HRP960024B1 - Guanine derivative - Google Patents

Guanine derivative

Info

Publication number: HRP960024B1
Authority: HR; Croatia
Prior art keywords: guanine derivative; guanine; derivative
Prior art date: 1995-01-20

Application number

HR960024A

Other languages

English (en)

Inventor

Howard Carter Barry

Muse Partin Jane

Gregory Varlashkin Peter

Augustus Winnike Richard

Bayne Grubb William Iii

Alan Conway Gregory

George Lake Philip

Michael Skinner David

James Whatrup David

Original Assignee

The Wellcome Foundation Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-20

Filing date

1996-01-19

Publication date

2005-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10768347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP960024(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-01-19 Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited

1997-10-31 Publication of HRP960024A2 publication Critical patent/HRP960024A2/hr

2005-08-31 Publication of HRP960024B1 publication Critical patent/HRP960024B1/xx

Links

WJSVJNDMOQTICG-UHFFFAOYSA-N 2-amino-1-[(2-methyl-4-methylidene-5-oxooxolan-2-yl)methyl]-7h-purin-6-one Chemical compound NC1=NC=2N=CNC=2C(=O)N1CC1(C)CC(=C)C(=O)O1 WJSVJNDMOQTICG-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

HR960024A 1995-01-20 1996-01-19 Guanine derivative HRP960024B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9501178.9A GB9501178D0 (en)	1995-01-20	1995-01-20	Guanine derivative

Publications (2)

Publication Number	Publication Date
HRP960024A2 HRP960024A2 (en)	1997-10-31
HRP960024B1 true HRP960024B1 (en)	2005-08-31

Family

ID=10768347

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR960024A HRP960024B1 (en)	1995-01-20	1996-01-19	Guanine derivative

Country Status (40)

Country	Link
US (1)	US6107302A (fr)
EP (1)	EP0804436B1 (fr)
JP (1)	JP3176633B2 (fr)
KR (1)	KR100376074B1 (fr)
CN (1)	CN1049893C (fr)
AP (1)	AP662A (fr)
AR (1)	AR002270A1 (fr)
AT (1)	ATE302777T1 (fr)
AU (1)	AU702794B2 (fr)
BG (1)	BG63393B1 (fr)
BR (1)	BR9606768A (fr)
CA (1)	CA2210799C (fr)
CY (1)	CY2531B1 (fr)
CZ (1)	CZ297065B6 (fr)
DE (1)	DE69635106T2 (fr)
DK (1)	DK0804436T3 (fr)
EA (1)	EA000364B1 (fr)
EE (1)	EE03528B1 (fr)
ES (1)	ES2248806T3 (fr)
FI (1)	FI973063L (fr)
GB (1)	GB9501178D0 (fr)
GE (1)	GEP20001940B (fr)
HR (1)	HRP960024B1 (fr)
HU (1)	HU222993B1 (fr)
IL (1)	IL116831A (fr)
IN (1)	IN182468B (fr)
IS (1)	IS2268B (fr)
NO (1)	NO315558B1 (fr)
NZ (1)	NZ298851A (fr)
OA (1)	OA10499A (fr)
PL (1)	PL182175B1 (fr)
RO (1)	RO118693B1 (fr)
RS (1)	RS49518B (fr)
SI (1)	SI0804436T1 (fr)
SK (1)	SK285329B6 (fr)
TR (1)	TR199700656T1 (fr)
UA (1)	UA46001C2 (fr)
UY (1)	UY25779A1 (fr)
WO (1)	WO1996022291A1 (fr)
ZA (1)	ZA96449B (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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GB9501178D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Guanine derivative
EP0874631B1 (fr) *	1996-01-19	2003-11-19	Glaxo Group Limited	Utilisation de valaciclovir dans la fabrication d'un medicament destine au traitement de l'herpes genital par administration journaliere unique
IT1283447B1 (it) *	1996-07-18	1998-04-21	Ind Chimica Srl	Processo di preparazione del valaciclovir e relativi intermedi
WO1998031683A1 (fr) *	1997-01-17	1998-07-23	Ajinomoto Co., Inc.	Nouveaux cristaux de z-valacyclovir
GB0010446D0 (en) *	2000-04-28	2000-06-14	Glaxo Wellcome Kk	Pharmaceutical formulation
KR100926247B1 (ko) *	2001-02-24	2009-11-12	베링거 잉겔하임 파르마 게엠베하 운트 코 카게	크산틴 유도체를 포함하는 약제학적 조성물 및 이의제조방법
CZ2004446A3 (cs) *	2001-09-07	2005-01-12	Teva Pharmaceutical Industries Ltd.	Krystalické formy valaciklovir hydrochloridu
WO2003040145A1 (fr) *	2001-11-05	2003-05-15	Glaxo Group Limited	Forme cristalline anhydre du valaciclovir chlorhydrate
CA2465928C (fr) *	2001-11-14	2010-01-19	Teva Pharmaceutical Industries Ltd.	Synthese et purification de valacyclovir
WO2004000265A2 (fr) *	2002-06-24	2003-12-31	Ranbaxy Laboratories Limited	Procede de preparation de formulations solides de comprimes de chlorhydrate de valacyclovir
US7407955B2 (en)	2002-08-21	2008-08-05	Boehringer Ingelheim Pharma Gmbh & Co., Kg	8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US20050043329A1 (en) *	2002-09-06	2005-02-24	Shlomit Wizel	Crystalline forms of valacyclovir hydrochloride
WO2004035583A1 (fr) *	2002-10-16	2004-04-29	Teva Pharmaceutical Industries Ltd.	Procede pour reduire la quantite d'alcools residuels dans de l'hydrochlorure de valacyclovir cristallin
US20050059684A1 (en) *	2002-10-16	2005-03-17	Ben-Zion Dolitzky	Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
CA2548608A1 (fr) *	2002-12-09	2004-06-24	Texcontor Etablissement	Forme cristalline anhydre d'hydrochlorure de valacyclovir
EP1633753A1 (fr) *	2003-05-30	2006-03-15	EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S.	Nouvelles formes cristallines de chlorhydrate de valacyclovir
TW200510414A (en) *	2003-06-02	2005-03-16	Teva Pharma	Novel crystalline forms of valacyclovir hydrochloride
JP2007522130A (ja) *	2004-01-21	2007-08-09	テバファーマシューティカルインダストリーズリミティド	塩酸バラシクロビルの調製方法
US7501426B2 (en)	2004-02-18	2009-03-10	Boehringer Ingelheim International Gmbh	8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
JP2008504255A (ja) *	2004-06-30	2008-02-14	テバファーマシューティカルインダストリーズリミティド	結晶塩酸バラシクロビル中の残留アルコールを低減する方法
DE102004054054A1 (de)	2004-11-05	2006-05-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
US20060178512A1 (en) *	2005-02-04	2006-08-10	Cheruthur Govindan	Method for preparing amino acid esters of nucleoside analogues
WO2006127217A2 (fr) *	2005-05-25	2006-11-30	Eli Lilly And Company	Esters de cyclopropanecarboxylate d'aciclovir
EP1746098A1 (fr)	2005-07-21	2007-01-24	SOLMAG S.p.A.	Des polymorphes de valacyclovir et procédé pour leur fabrication
DE102005035891A1 (de) *	2005-07-30	2007-02-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US20070112193A1 (en) *	2005-11-14	2007-05-17	Khunt Mayur D	Valacyclovir process
PE20110235A1 (es)	2006-05-04	2011-04-14	Boehringer Ingelheim Int	Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
KR101452915B1 (ko) *	2006-05-04	2014-10-21	베링거 인겔하임 인터내셔날 게엠베하	다형태
EP1852108A1 (fr)	2006-05-04	2007-11-07	Boehringer Ingelheim Pharma GmbH & Co.KG	Compositions d'inhibiteurs de la DPP IV
CN1903854B (zh) *	2006-08-09	2012-05-23	丽珠医药集团股份有限公司	一种合成盐酸伐昔洛韦的方法
US20080167325A1 (en) *	2006-12-27	2008-07-10	Bs Praveen Kumar	Valacyclovir compositions
US20080281099A1 (en) *	2007-05-07	2008-11-13	Mayur Devjibhai Khunt	Process for purifying valacyclovir hydrochloride and intermediates thereof
GB0710277D0 (en) *	2007-05-30	2007-07-11	Univ Birmingham	Use of antivirals in the treatment of medical disorders
BRPI0815405A2 (pt) *	2007-08-17	2015-02-03	Boehringer Ingelheim Int	Compostos derivados de purina, processo para a preparação de uma composição farmacêutica e uso dos mesmos
WO2009031576A1 (fr) *	2007-09-03	2009-03-12	Ajinomoto Co., Inc.	Procédé de fabrication de cristaux de chlorhydrate de valacyclovir
US20090076039A1 (en) *	2007-09-14	2009-03-19	Protia, Llc	Deuterium-enriched valacyclovir
PE20091730A1 (es)	2008-04-03	2009-12-10	Boehringer Ingelheim Int	Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) *	2008-06-03	2010-02-23	Boehringer Ingelheim Int	Tratamiento de nafld
UY32030A (es)	2008-08-06	2010-03-26	Boehringer Ingelheim Int	"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20190016601A (ko)	2008-08-06	2019-02-18	베링거 인겔하임 인터내셔날 게엠베하	메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UA119131C2 (uk) *	2008-08-15	2019-05-10	Бьорінгер Інгельхайм Інтернаціональ Гмбх	Похідні пурину для застосування при лікуванні пов'язаних із fab захворювань
CA2736421A1 (fr)	2008-09-10	2010-03-18	Boehringer Ingelheim International Gmbh	Polytherapie pour le traitement du diabete et des etats pathologiques apparentes
US20200155558A1 (en)	2018-11-20	2020-05-21	Boehringer Ingelheim International Gmbh	Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
JP2012512848A (ja)	2008-12-23	2012-06-07	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	有機化合物の塩の形態
TW201036975A (en)	2009-01-07	2010-10-16	Boehringer Ingelheim Int	Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
KR20240090632A (ko)	2009-11-27	2024-06-21	베링거 인겔하임 인터내셔날 게엠베하	리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
CA3070513C (fr)	2010-05-05	2023-01-03	Boehringer Ingelheim International Gmbh	Inhibiteur de dpp-4 a utiliser dans le traitement des transformations dela peau ou de la necrose
WO2011158252A1 (fr)	2010-06-15	2011-12-22	Matrix Laboratories Ltd	Méthode de préparation de la forme polymorphe ii du chlorhydrate de valacyclovir
KR20130093012A (ko)	2010-06-24	2013-08-21	베링거 인겔하임 인터내셔날 게엠베하	당뇨병 요법
AR083878A1 (es)	2010-11-15	2013-03-27	Boehringer Ingelheim Int	Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
CN102584825B (zh) *	2011-01-17	2014-04-02	四川科伦药物研究有限公司	一种合成盐酸伐昔洛韦的方法
DK2731947T3 (en)	2011-07-15	2019-04-23	Boehringer Ingelheim Int	SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES
US20140296520A1 (en) *	2011-11-25	2014-10-02	Piramal Enterprises Limited	Process for the preparation of valacyclovir hydrochloride
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
WO2013171167A1 (fr)	2012-05-14	2013-11-21	Boehringer Ingelheim International Gmbh	Dérivé de xanthine en tant qu'inhibiteur de dpp-4 pour l'utilisation dans le traitement de troubles associés aux podocytes et/ou un syndrome néphrotique
WO2013171166A1 (fr)	2012-05-14	2013-11-21	Boehringer Ingelheim International Gmbh	Dérivé de xanthine en tant qu'inhibiteur de dpp-4 pour l'utilisation dans le traitement de sirs et/ou d'une sepsie
WO2013174767A1 (fr)	2012-05-24	2013-11-28	Boehringer Ingelheim International Gmbh	Dérivé de xanthine en tant qu'inhibiteur de la dpp-4 à utiliser dans la modification de l'apport alimentaire et dans la régulation des préférences alimentaires
EP3110449B1 (fr)	2014-02-28	2023-06-28	Boehringer Ingelheim International GmbH	Utilisation médicale d'un inhibiteur de dpp-4
EP4233840A3 (fr)	2016-06-10	2023-10-18	Boehringer Ingelheim International GmbH	Combinaisons de linagliptine et de metformine
CN110437231B (zh) *	2019-09-04	2022-04-29	上药康丽（常州）药业有限公司	一种盐酸伐昔洛韦无水晶型ⅰ的制备方法
US20230218644A1 (en)	2020-04-16	2023-07-13	Som Innovation Biotech, S.A.	Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.
DE69426880T2 (de) *	1993-06-10	2001-10-31	Rolabo S.L., Zaragoza	Verfahren zur herstellung von aminosäureester von nukleosid analogen
GB9501178D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Guanine derivative

1995
- 1995-01-20 GB GBGB9501178.9A patent/GB9501178D0/en active Pending
1996
- 1996-01-19 RS YU3396A patent/RS49518B/sr unknown
- 1996-01-19 IL IL11683196A patent/IL116831A/en not_active IP Right Cessation
- 1996-01-19 DE DE69635106T patent/DE69635106T2/de not_active Expired - Lifetime
- 1996-01-19 RO RO97-01334A patent/RO118693B1/ro unknown
- 1996-01-19 HR HR960024A patent/HRP960024B1/xx not_active IP Right Cessation
- 1996-01-19 US US08/875,173 patent/US6107302A/en not_active Expired - Lifetime
- 1996-01-19 CA CA002210799A patent/CA2210799C/fr not_active Expired - Fee Related
- 1996-01-19 SI SI9630717T patent/SI0804436T1/sl unknown
- 1996-01-19 SK SK965-97A patent/SK285329B6/sk not_active IP Right Cessation
- 1996-01-19 ZA ZA96449A patent/ZA96449B/xx unknown
- 1996-01-19 DK DK96900631T patent/DK0804436T3/da active
- 1996-01-19 EP EP96900631A patent/EP0804436B1/fr not_active Expired - Lifetime
- 1996-01-19 EE EE9700175A patent/EE03528B1/xx not_active IP Right Cessation
- 1996-01-19 AU AU44539/96A patent/AU702794B2/en not_active Ceased
- 1996-01-19 KR KR1019970704916A patent/KR100376074B1/ko not_active Expired - Lifetime
- 1996-01-19 AP APAP/P/1997/001058A patent/AP662A/en active
- 1996-01-19 EA EA199700124A patent/EA000364B1/ru not_active IP Right Cessation
- 1996-01-19 AT AT96900631T patent/ATE302777T1/de not_active IP Right Cessation
- 1996-01-19 TR TR97/00656T patent/TR199700656T1/xx unknown
- 1996-01-19 CN CN96192662A patent/CN1049893C/zh not_active Expired - Fee Related
- 1996-01-19 NZ NZ298851A patent/NZ298851A/xx not_active IP Right Cessation
- 1996-01-19 FI FI973063A patent/FI973063L/fi not_active Application Discontinuation
- 1996-01-19 UA UA97084268A patent/UA46001C2/uk unknown
- 1996-01-19 ES ES96900631T patent/ES2248806T3/es not_active Expired - Lifetime
- 1996-01-19 JP JP52213196A patent/JP3176633B2/ja not_active Expired - Fee Related
- 1996-01-19 PL PL96321326A patent/PL182175B1/pl not_active IP Right Cessation
- 1996-01-19 CZ CZ0229497A patent/CZ297065B6/cs not_active IP Right Cessation
- 1996-01-19 AR ARP960101082A patent/AR002270A1/es not_active Application Discontinuation
- 1996-01-19 HU HU9801836A patent/HU222993B1/hu not_active IP Right Cessation
- 1996-01-19 BR BR9606768A patent/BR9606768A/pt active IP Right Grant
- 1996-01-19 GE GEAP19963845A patent/GEP20001940B/en unknown
- 1996-01-19 IN IN102MA1996 patent/IN182468B/en unknown
- 1996-01-19 WO PCT/GB1996/000117 patent/WO1996022291A1/fr not_active Ceased
1997
- 1997-07-15 IS IS4527A patent/IS2268B/is unknown
- 1997-07-16 OA OA70051A patent/OA10499A/en unknown
- 1997-07-18 NO NO19973326A patent/NO315558B1/no not_active IP Right Cessation
- 1997-08-14 BG BG101833A patent/BG63393B1/bg unknown
1999
- 1999-10-29 UY UY25779A patent/UY25779A1/es not_active IP Right Cessation
2005
- 2005-11-16 CY CY0500061A patent/CY2531B1/xx unknown

Also Published As

Publication number	Publication date
CY2531B1 (en)	2006-04-12
HUP9801836A3 (en)	1999-06-28
PL182175B1 (pl)	2001-11-30
IS2268B (is)	2007-07-15
TR199700656T1 (xx)	1998-03-21
MX9705462A (es)	1997-10-31
CA2210799C (fr)	2008-06-10
JPH11503718A (ja)	1999-03-30
GEP20001940B (en)	2000-02-05
YU3396A (sh)	1998-12-23
NO315558B1 (no)	2003-09-22
WO1996022291A1 (fr)	1996-07-25
CZ229497A3 (en)	1997-12-17
DK0804436T3 (da)	2005-12-27
SI0804436T1 (sl)	2006-02-28
IL116831A0 (en)	1996-05-14
SK285329B6 (sk)	2006-11-03
CA2210799A1 (fr)	1996-07-25
EE9700175A (et)	1998-02-16
AP9701058A0 (en)	1997-10-31
DE69635106T2 (de)	2006-06-08
IN182468B (fr)	1999-04-17
RO118693B1 (ro)	2003-09-30
PL321326A1 (en)	1997-12-08
AU702794B2 (en)	1999-03-04
JP3176633B2 (ja)	2001-06-18
UY25779A1 (es)	2000-08-21
AR002270A1 (es)	1998-03-11
KR19980701525A (ko)	1998-05-15
AP662A (en)	1998-08-19
BG63393B1 (bg)	2001-12-29
CN1049893C (zh)	2000-03-01
ZA96449B (en)	1996-08-07
FI973063A7 (fi)	1997-09-18
DE69635106D1 (de)	2005-09-29
FI973063L (fi)	1997-09-18
CN1179159A (zh)	1998-04-15
IL116831A (en)	1998-10-30
EE03528B1 (et)	2001-10-15
RS49518B (sr)	2006-10-27
NZ298851A (en)	1999-01-28
BR9606768A (pt)	1997-12-30
KR100376074B1 (ko)	2003-06-02
ES2248806T3 (es)	2006-03-16
HUP9801836A2 (hu)	1999-05-28
HRP960024A2 (en)	1997-10-31
BG101833A (bg)	1998-04-30
IS4527A (is)	1997-07-15
ATE302777T1 (de)	2005-09-15
GB9501178D0 (en)	1995-03-08
AU4453996A (en)	1996-08-07
EP0804436B1 (fr)	2005-08-24
EA000364B1 (ru)	1999-06-24
HU222993B1 (hu)	2004-01-28
CZ297065B6 (cs)	2006-08-16
NO973326D0 (no)	1997-07-18
NO973326L (no)	1997-09-16
EP0804436A1 (fr)	1997-11-05
SK96597A3 (en)	1998-02-04
OA10499A (en)	2002-04-10
EA199700124A1 (ru)	1997-12-30
UA46001C2 (uk)	2002-05-15
US6107302A (en)	2000-08-22
FI973063A0 (fi)	1997-07-18

Legal Events

Date	Code	Title	Description
1997-10-31	A1OB	Publication of a patent application
1998-01-13	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2005-08-31	B1PR	Patent granted
2010-01-08	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20100108 Year of fee payment: 15
2011-07-20	PBON	Lapse due to non-payment of renewal fee	Effective date: 20110120

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