HUP0300651A2 - Nátrium-hidrogén-cserélő 1-es típusú inhibitor (NHE-1) alkalmazása gyógyszerkészítmények előállítására és ezt tartalmazó gyógyszerkészítmények - Google Patents

Nátrium-hidrogén-cserélő 1-es típusú inhibitor (NHE-1) alkalmazása gyógyszerkészítmények előállítására és ezt tartalmazó gyógyszerkészítmények Download PDF

Info

Publication number: HUP0300651A2
Authority: HU; Hungary
Prior art keywords: tissue; compound; prodrug; pharmaceutically acceptable; acceptable salt
Prior art date: 2000-04-28

Application number

HU0300651A

Other languages

English (en)

Hungarian (hu)

Inventor

Weichao George Chen

Eric David Cox

Angel Guzman-Perez

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-28

Filing date

2001-02-28

Publication date

2003-07-28

2001-02-28 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2003-07-28 Publication of HUP0300651A2 publication Critical patent/HUP0300651A2/hu

Links

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239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000012453 solvate Substances 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
230000036262 stenosis Effects 0.000 description 1
208000037804 stenosis Diseases 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
230000035488 systolic blood pressure Effects 0.000 description 1
239000003826 tablet Substances 0.000 description 1
238000004885 tandem mass spectrometry Methods 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000002537 thrombolytic effect Effects 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
230000009092 tissue dysfunction Effects 0.000 description 1
230000000287 tissue oxygenation Effects 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
239000006211 transdermal dosage form Substances 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical compound C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
229960000281 trometamol Drugs 0.000 description 1
210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Treatment Of Water By Ion Exchange (AREA)
Preventing Corrosion Or Incrustation Of Metals (AREA)
Plural Heterocyclic Compounds (AREA)

HU0300651A 2000-04-28 2001-02-28 Nátrium-hidrogén-cserélő 1-es típusú inhibitor (NHE-1) alkalmazása gyógyszerkészítmények előállítására és ezt tartalmazó gyógyszerkészítmények HUP0300651A2 (hu)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20043200P	2000-04-28	2000-04-28
PCT/IB2001/000277 WO2001083470A1 (en)	2000-04-28	2001-02-28	Sodium-hydrogen exchanger type 1 inhibitor (nhe-1)

Publications (1)

Publication Number	Publication Date
HUP0300651A2 true HUP0300651A2 (hu)	2003-07-28

Family

ID=22741697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0300651A HUP0300651A2 (hu)	2000-04-28	2001-02-28	Nátrium-hidrogén-cserélő 1-es típusú inhibitor (NHE-1) alkalmazása gyógyszerkészítmények előállítására és ezt tartalmazó gyógyszerkészítmények

Country Status (40)

Country	Link
EP (1)	EP1276737A1 (pl)
JP (1)	JP2003531900A (pl)
KR (1)	KR20020093079A (pl)
CN (1)	CN1225466C (pl)
AP (1)	AP2002002651A0 (pl)
AR (1)	AR028375A1 (pl)
AU (1)	AU2001235896A1 (pl)
BG (1)	BG107139A (pl)
BR (1)	BR0110268A (pl)
CA (1)	CA2407535A1 (pl)
CO (1)	CO5221125A1 (pl)
CR (1)	CR6797A (pl)
CZ (1)	CZ20023408A3 (pl)
DZ (1)	DZ3310A1 (pl)
EA (1)	EA004882B1 (pl)
EE (1)	EE200200615A (pl)
GT (1)	GT200100064A (pl)
HN (1)	HN2001000042A (pl)
HR (1)	HRP20020851A2 (pl)
HU (1)	HUP0300651A2 (pl)
IL (1)	IL152075A0 (pl)
IS (2)	IS6567A (pl)
MA (1)	MA26897A1 (pl)
MX (1)	MXPA02010600A (pl)
MY (1)	MY133842A (pl)
NO (1)	NO20025132L (pl)
NZ (1)	NZ521348A (pl)
OA (1)	OA12256A (pl)
PA (1)	PA8513301A1 (pl)
PE (1)	PE20011270A1 (pl)
PL (1)	PL357765A1 (pl)
SK (1)	SK14872002A3 (pl)
SV (1)	SV2002000418A (pl)
TN (1)	TNSN01065A1 (pl)
TR (1)	TR200202439T2 (pl)
UA (1)	UA73348C2 (pl)
UY (1)	UY26680A1 (pl)
WO (1)	WO2001083470A1 (pl)
YU (1)	YU79602A (pl)
ZA (1)	ZA200208605B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1479737A (zh) *	2001-01-31	2004-03-03	�Ʒ�	钠-质子交换蛋白1型抑制剂的乙醇盐
EP1456181A1 (en) *	2001-12-19	2004-09-15	Pfizer Products Inc.	Methods for preparing sodium-hydrogen exchanger type-1 inhibitors
MXPA04008646A (es) *	2002-05-02	2004-12-06	Pfizer Prod Inc	Tratamiento para la diabetes y complicaciones diabeticas con inhibidores del nhe-1.
FR2840302B1 (fr) *	2002-06-03	2004-07-16	Aventis Pharma Sa	Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
ES2220185B1 (es) *	2002-07-16	2006-04-01	Consejo Sup. De Investig. Cientificas	Nuevo peptido inhibidor del intercambiador na+/h+ (pinhe), y sus aplicaciones.
PL378111A1 (pl) *	2003-02-14	2006-03-06	Smithkline Beecham Corporation	Nowe związki
RU2518741C1 (ru) *	2013-03-22	2014-06-10	Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ"	СРЕДСТВО, ИНГИБИРУЮЩЕЕ Na+/H+-ОБМЕН, И ГАЛОГЕНИДЫ 1-ДИАЛКИЛАМИНОЭТИЛ-3-[ЗАМЕЩЕННЫЙ(ДИЗАМЕЩЕННЫЙ) ФЕНАЦИЛ]-2-АМИНОБЕНЗИМИДАЗОЛИЯ

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1056729E (pt) *	1998-02-27	2005-04-29	Pfizer Prod Inc	Derivados de n-[ciclo di- ou tri-aza di-insaturado de cinco membros substituido) carbonil] guanidina para o tratamento de isquemia

2001
- 2001-02-28 EP EP01908037A patent/EP1276737A1/en not_active Withdrawn
- 2001-02-28 NZ NZ521348A patent/NZ521348A/en unknown
- 2001-02-28 AU AU2001235896A patent/AU2001235896A1/en not_active Abandoned
- 2001-02-28 PL PL01357765A patent/PL357765A1/pl not_active Application Discontinuation
- 2001-02-28 MX MXPA02010600A patent/MXPA02010600A/es active IP Right Grant
- 2001-02-28 EA EA200201023A patent/EA004882B1/ru not_active IP Right Cessation
- 2001-02-28 CZ CZ20023408A patent/CZ20023408A3/cs unknown
- 2001-02-28 TR TR2002/02439T patent/TR200202439T2/xx unknown
- 2001-02-28 CN CNB018087256A patent/CN1225466C/zh not_active Expired - Fee Related
- 2001-02-28 IL IL15207501A patent/IL152075A0/xx unknown
- 2001-02-28 KR KR1020027014355A patent/KR20020093079A/ko not_active Abandoned
- 2001-02-28 CA CA002407535A patent/CA2407535A1/en not_active Abandoned
- 2001-02-28 WO PCT/IB2001/000277 patent/WO2001083470A1/en not_active Ceased
- 2001-02-28 SK SK1487-2002A patent/SK14872002A3/sk unknown
- 2001-02-28 YU YUP-796/02A patent/YU79602A/sh unknown
- 2001-02-28 HU HU0300651A patent/HUP0300651A2/hu unknown
- 2001-02-28 OA OA1200200331A patent/OA12256A/en unknown
- 2001-02-28 AP APAP/P/2002/002651A patent/AP2002002651A0/en unknown
- 2001-02-28 BR BR0110268-0A patent/BR0110268A/pt not_active IP Right Cessation
- 2001-02-28 HR HR20020851A patent/HRP20020851A2/hr not_active Application Discontinuation
- 2001-02-28 UA UA2002108497A patent/UA73348C2/uk unknown
- 2001-02-28 JP JP2001580898A patent/JP2003531900A/ja active Pending
- 2001-02-28 EE EEP200200615A patent/EE200200615A/xx unknown
- 2001-02-28 DZ DZ013310A patent/DZ3310A1/fr active
- 2001-03-06 HN HN2001000042A patent/HN2001000042A/es unknown
- 2001-03-12 PA PA20018513301A patent/PA8513301A1/es unknown
- 2001-04-20 GT GT200100064A patent/GT200100064A/es unknown
- 2001-04-24 UY UY26680A patent/UY26680A1/es not_active Application Discontinuation
- 2001-04-26 AR ARP010101970A patent/AR028375A1/es unknown
- 2001-04-26 MY MYPI20011977A patent/MY133842A/en unknown
- 2001-04-26 PE PE2001000376A patent/PE20011270A1/es not_active Application Discontinuation
- 2001-04-27 SV SV2001000418A patent/SV2002000418A/es not_active Application Discontinuation
- 2001-04-27 TN TNTNSN01065A patent/TNSN01065A1/fr unknown
- 2001-04-27 CO CO01032977A patent/CO5221125A1/es not_active Application Discontinuation
2002
- 2002-09-23 BG BG107139A patent/BG107139A/bg unknown
- 2002-09-24 IS IS6567A patent/IS6567A/is unknown
- 2002-10-18 MA MA26875A patent/MA26897A1/fr unknown
- 2002-10-18 CR CR6797A patent/CR6797A/es not_active Application Discontinuation
- 2002-10-21 IS IS6588A patent/IS6588A/is unknown
- 2002-10-24 ZA ZA200208605A patent/ZA200208605B/en unknown
- 2002-10-25 NO NO20025132A patent/NO20025132L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CR6797A (es)	2004-05-17
CZ20023408A3 (cs)	2004-01-14
BR0110268A (pt)	2003-12-30
AU2001235896A1 (en)	2001-11-12
AR028375A1 (es)	2003-05-07
DZ3310A1 (fr)	2001-11-07
NO20025132L (no)	2002-12-12
CN1225466C (zh)	2005-11-02
EA200201023A1 (ru)	2003-02-27
NO20025132D0 (no)	2002-10-25
OA12256A (en)	2003-11-06
MY133842A (en)	2007-11-30
SV2002000418A (es)	2002-07-03
TNSN01065A1 (fr)	2005-11-10
PE20011270A1 (es)	2001-12-12
NZ521348A (en)	2004-09-24
IS6588A (is)	2002-10-21
WO2001083470A1 (en)	2001-11-08
TR200202439T2 (tr)	2003-02-21
UA73348C2 (en)	2005-07-15
HN2001000042A (es)	2001-07-09
CA2407535A1 (en)	2001-11-08
IL152075A0 (en)	2003-05-29
SK14872002A3 (sk)	2004-03-02
EE200200615A (et)	2004-04-15
CN1426404A (zh)	2003-06-25
IS6567A (is)	2002-09-24
PL357765A1 (pl)	2004-07-26
MXPA02010600A (es)	2003-03-10
PA8513301A1 (es)	2003-09-05
KR20020093079A (ko)	2002-12-12
CO5221125A1 (es)	2002-11-28
ZA200208605B (en)	2003-10-24
GT200100064A (es)	2002-03-22
EA004882B1 (ru)	2004-08-26
AP2002002651A0 (en)	2002-12-31
JP2003531900A (ja)	2003-10-28
MA26897A1 (fr)	2004-12-20
YU79602A (en)	2006-05-25
HRP20020851A2 (en)	2005-02-28
BG107139A (bg)	2003-07-31
EP1276737A1 (en)	2003-01-22
UY26680A1 (es)	2001-12-28

Legal Events

Date	Code	Title	Description
2006-11-28	FD9A	Lapse of provisional protection due to non-payment of fees

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