HUP9900501A2 - Muszkarin receptor antagonista hatású oxa- és tiadiazolszármazékok, intermedierjeik, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Muszkarin receptor antagonista hatású oxa- és tiadiazolszármazékok, intermedierjeik, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9900501A2
HUP9900501A2 HU9900501A HUP9900501A HUP9900501A2 HU P9900501 A2 HUP9900501 A2 HU P9900501A2 HU 9900501 A HU9900501 A HU 9900501A HU P9900501 A HUP9900501 A HU P9900501A HU P9900501 A2 HUP9900501 A2 HU P9900501A2
Authority
HU
Hungary
Prior art keywords
compounds
intermediates
receptor antagonists
thia
oxa
Prior art date
Application number
HU9900501A
Other languages
English (en)
Inventor
Robert John Bass
Alexander Roderick Mackenzie
Anthony Wood
Original Assignee
Pfizer Research And Development Company N.V./S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Research And Development Company N.V./S.A. filed Critical Pfizer Research And Development Company N.V./S.A.
Publication of HUP9900501A2 publication Critical patent/HUP9900501A2/hu
Publication of HUP9900501A3 publication Critical patent/HUP9900501A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A cím szerinti vegyületek (I), és intermedierjeik (II) általánősképletében R1 jelentése alkil-, halőgén-alkil-, ciklőalkil-, alkinil-,hidrőxi-alkinil-, alkőxi-alkinil-, aril-, aril-alkil-, heterőaril-vagy heterőaril-alkil-csőpőrt; R2 jelentése hidrőgénatőm vagyalkilcsőpőrt; R3 jelentése aril-, heterőaril-, 2,3-dihidrő-benzőfűranil- vagy ciklőakilcsőpőrt; X jelentése őxigén- vagy kénatőm;és Y jelentése közvetlen kémiai kötés vagy -CH2, -(CH2)2- vagy -CH2O-képletű csőpőrt. A vegyületek új, műszkarin receptőr antagőnistakéntpéldáűl irritábilis bélszindróma, vizelet-visszatartás vagy kőgnitívrendellenességek kezelésére alkalmazhatók ŕ
HU9900501A 1996-02-22 1997-02-04 Oxa- and thia-diazole derivatives as muscarinic receptor antagonists, intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds HUP9900501A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9603755.1A GB9603755D0 (en) 1996-02-22 1996-02-22 Therapeutic agents

Publications (2)

Publication Number Publication Date
HUP9900501A2 true HUP9900501A2 (hu) 1999-06-28
HUP9900501A3 HUP9900501A3 (en) 2001-02-28

Family

ID=10789217

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900501A HUP9900501A3 (en) 1996-02-22 1997-02-04 Oxa- and thia-diazole derivatives as muscarinic receptor antagonists, intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds

Country Status (42)

Country Link
US (1) US5977142A (hu)
EP (1) EP0885218B1 (hu)
JP (1) JP3148252B2 (hu)
KR (1) KR100315934B1 (hu)
CN (1) CN1089340C (hu)
AP (1) AP751A (hu)
AR (1) AR005916A1 (hu)
AT (1) ATE200899T1 (hu)
AU (1) AU712230B2 (hu)
BG (2) BG102699A (hu)
BR (1) BR9707733A (hu)
CA (1) CA2247164C (hu)
CO (1) CO4650040A1 (hu)
CZ (1) CZ292650B6 (hu)
DE (1) DE69704701T2 (hu)
DK (1) DK0885218T3 (hu)
DZ (1) DZ2181A1 (hu)
ES (1) ES2156357T3 (hu)
GB (1) GB9603755D0 (hu)
GR (1) GR3036032T3 (hu)
HN (1) HN1997000020A (hu)
HR (1) HRP970098B1 (hu)
HU (1) HUP9900501A3 (hu)
ID (1) ID16642A (hu)
IL (1) IL125413A (hu)
IS (1) IS4803A (hu)
MY (1) MY129729A (hu)
NO (1) NO313414B1 (hu)
NZ (1) NZ331039A (hu)
OA (1) OA10838A (hu)
PE (1) PE42798A1 (hu)
PL (1) PL186879B1 (hu)
PT (1) PT885218E (hu)
RU (1) RU2162848C2 (hu)
SK (1) SK283461B6 (hu)
TN (1) TNSN97039A1 (hu)
TR (1) TR199801644T2 (hu)
TW (1) TW492961B (hu)
UA (1) UA61068C2 (hu)
WO (1) WO1997030994A1 (hu)
YU (1) YU35698A (hu)
ZA (1) ZA971513B (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
CA2438991C (en) * 2001-02-21 2010-08-17 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
GB0510141D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B3
GB0510139D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
GB0516313D0 (en) 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
WO2008017827A2 (en) * 2006-08-08 2008-02-14 Argenta Discovery Limited Azole and thiazole derivatives and their uses
JP2010501533A (ja) * 2006-08-21 2010-01-21 アージェンタ ディスカバリー リミテッド Ｍ３レセプター調節物質として有用な窒素含有複素環化合物
WO2008096093A1 (en) * 2007-02-06 2008-08-14 Argenta Discovery Ltd. Oxazole and thiazole derivatives and their uses
GB0702414D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd Oxazole and thiazole derivatives and their uses 2
GB0702385D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New combination
BRPI0807004A2 (pt) * 2007-02-07 2014-04-15 Argenta Discovery Ltd Sal
GB0702382D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New salt
GB0702416D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New combination
TW200843759A (en) * 2007-02-15 2008-11-16 Argenta Discovery Ltd Compounds and their use II
WO2009098453A1 (en) * 2008-02-06 2009-08-13 Astrazeneca Ab Azonia bicycloalkanes as m3 muscarinic acetylcholin receptor antagonists
US8263623B2 (en) 2008-07-11 2012-09-11 Pfizer Inc. Triazol derivatives useful for the treatment of diseases
WO2010018352A1 (en) * 2008-08-12 2010-02-18 Argenta Discovery Limited Heterocyclic compounds used in the treatment of diseases where enhanced m3 receptor activation is implicated
JP2014065387A (ja) * 2012-09-25 2014-04-17 Showa Corp 自動二輪車の車高調整装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0619814A1 (en) * 1991-12-31 1994-10-19 Fujisawa Pharmaceutical Co., Ltd. Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
TW360653B (en) * 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition

Also Published As

Publication number Publication date
CN1211981A (zh) 1999-03-24
BG63971B1 (bg) 2003-08-29
CN1089340C (zh) 2002-08-21
GR3036032T3 (en) 2001-09-28
CO4650040A1 (es) 1998-09-03
HRP970098A2 (en) 1999-04-30
WO1997030994A1 (en) 1997-08-28
DZ2181A1 (fr) 2002-12-01
IS4803A (is) 1998-07-21
ID16642A (id) 1997-10-23
SK283461B6 (sk) 2003-08-05
KR19990087143A (ko) 1999-12-15
TR199801644T2 (xx) 1998-11-23
BG102699A (en) 1999-09-30
PE42798A1 (es) 1998-08-18
TW492961B (en) 2002-07-01
SK112398A3 (en) 2000-04-10
DE69704701T2 (de) 2001-08-16
HN1997000020A (es) 1997-06-05
AR005916A1 (es) 1999-07-21
NO313414B1 (no) 2002-09-30
US5977142A (en) 1999-11-02
AU712230B2 (en) 1999-11-04
JPH11504051A (ja) 1999-04-06
HRP970098B1 (en) 2001-12-31
AP751A (en) 1999-07-12
AP9700930A0 (en) 1997-04-30
NO983871D0 (no) 1998-08-21
RU2162848C2 (ru) 2001-02-10
UA61068C2 (en) 2003-11-17
CA2247164C (en) 2004-11-16
KR100315934B1 (ko) 2002-03-21
CZ267898A3 (cs) 1999-08-11
MY129729A (en) 2007-04-30
OA10838A (en) 2001-08-13
CA2247164A1 (en) 1997-08-28
IL125413A0 (en) 1999-03-12
EP0885218B1 (en) 2001-05-02
ES2156357T3 (es) 2001-06-16
EP0885218A1 (en) 1998-12-23
PT885218E (pt) 2001-08-30
TNSN97039A1 (fr) 2005-03-15
HK1018274A1 (en) 1999-12-17
ZA971513B (en) 1998-08-21
JP3148252B2 (ja) 2001-03-19
AU1601497A (en) 1997-09-10
BR9707733A (pt) 1999-07-27
DE69704701D1 (de) 2001-06-07
PL186879B1 (pl) 2004-03-31
IL125413A (en) 2002-09-12
HUP9900501A3 (en) 2001-02-28
YU35698A (sh) 1999-07-28
NZ331039A (en) 1999-10-28
NO983871L (no) 1998-08-21
GB9603755D0 (en) 1996-04-24
DK0885218T3 (da) 2001-05-28
CZ292650B6 (cs) 2003-11-12
PL328633A1 (en) 1999-02-15
ATE200899T1 (de) 2001-05-15

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