HUP0001022A2 - Arterioszklerozis és hiperlipoproteinémia kezelésére alkalmas 2-amino-szubsztituált piridinszármazékok, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Arterioszklerozis és hiperlipoproteinémia kezelésére alkalmas 2-amino-szubsztituált piridinszármazékok, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0001022A2 HUP0001022A2 HU0001022A HUP0001022A HUP0001022A2 HU P0001022 A2 HUP0001022 A2 HU P0001022A2 HU 0001022 A HU0001022 A HU 0001022A HU P0001022 A HUP0001022 A HU P0001022A HU P0001022 A2 HUP0001022 A2 HU P0001022A2
- Authority
- HU
- Hungary
- Prior art keywords
- powder
- pipe
- alkyl
- tube
- pipe powder
- Prior art date
Links
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 title 1
- 206010003210 Arteriosclerosis Diseases 0.000 title 1
- 208000031226 Hyperlipidaemia Diseases 0.000 title 1
- 208000011775 arteriosclerosis disease Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 29
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 102000012336 Cholesterol Ester Transfer Proteins Human genes 0.000 abstract 1
- 108010061846 Cholesterol Ester Transfer Proteins Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005282 allenyl group Chemical group 0.000 abstract 1
- UKFWSNCTAHXBQN-UHFFFAOYSA-N ammonium iodide Chemical group [NH4+].[I-] UKFWSNCTAHXBQN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19704243A DE19704243A1 (de) | 1997-02-05 | 1997-02-05 | Neue 2-Amino-substituierte Pyridine |
| PCT/EP1998/000362 WO1998034920A1 (de) | 1997-02-05 | 1998-01-23 | 2-amino-substituierte pyridine verwendbar zur behandlung von arteriosklerose und hyperlipoproteinemie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0001022A2 true HUP0001022A2 (hu) | 2000-09-28 |
Family
ID=7819326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001022A HUP0001022A2 (hu) | 1997-02-05 | 1998-01-23 | Arterioszklerozis és hiperlipoproteinémia kezelésére alkalmas 2-amino-szubsztituált piridinszármazékok, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0973744A1 (de) |
| JP (1) | JP2001510478A (de) |
| KR (1) | KR20000070756A (de) |
| CN (1) | CN1252057A (de) |
| AU (1) | AU730109B2 (de) |
| BG (1) | BG103631A (de) |
| BR (1) | BR9807181A (de) |
| CA (1) | CA2279636A1 (de) |
| CZ (1) | CZ279299A3 (de) |
| DE (1) | DE19704243A1 (de) |
| HU (1) | HUP0001022A2 (de) |
| ID (1) | ID24208A (de) |
| IL (1) | IL131127A0 (de) |
| NO (1) | NO993738L (de) |
| NZ (1) | NZ337011A (de) |
| PL (1) | PL334899A1 (de) |
| SK (1) | SK104099A3 (de) |
| TR (1) | TR199901857T2 (de) |
| WO (1) | WO1998034920A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19845402B4 (de) * | 1998-10-02 | 2005-04-07 | Aventis Pharma Deutschland Gmbh | Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| OA12625A (en) | 2001-06-22 | 2006-06-12 | Pfizer Prod Inc | Pharmaceutical compositions of adsorbates of amorphous drug. |
| JP2004534812A (ja) | 2001-06-22 | 2004-11-18 | ファイザー・プロダクツ・インク | 薬物および中性ポリマーの分散物の医薬組成物 |
| DE60320940D1 (de) | 2002-02-01 | 2008-06-26 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien |
| WO2004082675A1 (en) | 2003-03-17 | 2004-09-30 | Japan Tobacco Inc. | Method for increasing the oral bioavailability of s-[2- ([[1- (2-ethylbutyl) cyclohexyl] carbonyl] amino) phenyl] 2-methylpropanethioate |
| CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| BRPI0413277A (pt) | 2003-08-04 | 2006-10-10 | Pfizer Prod Inc | composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas |
| MXPA06003357A (es) | 2003-09-26 | 2006-06-08 | Japan Tobacco Inc | Metodo para inhibir la produccion de lipoproteina remanente. |
| DOP2005000123A (es) * | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
| WO2006032987A1 (en) * | 2004-09-23 | 2006-03-30 | Pfizer Products Inc. | Indoline compounds and their use in the treatment of arteriosclerosis |
| WO2006082518A1 (en) | 2005-02-03 | 2006-08-10 | Pfizer Products Inc. | Pharmaceutical compositions with enhanced performance |
| US20100113473A1 (en) | 2008-10-30 | 2010-05-06 | Player Mark R | Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169857A (en) * | 1988-01-20 | 1992-12-08 | Bayer Aktiengesellschaft | 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis |
-
1997
- 1997-02-05 DE DE19704243A patent/DE19704243A1/de not_active Withdrawn
-
1998
- 1998-01-23 CN CN98803916A patent/CN1252057A/zh active Pending
- 1998-01-23 ID IDW990821D patent/ID24208A/id unknown
- 1998-01-23 CA CA002279636A patent/CA2279636A1/en not_active Abandoned
- 1998-01-23 HU HU0001022A patent/HUP0001022A2/hu unknown
- 1998-01-23 NZ NZ337011A patent/NZ337011A/en unknown
- 1998-01-23 JP JP53369198A patent/JP2001510478A/ja active Pending
- 1998-01-23 CZ CZ992792A patent/CZ279299A3/cs unknown
- 1998-01-23 EP EP98904126A patent/EP0973744A1/de not_active Ceased
- 1998-01-23 IL IL13112798A patent/IL131127A0/xx unknown
- 1998-01-23 BR BR9807181-5A patent/BR9807181A/pt not_active IP Right Cessation
- 1998-01-23 WO PCT/EP1998/000362 patent/WO1998034920A1/de not_active Ceased
- 1998-01-23 KR KR1019997007015A patent/KR20000070756A/ko not_active Withdrawn
- 1998-01-23 SK SK1040-99A patent/SK104099A3/sk unknown
- 1998-01-23 TR TR1999/01857T patent/TR199901857T2/xx unknown
- 1998-01-23 AU AU62123/98A patent/AU730109B2/en not_active Ceased
- 1998-01-23 PL PL98334899A patent/PL334899A1/xx unknown
-
1999
- 1999-08-02 NO NO993738A patent/NO993738L/no not_active Application Discontinuation
- 1999-08-03 BG BG103631A patent/BG103631A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ279299A3 (cs) | 1999-11-17 |
| SK104099A3 (en) | 2000-01-18 |
| JP2001510478A (ja) | 2001-07-31 |
| BG103631A (en) | 2000-11-30 |
| IL131127A0 (en) | 2001-01-28 |
| AU6212398A (en) | 1998-08-26 |
| AU730109B2 (en) | 2001-02-22 |
| PL334899A1 (en) | 2000-03-27 |
| CN1252057A (zh) | 2000-05-03 |
| EP0973744A1 (de) | 2000-01-26 |
| TR199901857T2 (xx) | 1999-10-21 |
| NO993738D0 (no) | 1999-08-02 |
| ID24208A (id) | 2000-07-13 |
| NO993738L (no) | 1999-09-17 |
| KR20000070756A (ko) | 2000-11-25 |
| CA2279636A1 (en) | 1998-08-13 |
| NZ337011A (en) | 2001-04-27 |
| BR9807181A (pt) | 2000-01-25 |
| DE19704243A1 (de) | 1998-08-06 |
| WO1998034920A1 (de) | 1998-08-13 |
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