifetime
- 1991-05-09 EG EG28291A patent/EG19762A/xx active
- 1991-05-09 MX MX2572391A patent/MX25723A/es unknown
- 1991-05-10 BR BR919101927A patent/BR9101927A/pt not_active Application Discontinuation
- 1991-05-10 PT PT97642A patent/PT97642B/pt not_active IP Right Cessation
- 1991-05-10 ZA ZA913538A patent/ZA913538B/xx unknown
- 1991-05-10 KR KR1019910007532A patent/KR910019612A/ko not_active Withdrawn
- 1991-05-10 CZ CS911384A patent/CZ279939B6/cs not_active IP Right Cessation
- 1991-05-10 JP JP3133262A patent/JP2504874B2/ja not_active Expired - Lifetime
- 1991-05-10 CA CA002042282A patent/CA2042282A1/en not_active Abandoned
- 1991-05-10 HU HU572/91A patent/HU217974B/hu not_active IP Right Cessation
- 1991-05-10 IE IE160891A patent/IE65298B1/en not_active IP Right Cessation
- 1991-05-10 IL IL9810991A patent/IL98109A/en unknown
- 1991-05-10 US US07/698,097 patent/US5204338A/en not_active Expired - Fee Related
- 1991-05-10 MA MA22422A patent/MA22152A1/fr unknown
- 1991-05-10 NZ NZ238112A patent/NZ238112A/en unknown
- 1991-05-10 RU SU914895308A patent/RU2025123C1/ru active
- 1991-05-10 MY MYPI91000793A patent/MY108608A/en unknown
- 1991-05-11 CN CN91103013A patent/CN1032253C/zh not_active Expired - Fee Related
1993
- 1993-05-07 LV LVP-93-303A patent/LV10387B/lv unknown
- 1993-11-12 LT LTIP1460A patent/LT3953B/lt not_active IP Right Cessation
1994
- 1994-10-19 HR HRP-809/91A patent/HRP940695B1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
MA22152A1 (fr)	1991-12-31
DE4015255A1 (de)	1991-11-14
ES2057655T3 (es)	1994-10-16
LV10387B (en)	1996-02-20
DK0457163T3 (da)	1994-10-17
JP2504874B2 (ja)	1996-06-05
IE911608A1 (en)	1991-11-20
HRP940695A2 (en)	1997-02-28
PT97642A (pt)	1992-02-28
IE65298B1 (en)	1995-10-18
LT3953B (en)	1996-05-27
HUT57581A (en)	1991-12-30
IL98109A0 (en)	1992-06-21
PT97642B (pt)	1998-08-31
RU2025123C1 (ru)	1994-12-30
MY108608A (en)	1996-10-31
CA2042282A1 (en)	1991-11-13
ATE108177T1 (de)	1994-07-15
ZA913538B (en)	1992-02-26
KR910019612A (ko)	1991-12-19
JPH04226913A (ja)	1992-08-17
BR9101927A (pt)	1991-12-17
TW225988B (cs)	1994-07-01
EG19762A (en)	1996-01-31
DE59102102D1 (de)	1994-08-11
US5204338A (en)	1993-04-20
AU7622191A (en)	1991-11-14
CZ279939B6 (cs)	1995-09-13
CN1032253C (zh)	1996-07-10
HU157291D0 (en)	1991-11-28
EP0457163B1 (de)	1994-07-06
LTIP1460A (en)	1995-05-25
LV10387A (lv)	1995-02-20
MX25723A (es)	1993-04-01
HU217974B (hu)	2000-05-28
CN1056683A (zh)	1991-12-04
EP0457163A1 (de)	1991-11-21
NZ238112A (en)	1993-12-23
IL98109A (en)	1995-07-31
AU641760B2 (en)	1993-09-30

Legal Events

Date	Code	Title	Description
1997-02-28	A1OB	Publication of a patent application
1997-08-27	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
1999-04-30	B1PR	Patent granted
2000-05-09	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20000509 Year of fee payment: 10
2001-11-10	PBON	Lapse due to non-payment of renewal fee	Effective date: 20010510

Publication	Publication Date	Title
HRP940695B1 (en)	1999-04-30	Oxalyl-aminoacid derivatives, process for their preparration and use as drug for inhibiting the prolyl-hydroxylase
ES2164218T3 (es)	2002-02-16	Derivados de camptotecina.
GR3032311T3 (en)	2000-04-27	Stilbene derivatives and pharmaceutical compositions containing them
ES2037613A1 (es)	1993-06-16	Procedimiento de obtencion de nuevos derivados dipeptidicos.
ES2057116T3 (es)	1994-10-16	Derivados de acido n-(5,6,7,8-tetrahidropirido-(2,3-d)pirimidin-6-ilalcanoil) glutamico.
GR3015512T3 (en)	1995-06-30	Thiophene derivatives, process for their preparation and pharmaceutical compositions containing them.
TW333533B (en)	1998-06-11	Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
DE68902627D1 (de)	1992-10-01	Verwendung von chromanderivaten zur herstellung eines medikamentes zur behandlung von depressiven zustaenden.
GB2250989B (en)	1994-08-17	Thioacid amide derivatives and fodder compositions containing the same