HU180425B - Process for the purification of casein hydrolysate - Google Patents

Process for the purification of casein hydrolysate Download PDF

Info

Publication number: HU180425B
Authority: HU; Hungary
Prior art keywords: casein hydrolyzate; hydrolyzate; casein; hydrolysis; purification
Prior art date: 1976-12-28

Application number

HU77BE1314A

Other languages

English (en)

French (fr)

Hungarian (hu)

Inventor

Hans Geipel

Klaus Rudnick

Original Assignee

Berlin Chemie Veb

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-12-28

Filing date

1977-12-28

Publication date

1983-03-28

1977-12-28 Application filed by Berlin Chemie Veb filed Critical Berlin Chemie Veb

1983-03-28 Publication of HU180425B publication Critical patent/HU180425B/hu

Links

238000000034 method Methods 0.000 title claims abstract description 13
238000000746 purification Methods 0.000 title claims description 3
108010079058 casein hydrolysate Proteins 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 19
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 18
239000000843 powder Substances 0.000 claims abstract description 10
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 8
239000000203 mixture Substances 0.000 claims abstract description 6
239000002904 solvent Substances 0.000 claims abstract description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
238000000605 extraction Methods 0.000 claims abstract description 3
-1 aliphatic alcohols Chemical class 0.000 claims abstract 3
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims abstract 2
239000005018 casein Substances 0.000 claims description 17
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 17
235000021240 caseins Nutrition 0.000 claims description 17
238000009835 boiling Methods 0.000 claims description 2
125000005907 alkyl ester group Chemical group 0.000 claims 2
230000007065 protein hydrolysis Effects 0.000 abstract description 3
238000009472 formulation Methods 0.000 abstract description 2
150000001298 alcohols Chemical class 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
235000021004 dietary regimen Nutrition 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000000047 product Substances 0.000 description 10
230000009965 odorless effect Effects 0.000 description 8
235000020776 essential amino acid Nutrition 0.000 description 7
239000003797 essential amino acid Substances 0.000 description 7
239000006227 byproduct Substances 0.000 description 6
230000007062 hydrolysis Effects 0.000 description 5
238000006460 hydrolysis reaction Methods 0.000 description 5
239000000243 solution Substances 0.000 description 5
238000001694 spray drying Methods 0.000 description 5
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 4
235000013922 glutamic acid Nutrition 0.000 description 4
239000004220 glutamic acid Substances 0.000 description 4
239000002198 insoluble material Substances 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 3
239000002253 acid Substances 0.000 description 3
235000003704 aspartic acid Nutrition 0.000 description 3
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 3
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 3
230000009967 tasteless effect Effects 0.000 description 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
239000004472 Lysine Substances 0.000 description 2
201000011252 Phenylketonuria Diseases 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
239000004473 Threonine Substances 0.000 description 2
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
150000001412 amines Chemical class 0.000 description 2
235000001014 amino acid Nutrition 0.000 description 2
229940024606 amino acid Drugs 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
150000003863 ammonium salts Chemical class 0.000 description 2
208000020832 chronic kidney disease Diseases 0.000 description 2
208000022831 chronic renal failure syndrome Diseases 0.000 description 2
230000000694 effects Effects 0.000 description 2
239000000796 flavoring agent Substances 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
235000013305 food Nutrition 0.000 description 2
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
239000003978 infusion fluid Substances 0.000 description 2
229960000310 isoleucine Drugs 0.000 description 2
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 2
229930182817 methionine Natural products 0.000 description 2
239000002304 perfume Substances 0.000 description 2
238000010992 reflux Methods 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000007921 spray Substances 0.000 description 2
239000004474 valine Substances 0.000 description 2
238000005406 washing Methods 0.000 description 2
101100456896 Drosophila melanogaster metl gene Proteins 0.000 description 1
239000004097 EU approved flavor enhancer Substances 0.000 description 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
108010009736 Protein Hydrolysates Proteins 0.000 description 1
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical class [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
235000004251 balanced diet Nutrition 0.000 description 1
244000309464 bull Species 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
238000004821 distillation Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
235000019264 food flavour enhancer Nutrition 0.000 description 1
235000014105 formulated food Nutrition 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000000463 material Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
239000003531 protein hydrolysate Substances 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000000926 separation method Methods 0.000 description 1
235000011121 sodium hydroxide Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
238000000967 suction filtration Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Seasonings (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

HU77BE1314A 1976-12-28 1977-12-28 Process for the purification of casein hydrolysate HU180425B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DD76196651A DD141235A3 (de)	1976-12-28	1976-12-28	Verfahren zur reinigung von proteinhydrolysaten

Publications (1)

Publication Number	Publication Date
HU180425B true HU180425B (en)	1983-03-28

Family

ID=5506904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU77BE1314A HU180425B (en)	1976-12-28	1977-12-28	Process for the purification of casein hydrolysate

Country Status (11)

Country	Link
BG (1)	BG40982A1 (de)
CS (1)	CS189550B1 (de)
DD (1)	DD141235A3 (de)
DE (1)	DE2751438A1 (de)
FI (1)	FI773940A7 (de)
FR (1)	FR2376158A1 (de)
GB (1)	GB1595499A (de)
HU (1)	HU180425B (de)
SE (1)	SE7714796L (de)
SU (1)	SU944529A1 (de)
YU (1)	YU315277A (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1212792B (it) *	1983-11-30	1989-11-30	Egidio Aldo Moja	Supplemento dietetico e alimento preconfezionato che lo contiene procedimento di preparazione e metodo di somministrazione

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2480654A (en) *	1947-07-29	1949-08-30	Merck & Co Inc	Recovery of arginine, histidine, and lysine from protein hydrolysates
DE1289400B (de) *	1965-07-19	1969-02-13	Maizena Werke Gmbh Deutsche	Verfahren zur Entfernung unerwuenschter Geschmackstoffe aus Eiweisshydrolysaten

1976
- 1976-12-28 DD DD76196651A patent/DD141235A3/de unknown
1977
- 1977-11-17 DE DE19772751438 patent/DE2751438A1/de not_active Withdrawn
- 1977-12-08 GB GB51135/77A patent/GB1595499A/en not_active Expired
- 1977-12-12 SU SU777770060A patent/SU944529A1/ru active
- 1977-12-15 CS CS778427A patent/CS189550B1/cs unknown
- 1977-12-22 YU YU03152/77A patent/YU315277A/xx unknown
- 1977-12-23 BG BG7738180A patent/BG40982A1/xx unknown
- 1977-12-27 SE SE7714796A patent/SE7714796L/ not_active Application Discontinuation
- 1977-12-27 FR FR7739310A patent/FR2376158A1/fr active Granted
- 1977-12-28 FI FI773940A patent/FI773940A7/fi not_active Application Discontinuation
- 1977-12-28 HU HU77BE1314A patent/HU180425B/hu unknown

Also Published As

Publication number	Publication date
FR2376158B1 (de)	1981-07-03
SE7714796L (sv)	1978-06-29
CS189550B1 (en)	1979-04-30
DE2751438A1 (de)	1978-06-29
YU315277A (en)	1983-06-30
SU944529A1 (ru)	1982-07-23
FI773940A7 (fi)	1978-06-29
BG40982A1 (en)	1987-04-15
GB1595499A (en)	1981-08-12
FR2376158A1 (fr)	1978-07-28
DD141235A3 (de)	1980-04-23

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