ATE194618T1 - Als immunosuppressiva nützliche trans- cyclopentanylpurinanaloge - Google Patents

Als immunosuppressiva nützliche trans- cyclopentanylpurinanaloge

Info

Publication number: ATE194618T1
Authority: AT; Austria
Prior art keywords: trans; immunosuppressants; cyclopentanyl; hydrogen; purine analogues
Prior art date: 1991-12-06

Application number

AT92120653T

Other languages

English (en)

Inventor

David R Borcherding

Ronald E Esser

Carl K Edwards Iii

Douglas L Cole Iii

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-06

Filing date

1992-12-03

Publication date

2000-07-15

1992-12-03 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2000-07-15 Application granted granted Critical

2000-07-15 Publication of ATE194618T1 publication Critical patent/ATE194618T1/de

Links

229960003444 immunosuppressant agent Drugs 0.000 title abstract 2
239000003018 immunosuppressive agent Substances 0.000 title abstract 2
229940045686 antimetabolites antineoplastic purine analogs Drugs 0.000 title 1
150000003212 purines Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
229910003204 NH2 Inorganic materials 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
CFTPMBWYBDKGSA-UHFFFAOYSA-N 2-cyclopentyl-7h-purine Chemical class C1CCCC1C1=NC=C(NC=N2)C2=N1 CFTPMBWYBDKGSA-UHFFFAOYSA-N 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
125000005251 aryl acyl group Chemical group 0.000 abstract 1
-1 cyclopentanyl ring Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Transplantation (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92120653T 1991-12-06 1992-12-03 Als immunosuppressiva nützliche trans- cyclopentanylpurinanaloge ATE194618T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US80415391A	1991-12-06	1991-12-06
US96560192A	1992-11-02	1992-11-02

Publications (1)

Publication Number	Publication Date
ATE194618T1 true ATE194618T1 (de)	2000-07-15

Family

ID=27122672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92120653T ATE194618T1 (de)	1991-12-06	1992-12-03	Als immunosuppressiva nützliche trans- cyclopentanylpurinanaloge

Country Status (17)

Country	Link
EP (1)	EP0545413B1 (de)
JP (1)	JP3264289B2 (de)
KR (1)	KR100251996B1 (de)
AT (1)	ATE194618T1 (de)
AU (1)	AU658698B2 (de)
CA (1)	CA2084222C (de)
DE (1)	DE69231242T2 (de)
DK (1)	DK0545413T3 (de)
ES (1)	ES2149163T3 (de)
FI (1)	FI109026B (de)
GR (1)	GR3034586T3 (de)
HU (2)	HU9203858D0 (de)
IL (1)	IL103962A (de)
MX (1)	MX9206963A (de)
NO (1)	NO305207B1 (de)
NZ (1)	NZ245342A (de)
PT (1)	PT545413E (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI956142A7 (fi)	1993-06-21	1995-12-20	Merrell Pharma Inc	Uudet proinflammatoristen sytokiinien selektiivisinä inhibiittoreina k äyttökelpoiset karbosykliset nukleosidiaineet
TW552261B (en) *	1996-07-03	2003-09-11	Japan Energy Corp	Novel purine derivative
US6413974B1 (en)	1998-02-26	2002-07-02	Aventis Pharmaceuticals Inc.	6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
US6479487B1 (en)	1998-02-26	2002-11-12	Aventis Pharmaceuticals Inc.	6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
FR2793794B1 (fr) *	1999-05-21	2001-07-27	Hoechst Marion Roussel Inc	Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
US6861524B2 (en)	2000-10-31	2005-03-01	Aventis Pharmaceuticals Inc.	Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4038479A (en) *	1969-11-17	1977-07-26	Burroughs Wellcome Co.	Amino purine derivatives
US4076711A (en) *	1976-04-05	1978-02-28	Schering Corporation	Triazolo [4,5-d]-pyrimidines
CA2001715C (en) *	1988-11-14	1999-12-28	Muzammil M. Mansuri	Carbocyclic nucleosides and nucleotides
EP0465297B1 (de) *	1990-07-04	1996-01-31	Merrell Dow Pharmaceuticals Inc.	9-Purinyl-Phosphonsäurederivate
AU647822B2 (en) *	1990-09-14	1994-03-31	Marion Merrell Dow Inc.	Novel carbocyclic adenosine analogs useful as immunosuppressants

1992
- 1992-12-01 AU AU29752/92A patent/AU658698B2/en not_active Ceased
- 1992-12-01 CA CA002084222A patent/CA2084222C/en not_active Expired - Fee Related
- 1992-12-02 NZ NZ245342A patent/NZ245342A/en unknown
- 1992-12-03 EP EP92120653A patent/EP0545413B1/de not_active Expired - Lifetime
- 1992-12-03 IL IL10396292A patent/IL103962A/xx not_active IP Right Cessation
- 1992-12-03 DK DK92120653T patent/DK0545413T3/da active
- 1992-12-03 PT PT92120653T patent/PT545413E/pt unknown
- 1992-12-03 AT AT92120653T patent/ATE194618T1/de not_active IP Right Cessation
- 1992-12-03 ES ES92120653T patent/ES2149163T3/es not_active Expired - Lifetime
- 1992-12-03 DE DE69231242T patent/DE69231242T2/de not_active Expired - Lifetime
- 1992-12-03 MX MX9206963A patent/MX9206963A/es not_active IP Right Cessation
- 1992-12-04 HU HU9203858A patent/HU9203858D0/hu unknown
- 1992-12-04 FI FI925520A patent/FI109026B/fi not_active IP Right Cessation
- 1992-12-04 JP JP35013492A patent/JP3264289B2/ja not_active Expired - Lifetime
- 1992-12-04 NO NO924691A patent/NO305207B1/no not_active IP Right Cessation
- 1992-12-04 HU HU9203858A patent/HU217077B/hu not_active IP Right Cessation
- 1992-12-05 KR KR1019920023426A patent/KR100251996B1/ko not_active Expired - Fee Related
2000
- 2000-10-09 GR GR20000402275T patent/GR3034586T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0545413A1 (de)	1993-06-09
HU217077B (hu)	1999-11-29
IL103962A (en)	1997-01-10
GR3034586T3 (en)	2001-01-31
JPH0656835A (ja)	1994-03-01
NO305207B1 (no)	1999-04-19
CA2084222C (en)	2004-04-06
FI109026B (fi)	2002-05-15
DE69231242T2 (de)	2000-12-21
KR100251996B1 (ko)	2000-09-01
HU9203858D0 (en)	1993-03-29
NO924691L (no)	1993-06-07
EP0545413B1 (de)	2000-07-12
AU658698B2 (en)	1995-04-27
NO924691D0 (no)	1992-12-04
CA2084222A1 (en)	1993-06-07
FI925520A0 (fi)	1992-12-04
ES2149163T3 (es)	2000-11-01
AU2975292A (en)	1993-06-10
DK0545413T3 (da)	2000-10-09
FI925520L (fi)	1993-06-07
NZ245342A (en)	1995-10-26
PT545413E (pt)	2000-10-31
JP3264289B2 (ja)	2002-03-11
IL103962A0 (en)	1993-05-13
HUT62896A (en)	1993-06-28
DE69231242D1 (de)	2000-08-17
MX9206963A (es)	1993-06-01

Legal Events

Date	Code	Title	Description
2000-11-15	UEP	Publication of translation of european patent specification
2005-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69324923D1 (de)	1999-06-17	Antiretrovirale, enantiomere Nukleotid-Analoge
PT1381366E (pt)	2009-07-21	Derivados indole, azaindole e heterocíclicos relacionados de amidopiperazina
FI935151A0 (fi)	1993-11-19	Foerfaranden foer diastereoselektiv syntes av nukleosider
DK0534709T3 (da)	2003-05-12	Substituerede taxaner som anti-tumormidler
ATE144513T1 (de)	1996-11-15	Pyrrolopyrimidinderivate, ihre herstellung und verwendung
MXPA04001240A (es)	2004-06-03	Analogos antitumorales.
HUP0001760A2 (hu)	2001-05-28	Aril-acil-piridazin-származékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és a vegyületek alkalmazása gyógyszerkészítmények előállítására
SE8500307D0 (sv)	1985-01-23	Nya, antiviruella medel
CA2051012A1 (en)	1992-03-15	Carbocyclic adenosine analogs useful as immunosupressants
ATE110382T1 (de)	1994-09-15	Oxetanocin.
FR2389623A1 (de)	1978-12-01
ATE194618T1 (de)	2000-07-15	Als immunosuppressiva nützliche trans- cyclopentanylpurinanaloge
ATE34394T1 (de)	1988-06-15	Therapeutisch aktive di-, tri-, tetra- und penta- aza-indene.
DE69509182D1 (de)	1999-05-27	Herstellung N-9-substituierter Guanin-Verbindungen
GB2233558B (en)	1993-12-15	Psychotropic use of aromatic amines
HUP9701134A2 (hu)	1998-12-28	Új kumarinszármazékok, eljárás előállításukra és intermedierként való alkalmazásuk új gyógyhatású kumarinszármazékok előállítására
ATE139444T1 (de)	1996-07-15	Carbocyklische nukleosidanaloge als immunsuppressoren
BG60248B2 (en)	1994-03-24	Process for the preparation of phenoxyethylamine derivatives
FI943360L (fi)	1994-07-14	Propoksibentseenijohdannaisia