HUE036265T2 - Új proNGF mutánsok és alkalmazásaik béta-NGF elõállításában - Google Patents
Új proNGF mutánsok és alkalmazásaik béta-NGF elõállításábanInfo
- Publication number
- HUE036265T2 HUE036265T2 HUE15157320A HUE15157320A HUE036265T2 HU E036265 T2 HUE036265 T2 HU E036265T2 HU E15157320 A HUE15157320 A HU E15157320A HU E15157320 A HUE15157320 A HU E15157320A HU E036265 T2 HUE036265 T2 HU E036265T2
- Authority
- HU
- Hungary
- Prior art keywords
- ngf
- beta
- applications
- new
- production
- Prior art date
Links
- 102100023995 Beta-nerve growth factor Human genes 0.000 title 1
- 101710129634 Beta-nerve growth factor Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Ophthalmology & Optometry (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11194208 | 2011-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE036265T2 true HUE036265T2 (hu) | 2018-06-28 |
Family
ID=47428641
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12805695A HUE027245T2 (hu) | 2011-12-19 | 2012-12-19 | Új prongf mutánsok és alkalmazásuk béta-NGF elõállítására |
| HUE15157320A HUE036265T2 (hu) | 2011-12-19 | 2012-12-19 | Új proNGF mutánsok és alkalmazásaik béta-NGF elõállításában |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12805695A HUE027245T2 (hu) | 2011-12-19 | 2012-12-19 | Új prongf mutánsok és alkalmazásuk béta-NGF elõállítására |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US9617322B2 (hu) |
| EP (2) | EP2907521B1 (hu) |
| JP (4) | JP6039146B2 (hu) |
| KR (2) | KR101837802B1 (hu) |
| CN (2) | CN104203264B (hu) |
| AU (1) | AU2012357052B2 (hu) |
| BR (1) | BR112014014913B1 (hu) |
| CA (1) | CA2859262C (hu) |
| CY (2) | CY1117016T1 (hu) |
| DK (2) | DK2907521T3 (hu) |
| EA (1) | EA031333B1 (hu) |
| ES (2) | ES2545701T3 (hu) |
| HR (2) | HRP20150900T1 (hu) |
| HU (2) | HUE027245T2 (hu) |
| IL (1) | IL233137A0 (hu) |
| LT (1) | LT2907521T (hu) |
| MX (2) | MX370861B (hu) |
| NO (1) | NO2907521T3 (hu) |
| PL (2) | PL2907521T3 (hu) |
| PT (2) | PT2907521T (hu) |
| RS (2) | RS56893B1 (hu) |
| SG (2) | SG10201605028VA (hu) |
| SI (2) | SI2907521T1 (hu) |
| SM (2) | SMT201800097T1 (hu) |
| TR (1) | TR201802360T4 (hu) |
| WO (1) | WO2013092776A1 (hu) |
| ZA (1) | ZA201403753B (hu) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104203264B (zh) | 2011-12-19 | 2018-08-28 | 瓦克化学有限公司 | 新型proNGF突变体及其在生产β-NGF中的用途 |
| WO2015038582A2 (en) * | 2013-09-11 | 2015-03-19 | New York University | Methods and compositions for treating bone diseases |
| EP3406259A1 (en) | 2017-05-24 | 2018-11-28 | Dompé farmaceutici S.p.A. | Neurotrophins for use in the treatment of hearing loss |
| CN108456681B (zh) * | 2018-03-26 | 2019-10-11 | 江苏中新医药有限公司 | 高效表达重组人神经生长因子的基因组合 |
| MA52351A (fr) | 2018-04-27 | 2021-05-26 | Chiesi Farm Spa | Production du facteur de croissance nerveuse (ngf) et de mutéines de celui-ci |
| CA3102755A1 (en) * | 2018-06-29 | 2020-01-02 | The Doshisha | Formulation containing emricasan |
| JP2022502359A (ja) | 2018-09-17 | 2022-01-11 | キエージ・フアルマチエウテイチ・エツセ・ピ・ア | 皮膚科障害の処置のための薬剤 |
| IT201900014646A1 (it) * | 2019-08-12 | 2021-02-12 | Consiglio Nazionale Ricerche | Peptide neurotrofico resistente alle proteasi per il trattamento terapeutico di patologie neurodegenerative e/o cutanee |
| HRP20241431T1 (hr) * | 2019-09-17 | 2024-12-20 | Chiesi Farmaceutici S.P.A. | Mutant ngf za upotrebu u liječenju ili prevenciji oftalmoloških poremećaja |
| IL302317A (en) | 2020-10-28 | 2023-06-01 | Dompe Farm Spa | Pharmaceutical packaging including polypropylene containers and aqueous formulations of NGF packed in them |
| EP4039269A1 (en) | 2021-02-05 | 2022-08-10 | Dompe' Farmaceutici S.P.A. | Ngf isoform for use in the treatment of ocular pathologies |
| WO2022221351A1 (en) | 2021-04-13 | 2022-10-20 | Dompé Farmaceutici S.P.A. | Treatment of neuropathic corneal pain with ngf |
| EP4311554A1 (en) | 2022-07-29 | 2024-01-31 | Dompé farmaceutici S.p.a. | Combination for use in ophthalmology |
| EP4316505A1 (en) | 2022-08-05 | 2024-02-07 | Dompé farmaceutici S.p.a. | Intranasal administration of ngf for the treatment of sensorineural hearing loss |
| EP4342485A1 (en) | 2022-09-23 | 2024-03-27 | Dompe' Farmaceutici S.P.A. | Ngf for the treatment of spasticity |
| EP4497431A1 (en) | 2023-07-27 | 2025-01-29 | Dompé farmaceutici S.p.A. | Pharmaceutical formulation comprising nerve growth factor |
| EP4623927A1 (en) | 2024-03-27 | 2025-10-01 | Dompe' Farmaceutici SpA | Ngf for use in the prevention or treatment of motor impairment caused by neonatal hypoxic-ischemic encephalopathy |
| EP4659759A1 (en) | 2024-06-04 | 2025-12-10 | Dompé farmaceutici SpA | Administration of ngf for the treatment of niemann-pick type c disease |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4139000A1 (de) * | 1991-11-27 | 1993-06-03 | Boehringer Mannheim Gmbh | Verfahren zur gentechnologischen herstellung von biologisch aktivem ss-ngf |
| US6261545B1 (en) * | 1996-09-13 | 2001-07-17 | Advanced Medicine Research Institute | Ophthalmic compositions of neurotrophic factors, remedies for optic nerve function disorders and method for treating optic nerve function disorders |
| ES2213861T3 (es) | 1998-10-09 | 2004-09-01 | Scil Proteins Gmbh | Procedimiento de obtencion de ngf-beta activa. |
| US20030040082A1 (en) | 2001-02-16 | 2003-02-27 | Mark Tuszynski | Mutant pro-neurotrophin with improved activity |
| CA2447986A1 (en) | 2001-05-25 | 2002-12-05 | Cornell Research Foundation, Inc. | High affinity ligand for p75 neurotrophin receptor |
| DE10360483B4 (de) | 2003-12-22 | 2007-11-15 | Scil Proteins Gmbh | Expressionsvektor und dessen Verwendung |
| DE602005010047D1 (de) * | 2004-01-19 | 2008-11-13 | Nsgene As | Nervenwachstumsfaktor sezernierende menschliche therapeutische zellen |
| US20080050776A1 (en) * | 2006-05-26 | 2008-02-28 | Kenneth Neet | Stable mutated pro nerve growth factors |
| CN101260398B (zh) | 2007-03-07 | 2013-06-05 | 舒泰神(北京)生物制药股份有限公司 | 神经生长因子基因定位改造动物及其制备方法和应用 |
| CN104203264B (zh) * | 2011-12-19 | 2018-08-28 | 瓦克化学有限公司 | 新型proNGF突变体及其在生产β-NGF中的用途 |
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2012
- 2012-12-19 CN CN201280062855.6A patent/CN104203264B/zh active Active
- 2012-12-19 BR BR112014014913-5A patent/BR112014014913B1/pt active IP Right Grant
- 2012-12-19 HR HRP20150900TT patent/HRP20150900T1/hr unknown
- 2012-12-19 MX MX2017012894A patent/MX370861B/es unknown
- 2012-12-19 LT LTEP15157320.1T patent/LT2907521T/lt unknown
- 2012-12-19 ES ES12805695.9T patent/ES2545701T3/es active Active
- 2012-12-19 ES ES15157320.1T patent/ES2657344T3/es active Active
- 2012-12-19 KR KR1020147019162A patent/KR101837802B1/ko active Active
- 2012-12-19 PL PL15157320T patent/PL2907521T3/pl unknown
- 2012-12-19 HU HUE12805695A patent/HUE027245T2/hu unknown
- 2012-12-19 SG SG10201605028VA patent/SG10201605028VA/en unknown
- 2012-12-19 SG SG11201402585PA patent/SG11201402585PA/en unknown
- 2012-12-19 PL PL12805695T patent/PL2672984T3/pl unknown
- 2012-12-19 DK DK15157320.1T patent/DK2907521T3/en active
- 2012-12-19 MX MX2014007317A patent/MX353074B/es active IP Right Grant
- 2012-12-19 PT PT151573201T patent/PT2907521T/pt unknown
- 2012-12-19 CN CN201711352074.1A patent/CN109400693A/zh active Pending
- 2012-12-19 KR KR1020167027254A patent/KR20160120788A/ko not_active Withdrawn
- 2012-12-19 RS RS20180159A patent/RS56893B1/sr unknown
- 2012-12-19 NO NO15157320A patent/NO2907521T3/no unknown
- 2012-12-19 WO PCT/EP2012/076251 patent/WO2013092776A1/en not_active Ceased
- 2012-12-19 EP EP15157320.1A patent/EP2907521B1/en active Active
- 2012-12-19 JP JP2014546588A patent/JP6039146B2/ja active Active
- 2012-12-19 SM SM20180097T patent/SMT201800097T1/it unknown
- 2012-12-19 US US14/366,460 patent/US9617322B2/en active Active
- 2012-12-19 PT PT128056959T patent/PT2672984E/pt unknown
- 2012-12-19 SI SI201231212T patent/SI2907521T1/en unknown
- 2012-12-19 EA EA201491155A patent/EA031333B1/ru unknown
- 2012-12-19 EP EP12805695.9A patent/EP2672984B1/en active Active
- 2012-12-19 DK DK12805695.9T patent/DK2672984T3/en active
- 2012-12-19 RS RS20150561A patent/RS54220B1/sr unknown
- 2012-12-19 AU AU2012357052A patent/AU2012357052B2/en active Active
- 2012-12-19 TR TR2018/02360T patent/TR201802360T4/tr unknown
- 2012-12-19 CA CA2859262A patent/CA2859262C/en active Active
- 2012-12-19 SI SI201230289T patent/SI2672984T1/sl unknown
- 2012-12-19 HU HUE15157320A patent/HUE036265T2/hu unknown
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2014
- 2014-05-22 ZA ZA2014/03753A patent/ZA201403753B/en unknown
- 2014-06-15 IL IL233137A patent/IL233137A0/en active IP Right Grant
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2015
- 2015-08-20 SM SM201500201T patent/SMT201500201B/xx unknown
- 2015-08-26 CY CY20151100747T patent/CY1117016T1/el unknown
- 2015-12-22 US US14/978,407 patent/US10308694B2/en active Active
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2016
- 2016-11-03 JP JP2016215749A patent/JP6622683B2/ja active Active
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2018
- 2018-02-21 HR HRP20180307TT patent/HRP20180307T1/hr unknown
- 2018-02-21 CY CY20181100195T patent/CY1119926T1/el unknown
- 2018-08-07 JP JP2018148261A patent/JP2019011330A/ja active Pending
- 2018-08-08 JP JP2018148957A patent/JP2019006781A/ja active Pending
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2019
- 2019-04-05 US US16/376,969 patent/US20200031893A1/en active Pending
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