HU183053B - Process for heatstabilizing and form-stabilizing soft gelatine capsules containing active agents inside the envelope utilizable perlingual and buccal application - Google Patents
Process for heatstabilizing and form-stabilizing soft gelatine capsules containing active agents inside the envelope utilizable perlingual and buccal application Download PDFInfo
- Publication number
- HU183053B HU183053B HU80177A HU17780A HU183053B HU 183053 B HU183053 B HU 183053B HU 80177 A HU80177 A HU 80177A HU 17780 A HU17780 A HU 17780A HU 183053 B HU183053 B HU 183053B
- Authority
- HU
- Hungary
- Prior art keywords
- capsules
- film
- gelatine capsules
- soft gelatine
- gelatin
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 77
- 238000000034 method Methods 0.000 title claims abstract description 14
- 229920000159 gelatin Polymers 0.000 title claims description 47
- 235000019322 gelatine Nutrition 0.000 title claims description 47
- 239000001828 Gelatine Substances 0.000 title claims description 28
- 239000013543 active substance Substances 0.000 title description 2
- 239000007888 film coating Substances 0.000 claims abstract description 19
- 238000009501 film coating Methods 0.000 claims abstract description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 17
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 10
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 10
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 6
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000008298 dragée Substances 0.000 claims description 3
- 230000000087 stabilizing effect Effects 0.000 claims description 2
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 abstract description 18
- 239000004480 active ingredient Substances 0.000 abstract description 16
- 238000003860 storage Methods 0.000 abstract description 5
- 229920000642 polymer Polymers 0.000 abstract description 4
- 239000002904 solvent Substances 0.000 abstract description 3
- 230000002035 prolonged effect Effects 0.000 abstract description 2
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 28
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 21
- 108010010803 Gelatin Proteins 0.000 description 19
- 239000008273 gelatin Substances 0.000 description 19
- 235000011852 gelatine desserts Nutrition 0.000 description 19
- 229920001223 polyethylene glycol Polymers 0.000 description 17
- 239000002202 Polyethylene glycol Substances 0.000 description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 15
- 238000002360 preparation method Methods 0.000 description 14
- 239000011877 solvent mixture Substances 0.000 description 11
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 10
- 239000004922 lacquer Substances 0.000 description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 10
- 235000013772 propylene glycol Nutrition 0.000 description 10
- 239000002966 varnish Substances 0.000 description 9
- 238000003756 stirring Methods 0.000 description 8
- 239000007921 spray Substances 0.000 description 7
- 238000004544 sputter deposition Methods 0.000 description 7
- 229920003091 Methocel™ Polymers 0.000 description 6
- 238000005243 fluidization Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 5
- 239000004014 plasticizer Substances 0.000 description 5
- 229920002494 Zein Polymers 0.000 description 4
- 108010055615 Zein Proteins 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000005019 zein Substances 0.000 description 4
- 229940093612 zein Drugs 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- -1 hydroxypropyl Chemical group 0.000 description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 3
- 229920000609 methyl cellulose Polymers 0.000 description 3
- 239000001923 methylcellulose Substances 0.000 description 3
- 235000010981 methylcellulose Nutrition 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 229920003148 Eudragit® E polymer Polymers 0.000 description 2
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 2
- 229920003086 cellulose ether Polymers 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- WROUWQQRXUBECT-UHFFFAOYSA-N 2-ethylacrylic acid Chemical compound CCC(=C)C(O)=O WROUWQQRXUBECT-UHFFFAOYSA-N 0.000 description 1
- TYCHBDHDMFEQMC-UHFFFAOYSA-N 3-(dimethylamino)-2-methylprop-2-enoic acid Chemical compound CN(C)C=C(C)C(O)=O TYCHBDHDMFEQMC-UHFFFAOYSA-N 0.000 description 1
- 244000304337 Cuminum cyminum Species 0.000 description 1
- 235000007129 Cuminum cyminum Nutrition 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229920003083 Kollidon® VA64 Polymers 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 229920003072 Plasdone™ povidone Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229940097217 cardiac glycoside Drugs 0.000 description 1
- 239000002368 cardiac glycoside Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- FHHZOYXKOICLGH-UHFFFAOYSA-N dichloromethane;ethanol Chemical compound CCO.ClCCl FHHZOYXKOICLGH-UHFFFAOYSA-N 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- FYUWIEKAVLOHSE-UHFFFAOYSA-N ethenyl acetate;1-ethenylpyrrolidin-2-one Chemical compound CC(=O)OC=C.C=CN1CCCC1=O FYUWIEKAVLOHSE-UHFFFAOYSA-N 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
- 125000005395 methacrylic acid group Chemical class 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- NGVNAUIRSOXAJB-UHFFFAOYSA-N prop-1-ene-1,2-diol Chemical compound CC(O)=CO NGVNAUIRSOXAJB-UHFFFAOYSA-N 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 229930002534 steroid glycoside Natural products 0.000 description 1
- 150000008143 steroidal glycosides Chemical class 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Die Erfindung betrifft ein Verfahren zur thermischen Stabilisierung und Verbesserung der Formbestaendigkeit von den pharmazeutischen Wirkstoff in der Huelle enthaltenden Weichgelatine-Kapseln, bei dem man die Kapseln mit einem Filmueberzug aus einem filmbildenden, in Wasser loeslichen oder anquellbaren und in Loesungsmitteln loeslichen Polymeren versieht. Hierdurch werden die Eigenschaften der Weichgelatine-Kapseln unter Erhalt ihrer sonstigen vorteilhaften Eigenschaften verbessert. So sind beispielsweise die erhaltenen Weichgelatine-Kapseln temperaturbestaendig und weniger feuchtigkeitsempfindlich und sie kleben im Vorratsbehaelter auch nach laengerer Lagerung nicht zusammen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2903778A DE2903778C2 (de) | 1979-02-01 | 1979-02-01 | Verwendung von Hydroxypropylmethylcellulose zum Überziehen von den pharmazeutischen Wirkstoff in der Hülle enthaltenden Weichgelatine-Buccalkapseln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU183053B true HU183053B (en) | 1984-04-28 |
Family
ID=6061893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU80177A HU183053B (en) | 1979-02-01 | 1980-01-28 | Process for heatstabilizing and form-stabilizing soft gelatine capsules containing active agents inside the envelope utilizable perlingual and buccal application |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS55104212A (de) |
| AR (1) | AR223202A1 (de) |
| AT (1) | AT372607B (de) |
| AU (1) | AU5488780A (de) |
| BE (1) | BE881462A (de) |
| CA (1) | CA1142084A (de) |
| CS (1) | CS222299B2 (de) |
| DD (1) | DD148584A5 (de) |
| DE (1) | DE2903778C2 (de) |
| DK (1) | DK42880A (de) |
| FR (1) | FR2447720A1 (de) |
| GB (1) | GB2043442A (de) |
| GR (1) | GR70084B (de) |
| HU (1) | HU183053B (de) |
| IL (1) | IL59137A (de) |
| IT (1) | IT8067057A0 (de) |
| NL (1) | NL8000634A (de) |
| PT (1) | PT70706A (de) |
| SE (1) | SE8000467L (de) |
| ZA (1) | ZA80382B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5953410A (ja) * | 1982-09-20 | 1984-03-28 | Fujisawa Pharmaceut Co Ltd | 新型ソフトカプセル剤 |
| CH666405A5 (de) * | 1985-06-24 | 1988-07-29 | Ciba Geigy Ag | Feste, haltbare darreichungsformen mit elastischem filmueberzug. |
| US5068110A (en) * | 1987-09-29 | 1991-11-26 | Warner-Lambert Company | Stabilization of enteric coated dosage form |
| JPH02205A (ja) * | 1987-11-09 | 1990-01-05 | Taisho Pharmaceut Co Ltd | 香料含有ソフトカプセル用コーティング剤 |
| FR2698560B1 (fr) * | 1992-11-30 | 1995-02-03 | Virbac Laboratoires | Principes actifs pulvérulents stabilisés, compositions les contenant, leur procédé d'obtention et leurs applications. |
| US6030641A (en) * | 1997-06-03 | 2000-02-29 | Uni Colloid Kabushiki Kaisha | Sustained release capsule and method for preparing the same |
| US20070053972A1 (en) * | 2005-09-08 | 2007-03-08 | Cadbury Adams Usa Llc. | Gelatin capsules containing actives |
| KR20240037990A (ko) * | 2021-07-06 | 2024-03-22 | 알.피.쉐러 테크놀러지즈 엘엘씨 | 소프트겔 캡슐 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE695234C (de) * | 1937-10-30 | 1940-08-20 | Schering Ag | Verfahren zum Schutz von in fester, kristalliner Fersplittern |
| CH476499A (de) * | 1964-12-31 | 1969-08-15 | Ciba Geigy | Mischung zum Überziehen von Rektal-Kapseln |
| DE1617671C3 (de) * | 1967-03-07 | 1980-07-03 | A. Nattermann & Cie Gmbh, 5000 Koeln | Weichgelatine-Kapseln mit erhöhter Wärmestabilität |
| DE1767425B2 (de) * | 1968-05-09 | 1973-05-17 | R P Scherer GmbH, 6930 Eberbach | Verfahren zur herstellung von magensaftresistenten gelatinekapseln |
| BE757715A (fr) * | 1969-10-21 | 1971-04-20 | Ciba Geigy | Revetement pour capsules en gelatine et procede pour leur preparation |
-
1979
- 1979-02-01 DE DE2903778A patent/DE2903778C2/de not_active Expired
-
1980
- 1980-01-15 AT AT0019280A patent/AT372607B/de not_active IP Right Cessation
- 1980-01-16 IT IT8067057A patent/IT8067057A0/it unknown
- 1980-01-16 IL IL59137A patent/IL59137A/xx unknown
- 1980-01-17 PT PT70706A patent/PT70706A/de unknown
- 1980-01-21 SE SE8000467A patent/SE8000467L/ not_active Application Discontinuation
- 1980-01-21 GR GR60993A patent/GR70084B/el unknown
- 1980-01-23 DD DD80218609A patent/DD148584A5/de unknown
- 1980-01-23 ZA ZA00800382A patent/ZA80382B/xx unknown
- 1980-01-23 AU AU54887/80A patent/AU5488780A/en not_active Abandoned
- 1980-01-24 AR AR279725A patent/AR223202A1/es active
- 1980-01-25 JP JP769480A patent/JPS55104212A/ja active Pending
- 1980-01-25 GB GB8002576A patent/GB2043442A/en not_active Withdrawn
- 1980-01-28 FR FR8001763A patent/FR2447720A1/fr not_active Withdrawn
- 1980-01-28 HU HU80177A patent/HU183053B/hu unknown
- 1980-01-28 CS CS80585A patent/CS222299B2/cs unknown
- 1980-01-31 BE BE0/199196A patent/BE881462A/fr not_active IP Right Cessation
- 1980-01-31 NL NL8000634A patent/NL8000634A/nl not_active Application Discontinuation
- 1980-01-31 CA CA000344841A patent/CA1142084A/en not_active Expired
- 1980-01-31 DK DK42880A patent/DK42880A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS55104212A (en) | 1980-08-09 |
| AT372607B (de) | 1983-10-25 |
| FR2447720A1 (fr) | 1980-08-29 |
| IL59137A (en) | 1983-10-31 |
| IT8067057A0 (it) | 1980-01-16 |
| GB2043442A (en) | 1980-10-08 |
| CS222299B2 (en) | 1983-06-24 |
| AU5488780A (en) | 1980-08-07 |
| DE2903778C2 (de) | 1982-06-03 |
| BE881462A (fr) | 1980-05-16 |
| DE2903778A1 (de) | 1980-08-07 |
| DK42880A (da) | 1980-08-02 |
| PT70706A (de) | 1980-02-01 |
| DD148584A5 (de) | 1981-06-03 |
| ZA80382B (en) | 1981-01-28 |
| CA1142084A (en) | 1983-03-01 |
| NL8000634A (nl) | 1980-08-05 |
| SE8000467L (sv) | 1980-08-02 |
| ATA19280A (de) | 1983-03-15 |
| AR223202A1 (es) | 1981-07-31 |
| GR70084B (de) | 1982-07-30 |
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