HRP970529B1 - Novel hydroxy and polyhydroxy derivatives of cumarin, preparation thereof and antiviral action thereof - Google Patents

Novel hydroxy and polyhydroxy derivatives of cumarin, preparation thereof and antiviral action thereof

Info

Publication number
HRP970529B1
HRP970529B1 HR970529A HRP970529A HRP970529B1 HR P970529 B1 HRP970529 B1 HR P970529B1 HR 970529 A HR970529 A HR 970529A HR P970529 A HRP970529 A HR P970529A HR P970529 B1 HRP970529 B1 HR P970529B1
Authority
HR
Croatia
Prior art keywords
preparation
antiviral action
polyhydroxy derivatives
cumarin
novel hydroxy
Prior art date
Application number
HR970529A
Other languages
English (en)
Inventor
Trkovnik Mladen
Ivezić Zrinka
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Priority to HR970529A priority Critical patent/HRP970529B1/xx
Priority to NZ332147A priority patent/NZ332147A/xx
Priority to EP98118508A priority patent/EP0906909B1/en
Priority to DK98118508T priority patent/DK0906909T3/da
Priority to CZ983143A priority patent/CZ314398A3/cs
Priority to JP10277382A priority patent/JP3139996B2/ja
Priority to SI9830141T priority patent/SI0906909T1/xx
Priority to PT98118508T priority patent/PT906909E/pt
Priority to HU9802178A priority patent/HUP9802178A3/hu
Priority to ES98118508T priority patent/ES2172072T3/es
Priority to CN98120642A priority patent/CN1101814C/zh
Priority to AT98118508T priority patent/ATE212625T1/de
Priority to DE69803642T priority patent/DE69803642T2/de
Priority to PL98328935A priority patent/PL328935A1/xx
Priority to CA002246052A priority patent/CA2246052A1/en
Priority to UA98105194A priority patent/UA63903C2/uk
Priority to AU87886/98A priority patent/AU747394B2/en
Priority to RU98118014/04A priority patent/RU2207338C2/ru
Priority to NO984590A priority patent/NO984590L/no
Priority to SK1367-98A priority patent/SK283173B6/sk
Priority to US09/165,424 priority patent/US6100409A/en
Priority to BG102813A priority patent/BG63543B1/bg
Publication of HRP970529A2 publication Critical patent/HRP970529A2/hr
Priority to US09/476,133 priority patent/US6291518B1/en
Priority to JP2000310091A priority patent/JP2001089466A/ja
Priority to JP2000310090A priority patent/JP2001089467A/ja
Publication of HRP970529B1 publication Critical patent/HRP970529B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
    • C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
    • C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
    • C07D311/48—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring with two such benzopyran radicals linked together by a carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR970529A 1997-10-02 1997-10-02 Novel hydroxy and polyhydroxy derivatives of cumarin, preparation thereof and antiviral action thereof HRP970529B1 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
HR970529A HRP970529B1 (en) 1997-10-02 1997-10-02 Novel hydroxy and polyhydroxy derivatives of cumarin, preparation thereof and antiviral action thereof
NZ332147A NZ332147A (en) 1997-10-02 1998-09-30 Hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids, preparation thereof and antiviral action against hiv thereof
EP98118508A EP0906909B1 (en) 1997-10-02 1998-09-30 Novel hydroxy and polyhydroxy derivatives of coumarin, peperation thereof and antiviral action thereof
DK98118508T DK0906909T3 (da) 1997-10-02 1998-09-30 Hydroxy- og polyhydroxyderivater af coumarin, deres fremstilling og antivirale virkning
CZ983143A CZ314398A3 (cs) 1997-10-02 1998-09-30 Nové hydroxyderiváty a polyhydroxyderiváty kumarinu, způsob jejich přípravy a jejich antivirový účinek
JP10277382A JP3139996B2 (ja) 1997-10-02 1998-09-30 新規ヒドロキシクマリン誘導体及びその製造方法
SI9830141T SI0906909T1 (en) 1997-10-02 1998-09-30 Novel hydroxy and polyhydroxy derivatives of coumarin, peperation thereof and antiviral action thereof
PT98118508T PT906909E (pt) 1997-10-02 1998-09-30 Novos derivados hidroxi e poli-hidroxi de coumarina, sua preparacao e sua accao antiviral
HU9802178A HUP9802178A3 (en) 1997-10-02 1998-09-30 Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof
ES98118508T ES2172072T3 (es) 1997-10-02 1998-09-30 Derivados hidroxi y polihidroxi de cumarina, su preparacion y su accion antiviral.
CN98120642A CN1101814C (zh) 1997-10-02 1998-09-30 新的香豆素羟基和多羟基衍生物,其制备和其抗病毒作用
AT98118508T ATE212625T1 (de) 1997-10-02 1998-09-30 Hydroxy und polyhydroxy derivate von coumarin, deren herstellung und deren antivirale wirkung
DE69803642T DE69803642T2 (de) 1997-10-02 1998-09-30 Hydroxy und Polyhydroxy Derivate von Coumarin, deren Herstellung und deren antivirale Wirkung
PL98328935A PL328935A1 (en) 1997-10-02 1998-10-01 Novel derivatives of hydroxy and polyhydroxy coumarins of antiviral action and method of obtaining them
CA002246052A CA2246052A1 (en) 1997-10-02 1998-10-01 Novel hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof
UA98105194A UA63903C2 (uk) 1997-10-02 1998-10-01 Гідрокси- та полігідроксипохідні кумарину, що проявляють антивірусну активність до вірусу віл-1, та спосіб їх одержання
AU87886/98A AU747394B2 (en) 1997-10-02 1998-10-01 Novel hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof
RU98118014/04A RU2207338C2 (ru) 1997-10-02 1998-10-01 Новые гидрокси- и полигидроксипроизводные кумарина и способ их получения
NO984590A NO984590L (no) 1997-10-02 1998-10-01 Nye hydroksy- og polyhydroksy-derivater av kumarin, fremstilling og anvendelse derav
SK1367-98A SK283173B6 (sk) 1997-10-02 1998-10-01 Hydroxyderiváty a polyhydroxyderiváty kumarínu, spôsob ich prípravy a ich použitie
US09/165,424 US6100409A (en) 1997-10-02 1998-10-02 Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof
BG102813A BG63543B1 (bg) 1997-10-02 1998-10-02 Нови хидрокси и полихидрокси производни на кумарина, получаването им и тяхното антивирусно действие
US09/476,133 US6291518B1 (en) 1997-10-02 2000-01-03 Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof
JP2000310091A JP2001089466A (ja) 1997-10-02 2000-10-11 新規ヒドロキシクマリン誘導体及びその製造方法
JP2000310090A JP2001089467A (ja) 1997-10-02 2000-10-11 新規ヒドロキシクマリン誘導体及びその製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR970529A HRP970529B1 (en) 1997-10-02 1997-10-02 Novel hydroxy and polyhydroxy derivatives of cumarin, preparation thereof and antiviral action thereof

Publications (2)

Publication Number Publication Date
HRP970529A2 HRP970529A2 (en) 1999-06-30
HRP970529B1 true HRP970529B1 (en) 2003-06-30

Family

ID=10946634

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970529A HRP970529B1 (en) 1997-10-02 1997-10-02 Novel hydroxy and polyhydroxy derivatives of cumarin, preparation thereof and antiviral action thereof

Country Status (22)

Country Link
US (2) US6100409A (cs)
EP (1) EP0906909B1 (cs)
JP (3) JP3139996B2 (cs)
CN (1) CN1101814C (cs)
AT (1) ATE212625T1 (cs)
AU (1) AU747394B2 (cs)
BG (1) BG63543B1 (cs)
CA (1) CA2246052A1 (cs)
CZ (1) CZ314398A3 (cs)
DE (1) DE69803642T2 (cs)
DK (1) DK0906909T3 (cs)
ES (1) ES2172072T3 (cs)
HR (1) HRP970529B1 (cs)
HU (1) HUP9802178A3 (cs)
NO (1) NO984590L (cs)
NZ (1) NZ332147A (cs)
PL (1) PL328935A1 (cs)
PT (1) PT906909E (cs)
RU (1) RU2207338C2 (cs)
SI (1) SI0906909T1 (cs)
SK (1) SK283173B6 (cs)
UA (1) UA63903C2 (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP970529B1 (en) * 1997-10-02 2003-06-30 Pliva Pharm & Chem Works Novel hydroxy and polyhydroxy derivatives of cumarin, preparation thereof and antiviral action thereof
FI20001593A7 (fi) * 2000-07-03 2002-01-04 Orion Yhtymo Oyj Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
CN1282944C (zh) 2000-12-10 2006-11-01 Vkr控股公司 遥控装置及其配置方法
EP1448543A1 (en) * 2001-10-01 2004-08-25 PLIVA-ISTRAZIVACKI INSTITUT d.o.o. Products of condensations of hydroxycoumarin derivatives with aromatic and aliphatic dialdehydes, their preparation and antiviral action thereof
HRP20030604A2 (en) * 2003-07-25 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromenes, preparation thereof andtheir antiinflammatory action
HRP20030603A2 (en) 2003-07-25 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromene compounds of antiinflammatory action
DE102004032440B4 (de) * 2004-07-05 2007-02-08 Bioplanta Arzneimittel Gmbh Verwendung von trisubstituierten Benzopyranonen
DE102009029050A1 (de) * 2009-08-31 2011-03-03 Evonik Oxeno Gmbh Organophosphorverbindungen basierend auf Tetraphenol(TP)-substituierten Strukturen
JP6863067B2 (ja) * 2017-05-17 2021-04-21 Dic株式会社 δ−バレロラクトン骨格含有樹脂
CN111297851B (zh) * 2020-04-02 2021-03-23 中国农业科学院蜜蜂研究所 香豆素在蜜蜂抗病毒感染中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU950728A1 (ru) * 1981-01-23 1982-08-15 Пермский государственный фармацевтический институт Способ получени 6-арил-3-ароил-4-окси-5-бромпиран-2-онов
RU2036917C1 (ru) * 1989-11-28 1995-06-09 Санкио Компани Лимитед Производные кумарина или их фармацевтически приемлемая соль
HUT63843A (en) * 1992-02-13 1993-10-28 Biosignal Kutato Fejlesztoe Kf Process for producing new kumarin derivatives and their analogs inhibiting mammal cell proliferation and tumour growth, as well as pharmaceutical comkpositions comprising such compounds
US5672607A (en) * 1993-01-29 1997-09-30 The United States Of America As Represented By The Department Of Health And Human Services Antiviral naphthoquinone compounds, compositions and uses thereof
HRP970529B1 (en) * 1997-10-02 2003-06-30 Pliva Pharm & Chem Works Novel hydroxy and polyhydroxy derivatives of cumarin, preparation thereof and antiviral action thereof

Also Published As

Publication number Publication date
ATE212625T1 (de) 2002-02-15
SI0906909T1 (en) 2002-06-30
EP0906909A1 (en) 1999-04-07
NO984590D0 (no) 1998-10-01
CZ314398A3 (cs) 1999-05-12
SK136798A3 (en) 1999-05-07
HUP9802178A3 (en) 2002-05-28
PT906909E (pt) 2002-07-31
SK283173B6 (sk) 2003-03-04
CA2246052A1 (en) 1999-04-02
AU747394B2 (en) 2002-05-16
NO984590L (no) 1999-04-06
HRP970529A2 (en) 1999-06-30
HUP9802178A2 (hu) 2000-05-28
AU8788698A (en) 1999-04-22
BG102813A (en) 1999-07-30
US6291518B1 (en) 2001-09-18
JP3139996B2 (ja) 2001-03-05
RU2207338C2 (ru) 2003-06-27
PL328935A1 (en) 1999-04-12
NZ332147A (en) 1999-05-28
CN1101814C (zh) 2003-02-19
DE69803642D1 (de) 2002-03-14
CN1220263A (zh) 1999-06-23
HU9802178D0 (en) 1998-11-30
DK0906909T3 (da) 2002-04-29
ES2172072T3 (es) 2002-09-16
JP2001089467A (ja) 2001-04-03
UA63903C2 (uk) 2004-02-16
BG63543B1 (bg) 2002-04-30
DE69803642T2 (de) 2002-10-02
JPH11158169A (ja) 1999-06-15
EP0906909B1 (en) 2002-01-30
JP2001089466A (ja) 2001-04-03
US6100409A (en) 2000-08-08

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