HUT62896A - Process for producing new trans-cyclopentanylpurine analogs having immunosuppressant activity and pharmaceutical compositions comprising same as active ingredient - Google Patents

Process for producing new trans-cyclopentanylpurine analogs having immunosuppressant activity and pharmaceutical compositions comprising same as active ingredient

Info

Publication number: HUT62896A
Authority: HU; Hungary
Prior art keywords: analogs; cyclopentanylpurine; active ingredient; pharmaceutical compositions; same
Prior art date: 1991-12-06

Application number

HU929203858A

Other languages

English (en)

Other versions

HU217077B (hu

Inventor

David Roger Borcherding

Carl Keith Edwards

Ronald Eugene Esser

Douglas Leon Cole

Original Assignee

Marion Merrell Dow Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-06

Filing date

1992-12-04

Publication date

1993-06-28

1992-12-04 Application filed by Marion Merrell Dow Inc filed Critical Marion Merrell Dow Inc

1993-06-28 Publication of HUT62896A publication Critical patent/HUT62896A/hu

1999-11-29 Publication of HU217077B publication Critical patent/HU217077B/hu

Links

239000004480 active ingredient Substances 0.000 title 1
230000001861 immunosuppressant effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
229910003204 NH2 Inorganic materials 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
CFTPMBWYBDKGSA-UHFFFAOYSA-N 2-cyclopentyl-7h-purine Chemical class C1CCCC1C1=NC=C(NC=N2)C2=N1 CFTPMBWYBDKGSA-UHFFFAOYSA-N 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
125000005251 aryl acyl group Chemical group 0.000 abstract 1
-1 cyclopentanyl ring Chemical group 0.000 abstract 1
229960003444 immunosuppressant agent Drugs 0.000 abstract 1
239000003018 immunosuppressive agent Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HU9203858A 1991-12-06 1992-12-04 Eljárás immunoszupresszáns hatású transz-ciklopentanil-purin-analógok és ezeket tartalmazó gyógyszerkészítmények előállítására HU217077B (hu)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US80415391A	1991-12-06	1991-12-06
US96560192A	1992-11-02	1992-11-02

Publications (2)

Publication Number	Publication Date
HUT62896A true HUT62896A (en)	1993-06-28
HU217077B HU217077B (hu)	1999-11-29

Family

ID=27122672

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HU9203858A HU217077B (hu)	1991-12-06	1992-12-04	Eljárás immunoszupresszáns hatású transz-ciklopentanil-purin-analógok és ezeket tartalmazó gyógyszerkészítmények előállítására
HU9203858A HU9203858D0 (en)	1991-12-06	1992-12-04	New trans-cyclopentanyl-purine analogues having immuno suppressing effect

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
HU9203858A HU9203858D0 (en)	1991-12-06	1992-12-04	New trans-cyclopentanyl-purine analogues having immuno suppressing effect

Country Status (17)

Country	Link
EP (1)	EP0545413B1 (hu)
JP (1)	JP3264289B2 (hu)
KR (1)	KR100251996B1 (hu)
AT (1)	ATE194618T1 (hu)
AU (1)	AU658698B2 (hu)
CA (1)	CA2084222C (hu)
DE (1)	DE69231242T2 (hu)
DK (1)	DK0545413T3 (hu)
ES (1)	ES2149163T3 (hu)
FI (1)	FI109026B (hu)
GR (1)	GR3034586T3 (hu)
HU (2)	HU217077B (hu)
IL (1)	IL103962A (hu)
MX (1)	MX9206963A (hu)
NO (1)	NO305207B1 (hu)
NZ (1)	NZ245342A (hu)
PT (1)	PT545413E (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2103131T3 (es)	1993-06-21	1997-08-16	Merrell Pharma Inc	Nuevos agentes de nucleosido carbociclico utiles como inhibidores selectivos de citoquinas proinflamatorias.
TW552261B (en) *	1996-07-03	2003-09-11	Japan Energy Corp	Novel purine derivative
US6479487B1 (en) *	1998-02-26	2002-11-12	Aventis Pharmaceuticals Inc.	6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
US6413974B1 (en)	1998-02-26	2002-07-02	Aventis Pharmaceuticals Inc.	6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
FR2793794B1 (fr) *	1999-05-21	2001-07-27	Hoechst Marion Roussel Inc	Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
US6861524B2 (en)	2000-10-31	2005-03-01	Aventis Pharmaceuticals Inc.	Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4038479A (en) *	1969-11-17	1977-07-26	Burroughs Wellcome Co.	Amino purine derivatives
US4076711A (en) *	1976-04-05	1978-02-28	Schering Corporation	Triazolo [4,5-d]-pyrimidines
CA2001715C (en) *	1988-11-14	1999-12-28	Muzammil M. Mansuri	Carbocyclic nucleosides and nucleotides
ATE133678T1 (de) *	1990-07-04	1996-02-15	Merrell Dow Pharma	9-purinyl-phosphonsäurederivate
AU647822B2 (en) *	1990-09-14	1994-03-31	Marion Merrell Dow Inc.	Novel carbocyclic adenosine analogs useful as immunosuppressants

1992
- 1992-12-01 AU AU29752/92A patent/AU658698B2/en not_active Ceased
- 1992-12-01 CA CA002084222A patent/CA2084222C/en not_active Expired - Fee Related
- 1992-12-02 NZ NZ245342A patent/NZ245342A/en unknown
- 1992-12-03 ES ES92120653T patent/ES2149163T3/es not_active Expired - Lifetime
- 1992-12-03 DK DK92120653T patent/DK0545413T3/da active
- 1992-12-03 PT PT92120653T patent/PT545413E/pt unknown
- 1992-12-03 DE DE69231242T patent/DE69231242T2/de not_active Expired - Lifetime
- 1992-12-03 EP EP92120653A patent/EP0545413B1/en not_active Expired - Lifetime
- 1992-12-03 MX MX9206963A patent/MX9206963A/es not_active IP Right Cessation
- 1992-12-03 AT AT92120653T patent/ATE194618T1/de not_active IP Right Cessation
- 1992-12-03 IL IL10396292A patent/IL103962A/xx not_active IP Right Cessation
- 1992-12-04 JP JP35013492A patent/JP3264289B2/ja not_active Expired - Lifetime
- 1992-12-04 NO NO924691A patent/NO305207B1/no not_active IP Right Cessation
- 1992-12-04 HU HU9203858A patent/HU217077B/hu not_active IP Right Cessation
- 1992-12-04 FI FI925520A patent/FI109026B/fi not_active IP Right Cessation
- 1992-12-04 HU HU9203858A patent/HU9203858D0/hu unknown
- 1992-12-05 KR KR1019920023426A patent/KR100251996B1/ko not_active Expired - Fee Related
2000
- 2000-10-09 GR GR20000402275T patent/GR3034586T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69231242T2 (de)	2000-12-21
IL103962A (en)	1997-01-10
FI925520A0 (fi)	1992-12-04
JP3264289B2 (ja)	2002-03-11
AU2975292A (en)	1993-06-10
EP0545413A1 (en)	1993-06-09
NO924691D0 (no)	1992-12-04
ATE194618T1 (de)	2000-07-15
IL103962A0 (en)	1993-05-13
DE69231242D1 (de)	2000-08-17
CA2084222C (en)	2004-04-06
PT545413E (pt)	2000-10-31
AU658698B2 (en)	1995-04-27
ES2149163T3 (es)	2000-11-01
HU217077B (hu)	1999-11-29
MX9206963A (es)	1993-06-01
CA2084222A1 (en)	1993-06-07
DK0545413T3 (da)	2000-10-09
FI109026B (fi)	2002-05-15
HU9203858D0 (en)	1993-03-29
FI925520L (fi)	1993-06-07
GR3034586T3 (en)	2001-01-31
NZ245342A (en)	1995-10-26
NO924691L (no)	1993-06-07
JPH0656835A (ja)	1994-03-01
NO305207B1 (no)	1999-04-19
EP0545413B1 (en)	2000-07-12
KR100251996B1 (ko)	2000-09-01

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Legal Events

Date	Code	Title	Description
2005-09-28	HMM4	Cancellation of final prot. due to non-payment of fee