HU184623B - Process for preparing new 4-deacetoxy-4-substituted-indole-dihydroindole derivatives - Google Patents
Process for preparing new 4-deacetoxy-4-substituted-indole-dihydroindole derivatives Download PDFInfo
- Publication number
- HU184623B HU184623B HU78EI818A HUEI000818A HU184623B HU 184623 B HU184623 B HU 184623B HU 78EI818 A HU78EI818 A HU 78EI818A HU EI000818 A HUEI000818 A HU EI000818A HU 184623 B HU184623 B HU 184623B
- Authority
- HU
- Hungary
- Prior art keywords
- hydroxy
- formula
- deacetoxy
- hydrogen
- methyl
- Prior art date
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- 238000004519 manufacturing process Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 claims abstract description 13
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- 229940127084 other anti-cancer agent Drugs 0.000 description 1
- 229960003552 other antineoplastic agent in atc Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000004544 spot-on Substances 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- KDQAABAKXDWYSZ-PNYVAJAMSA-N vinblastine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KDQAABAKXDWYSZ-PNYVAJAMSA-N 0.000 description 1
- 229960004982 vinblastine sulfate Drugs 0.000 description 1
- CXBGOBGJHGGWIE-IYJDUVQVSA-N vindoline Chemical compound CN([C@H]1[C@](O)([C@@H]2OC(C)=O)C(=O)OC)C3=CC(OC)=CC=C3[C@]11CCN3CC=C[C@]2(CC)[C@@H]13 CXBGOBGJHGGWIE-IYJDUVQVSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/848,837 US4122082A (en) | 1977-11-07 | 1977-11-07 | 4-Desacetoxy-4-oxovinblastine |
| US05/890,422 US4195022A (en) | 1978-03-27 | 1978-03-27 | 4-Desacetoxy-4α-hydroxyvinblastine and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU184623B true HU184623B (en) | 1984-09-28 |
Family
ID=27126805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU78EI818A HU184623B (en) | 1977-11-07 | 1978-11-04 | Process for preparing new 4-deacetoxy-4-substituted-indole-dihydroindole derivatives |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5473796A (it) |
| AR (1) | AR227620A1 (it) |
| CH (1) | CH638814A5 (it) |
| DK (1) | DK147302C (it) |
| FR (1) | FR2407935A1 (it) |
| GB (2) | GB2012260B (it) |
| HU (1) | HU184623B (it) |
| IE (1) | IE47489B1 (it) |
| IL (1) | IL55865A (it) |
| IT (1) | IT1100920B (it) |
| LU (1) | LU80474A1 (it) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU185691B (en) * | 1982-02-09 | 1985-03-28 | Richter Gedeon Vegyeszet | Process for preparing a new analgetic pharmaceutical composition |
| FR2894966B1 (fr) * | 2005-12-20 | 2008-03-14 | Pierre Fabre Medicament Sa | Nouvelle forme cristalline de la vinflunine |
| USD973040S1 (en) * | 2020-11-06 | 2022-12-20 | Lite-On Electronics (Guangzhou) Limited | Antenna monitoring tool box |
-
1978
- 1978-11-02 GB GB7843032A patent/GB2012260B/en not_active Expired
- 1978-11-02 GB GB8200664A patent/GB2089806B/en not_active Expired
- 1978-11-03 IT IT29435/78A patent/IT1100920B/it active
- 1978-11-03 AR AR274332A patent/AR227620A1/es active
- 1978-11-03 FR FR7831134A patent/FR2407935A1/fr active Granted
- 1978-11-03 LU LU80474A patent/LU80474A1/xx unknown
- 1978-11-03 IL IL55865A patent/IL55865A/xx unknown
- 1978-11-04 HU HU78EI818A patent/HU184623B/hu unknown
- 1978-11-06 IE IE2189/78A patent/IE47489B1/en unknown
- 1978-11-06 CH CH1141978A patent/CH638814A5/fr not_active IP Right Cessation
- 1978-11-06 DK DK494178A patent/DK147302C/da not_active IP Right Cessation
- 1978-11-07 JP JP13723678A patent/JPS5473796A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IE782189L (en) | 1979-05-07 |
| DK147302B (da) | 1984-06-12 |
| IL55865A0 (en) | 1979-01-31 |
| GB2012260A (en) | 1979-07-25 |
| FR2407935A1 (fr) | 1979-06-01 |
| FR2407935B1 (it) | 1981-06-26 |
| GB2089806B (en) | 1982-11-24 |
| LU80474A1 (fr) | 1979-03-19 |
| GB2012260B (en) | 1982-11-03 |
| IL55865A (en) | 1982-11-30 |
| IT1100920B (it) | 1985-09-28 |
| DK147302C (da) | 1985-01-02 |
| CH638814A5 (fr) | 1983-10-14 |
| GB2089806A (en) | 1982-06-30 |
| JPS5473796A (en) | 1979-06-13 |
| IE47489B1 (en) | 1984-04-04 |
| IT7829435A0 (it) | 1978-11-03 |
| DK494178A (da) | 1979-05-08 |
| AR227620A1 (es) | 1982-11-30 |
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