HUE036265T2 - Új proNGF mutánsok és alkalmazásaik béta-NGF elõállításában - Google Patents

Új proNGF mutánsok és alkalmazásaik béta-NGF elõállításában

Info

Publication number
HUE036265T2
HUE036265T2 HUE15157320A HUE15157320A HUE036265T2 HU E036265 T2 HUE036265 T2 HU E036265T2 HU E15157320 A HUE15157320 A HU E15157320A HU E15157320 A HUE15157320 A HU E15157320A HU E036265 T2 HUE036265 T2 HU E036265T2
Authority
HU
Hungary
Prior art keywords
ngf
beta
applications
new
production
Prior art date
Application number
HUE15157320A
Other languages
English (en)
Inventor
Susan Lorey
Bernhard Janowski
Heiko Pultke
Daniela Kathmann
Antje Parthier
Andreas Anton
Original Assignee
Wacker Chemie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47428641&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE036265(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wacker Chemie Ag filed Critical Wacker Chemie Ag
Publication of HUE036265T2 publication Critical patent/HUE036265T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/48Nerve growth factor [NGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/185Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/165Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HUE15157320A 2011-12-19 2012-12-19 Új proNGF mutánsok és alkalmazásaik béta-NGF elõállításában HUE036265T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11194208 2011-12-19

Publications (1)

Publication Number Publication Date
HUE036265T2 true HUE036265T2 (hu) 2018-06-28

Family

ID=47428641

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE12805695A HUE027245T2 (hu) 2011-12-19 2012-12-19 Új prongf mutánsok és alkalmazásuk béta-NGF elõállítására
HUE15157320A HUE036265T2 (hu) 2011-12-19 2012-12-19 Új proNGF mutánsok és alkalmazásaik béta-NGF elõállításában

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HUE12805695A HUE027245T2 (hu) 2011-12-19 2012-12-19 Új prongf mutánsok és alkalmazásuk béta-NGF elõállítására

Country Status (27)

Country Link
US (3) US9617322B2 (hu)
EP (2) EP2907521B1 (hu)
JP (4) JP6039146B2 (hu)
KR (2) KR101837802B1 (hu)
CN (2) CN104203264B (hu)
AU (1) AU2012357052B2 (hu)
BR (1) BR112014014913B1 (hu)
CA (1) CA2859262C (hu)
CY (2) CY1117016T1 (hu)
DK (2) DK2907521T3 (hu)
EA (1) EA031333B1 (hu)
ES (2) ES2545701T3 (hu)
HR (2) HRP20150900T1 (hu)
HU (2) HUE027245T2 (hu)
IL (1) IL233137A0 (hu)
LT (1) LT2907521T (hu)
MX (2) MX370861B (hu)
NO (1) NO2907521T3 (hu)
PL (2) PL2907521T3 (hu)
PT (2) PT2907521T (hu)
RS (2) RS56893B1 (hu)
SG (2) SG10201605028VA (hu)
SI (2) SI2907521T1 (hu)
SM (2) SMT201800097T1 (hu)
TR (1) TR201802360T4 (hu)
WO (1) WO2013092776A1 (hu)
ZA (1) ZA201403753B (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104203264B (zh) 2011-12-19 2018-08-28 瓦克化学有限公司 新型proNGF突变体及其在生产β-NGF中的用途
WO2015038582A2 (en) * 2013-09-11 2015-03-19 New York University Methods and compositions for treating bone diseases
EP3406259A1 (en) 2017-05-24 2018-11-28 Dompé farmaceutici S.p.A. Neurotrophins for use in the treatment of hearing loss
CN108456681B (zh) * 2018-03-26 2019-10-11 江苏中新医药有限公司 高效表达重组人神经生长因子的基因组合
MA52351A (fr) 2018-04-27 2021-05-26 Chiesi Farm Spa Production du facteur de croissance nerveuse (ngf) et de mutéines de celui-ci
CA3102755A1 (en) * 2018-06-29 2020-01-02 The Doshisha Formulation containing emricasan
JP2022502359A (ja) 2018-09-17 2022-01-11 キエージ・フアルマチエウテイチ・エツセ・ピ・ア 皮膚科障害の処置のための薬剤
IT201900014646A1 (it) * 2019-08-12 2021-02-12 Consiglio Nazionale Ricerche Peptide neurotrofico resistente alle proteasi per il trattamento terapeutico di patologie neurodegenerative e/o cutanee
HRP20241431T1 (hr) * 2019-09-17 2024-12-20 Chiesi Farmaceutici S.P.A. Mutant ngf za upotrebu u liječenju ili prevenciji oftalmoloških poremećaja
IL302317A (en) 2020-10-28 2023-06-01 Dompe Farm Spa Pharmaceutical packaging including polypropylene containers and aqueous formulations of NGF packed in them
EP4039269A1 (en) 2021-02-05 2022-08-10 Dompe' Farmaceutici S.P.A. Ngf isoform for use in the treatment of ocular pathologies
WO2022221351A1 (en) 2021-04-13 2022-10-20 Dompé Farmaceutici S.P.A. Treatment of neuropathic corneal pain with ngf
EP4311554A1 (en) 2022-07-29 2024-01-31 Dompé farmaceutici S.p.a. Combination for use in ophthalmology
EP4316505A1 (en) 2022-08-05 2024-02-07 Dompé farmaceutici S.p.a. Intranasal administration of ngf for the treatment of sensorineural hearing loss
EP4342485A1 (en) 2022-09-23 2024-03-27 Dompe' Farmaceutici S.P.A. Ngf for the treatment of spasticity
EP4497431A1 (en) 2023-07-27 2025-01-29 Dompé farmaceutici S.p.A. Pharmaceutical formulation comprising nerve growth factor
EP4623927A1 (en) 2024-03-27 2025-10-01 Dompe' Farmaceutici SpA Ngf for use in the prevention or treatment of motor impairment caused by neonatal hypoxic-ischemic encephalopathy
EP4659759A1 (en) 2024-06-04 2025-12-10 Dompé farmaceutici SpA Administration of ngf for the treatment of niemann-pick type c disease

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4139000A1 (de) * 1991-11-27 1993-06-03 Boehringer Mannheim Gmbh Verfahren zur gentechnologischen herstellung von biologisch aktivem ss-ngf
US6261545B1 (en) * 1996-09-13 2001-07-17 Advanced Medicine Research Institute Ophthalmic compositions of neurotrophic factors, remedies for optic nerve function disorders and method for treating optic nerve function disorders
ES2213861T3 (es) 1998-10-09 2004-09-01 Scil Proteins Gmbh Procedimiento de obtencion de ngf-beta activa.
US20030040082A1 (en) 2001-02-16 2003-02-27 Mark Tuszynski Mutant pro-neurotrophin with improved activity
CA2447986A1 (en) 2001-05-25 2002-12-05 Cornell Research Foundation, Inc. High affinity ligand for p75 neurotrophin receptor
DE10360483B4 (de) 2003-12-22 2007-11-15 Scil Proteins Gmbh Expressionsvektor und dessen Verwendung
DE602005010047D1 (de) * 2004-01-19 2008-11-13 Nsgene As Nervenwachstumsfaktor sezernierende menschliche therapeutische zellen
US20080050776A1 (en) * 2006-05-26 2008-02-28 Kenneth Neet Stable mutated pro nerve growth factors
CN101260398B (zh) 2007-03-07 2013-06-05 舒泰神(北京)生物制药股份有限公司 神经生长因子基因定位改造动物及其制备方法和应用
CN104203264B (zh) * 2011-12-19 2018-08-28 瓦克化学有限公司 新型proNGF突变体及其在生产β-NGF中的用途

Also Published As

Publication number Publication date
PT2672984E (pt) 2015-10-01
AU2012357052B2 (en) 2015-06-25
CN104203264B (zh) 2018-08-28
EP2907521B1 (en) 2017-11-22
EP2672984B1 (en) 2015-05-27
NZ627054A (en) 2015-06-26
PT2907521T (pt) 2018-02-22
HRP20150900T1 (hr) 2015-10-09
JP2017071611A (ja) 2017-04-13
PL2907521T3 (pl) 2018-04-30
CA2859262A1 (en) 2013-06-27
DK2672984T3 (en) 2015-08-24
CN109400693A (zh) 2019-03-01
KR20160120788A (ko) 2016-10-18
HK1202055A1 (en) 2015-09-18
EP2907521A1 (en) 2015-08-19
JP6039146B2 (ja) 2016-12-07
ZA201403753B (en) 2015-11-25
MX370861B (es) 2020-01-08
HRP20180307T1 (hr) 2018-03-23
TR201802360T4 (tr) 2018-03-21
ES2545701T3 (es) 2015-09-15
RS56893B1 (sr) 2018-04-30
JP2019006781A (ja) 2019-01-17
NO2907521T3 (hu) 2018-04-21
WO2013092776A1 (en) 2013-06-27
DK2907521T3 (en) 2018-03-05
US9617322B2 (en) 2017-04-11
BR112014014913A2 (pt) 2017-06-13
CY1119926T1 (el) 2018-12-12
SG10201605028VA (en) 2016-07-28
CA2859262C (en) 2021-04-06
MX2014007317A (es) 2014-11-25
LT2907521T (lt) 2018-05-10
CN104203264A (zh) 2014-12-10
BR112014014913B1 (pt) 2020-12-01
KR20140103318A (ko) 2014-08-26
EP2672984A1 (en) 2013-12-18
JP6622683B2 (ja) 2019-12-18
HUE027245T2 (hu) 2016-10-28
AU2012357052A1 (en) 2014-07-24
PL2672984T3 (pl) 2015-10-30
MX353074B (es) 2017-12-19
EA031333B1 (ru) 2018-12-28
ES2657344T3 (es) 2018-03-02
JP2019011330A (ja) 2019-01-24
SI2907521T1 (en) 2018-03-30
US10308694B2 (en) 2019-06-04
US20150087020A1 (en) 2015-03-26
IL233137A0 (en) 2014-07-31
KR101837802B1 (ko) 2018-03-12
SMT201800097T1 (it) 2018-03-08
EA201491155A1 (ru) 2015-01-30
SG11201402585PA (en) 2014-10-30
US20160244496A1 (en) 2016-08-25
CY1117016T1 (el) 2017-04-05
RS54220B1 (sr) 2015-12-31
SMT201500201B (it) 2015-10-30
SI2672984T1 (sl) 2015-11-30
JP2015501828A (ja) 2015-01-19
US20200031893A1 (en) 2020-01-30

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