ATE133678T1 - 9-purinyl-phosphonsäurederivate - Google Patents

9-purinyl-phosphonsäurederivate

Info

Publication number: ATE133678T1
Authority: AT; Austria
Prior art keywords: acid derivatives; phosphonic acid; purinyl; purinyl phosphonic; antilymphoma
Prior art date: 1990-07-04

Application number

AT91401700T

Other languages

English (en)

Inventor

Serge Halazy

Charles Danzin

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-04

Filing date

1991-06-24

Publication date

1996-02-15

1991-06-24 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1996-02-15 Application granted granted Critical

1996-02-15 Publication of ATE133678T1 publication Critical patent/ATE133678T1/de

Links

KVRVLSICJKOUET-UHFFFAOYSA-N purin-9-ylphosphonic acid Chemical class N1=CN=C2N(P(O)(=O)O)C=NC2=C1 KVRVLSICJKOUET-UHFFFAOYSA-N 0.000 title 1
230000000719 anti-leukaemic effect Effects 0.000 abstract 1
230000000690 anti-lymphoma Effects 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
239000000063 antileukemic agent Substances 0.000 abstract 1
-1 antilymphoma Substances 0.000 abstract 1
239000003904 antiprotozoal agent Substances 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
229960003444 immunosuppressant agent Drugs 0.000 abstract 1
239000003018 immunosuppressive agent Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000000784 purine nucleoside phosphorylase inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT91401700T 1990-07-04 1991-06-24 9-purinyl-phosphonsäurederivate ATE133678T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP90401940		1990-07-04

Publications (1)

Publication Number	Publication Date
ATE133678T1 true ATE133678T1 (de)	1996-02-15

Family

ID=8205733

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91401700T ATE133678T1 (de)	1990-07-04	1991-06-24	9-purinyl-phosphonsäurederivate

Country Status (22)

Country	Link
US (2)	US5538978A (de)
EP (1)	EP0465297B1 (de)
JP (1)	JP3006919B2 (de)
KR (1)	KR100217807B1 (de)
CN (1)	CN1031713C (de)
AT (1)	ATE133678T1 (de)
AU (1)	AU643533B2 (de)
CA (1)	CA2045783C (de)
DE (1)	DE69116750T2 (de)
DK (1)	DK0465297T3 (de)
ES (1)	ES2085446T3 (de)
FI (1)	FI101793B (de)
GR (1)	GR3019793T3 (de)
HU (1)	HU208832B (de)
IE (1)	IE72096B1 (de)
IL (1)	IL98702A (de)
MX (1)	MX9203682A (de)
NO (1)	NO180541C (de)
NZ (1)	NZ238774A (de)
PT (1)	PT98198B (de)
TW (1)	TW199896B (de)
ZA (1)	ZA914978B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0465297B1 (de) *	1990-07-04	1996-01-31	Merrell Dow Pharmaceuticals Inc.	9-Purinyl-Phosphonsäurederivate
EP0531597A1 (de) *	1991-09-12	1993-03-17	Merrell Dow Pharmaceuticals Inc.	Ungesättigte azyklische Phosphonsäure Purinderivats und Pyrimidinderivate
US5817672A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817660A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5723466A (en) *	1991-12-06	1998-03-03	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817661A (en)	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
AU658698B2 (en) *	1991-12-06	1995-04-27	Aventis Pharmaceuticals Inc.	Novel trans cyclopentanyl purine analogs useful as immunosuppressants
CA2171868A1 (en) *	1993-09-17	1995-03-23	Petr Alexander	Method for dosing therapeutic compounds
US5798340A (en)	1993-09-17	1998-08-25	Gilead Sciences, Inc.	Nucleotide analogs
US5656745A (en) *	1993-09-17	1997-08-12	Gilead Sciences, Inc.	Nucleotide analogs
US5703058A (en) *	1995-01-27	1997-12-30	Emory University	Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
MY141789A (en) *	2001-01-19	2010-06-30	Lg Chem Investment Ltd	Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
WO2003037860A2 (en)	2001-10-30	2003-05-08	Conforma Therapeutics Corporation	Purine analogs having hsp90-inhibiting activity
WO2003091264A2 (en)	2002-04-26	2003-11-06	Gilead Sciences, Inc.	Non nucleoside reverse transcriptase inhibitors
EA014685B1 (ru)	2003-04-25	2010-12-30	Джилид Сайэнс, Инк.	Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе
US7407965B2 (en)	2003-04-25	2008-08-05	Gilead Sciences, Inc.	Phosphonate analogs for treating metabolic diseases
KR20060022647A (ko)	2003-04-25	2006-03-10	길리애드 사이언시즈, 인코포레이티드	키나아제 억제 포스포네이트 유사체
US7452901B2 (en)	2003-04-25	2008-11-18	Gilead Sciences, Inc.	Anti-cancer phosphonate analogs
WO2005002626A2 (en)	2003-04-25	2005-01-13	Gilead Sciences, Inc.	Therapeutic phosphonate compounds
US7432261B2 (en)	2003-04-25	2008-10-07	Gilead Sciences, Inc.	Anti-inflammatory phosphonate compounds
US7470724B2 (en)	2003-04-25	2008-12-30	Gilead Sciences, Inc.	Phosphonate compounds having immuno-modulatory activity
US7427636B2 (en)	2003-04-25	2008-09-23	Gilead Sciences, Inc.	Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
US7300924B2 (en)	2003-04-25	2007-11-27	Gilead Sciences, Inc.	Anti-infective phosphonate analogs
MXPA06002997A (es)	2003-09-18	2007-02-08	Conforma Therapeutics Corp	Novedosos compuestos heterociclicos como inhibidores- hsp90.
WO2005042773A1 (en)	2003-10-24	2005-05-12	Gilead Sciences, Inc.	Methods and compositions for identifying therapeutic compounds
WO2005044308A1 (en)	2003-10-24	2005-05-19	Gilead Sciences, Inc.	Phosphonate analogs of antimetabolites
WO2005044279A1 (en) *	2003-10-24	2005-05-19	Gilead Sciences, Inc.	Purine nucleoside phosphonate conjugates
BRPI0417988A (pt)	2003-12-22	2007-04-27	Gilead Sciences Inc	análogos de fosfonato antivirais
AU2005330489B2 (en)	2004-07-27	2011-08-25	Gilead Sciences, Inc.	Nucleoside phosphonate conjugates as anti HIV agents
AU2006230447A1 (en)	2005-03-30	2006-10-05	Conforma Therapeutics Corporation	Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors
US8158108B2 (en) *	2006-06-28	2012-04-17	S.C. Johnson & Son, Inc.	VOC-free compressed gas aerosol compositions
US8178078B2 (en) *	2008-06-13	2012-05-15	S.C. Johnson & Son, Inc.	Compositions containing a solvated active agent suitable for dispensing as a compressed gas aerosol
US8658617B2 (en)	2008-07-08	2014-02-25	Gilead Sciences, Inc.	Salts of HIV inhibitor compounds
KR101692133B1 (ko)	2015-01-13	2017-01-02	연세대학교 원주산학협력단	폴리이미드 수용액을 이용한 폴리이미드 성형방법
CN105061504A (zh) *	2015-09-16	2015-11-18	湖南大学	P-炔基磷酸酯类化合物的制备方法
SI3661937T1 (sl)	2017-08-01	2021-11-30	Gilead Sciences, Inc.	Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1288098C (en) *	1984-08-24	1991-08-27	Richard L. Tolman	4-(guanin-9-yl)butanals and their 3-oxa, 3-thia and 2-ene derivatives having antiviral and antitumor activity
US4988702A (en) *	1986-08-26	1991-01-29	Warner-Lambert Company	Novel 9-deazaguanines
EP0328834A1 (de) *	1988-02-16	1989-08-23	Merrell Dow Pharmaceuticals Inc.	Aspartat Transcarbamylase Inhibitoren
EP0335770B1 (de) *	1988-04-01	1997-01-15	Merrell Pharmaceuticals Inc.	Derivate von Fluorphosphonat-Nukleotiden
US4927830A (en) *	1988-04-08	1990-05-22	The Regents Of The University Of Michigan	Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents
EP0338168A1 (de) *	1988-04-19	1989-10-25	Merrell Dow Pharmaceuticals Inc.	Phosphonoalkylpurin-Derivate
EP0338887B1 (de) *	1988-04-19	1993-12-08	Merrell Dow Pharmaceuticals Inc.	Phosphonoalkylpurin-Derivate
JPH02124898A (ja) *	1988-04-28	1990-05-14	Nippon Kayaku Co Ltd	プリン塩基を有する新規化合物、その用途及び中間体
JPH02124897A (ja) *	1988-07-28	1990-05-14	Nippon Kayaku Co Ltd	エリスロフラノシルヌクレオシド誘導体の製造法及び新規誘導体
GB8827339D0 (en) *	1988-11-23	1988-12-29	Wellcome Found	Antiviral compounds
EP0374096B1 (de) *	1988-12-14	1992-12-02	Ciba-Geigy Ag	2',3'-Dideoxypurinnucleosid/Purinnucleosid-Phosphorylase-Inhibitor Kombinationstherapie und Zusammensetzungen dafür
EP0465297B1 (de) *	1990-07-04	1996-01-31	Merrell Dow Pharmaceuticals Inc.	9-Purinyl-Phosphonsäurederivate
EP0468119A1 (de) *	1990-07-24	1992-01-29	Merrell Dow Pharmaceuticals Inc.	Neue Carbocyclische Analoge einiger Nukleoside
EP0477454A1 (de) *	1990-09-28	1992-04-01	Merrell Dow Pharmaceuticals Inc.	Phosphonatderivate von bestimmten Nucleosiden

1991
- 1991-06-24 EP EP91401700A patent/EP0465297B1/de not_active Expired - Lifetime
- 1991-06-24 AT AT91401700T patent/ATE133678T1/de not_active IP Right Cessation
- 1991-06-24 ES ES91401700T patent/ES2085446T3/es not_active Expired - Lifetime
- 1991-06-24 DE DE69116750T patent/DE69116750T2/de not_active Expired - Lifetime
- 1991-06-24 DK DK91401700.9T patent/DK0465297T3/da active
- 1991-06-27 AU AU79414/91A patent/AU643533B2/en not_active Ceased
- 1991-06-27 CA CA002045783A patent/CA2045783C/en not_active Expired - Lifetime
- 1991-06-27 ZA ZA914978A patent/ZA914978B/xx unknown
- 1991-06-28 NZ NZ238774A patent/NZ238774A/en unknown
- 1991-06-28 TW TW080105043A patent/TW199896B/zh active
- 1991-07-01 IL IL9870291A patent/IL98702A/xx not_active IP Right Cessation
- 1991-07-03 CN CN91104477A patent/CN1031713C/zh not_active Expired - Fee Related
- 1991-07-03 FI FI913236A patent/FI101793B/fi active
- 1991-07-03 PT PT98198A patent/PT98198B/pt not_active IP Right Cessation
- 1991-07-03 HU HU912253A patent/HU208832B/hu not_active IP Right Cessation
- 1991-07-03 NO NO912606A patent/NO180541C/no unknown
- 1991-07-03 IE IE232991A patent/IE72096B1/en not_active IP Right Cessation
- 1991-07-04 KR KR1019910011290A patent/KR100217807B1/ko not_active Expired - Fee Related
- 1991-07-04 JP JP3189498A patent/JP3006919B2/ja not_active Expired - Lifetime
1992
- 1992-06-29 MX MX9203682A patent/MX9203682A/es unknown
1994
- 1994-11-08 US US08/336,703 patent/US5538978A/en not_active Expired - Lifetime
1995
- 1995-06-06 US US08/469,097 patent/US5527803A/en not_active Expired - Fee Related
1996
- 1996-04-29 GR GR960401173T patent/GR3019793T3/el unknown

Also Published As

Publication number	Publication date
NO180541C (no)	1997-05-07
NO912606L (no)	1992-01-06
GR3019793T3 (en)	1996-07-31
CN1058021A (zh)	1992-01-22
HUT59151A (en)	1992-04-28
US5538978A (en)	1996-07-23
PT98198A (pt)	1992-04-30
CN1031713C (zh)	1996-05-01
IE912329A1 (en)	1992-01-15
IE72096B1 (en)	1997-03-12
EP0465297B1 (de)	1996-01-31
AU643533B2 (en)	1993-11-18
TW199896B (de)	1993-02-11
KR100217807B1 (ko)	1999-10-01
KR920002622A (ko)	1992-02-28
DE69116750T2 (de)	1996-11-14
JP3006919B2 (ja)	2000-02-07
HU912253D0 (en)	1991-12-30
IL98702A (en)	1997-02-18
EP0465297A1 (de)	1992-01-08
NO180541B (no)	1997-01-27
CA2045783C (en)	2001-09-18
JPH04253989A (ja)	1992-09-09
US5527803A (en)	1996-06-18
HU208832B (en)	1994-01-28
IL98702A0 (en)	1992-07-15
ZA914978B (en)	1992-04-29
DK0465297T3 (da)	1996-02-19
MX9203682A (es)	1992-08-01
FI101793B1 (fi)	1998-08-31
ES2085446T3 (es)	1996-06-01
FI913236A0 (fi)	1991-07-03
PT98198B (pt)	1998-12-31
DE69116750D1 (de)	1996-03-14
FI913236L (fi)	1992-01-05
CA2045783A1 (en)	1992-01-05
FI101793B (fi)	1998-08-31
NO912606D0 (no)	1991-07-03
AU7941491A (en)	1992-01-09
NZ238774A (en)	1993-08-26

Legal Events

Date	Code	Title	Description
2004-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE133678T1 (de)	1996-02-15	9-purinyl-phosphonsäurederivate
KR950700298A (ko)	1995-01-16	뉴클레오시드 치료제(Therapeutic Nucleosides)
DK0494370T3 (da)	1995-08-28	Antivirale (phosphonomethoxy)methoxypurin/pyrimidinderivater
ES8602840A1 (es)	1985-12-01	Un procedimiento para la preparacion de un nucleosido.
ES2076146T3 (es)	1995-11-01	Derivados de desaza-purina-nucleosidos, procedimiento para su preparacion asi como su utilizacion en el secuenciamiento de acidos nucleicos y en calidad de agentes antiviricos.
ATE124936T1 (de)	1995-07-15	5-benzyl barbitursäurederivate.
ATE254132T1 (de)	2003-11-15	Antivirale pyrimidin nucleoside derivate
ZA913033B (en)	1992-01-29	N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic basis,their preparation and use
IE900275L (en)	1990-07-24	Antivirals and methods of increasing the antiviral activity¹of azt
ATE147746T1 (de)	1997-02-15	Derivate von fluorphosphonat-nukleotiden
DE69927251D1 (de)	2005-10-20	Verfahren zur herstellung von purinderivaten und dessen zwischenprodukte
SE8504657L (sv)	1986-04-10	Nya 5-fluor-2'-deoxiuridinderivat och salter derav, forfarande for deras framstellning och antitumormedel innehallande dessa
EP0335770A3 (de)	1990-12-27	Derivate von Fluorphosphonat-Nukleotiden
NZ219440A (en)	1989-10-27	Nucleoside of c 5 sugar
EP0566140A3 (de)	1994-11-30	Verfahren zur Herstellung von Dinukleosid-Polyphosphat, Nukleosid-Polyphosphat oder Derivate davon.
NO974512L (no)	1997-09-29	Fremgangsmåte for syntese av nukleosid-analoger
TH9308A (th)	1991-08-01	พิริมิดีนคลีโอไซด์ที่ใช้ต้านไวรัส