NO952021L - Regioselektiv syntese av 4-klor-2-tiofenkarboksylsyre - Google Patents

Regioselektiv syntese av 4-klor-2-tiofenkarboksylsyre

Info

Publication number
NO952021L
NO952021L NO952021A NO952021A NO952021L NO 952021 L NO952021 L NO 952021L NO 952021 A NO952021 A NO 952021A NO 952021 A NO952021 A NO 952021A NO 952021 L NO952021 L NO 952021L
Authority
NO
Norway
Prior art keywords
chloro
thiophenecarboxylic acid
regioselective synthesis
compound
formula
Prior art date
Application number
NO952021A
Other languages
English (en)
Other versions
NO952021D0 (no
Inventor
Laurence E Burgess
Gary R Schulte
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO952021D0 publication Critical patent/NO952021D0/no
Publication of NO952021L publication Critical patent/NO952021L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Seasonings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Paper (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

4-klor-2-tiofenkarboksylsyre fremstilles ved å danne en forbindelse med formel (Ia), hvori R3 er (CCJalkyl, fenyl eller benzyl; overføre forbindelsen i en forbindelse med formel (IVa); og fjerne silylgruppe RSi-. Produktet er anvendelig som et mellomprodukt ved fremstilling av farmasøy-tiske produkter.
NO952021A 1992-11-23 1995-05-22 Regioselektiv syntese av 4-klor-2-tiofenkarboksylsyre NO952021L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97998392A 1992-11-23 1992-11-23
PCT/US1993/008613 WO1994012505A1 (en) 1992-11-23 1993-09-17 Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acid

Publications (2)

Publication Number Publication Date
NO952021D0 NO952021D0 (no) 1995-05-22
NO952021L true NO952021L (no) 1995-05-22

Family

ID=25527268

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952021A NO952021L (no) 1992-11-23 1995-05-22 Regioselektiv syntese av 4-klor-2-tiofenkarboksylsyre

Country Status (26)

Country Link
US (1) US5648502A (no)
EP (1) EP0669924B1 (no)
JP (2) JP2706573B2 (no)
KR (1) KR950704727A (no)
CN (4) CN1036001C (no)
AT (1) ATE146181T1 (no)
AU (1) AU670454B2 (no)
BR (1) BR9307503A (no)
CA (1) CA2148616C (no)
CZ (1) CZ131695A3 (no)
DE (1) DE69306595T2 (no)
DK (1) DK0669924T3 (no)
EG (1) EG20200A (no)
ES (1) ES2095080T3 (no)
FI (1) FI935168A7 (no)
GR (1) GR3022396T3 (no)
HU (1) HUT68757A (no)
IL (2) IL107612A0 (no)
MX (1) MX9307292A (no)
MY (1) MY109037A (no)
NO (1) NO952021L (no)
NZ (1) NZ256279A (no)
PL (1) PL174312B1 (no)
RU (1) RU2114854C1 (no)
WO (1) WO1994012505A1 (no)
ZA (1) ZA938705B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6226598A (en) * 1997-04-04 1998-10-30 Pfizer Inc. Processes and intermediates for preparing 2-fluorothiophene derivatives
US7402608B2 (en) * 2002-12-10 2008-07-22 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of Flavivirus infections
US7560551B2 (en) 2006-01-23 2009-07-14 Amgen Inc. Aurora kinase modulators and method of use
RU2359968C2 (ru) * 2007-01-17 2009-06-27 Институт нефтехимии и катализа РАН Способ получения метиловых эфиров 2-тиофенкарбоновой кислоты и ее производных
JP5411141B2 (ja) 2007-09-10 2014-02-12 カルシメディカ，インク． 細胞内カルシウムを調節する化合物
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
US8389567B2 (en) 2007-12-12 2013-03-05 Calcimedica, Inc. Compounds that modulate intracellular calcium
US7906553B2 (en) 2008-08-27 2011-03-15 Calcimedica, Inc. Substituted thiophene modulators of intracellular calcium
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
CN101987842A (zh) * 2009-07-31 2011-03-23 上海开拓者医药发展有限公司 一种2-甲基噻吩衍生物的制备方法
WO2011034962A2 (en) 2009-09-16 2011-03-24 Calcimedica Inc. Compounds that modulate intracellular calcium
EP2609095A4 (en) 2010-08-27 2014-06-18 Calcimedica Inc COMPOUNDS MODULATING INTRACELLULAR CALCIUM
WO2014059333A1 (en) 2012-10-12 2014-04-17 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN109096245A (zh) * 2018-09-27 2018-12-28 上海雅本化学有限公司 一种5-氯噻吩-2-甲酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1015622A1 (ru) * 1981-07-02 1985-11-30 Всесоюзный Ордена Трудового Красного Знамени Научно-Исследовательский Химико-Фармацевтический Институт Им.Серго Орджоникидзе 2-Замещенные 3-окси-5-метил-4-тиофенуксусные кислоты,обладающие противовоспалительной и анальгетической активностью и способ их получени
US4432974A (en) * 1982-03-04 1984-02-21 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes
DE3534286A1 (de) * 1985-09-26 1987-04-02 Hoechst Ag Verfahren zur herstellung von halogenthiophen-2-carbonsaeuren
MX18021A (es) * 1988-10-18 1993-11-01 Pfizer Pro-farmacos de la 3-acil-2-oxindol-1-carboxamidasanti-inflamatorias
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
FR2655655A1 (fr) * 1989-12-07 1991-06-14 Rhone Poulenc Chimie Procede de preparation de polysilthiophenediyle et polymeres obtenus a l'issue de ce procede.
CA2119155C (en) * 1991-10-18 1999-06-15 Dennis Paul Phillion Fungicides for the control of take-all disease of plants

Also Published As

Publication number Publication date
FI935168A0 (fi) 1993-11-22
CZ131695A3 (en) 1996-05-15
AU670454B2 (en) 1996-07-18
FI935168L (fi) 1994-05-24
MY109037A (en) 1996-11-30
BR9307503A (pt) 1999-06-29
DE69306595T2 (de) 1997-04-03
CN1158853A (zh) 1997-09-10
JPH1081683A (ja) 1998-03-31
JP2706573B2 (ja) 1998-01-28
CA2148616A1 (en) 1994-06-09
NO952021D0 (no) 1995-05-22
IL107612A0 (en) 1994-02-27
KR950704727A (ko) 1995-11-20
DE69306595D1 (en) 1997-01-23
EG20200A (en) 1997-10-30
CN1093704A (zh) 1994-10-19
ATE146181T1 (de) 1996-12-15
PL309048A1 (en) 1995-09-18
AU4858793A (en) 1994-06-22
EP0669924A1 (en) 1995-09-06
DK0669924T3 (da) 1997-06-16
CN1156725A (zh) 1997-08-13
WO1994012505A1 (en) 1994-06-09
US5648502A (en) 1997-07-15
RU2114854C1 (ru) 1998-07-10
FI935168A7 (fi) 1994-05-24
IL120461A0 (en) 1997-07-13
ZA938705B (en) 1995-05-22
PL174312B1 (pl) 1998-07-31
JP2795642B2 (ja) 1998-09-10
CA2148616C (en) 1998-02-03
GR3022396T3 (en) 1997-04-30
CN1036001C (zh) 1997-10-01
CN1158851A (zh) 1997-09-10
MX9307292A (es) 1994-05-31
ES2095080T3 (es) 1997-02-01
JPH07508761A (ja) 1995-09-28
NZ256279A (en) 1996-11-26
HUT68757A (en) 1995-07-28
EP0669924B1 (en) 1996-12-11

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