HRP940752B1 - Benzimidazol, medicaments containing them and process for their preparation - Google Patents

Benzimidazol, medicaments containing them and process for their preparation

Info

Publication number: HRP940752B1
Authority: HR; Croatia
Prior art keywords: benzimidazolyl; alkyl; substd; opt; cooh
Prior art date: 1991-02-06

Application number

Other languages

English (en)

Inventor

Norbert Hauel

Berthold Narr

Uwe Ries

Jacques Van Meel

Wolfgang Wienen

Michael Entzeroth

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-06

Filing date

1994-10-25

Publication date

2001-02-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27202166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP940752(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-02-06 Priority claimed from DE4103492A external-priority patent/DE4103492A1/de

1994-10-25 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1997-04-30 Publication of HRP940752A2 publication Critical patent/HRP940752A2/hr

2001-02-28 Publication of HRP940752B1 publication Critical patent/HRP940752B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Electroluminescent Light Sources (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Professional, Industrial, Or Sporting Protective Garments (AREA)
Battery Electrode And Active Subsutance (AREA)

HRP-98/92 1991-02-06 1994-10-25 Benzimidazol, medicaments containing them and process for their preparation HRP940752B1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE4103492A DE4103492A1 (de)	1991-02-06	1991-02-06	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4117121A DE4117121A1 (de)	1991-02-06	1991-05-25	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4137812A DE4137812A1 (de)	1991-02-06	1991-11-16	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
YU9892A YU48849B (sh)	1991-02-06	1992-01-30	Benzimidazoli, njihove 1-,3-izomerne smeše i njihove soli kao i postupak za njihovo dobijanje

Publications (2)

Publication Number	Publication Date
HRP940752A2 HRP940752A2 (en)	1997-04-30
HRP940752B1 true HRP940752B1 (en)	2001-02-28

Family

ID=27202166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HRP-98/92 HRP940752B1 (en)	1991-02-06	1994-10-25	Benzimidazol, medicaments containing them and process for their preparation

Country Status (25)

Country	Link
EP (1)	EP0502314B1 (cs)
JP (1)	JP2709225B2 (cs)
AT (1)	ATE166346T1 (cs)
BG (1)	BG62309B2 (cs)
CA (1)	CA2060624C (cs)
CH (1)	CH0502314H1 (cs)
CZ (1)	CZ287607B6 (cs)
DE (2)	DE10299029I2 (cs)
DK (1)	DK0502314T3 (cs)
ES (1)	ES2118095T4 (cs)
FI (1)	FI105547B (cs)
HR (1)	HRP940752B1 (cs)
HU (2)	HU217084B (cs)
IE (1)	IE81111B1 (cs)
IL (1)	IL100864A (cs)
LU (3)	LU90372I2 (cs)
MX (1)	MX9200509A (cs)
NL (2)	NL990007I2 (cs)
NO (3)	NO301585B1 (cs)
NZ (1)	NZ241515A (cs)
PL (1)	PL169675B1 (cs)
RU (1)	RU2053229C1 (cs)
SG (1)	SG50481A1 (cs)
SI (1)	SI9210098B (cs)
SK (1)	SK279261B6 (cs)

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SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
PE20020617A1 (es)	2000-08-22	2002-08-05	Novartis Ag	Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina
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HRP20040649B1 (en) †	2002-01-16	2012-12-31	Boehringer Ingelheim Pharma	Bilayer pharmaceutical tablet comprising telmisartan and a diuretic and preparation thereof
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1992
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- 1992-01-31 DE DE2002199029 patent/DE10299029I2/de active Active
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- 1992-02-05 RU SU5010824/04A patent/RU2053229C1/ru active Protection Beyond IP Right Term
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1995
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1999
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2002
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- 2002-08-30 LU LU90950C patent/LU90950I2/fr unknown
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Also Published As

Publication number	Publication date
LU90950I2 (fr)	2002-10-30
PL169675B1 (pl)	1996-08-30
ATE166346T1 (de)	1998-06-15
DE10299029I2 (de)	2006-06-29
HK1011145A1 (en)	1999-07-02
NZ241515A (en)	1994-10-26
CS30692A3 (en)	1992-08-12
DE59209330D1 (de)	1998-06-25
MX9200509A (es)	1992-08-01
IL100864A (en)	1996-01-19
AU655794B2 (en)	1995-01-12
SK279261B6 (sk)	1998-08-05
NL300095I1 (nl)	2002-09-02
NO2002011I2 (no)	2008-03-03
RU2053229C1 (ru)	1996-01-27
DK0502314T3 (da)	1999-03-29
CA2060624C (en)	1999-12-21
IE920373A1 (en)	1992-08-12
HU9200355D0 (en)	1992-04-28
SI9210098A (en)	1994-12-31
JPH04346978A (ja)	1992-12-02
FI920486A0 (fi)	1992-02-05
NL990007I2 (nl)	1999-07-01
LU91802I2 (fr)	2011-05-30
CA2060624A1 (en)	1992-08-07
BG62309B2 (bg)	1999-07-30
DE10299029I1 (de)	2003-01-23
NO920476L (no)	1992-08-07
ES2118095T3 (es)	1998-09-16
ES2118095T4 (es)	2011-04-07
EP0502314A1 (de)	1992-09-09
NO301585B1 (no)	1997-11-17
NL300095I2 (nl)	2002-11-01
CH0502314H1 (cs)	2012-03-15
NO2011005I1 (no)	2011-05-16
IL100864A0 (en)	1992-11-15
HUT60493A (en)	1992-09-28
HRP940752A2 (en)	1997-04-30
JP2709225B2 (ja)	1998-02-04
FI105547B (fi)	2000-09-15
NO920476D0 (no)	1992-02-05
FI920486L (fi)	1992-08-07
SI9210098B (sl)	2000-06-30
LU90372I2 (fr)	1999-05-12
AU1070792A (en)	1992-08-13
DE59209330C5 (de)	2013-10-31
HU217084B (hu)	1999-11-29
CZ287607B6 (cs)	2001-01-17
SG50481A1 (en)	1998-07-20
IE81111B1 (en)	2000-03-08
PL293387A1 (en)	1993-01-25
NL990007I1 (nl)	1999-06-01
EP0502314B1 (de)	1998-05-20
HU211524A9 (en)	1995-11-28

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Nam et al.	1990	New Thiazolo [3, 2-b][1, 2, 4] triazole Derivatives: Useful Compounds for the Preparation of 7-Substituted Cephalosporins
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EP0072508A3 (de)	1983-03-16	Pyrazolonderivate, ihre Herstellung und ihre Verwendung als Kupplungskomponenten
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GB1169543A (en)	1969-11-05	Tropyl Tropate Derivatives
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IT1230754B (it)	1991-10-29	Camposti con attivita' analgesica centrale.

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