HUP0200418A2 - Új citokin zalpha 11 ligandum - Google Patents

Új citokin zalpha 11 ligandum

Info

Publication number
HUP0200418A2
HUP0200418A2 HU0200418A HUP0200418A HUP0200418A2 HU P0200418 A2 HUP0200418 A2 HU P0200418A2 HU 0200418 A HU0200418 A HU 0200418A HU P0200418 A HUP0200418 A HU P0200418A HU P0200418 A2 HUP0200418 A2 HU P0200418A2
Authority
HU
Hungary
Prior art keywords
ligand
human cytokine
zalpha
receptor
protein
Prior art date
Application number
HU0200418A
Other languages
English (en)
Inventor
Stacey R. Dillon
Donald C. Foster
Jane A. Gross
Angela K. Hammond
Richard D. Holly
Janet V. Johnston
Andrew J. Nelson
Julia E. Novak
Scott R. Presnell
Cindy A. Sprecher
Original Assignee
Zymogenetics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27385745&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0200418(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zymogenetics, Inc. filed Critical Zymogenetics, Inc.
Publication of HUP0200418A2 publication Critical patent/HUP0200418A2/hu
Publication of HUP0200418A3 publication Critical patent/HUP0200418A3/hu
Publication of HU229148B1 publication Critical patent/HU229148B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A találmány tárgyát zalpha11 ligandum polinukleotid és polipeptidmolekulák képezik. A zalpha11 ligandum egy új citokin. Apolipeptideket hematopoietikus sejtek in vitro és in vivoszaporodásának és/vagy fejlődésének stimulálására használjuk. Atalálmány tárgát képezik továbbá a fehérje előállítási módszerei, afehérje használata és az ellene készített ellenanyagok. Ó
HU0200418A 1999-03-09 2000-03-09 Human cytokine as ligand of the zalpha receptor and uses thereof HU229148B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26490899A 1999-03-09 1999-03-09
US26599299A 1999-03-11 1999-03-11
US14201399P 1999-07-01 1999-07-01
PCT/US2000/006067 WO2000053761A2 (en) 1999-03-09 2000-03-09 Human cytokine as ligand of the zalpha receptor and uses thereof

Publications (3)

Publication Number Publication Date
HUP0200418A2 true HUP0200418A2 (hu) 2002-05-29
HUP0200418A3 HUP0200418A3 (en) 2003-12-29
HU229148B1 HU229148B1 (en) 2013-09-30

Family

ID=27385745

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0200418A HU229148B1 (en) 1999-03-09 2000-03-09 Human cytokine as ligand of the zalpha receptor and uses thereof

Country Status (23)

Country Link
EP (3) EP1165791B1 (hu)
JP (1) JP4405686B2 (hu)
KR (1) KR100743640B1 (hu)
CN (5) CN1827639A (hu)
AT (1) ATE377076T1 (hu)
AU (2) AU777842B2 (hu)
BR (1) BR0008772B1 (hu)
CA (1) CA2366921C (hu)
CZ (1) CZ302921B6 (hu)
DE (1) DE60036930T2 (hu)
DK (1) DK1165791T3 (hu)
ES (1) ES2295019T3 (hu)
HU (1) HU229148B1 (hu)
IL (5) IL145288A0 (hu)
MX (1) MXPA01009074A (hu)
NO (2) NO331551B1 (hu)
NZ (1) NZ514708A (hu)
PL (1) PL207350B1 (hu)
PT (1) PT1165791E (hu)
RU (1) RU2346951C2 (hu)
UA (1) UA84387C2 (hu)
WO (1) WO2000053761A2 (hu)
ZA (1) ZA017370B (hu)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189400B2 (en) 1998-03-17 2007-03-13 Genetics Institute, Llc Methods of treatment with antagonists of MU-1
US6057128A (en) 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
US7198789B2 (en) 1998-03-17 2007-04-03 Genetics Institute, Llc Methods and compositions for modulating interleukin-21 receptor activity
DK1165791T3 (da) * 1999-03-09 2008-02-11 Zymogenetics Inc Humant cytokin som zalpha-receptor-ligand og anvendelse deraf
ES2629395T3 (es) * 2001-10-04 2017-08-09 Genetics Institute, Llc Métodos y composiciones para modular la actividad de la interleucina-21
MXPA04004167A (es) 2001-11-05 2004-07-08 Zymogenetics Inc Antagonistas de interleucina-21.
DK1531850T3 (da) * 2002-06-07 2012-06-04 Zymogenetics Inc Anvendelse af 1L-21 og monoklonalt antistof til behandling af solide cancere
CN1688340A (zh) 2002-07-15 2005-10-26 韦思公司 调节t辅助(th)细胞发育和功能的方法和组合物
JP2006525223A (ja) * 2002-10-11 2006-11-09 ノボ・ノルデイスク・エー／エス Ｉｌ２１の使用によるアレルギー症状の治療
RU2005113992A (ru) * 2002-10-11 2005-10-27 Ново Нордиск А/С (DK) Лечение аллергических состояний с использованием il-21
KR101098897B1 (ko) * 2002-12-13 2011-12-26 지모제넥틱스, 인코포레이티드 원핵생물 숙주 내 ｉｌ-21 생산
DE602004025332D1 (de) * 2003-03-14 2010-03-18 Wyeth Corp Antikörper gegen il21-rezeptor und deren verwendung
CA2529520A1 (en) * 2003-06-19 2004-12-29 Centocor, Inc. Interleukin-21 analogs
DE602004031341D1 (de) 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
DE602004031681D1 (de) * 2003-07-21 2011-04-14 Transgene Sa Multifunktionelle Cytokine
JP2007506789A (ja) * 2003-09-25 2007-03-22 ザイモジェネティクス， インコーポレイテッド Ｉｌ−２１を用いた自己免疫疾患の治療方法
EP2263684A1 (en) 2003-10-10 2010-12-22 Novo Nordisk A/S IL-21 derivatives
US20060228331A1 (en) 2003-10-10 2006-10-12 Novo Nordisk A/S IL-21 Derivatives and variants
ES2428358T3 (es) 2003-10-17 2013-11-07 Novo Nordisk A/S Terapia de combinación
EP1708737A2 (en) * 2004-01-15 2006-10-11 Novo Nordisk A/S Use of interleukin-21 for the treatment of autoimmune diseases and allograft rejection
ES2642214T3 (es) 2004-01-21 2017-11-15 Novo Nordisk Health Care Ag Conjugación de péptidos mediante transglutaminasa
GT200600148A (es) 2005-04-14 2006-11-22 Metodos para el tratamiento y la prevencion de fibrosis
MX2007012887A (es) 2005-04-18 2007-12-10 Novo Nordisk As Variantes il-21.
EP2805971A1 (en) * 2005-11-28 2014-11-26 ZymoGenetics, Inc. IL-21 antagonists
WO2008049920A2 (en) 2006-10-26 2008-05-02 Novo Nordisk A/S Il-21 variants
WO2008074863A1 (en) 2006-12-21 2008-06-26 Novo Nordisk A/S Interleukin-21 variants with altered binding to the il-21 receptor
EP3103813A1 (en) 2007-12-07 2016-12-14 ZymoGenetics, Inc. Anti-human il-21 monoclonal antibodies
RU2010152689A (ru) 2008-05-23 2012-06-27 УАЙТ ЭлЭлСи (US) Способы лечения с применением белков, связывающих рецептор интерлейкина-21
AR071885A1 (es) 2008-05-23 2010-07-21 Wyeth Corp Proteinas de union al receptor de interleuquina 21
US20100075329A1 (en) 2008-09-23 2010-03-25 O'toole Margot Methods for predicting production of activating signals by cross-linked binding proteins
CN102021196B (zh) * 2009-11-20 2013-06-26 上海杰隆生物工程股份有限公司 毕赤酵母生产重组人白细胞介素21的方法
CA2877933A1 (en) 2012-06-27 2014-01-03 Yuri Bushkin Rapid assays for t-cell activation by rna measurements using flow cytometry
WO2015110930A1 (en) 2014-01-24 2015-07-30 Pfizer Inc. Modified interleukin 21 receptor proteins
EP2982693A1 (en) * 2014-08-07 2016-02-10 Affimed Therapeutics AG CD3 binding domain
WO2021231923A1 (en) * 2020-05-14 2021-11-18 Metaclipse Therapeutics Corporation Compositions and methods for detecting and treating a sars-cov-2 infection
US12012441B2 (en) 2020-10-26 2024-06-18 Neptune Biosciences Llc Engineered human IL-21 cytokines and methods for using the same
CN112662694A (zh) * 2020-12-25 2021-04-16 康九生物科技(长春)有限公司 一种麦芽糖结合蛋白、麦芽糖结合蛋白表达载体、重组工程菌及其应用
JP2024536840A (ja) * 2021-09-26 2024-10-08 ウーシー バイオロジクス アイルランド リミテッド Ｉｌ－２バリアント及びその融合タンパク質

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU560472B2 (en) 1981-08-25 1987-04-09 Celltech Limited Yeast expression vectors
US4579821A (en) 1981-11-23 1986-04-01 University Patents, Inc. Control of DNA sequence transcription
US4656134A (en) 1982-01-11 1987-04-07 Board Of Trustees Of Leland Stanford Jr. University Gene amplification in eukaryotic cells
US4486533A (en) 1982-09-02 1984-12-04 St. Louis University Filamentous fungi functional replicating extrachromosomal element
US4599311A (en) 1982-08-13 1986-07-08 Kawasaki Glenn H Glycolytic promotersfor regulated protein expression: protease inhibitor
US4977092A (en) 1985-06-26 1990-12-11 Amgen Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
US4661454A (en) 1983-02-28 1987-04-28 Collaborative Research, Inc. GAL1 yeast promoter linked to non galactokinase gene
US5139936A (en) 1983-02-28 1992-08-18 Collaborative Research, Inc. Use of the GAL1 yeast promoter
US4650764A (en) 1983-04-12 1987-03-17 Wisconsin Alumni Research Foundation Helper cell
US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US4931373A (en) 1984-05-25 1990-06-05 Zymogenetics, Inc. Stable DNA constructs for expression of α-1 antitrypsin
US4766073A (en) 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
EP0184576B1 (en) 1984-12-06 1990-06-27 Fina Research S.A. Promoters for the expression of foreign genes in yeast, plasmids comprising them, and uses thereof for the production of polypeptides
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GR860984B (en) 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
US4882279A (en) 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US4935349A (en) 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
US4980289A (en) 1987-04-27 1990-12-25 Wisconsin Alumni Research Foundation Promoter deficient retroviral vector
US5063154A (en) 1987-06-24 1991-11-05 Whitehead Institute For Biomedical Research Pheromone - inducible yeast promoter
EP0721983A1 (en) 1988-01-22 1996-07-17 ZymoGenetics, Inc. Methods of producing biologically active peptide dimers
US5567584A (en) 1988-01-22 1996-10-22 Zymogenetics, Inc. Methods of using biologically active dimerized polypeptide fusions to detect PDGF
US4956288A (en) 1988-04-22 1990-09-11 Biogen, Inc. Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5162228A (en) 1988-12-28 1992-11-10 Takeda Chemical Industries, Ltd. Gylceraldehyde-3-phosphate dehydrogenase gene and promoter
US5124263A (en) 1989-01-12 1992-06-23 Wisconsin Alumni Research Foundation Recombination resistant retroviral helper cell and products produced thereby
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5162222A (en) 1989-07-07 1992-11-10 Guarino Linda A Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
US5298418A (en) 1991-09-16 1994-03-29 Boyce Thompson Institute For Plant Research, Inc. Cell line isolated from larval midgut tissue of Trichoplusia ni
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
CA2144651A1 (en) 1992-09-14 1994-03-31 Timothy J. Miller Immortalized cells and uses therefor
WO1995007358A1 (en) 1993-07-30 1995-03-16 University Of Medicine & Dentistry Of New Jersey Efficient gene transfer into primary lymphocytes
RU2220979C2 (ru) * 1993-08-12 2004-01-10 Иммьюнекс Корпорейшн ПОЛИПЕПТИД ЛИГАНДА flt3 (ВАРИАНТЫ), ПОЛИНУКЛЕОТИД(ВАРИАНТЫ), ЭКСПРЕССИРУЮЩИЙ ВЕКТОР(ВАРИАНТЫ), ЛИНИЯ КЛЕТОК СНО (ВАРИАНТЫ), СПОСОБ ПРОДУЦИРОВАНИЯ ПОЛИПЕПТИДА ЛИГАНДА flt3 (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ (ВАРИАНТЫ)
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5795966A (en) * 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
WO1997017450A2 (en) 1995-11-09 1997-05-15 Zymogenetics, Inc. Compositions and methods for producing heterologous polypeptides in pichia methanolica
CN1238806A (zh) 1996-07-17 1999-12-15 津莫吉尼蒂克斯公司 甲醇毕赤酵母营养突变体的制备
WO1998002565A1 (en) 1996-07-17 1998-01-22 Zymogenetics, Inc. TRANSFORMATION OF $i(PICHIA METHANOLICA)
ATE549918T1 (de) 1996-12-03 2012-04-15 Amgen Fremont Inc Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden
IL122818A0 (en) * 1997-07-10 1998-08-16 Yeda Res & Dev Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
US6057128A (en) * 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
DK1165791T3 (da) * 1999-03-09 2008-02-11 Zymogenetics Inc Humant cytokin som zalpha-receptor-ligand og anvendelse deraf
US9418201B1 (en) 2015-11-19 2016-08-16 International Business Machines Corporation Integration of functional analysis and common path pessimism removal in static timing analysis

Also Published As

Publication number Publication date
EP1881070B1 (en) 2012-10-03
CZ20013184A3 (cs) 2002-04-17
CA2366921C (en) 2013-12-17
UA84387C2 (ru) 2008-10-27
EP1165791A2 (en) 2002-01-02
NO20111085L (no) 2001-11-09
CN1927883A (zh) 2007-03-14
MXPA01009074A (es) 2002-03-27
EP1165791B1 (en) 2007-10-31
HUP0200418A3 (en) 2003-12-29
RU2004126135A (ru) 2006-02-10
IL145288A0 (en) 2002-06-30
EP2295577A3 (en) 2012-08-08
CN100500846C (zh) 2009-06-17
DE60036930D1 (de) 2007-12-13
KR20010103794A (ko) 2001-11-23
EP1881070A3 (en) 2008-03-05
JP2002537839A (ja) 2002-11-12
NO331551B1 (no) 2012-01-23
WO2000053761A2 (en) 2000-09-14
CZ302921B6 (cs) 2012-01-18
IL207424A (en) 2013-04-30
EP1881070A2 (en) 2008-01-23
IL195713A (en) 2010-11-30
IL207403A (en) 2012-03-29
NO20014364D0 (no) 2001-09-07
CN101575377B (zh) 2012-12-26
KR100743640B1 (ko) 2007-07-27
WO2000053761A3 (en) 2000-12-21
BR0008772B1 (pt) 2011-11-01
DK1165791T3 (da) 2008-02-11
CA2366921A1 (en) 2000-09-14
BR0008772A (pt) 2002-05-07
CN1378595A (zh) 2002-11-06
CN102406937A (zh) 2012-04-11
AU3731200A (en) 2000-09-28
DE60036930T2 (de) 2008-10-09
AU2005200240A1 (en) 2005-02-17
ZA017370B (en) 2002-06-26
PT1165791E (pt) 2008-01-16
ATE377076T1 (de) 2007-11-15
AU777842B2 (en) 2004-11-04
NZ514708A (en) 2005-01-28
ES2295019T3 (es) 2008-04-16
JP4405686B2 (ja) 2010-01-27
RU2346951C2 (ru) 2009-02-20
NO20014364L (no) 2001-11-09
EP2295577A2 (en) 2011-03-16
IL145288A (en) 2010-11-30
CN1827639A (zh) 2006-09-06
CN101575377A (zh) 2009-11-11
PL351160A1 (en) 2003-03-24
PL207350B1 (pl) 2010-12-31
CN1927883B (zh) 2011-09-21
HU229148B1 (en) 2013-09-30

Similar Documents

Publication Publication Date Title
UA84387C2 (ru) Человеческий цитокин как лиганд зальфа рецептора и его применение
HUP0402162A2 (hu) A humán angiopoietin-2 specifikus kötőanyagai
IL127558A0 (en) Hepatocyte growth factor receptor agonists and uses thereof
ZA200405388B (en) Binding proteins as biosensors
ZA200405390B (en) Entrapped binding proteins as biosensors
DK1053256T3 (da) Antistoffer mod Dødsreceptor 4 (DR4) og anvendelser deraf
ATE265219T1 (de) Verwendung von cxcr4 antagonisten zur behandlung von krebs und autoimmunkrankheiten
CY1118115T1 (el) Υποδοχεας κυτοκινης zcytor17
HUP0100436A2 (hu) Emlős citokinszerű polipeptid-10
ATE465255T1 (de) Verabreichung von sirnas
BRPI0507680A (pt) partìculas de fosfato de cálcio terapêuticas e métodos de fabricação e uso das mesmas
ATE440951T1 (de) Verlängerte cdns, die für sekretierte proteine kodieren
DE68929043D1 (de) Für androgen-rezeptor-protein kodierende dna
ZA200405389B (en) Binding proteins as biosensors
ATE495739T1 (de) Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa
AU2002241533A1 (en) Cytonkine receptor zcytor19
NO971341D0 (no) Promoter for reseptor tyrosinkinase TIE
NO20011460L (no) Cytokinreseptor zalphall
MXPA04001720A (es) Acido nucleicos bv8 y polipeptidos con actividad mitogenica.
BR9712793A (pt) Fatores homólogos (fhfs) ao fator do desenvolvimento de fibroblasto e métodos de uso
EP2116616A3 (en) Genes differentially expressed in activated T cells and uses thereof
HUP0400340A2 (hu) Polipeptidek immunogenitásának csökkentésére szolgáló eljárások
ATE363072T1 (de) Monoklonaler antikörper gegen mxa und mxb
ATE420890T1 (de) Isoleucyl-valyl-threonyl-asparaginyl-threonyl- threonin (ivtntt) enthaltende biologisch wirksame peptide
ATE321868T1 (de) Genkonstrukt zur aktivierung von arzneimittelvorstufen, das für eine heterologe, glycosylphophatidylinositol-modifizierte carboxypeptidase g2 und für ein zelloberfläche- gerichtetes signalpeptid kodiert

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees