HUP0103660A2 - Mikróbaeredetű hialuronsavbontó enzimet tartalmazó gyógyászati készítmény - Google Patents

Mikróbaeredetű hialuronsavbontó enzimet tartalmazó gyógyászati készítmény Download PDF

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Publication number
HUP0103660A2
HUP0103660A2 HU0103660A HUP0103660A HUP0103660A2 HU P0103660 A2 HUP0103660 A2 HU P0103660A2 HU 0103660 A HU0103660 A HU 0103660A HU P0103660 A HUP0103660 A HU P0103660A HU P0103660 A2 HUP0103660 A2 HU P0103660A2
Authority
HU
Hungary
Prior art keywords
fragment
hyaluronate lyase
hyaluronate
enzyme
pharmaceutical composition
Prior art date
Application number
HU0103660A
Other languages
English (en)
Hungarian (hu)
Inventor
Albert Härtl
Peter-Jürgen Müller
Jörg-Hermann Ozegowski
Gundela Peschel
Norbert Presselt
Original Assignee
Id-Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1998160541 external-priority patent/DE19860541A1/de
Priority claimed from DE1998160542 external-priority patent/DE19860542A1/de
Application filed by Id-Pharma Gmbh filed Critical Id-Pharma Gmbh
Publication of HUP0103660A2 publication Critical patent/HUP0103660A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
    • C12Y402/02001—Hyaluronate lyase (4.2.2.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
HU0103660A 1998-12-23 1999-12-22 Mikróbaeredetű hialuronsavbontó enzimet tartalmazó gyógyászati készítmény HUP0103660A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1998160541 DE19860541A1 (de) 1998-12-23 1998-12-23 Pharazeutische Formulierung enthaltend glycosaminoglycanspaltendes Enzym
DE1998160542 DE19860542A1 (de) 1998-12-23 1998-12-23 Hyaluronatspaltendes Enzymfragment
PCT/DE1999/004108 WO2000039290A2 (de) 1998-12-23 1999-12-22 Pharmazeutische formulierung enthaltend ein hyaluronsäure-spaltendes enzym mikrobieller herkunft

Publications (1)

Publication Number Publication Date
HUP0103660A2 true HUP0103660A2 (hu) 2002-01-28

Family

ID=26051101

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103660A HUP0103660A2 (hu) 1998-12-23 1999-12-22 Mikróbaeredetű hialuronsavbontó enzimet tartalmazó gyógyászati készítmény

Country Status (10)

Country Link
EP (1) EP1056839A1 (de)
JP (1) JP2002533473A (de)
KR (1) KR20010041235A (de)
AU (1) AU3032400A (de)
CA (1) CA2318356A1 (de)
DE (1) DE19982882D2 (de)
HU (1) HUP0103660A2 (de)
IL (1) IL138051A0 (de)
PL (1) PL344745A1 (de)
WO (1) WO2000039290A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19963538A1 (de) * 1999-12-22 2001-07-05 Univ Schiller Jena Verwendung eines Enzyms zur Verbesserung der Geweberesorption von Arzneimitteln
DE10103271A1 (de) * 2001-01-23 2002-07-25 Knoell Hans Forschung Ev Pharmazeutische Formulierungen zur Erweichung von Bindegewebe, insbesondere zur Formkorrektur von Bindegewebe und Bindegewebestrukturen
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
NZ542873A (en) 2003-03-05 2008-07-31 Halozyme Inc Soluble, neutral-active hyaluronidase activity glycoprotein (sHASEGP) that is produced with high yield in a mammalian expression system by introducing nucleic acids that lack a narrow region encoding amino acids in the carboxy terminus of the human PH20 cDNA
US20060104968A1 (en) * 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
AU2003239763A1 (en) * 2003-05-27 2005-01-04 Friedrich-Schiller- Universität Jena Hyaluronate lyase-containing agent for treating acute myocardial infarction or symptoms thereof and for the treatment of postinfarction myocarditis and myocardial ischaemia
DE102007031417A1 (de) 2007-07-04 2009-01-08 Friedrich-Schiller-Universität Jena Hyaluronatlyase mit erhöhter Wirksamkeit, insbesondere für die Herstellung von pharmazeutischen Formulierungen und Medizinprodukten, sowie deren Verwendung
CN101855248B (zh) 2007-11-13 2012-08-22 生物技术通用（以色列）有限公司 用于粘弹性生物聚合物的稀释过滤灭菌方法
EA022752B1 (ru) 2008-12-09 2016-02-29 Галозим, Инк. Длинные растворимые полипептиды рн20 и их использование

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1120298A (en) * 1966-07-11 1968-07-17 Biorex Laboratories Ltd Stabilised enzymes
US3708575A (en) * 1970-05-13 1973-01-02 Biorex Laboratories Ltd Method for the treatment of atherosclerosis employing glucuronoglycos-aminoglycan-hyaluronate-lyase
US3728223A (en) * 1971-10-08 1973-04-17 Amano Pharma Co Ltd Production of hyaluronidase from a strain of streptomyces
ATE245452T1 (de) * 1998-12-23 2003-08-15 Esparma Gmbh Hyaluronatlyase als penetrationsförderer in topischen mitteln

Also Published As

Publication number Publication date
JP2002533473A (ja) 2002-10-08
EP1056839A1 (de) 2000-12-06
KR20010041235A (ko) 2001-05-15
CA2318356A1 (en) 2000-07-06
PL344745A1 (en) 2001-11-19
AU3032400A (en) 2000-07-31
IL138051A0 (en) 2001-10-31
DE19982882D2 (de) 2001-10-04
WO2000039290A2 (de) 2000-07-06
WO2000039290A8 (de) 2000-10-19
WO2000039290A3 (de) 2001-03-08

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