HU193923B - Process for preparing pyrimidine derivatives and pharmaceuticals comprising the same - Google Patents

Process for preparing pyrimidine derivatives and pharmaceuticals comprising the same Download PDF

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Publication number
HU193923B
HU193923B HU841409A HU140984A HU193923B HU 193923 B HU193923 B HU 193923B HU 841409 A HU841409 A HU 841409A HU 140984 A HU140984 A HU 140984A HU 193923 B HU193923 B HU 193923B
Authority
HU
Hungary
Prior art keywords
diamino
pyrimidine
formula
exo
azabicyclo
Prior art date
Application number
HU841409A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT34017A (en
Inventor
Ivan Kompts
Rita Locher
Hans Maag
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HUT34017A publication Critical patent/HUT34017A/hu
Publication of HU193923B publication Critical patent/HU193923B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU841409A 1983-04-14 1984-04-11 Process for preparing pyrimidine derivatives and pharmaceuticals comprising the same HU193923B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH200383 1983-04-14
CH63384 1984-02-10

Publications (2)

Publication Number Publication Date
HUT34017A HUT34017A (en) 1985-01-28
HU193923B true HU193923B (en) 1987-12-28

Family

ID=25685195

Family Applications (1)

Application Number Title Priority Date Filing Date
HU841409A HU193923B (en) 1983-04-14 1984-04-11 Process for preparing pyrimidine derivatives and pharmaceuticals comprising the same

Country Status (19)

Country Link
US (2) US4590270A (2)
EP (1) EP0122580B1 (2)
KR (1) KR840008352A (2)
AT (1) ATE30423T1 (2)
AU (1) AU567731B2 (2)
CA (1) CA1244028A (2)
DE (1) DE3466988D1 (2)
DK (1) DK169984A (2)
ES (3) ES531578A0 (2)
FI (1) FI841429A7 (2)
GR (1) GR81833B (2)
HU (1) HU193923B (2)
IE (1) IE57201B1 (2)
IL (1) IL71478A (2)
MC (1) MC1599A1 (2)
NO (1) NO158420C (2)
NZ (1) NZ207761A (2)
PH (1) PH20484A (2)
PT (1) PT78427B (2)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
US5260293A (en) * 1988-01-30 1993-11-09 Merck Sharp & Dohme Limited Pyrazines, pyrimidines and pyridazines useful in the treatment of senile dementia
JPH07509215A (ja) * 1990-11-14 1995-10-12 カイロン　コーポレイション ジヒドロ葉酸還元酵素の特異的阻害およびそのための化合物
GB9510459D0 (en) * 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
WO1997043286A1 (en) * 1996-05-13 1997-11-20 Zeneca Limited Bicyclic amines as insecticides
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
GB9624611D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
WO1998025924A1 (en) 1996-11-26 1998-06-18 Zeneca Limited 8-azabicyclo[3.2.1]octane-, 8-azabicyclo[3.2.1]oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives, their preparation and their use as insecticides
CA2289574C (en) 1997-05-30 2007-04-24 Neurosearch A/S 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors
EP2075014B9 (en) * 2002-05-24 2012-02-01 Angiotech International Ag Compositions and methods for coating medical implants
US8313760B2 (en) * 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
CN102649786B (zh) * 2011-02-28 2014-08-27 郑州福源动物药业有限公司 一种2，4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2，4-(1h，3h)嘧啶的制备方法
MX2018009504A (es) 2016-02-05 2019-05-06 Vyera Pharmaceuticals Llc Composiciones y metodos para tratar infecciones.
CN111225908A (zh) * 2017-08-07 2020-06-02 维耶拉制药有限责任公司 Dhfr抑制剂、组合物及其相关方法
US11472295B2 (en) 2018-12-27 2022-10-18 Msns, Llc Regenerative braking energy dissipater and system and method of using same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB762256A (en) * 1953-09-17 1956-11-28 Sterling Drug Inc Tertiary-amino-substituted compounds of the tropane and granatanine series
US3133073A (en) * 1959-12-10 1964-05-12 Sterling Drug Inc 3-aryl-1, 5-iminocycloalkanes and preparation thereof
JPS4911710A (2) * 1972-05-15 1974-02-01
US4008235A (en) * 1975-03-07 1977-02-15 Sterling Drug Inc. N-[2-(pyridinyl)-4-pyrimidinyl]ureas
US4053475A (en) * 1975-03-07 1977-10-11 Sterling Drug Inc. N-[2-(Pyridinyl)-4-pyrimidinyl]ureas preparation
US4109092A (en) * 1976-10-07 1978-08-22 Sterling Drug Inc. Preparation of 2-(pyridinyl)-4-pyrimidinamines
FR2476088A2 (fr) * 1979-01-16 1981-08-21 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
FR2493848B2 (fr) * 1980-11-07 1986-05-16 Delalande Sa Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives

Also Published As

Publication number Publication date
IE840919L (en) 1984-10-14
AU567731B2 (en) 1987-12-03
IL71478A0 (en) 1984-07-31
ES8602751A1 (es) 1985-12-01
EP0122580A1 (de) 1984-10-24
ES8601184A1 (es) 1985-11-01
CA1244028A (en) 1988-11-01
DE3466988D1 (en) 1987-12-03
ES8601925A1 (es) 1985-11-16
IL71478A (en) 1987-07-31
AU2664284A (en) 1984-10-18
KR840008352A (ko) 1984-12-14
FI841429A0 (fi) 1984-04-11
US4774249A (en) 1988-09-27
EP0122580B1 (de) 1987-10-28
PH20484A (en) 1987-01-16
HUT34017A (en) 1985-01-28
ATE30423T1 (de) 1987-11-15
PT78427B (en) 1986-08-22
DK169984D0 (da) 1984-03-27
IE57201B1 (en) 1992-06-03
US4590270A (en) 1986-05-20
PT78427A (en) 1984-05-01
ES531578A0 (es) 1985-12-01
GR81833B (2) 1984-12-12
DK169984A (da) 1984-10-15
ES539537A0 (es) 1985-11-01
ES539536A0 (es) 1985-11-16
FI841429L (fi) 1984-10-15
MC1599A1 (fr) 1985-05-09
FI841429A7 (fi) 1984-10-15
NO158420B (no) 1988-05-30
NO158420C (no) 1988-09-07
NO841508L (no) 1984-10-15
NZ207761A (en) 1987-01-23

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