HUP9800511A2 - Eljárás 4-(4-(4-(hidroxi-difenil)-1-piperidinil)-1-hidroxi-butil)-alfa, alfa-dimetil-fenil-ecetsav és foszforilezett származékai előállítására - Google Patents

Eljárás 4-(4-(4-(hidroxi-difenil)-1-piperidinil)-1-hidroxi-butil)-alfa, alfa-dimetil-fenil-ecetsav és foszforilezett származékai előállítására

Info

Publication number
HUP9800511A2
HUP9800511A2 HU9800511A HUP9800511A HUP9800511A2 HU P9800511 A2 HUP9800511 A2 HU P9800511A2 HU 9800511 A HU9800511 A HU 9800511A HU P9800511 A HUP9800511 A HU P9800511A HU P9800511 A2 HUP9800511 A2 HU P9800511A2
Authority
HU
Hungary
Prior art keywords
alpha
hydroxy
formula
piperidinyl
dimethyl
Prior art date
Application number
HU9800511A
Other languages
English (en)
Inventor
Johannes Meiwes
Manfred Worm
Original Assignee
Hoechst Marion Roussel Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19709898A external-priority patent/DE19709898A1/de
Priority claimed from DE19751498A external-priority patent/DE19751498A1/de
Application filed by Hoechst Marion Roussel Deutschland Gmbh. filed Critical Hoechst Marion Roussel Deutschland Gmbh.
Publication of HU9800511D0 publication Critical patent/HU9800511D0/hu
Publication of HUP9800511A2 publication Critical patent/HUP9800511A2/hu
Publication of HUP9800511A3 publication Critical patent/HUP9800511A3/hu
Publication of HU224690B1 publication Critical patent/HU224690B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A találmány tárgya aljárás (II) általánős képletű vegyületekelőállítására, a képletben R1 jelentése hidrőxilcsőpőrt vagy -CH2-O-P(O)(OH2) képletű csőpőrt és R2jelentése hidrőxilcsőpőrt, R1 jelentése -CH3 és R2 jelentése -O-P(O)(OH2) képletű csőpőrt, vagy R2 jelentése -O-P(O)(OH2) képletű csőpőrt és R1 jelentése -COOH képletűcsőpőrt, valamint 4-(4-(4-hidrőxi-difenil)-1-piperidinil)-1-hidrőxibűtil)-a,a-dimetil-fenil-ecetsav előállítására Cűnninghamella vagy Absidia fajbatartőzó gőmba segítségével. A találmány kiterjed a fenti vegyületek szűkebb körét képező újvegyületekre, valamint ezeket tartalmazó gyógyszerkészítményekre. ŕ
HU9800511A 1997-03-11 1998-03-09 4-(4-(4-(hidroxi-difenil)-1-piperidinil)-1-hidroxi-butil)-alfa, alfa-dimetil-fenil-ecetsav foszforilezett származékai és eljárás ezek előállítására HU224690B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19709898A DE19709898A1 (de) 1997-03-11 1997-03-11 Verfahren zur Herstellung von 4-(4-(4-(Hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)-alpha,alpha-dimethylphenylessigsäure
DE19751498A DE19751498A1 (de) 1997-11-21 1997-11-21 Verfahren zur Herstellung von 4-(4-(4-(Hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)-alpha,alpha-dimethylphenylessigsäure und phosphorylierter Derivate

Publications (4)

Publication Number Publication Date
HU9800511D0 HU9800511D0 (en) 1998-04-28
HUP9800511A2 true HUP9800511A2 (hu) 1999-03-29
HUP9800511A3 HUP9800511A3 (en) 2001-06-28
HU224690B1 HU224690B1 (hu) 2005-12-28

Family

ID=26034703

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9800511A HU224690B1 (hu) 1997-03-11 1998-03-09 4-(4-(4-(hidroxi-difenil)-1-piperidinil)-1-hidroxi-butil)-alfa, alfa-dimetil-fenil-ecetsav foszforilezett származékai és eljárás ezek előállítására

Country Status (16)

Country Link
US (1) US5990127A (hu)
EP (1) EP0864653B1 (hu)
JP (1) JP4077551B2 (hu)
AR (1) AR011185A1 (hu)
AT (1) ATE260983T1 (hu)
BR (1) BR9803289A (hu)
CA (1) CA2231588C (hu)
CZ (1) CZ296318B6 (hu)
DE (1) DE59810863D1 (hu)
DK (1) DK0864653T3 (hu)
ES (1) ES2216191T3 (hu)
HU (1) HU224690B1 (hu)
PL (1) PL185768B1 (hu)
PT (1) PT864653E (hu)
RU (1) RU2202556C2 (hu)
TR (1) TR199800422A2 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2776302B1 (fr) * 1998-03-19 2002-04-12 Hoechst Marion Roussel Inc Nouveau procede de preparation de la fexofenadine
US6613907B2 (en) * 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
IL158334A0 (en) * 2001-04-09 2004-05-12 Teva Pharma Polymorphs of fexofenadine hydrochloride
US20040044038A1 (en) * 2002-06-10 2004-03-04 Barnaba Krochmal Polymorphic form XVI of fexofenadine hydrochloride
JP2007532687A (ja) * 2004-04-26 2007-11-15 テバ ファーマシューティカル インダストリーズ リミティド フェキソフェナジン塩酸塩の結晶形およびその製造方法
JP2008514641A (ja) * 2004-09-28 2008-05-08 テバ ファーマシューティカル インダストリーズ リミティド 結晶形フェキソフェナジン、およびその調製方法
US8551560B2 (en) * 2008-05-23 2013-10-08 Intermolecular, Inc. Methods for improving selectivity of electroless deposition processes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA728544B (en) * 1972-01-28 1974-02-27 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US4285957A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
JP2954959B2 (ja) * 1989-02-02 1999-09-27 三共株式会社 新規ミルベマイシン類およびその製造法
JPH06502536A (ja) * 1990-10-09 1994-03-24 メルク　エンド　カンパニー　インコーポレーテッド 有機化合物の新規生物学的リン酸化方法
DE4034218A1 (de) * 1990-10-27 1992-04-30 Merck Patent Gmbh Verfahren zur herstellung von carebastin

Also Published As

Publication number Publication date
EP0864653B1 (de) 2004-03-03
TR199800422A3 (hu) 1998-09-21
US5990127A (en) 1999-11-23
JPH10259191A (ja) 1998-09-29
CZ71398A3 (cs) 1998-09-16
PT864653E (pt) 2004-08-31
JP4077551B2 (ja) 2008-04-16
PL325264A1 (en) 1998-09-14
PL185768B1 (pl) 2003-07-31
HU224690B1 (hu) 2005-12-28
RU2202556C2 (ru) 2003-04-20
ES2216191T3 (es) 2004-10-16
ATE260983T1 (de) 2004-03-15
HU9800511D0 (en) 1998-04-28
AR011185A1 (es) 2000-08-02
TR199800422A2 (hu) 1998-09-21
HUP9800511A3 (en) 2001-06-28
DK0864653T3 (da) 2004-07-12
CZ296318B6 (cs) 2006-02-15
EP0864653A1 (de) 1998-09-16
BR9803289A (pt) 2000-05-02
CA2231588C (en) 2007-10-30
CA2231588A1 (en) 1998-09-11
DE59810863D1 (de) 2004-04-08

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HFG4 Patent granted, date of granting

Effective date: 20051103

RH9A Decision on the lapse of patent protection withdrawn