HRP960267B1 - Novel crystal form of anhydrous 7-(/1'alpha, 5'alpha, 6'alpha/-6-amino-3-azabicyclo/3.1.0/hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt - Google Patents

Novel crystal form of anhydrous 7-(/1'alpha, 5'alpha, 6'alpha/-6-amino-3-azabicyclo/3.1.0/hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt

Info

Publication number
HRP960267B1
HRP960267B1 HR960267A HRP960267A HRP960267B1 HR P960267 B1 HRP960267 B1 HR P960267B1 HR 960267 A HR960267 A HR 960267A HR P960267 A HRP960267 A HR P960267A HR P960267 B1 HRP960267 B1 HR P960267B1
Authority
HR
Croatia
Prior art keywords
alpha
naphthyridine
azabicyclo
difluorophenyl
hex
Prior art date
Application number
HR960267A
Other languages
English (en)
Inventor
Lynne A Handanyan
Robert L Hendrickson
Phillip J Johnson
Thomas A Morris
Tymothy Norris
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of HRP960267A2 publication Critical patent/HRP960267A2/hr
Publication of HRP960267B1 publication Critical patent/HRP960267B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR960267A 1995-06-06 1996-06-06 Novel crystal form of anhydrous 7-(/1'alpha, 5'alpha, 6'alpha/-6-amino-3-azabicyclo/3.1.0/hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt HRP960267B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1995/007211 WO1996039406A1 (en) 1995-06-06 1995-06-06 NOVEL CRYSTAL FORM OF ANHYDROUS 7-([1α, 5α, 6α]-6-AMINO-3-AZABICYCLO[3.1.0]HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, METHANESULFONIC ACID SALT

Publications (2)

Publication Number Publication Date
HRP960267A2 HRP960267A2 (en) 1997-08-31
HRP960267B1 true HRP960267B1 (en) 2000-06-30

Family

ID=39431076

Family Applications (1)

Application Number Title Priority Date Filing Date
HR960267A HRP960267B1 (en) 1995-06-06 1996-06-06 Novel crystal form of anhydrous 7-(/1'alpha, 5'alpha, 6'alpha/-6-amino-3-azabicyclo/3.1.0/hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt

Country Status (38)

Country Link
US (1) US5763454A (da)
EP (1) EP0789697B1 (da)
JP (1) JP3145715B2 (da)
KR (1) KR100191989B1 (da)
CN (1) CN1055474C (da)
AR (1) AR002753A1 (da)
AU (1) AU703634B2 (da)
BG (1) BG62443B1 (da)
BR (1) BR9602630A (da)
CA (1) CA2223404C (da)
CZ (1) CZ285878B6 (da)
DE (1) DE69503066T2 (da)
DK (1) DK0789697T3 (da)
DZ (1) DZ2046A1 (da)
ES (1) ES2117426T3 (da)
FI (1) FI974441L (da)
HR (1) HRP960267B1 (da)
HU (1) HUP9601540A3 (da)
IL (1) IL118488A (da)
IS (1) IS4351A (da)
LV (1) LV11619B (da)
MA (1) MA23892A1 (da)
NO (1) NO305599B1 (da)
NZ (1) NZ286735A (da)
OA (1) OA10293A (da)
PE (1) PE38097A1 (da)
PL (1) PL314604A1 (da)
RU (1) RU2125571C1 (da)
SG (1) SG54339A1 (da)
SI (1) SI9600185A (da)
SK (1) SK280535B6 (da)
TN (1) TNSN96084A1 (da)
TW (2) TW580389B (da)
UA (1) UA44718C2 (da)
UY (1) UY25459A1 (da)
WO (1) WO1996039406A1 (da)
YU (1) YU34596A (da)
ZA (1) ZA964647B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
MA24500A1 (fr) 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
HN1998000106A (es) 1997-08-01 1999-01-08 Pfizer Prod Inc Composiciones parenterales de alatroflaxacino
DE19800214A1 (de) * 1998-01-06 1999-07-15 Knoll Ag Verfahren zur Herstellung von Doxazosin-Mcsylat in einer als Form A bezeichneten Kristallmodifikation und ein Zwischenprodukt dafür
US7019142B2 (en) * 1998-01-16 2006-03-28 Pfizer Inc. Process for preparing naphthyridones and intermediates
GB9818258D0 (en) * 1998-08-21 1998-10-14 Pfizer Ltd Antifungal compositions
HN1999000141A (es) * 1998-09-03 2000-06-19 Pfizer Prod Inc Procedimiento para preparar sales de trovafloxacina de adicion de acidos.
GB9820405D0 (en) * 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
ES2164520B1 (es) * 1999-03-16 2003-04-01 Medichem Sa "procedimiento de obtencion del polimorfo a del mesilato de doxazosina"
US6239141B1 (en) 1999-06-04 2001-05-29 Pfizer Inc. Trovafloxacin oral suspensions
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
CN102512364A (zh) * 2011-12-30 2012-06-27 天津市嵩锐医药科技有限公司 一种供注射用的甲磺酸阿拉曲伐沙星药物组合物
JP6420544B2 (ja) * 2013-01-11 2018-11-07 参天製薬株式会社 中栓とその中栓を備えた液体収容容器、及びノズルの先端構造とその構造を備えた液体収容容器

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2049777C1 (ru) * 1989-08-16 1995-12-10 Пфайзер Инк. Азабицикло-хинолон-карбоновые кислоты или их фармацевтически приемлемые кислотно-аддитивные соли и промежуточные продукты для их получения
US5164402A (en) * 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
PL179996B1 (en) * 1994-01-18 2000-11-30 Pfizer Method of and intermediate products for obtaining salts of naphtyridinocarboxylic acids
GB2289674A (en) * 1994-05-23 1995-11-29 Pfizer Antibacterial naphthyridine

Also Published As

Publication number Publication date
IS4351A (is) 1996-12-07
UA44718C2 (uk) 2002-03-15
KR100191989B1 (ko) 1999-06-15
MX9709873A (es) 1998-03-31
BR9602630A (pt) 1998-09-08
OA10293A (en) 1997-09-19
ES2117426T3 (es) 1998-08-01
ZA964647B (en) 1997-10-22
LV11619B (en) 1997-04-20
NZ286735A (en) 1998-01-26
TNSN96084A1 (fr) 2005-03-15
NO962321D0 (no) 1996-06-05
HUP9601540A2 (en) 1997-02-28
BG100639A (bg) 1997-02-28
EP0789697A1 (en) 1997-08-20
TW403751B (en) 2000-09-01
LV11619A (lv) 1996-12-20
PL314604A1 (en) 1996-12-09
CZ162596A3 (cs) 1998-09-16
HU9601540D0 (en) 1996-07-29
IL118488A0 (en) 1996-09-12
FI974441A7 (fi) 1997-12-05
FI974441A0 (fi) 1997-12-05
YU34596A (sh) 1999-03-04
SG54339A1 (en) 1998-11-16
DE69503066D1 (de) 1998-07-23
JP3145715B2 (ja) 2001-03-12
CN1148596A (zh) 1997-04-30
HRP960267A2 (en) 1997-08-31
UY25459A1 (es) 1999-11-17
CZ285878B6 (cs) 1999-11-17
WO1996039406A1 (en) 1996-12-12
AR002753A1 (es) 1998-04-29
TW580389B (en) 2004-03-21
NO962321L (no) 1996-12-09
SK280535B6 (sk) 2000-03-13
EP0789697B1 (en) 1998-06-17
FI974441L (fi) 1997-12-05
HUP9601540A3 (en) 1997-05-28
JPH10506650A (ja) 1998-06-30
US5763454A (en) 1998-06-09
KR970001352A (ko) 1997-01-24
SK71996A3 (en) 1997-03-05
BG62443B1 (bg) 1999-11-30
SI9600185A (en) 1997-04-30
DK0789697T3 (da) 1998-10-19
AU5474996A (en) 1996-12-19
AU703634B2 (en) 1999-03-25
RU2125571C1 (ru) 1999-01-27
IL118488A (en) 1999-01-26
MA23892A1 (fr) 1996-12-31
NO305599B1 (no) 1999-06-28
DE69503066T2 (de) 1998-10-15
CA2223404A1 (en) 1996-12-12
DZ2046A1 (fr) 2002-10-22
CN1055474C (zh) 2000-08-16
PE38097A1 (es) 1997-10-10
CA2223404C (en) 2001-01-16

Similar Documents

Publication Publication Date Title
HU9601540D0 (en) Novel crystal form of anhydrous 7-([1 , 5 , 6 ]-6-amino-3-azabicyclo[3.1.0]hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic-acid, methanesulfonic acid salt
AP9600817A0 (en) Novel cryatal form of anhydrous 7-( [1A,5A,6A]-6-amino3-3-azabicyclo [3.1.0.] hex-3-yl) -6-fluro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt.
HUT68251A (en) Antiviral 2-ethyl-1h-imidazo(4,5-c)quinolin-4-amines and pharmaceutical compositions containing them
FI104174B1 (fi) Menetelmä terapeuttisesti käyttökelpoisten, 1,4-dihydro-4-okso-3-kinoliinikarboksyylihapon 7-[S,S]-2,8-diatsabisyklo[4.3.0]nonaani-isomeeriven valmistamiseksi
GB8709448D0 (en) Heterobicyclic quinoline derivatives
HUP0101854A3 (en) The use of fumaric acid derivatives in transplant medicine
FI913510A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten, raseemisten tai optisesti aktiivisten pyrido/1,2-a/pyratsiinien valmistamiseksi
IT1307267B1 (it) Procedimento di rafforzamento di attivita' antitumorale di farmacigrezzi, composizione contenente un farmaco grezzo rafforzante
NO170330C (no) Fremgangsmaate for fremstilling av vesentlig optisk rent monohydrat av s-(-)-propyl-2',6'-pipekoloksylididhydroklorid
FI921641A7 (fi) Menetelmä lääkeaineina käyttökelpoisten 1-(pyrido/3,4-b/-1,4-oksatsin-4-yyli)-1H-indolien valmistamiseksi
IT1226548B (it) Benzazepine 3-sostituite ad attivita' farmaceutica
ES2003828A6 (es) Mejoras introducidas en el objeto de la patente principal n 552684 por un procedimiento para la obtencion de derivados 4 1 (5,6,7,8-tetrahidropirido(2,3-d)pirimidin-6-il-alquil-2 benzoil de acido l-glutamico
IL142695A0 (en) Crystal modification b of 8-cyano-1-cyclopropyl-7-(1s,6s,-2, 8-diazabicyclo [4.3.0] nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
AP9600851A0 (en) Novel crystal form of anhydrous 7-(1A,5A,6A) -6- amino-3- azabicyclo(3.1.0)hex-3-YL) -6- fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo1,8-naphthyridine S-3-carboxylic acid methanesulfonic acid salt
ATE167478T1 (de) Kristallform von wasserfreien 7-((1a,5a,6a)-6- amino-3-azabicyclo (3.1.0.) hex-3-yl)-6-fluoro-1- (2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8- naphthyridin-carbonsäure methanesulfonsäure salz
PL349394A1 (en) Crystal modification d of 8-cyano-1-cyclopropyl-7- (1s, 6s- 2,8- diazabicyclo- [4.3.0] nonan-8-yl) -6-fluoro -1,4-dihydro -4-oxo -3-quinoline carboxylic acid
EP0276805A3 (en) Substituted 3-phenyl-7h-thiazoloû3,2-b¨û1,2,4¨triazin-7-ones, processes for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds
KR950700295A (ko) 키랄 에틸(5-아미노-1,2-디히드로-2-메틸-3-페닐피리도[3,4-b]피라진-7-일)카르바메이트의 제조방법(Process for Preparing Chiral Ethyl(5-Amino-1,2-Dihydro-2-Methyl-3-Phenylpyrido[3,4-b]Pyrazin-7-yl(Carbamate)
EP0330468A3 (en) Use of heterocyclic derivatives as kappa-opioid receptor agonists in the treatment of cerebral ischaemia
PL299530A1 (en) Novel derivative of pyrido [3,2-3]-1,2-thiazine system
HU9203600D0 (en) Method for producing 1-phenyl-1a,2,3,4,6,7,12,12b-octahydro-pyrimido/1',6',:1,2/pyrido /3,4-b/ indole derivatives and pharmaceutical preparatives containing them
FI943730A0 (fi) Menetelmä angiotensiini-II-antagonistina aktiivisen 3-(2'-N-bentsoyylisulfonamido-bifen-4-yyli)metyyli-5,7-dimetyyli-2-etyyli-3H-imidatso/4,5-b/pyridiinin valmistamiseksi
ITMI910953A0 (it) Procedimento elettrochimico per la preparazione di lattami non sostituiti all'azoto
YU106787A (en) Process for obtaining monohydrate of optically pure s-(-)-1-propyl-2',6'pipecoloxylidid chlorinehydrate
ITPN920037A1 (it) Macchina rincalzatrice impiegabile particolarmente per la coltivazione di asparagi

Legal Events

Date Code Title Description
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
A1OB Publication of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20030415

Year of fee payment: 8

PBON Lapse due to non-payment of renewal fee

Effective date: 20040607