NO924691L - Nye trans-cyklopentanylpurinanaloger som er anvendbare som immunoundertrykkende midler - Google Patents

Nye trans-cyklopentanylpurinanaloger som er anvendbare som immunoundertrykkende midler

Info

Publication number: NO924691L
Authority: NO; Norway
Prior art keywords: cyclopentanyl; purinal; immuno; analysis used; hydrogen
Prior art date: 1991-12-06

Application number

NO92924691A

Other languages

English (en)

Other versions

NO924691D0 (no

NO305207B1 (no

Inventor

David Roger Borcherding

Iii Carl Keith Edwards

Ronald Eugene Esser

Douglas Leon Cole

Original Assignee

Marion Merrell Dow Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-06

Filing date

1992-12-04

Publication date

1993-06-07

1992-12-04 Application filed by Marion Merrell Dow Inc filed Critical Marion Merrell Dow Inc

1992-12-04 Publication of NO924691D0 publication Critical patent/NO924691D0/no

1993-06-07 Publication of NO924691L publication Critical patent/NO924691L/no

1999-04-19 Publication of NO305207B1 publication Critical patent/NO305207B1/no

Links

239000003018 immunosuppressive agent Substances 0.000 title abstract 2
ZZBAGJPKGRJIJH-UHFFFAOYSA-N 7h-purine-2-carbaldehyde Chemical compound O=CC1=NC=C2NC=NC2=N1 ZZBAGJPKGRJIJH-UHFFFAOYSA-N 0.000 title 1
229940125721 immunosuppressive agent Drugs 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
229910003204 NH2 Inorganic materials 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
CFTPMBWYBDKGSA-UHFFFAOYSA-N 2-cyclopentyl-7h-purine Chemical class C1CCCC1C1=NC=C(NC=N2)C2=N1 CFTPMBWYBDKGSA-UHFFFAOYSA-N 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
125000005251 aryl acyl group Chemical group 0.000 abstract 1
-1 cyclopentanyl ring Chemical group 0.000 abstract 1
229960003444 immunosuppressant agent Drugs 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Neurology (AREA)
Endocrinology (AREA)
Oncology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Transplantation (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO924691A 1991-12-06 1992-12-04 Nye trans-syklopentanylpurinanaloger som er anvendbare som immunoundertrykkende midler NO305207B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US80415391A	1991-12-06	1991-12-06
US96560192A	1992-11-02	1992-11-02

Publications (3)

Publication Number	Publication Date
NO924691D0 NO924691D0 (no)	1992-12-04
NO924691L true NO924691L (no)	1993-06-07
NO305207B1 NO305207B1 (no)	1999-04-19

Family

ID=27122672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO924691A NO305207B1 (no)	1991-12-06	1992-12-04	Nye trans-syklopentanylpurinanaloger som er anvendbare som immunoundertrykkende midler

Country Status (17)

Country	Link
EP (1)	EP0545413B1 (no)
JP (1)	JP3264289B2 (no)
KR (1)	KR100251996B1 (no)
AT (1)	ATE194618T1 (no)
AU (1)	AU658698B2 (no)
CA (1)	CA2084222C (no)
DE (1)	DE69231242T2 (no)
DK (1)	DK0545413T3 (no)
ES (1)	ES2149163T3 (no)
FI (1)	FI109026B (no)
GR (1)	GR3034586T3 (no)
HU (2)	HU217077B (no)
IL (1)	IL103962A (no)
MX (1)	MX9206963A (no)
NO (1)	NO305207B1 (no)
NZ (1)	NZ245342A (no)
PT (1)	PT545413E (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2103131T3 (es)	1993-06-21	1997-08-16	Merrell Pharma Inc	Nuevos agentes de nucleosido carbociclico utiles como inhibidores selectivos de citoquinas proinflamatorias.
ATE283855T1 (de) *	1996-07-03	2004-12-15	Sumitomo Pharma	Neue purinderivate
US6479487B1 (en) *	1998-02-26	2002-11-12	Aventis Pharmaceuticals Inc.	6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
US6413974B1 (en)	1998-02-26	2002-07-02	Aventis Pharmaceuticals Inc.	6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
FR2793794B1 (fr) *	1999-05-21	2001-07-27	Hoechst Marion Roussel Inc	Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
US6861524B2 (en)	2000-10-31	2005-03-01	Aventis Pharmaceuticals Inc.	Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4038479A (en) *	1969-11-17	1977-07-26	Burroughs Wellcome Co.	Amino purine derivatives
US4076711A (en) *	1976-04-05	1978-02-28	Schering Corporation	Triazolo [4,5-d]-pyrimidines
CA2001715C (en) *	1988-11-14	1999-12-28	Muzammil M. Mansuri	Carbocyclic nucleosides and nucleotides
EP0465297B1 (en) *	1990-07-04	1996-01-31	Merrell Dow Pharmaceuticals Inc.	9-Purinyl phosphonic acid derivatives
CA2051012C (en) *	1990-09-14	2002-04-02	David R. Borcherding	Carbocyclic adenosine analogs useful as immunosupressants

1992
- 1992-12-01 CA CA002084222A patent/CA2084222C/en not_active Expired - Fee Related
- 1992-12-01 AU AU29752/92A patent/AU658698B2/en not_active Ceased
- 1992-12-02 NZ NZ245342A patent/NZ245342A/en unknown
- 1992-12-03 EP EP92120653A patent/EP0545413B1/en not_active Expired - Lifetime
- 1992-12-03 PT PT92120653T patent/PT545413E/pt unknown
- 1992-12-03 ES ES92120653T patent/ES2149163T3/es not_active Expired - Lifetime
- 1992-12-03 MX MX9206963A patent/MX9206963A/es not_active IP Right Cessation
- 1992-12-03 DK DK92120653T patent/DK0545413T3/da active
- 1992-12-03 IL IL10396292A patent/IL103962A/xx not_active IP Right Cessation
- 1992-12-03 DE DE69231242T patent/DE69231242T2/de not_active Expired - Lifetime
- 1992-12-03 AT AT92120653T patent/ATE194618T1/de not_active IP Right Cessation
- 1992-12-04 HU HU9203858A patent/HU217077B/hu not_active IP Right Cessation
- 1992-12-04 HU HU9203858A patent/HU9203858D0/hu unknown
- 1992-12-04 FI FI925520A patent/FI109026B/fi not_active IP Right Cessation
- 1992-12-04 JP JP35013492A patent/JP3264289B2/ja not_active Expired - Lifetime
- 1992-12-04 NO NO924691A patent/NO305207B1/no not_active IP Right Cessation
- 1992-12-05 KR KR1019920023426A patent/KR100251996B1/ko not_active Expired - Fee Related
2000
- 2000-10-09 GR GR20000402275T patent/GR3034586T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2084222C (en)	2004-04-06
AU658698B2 (en)	1995-04-27
IL103962A (en)	1997-01-10
DE69231242T2 (de)	2000-12-21
MX9206963A (es)	1993-06-01
DE69231242D1 (de)	2000-08-17
IL103962A0 (en)	1993-05-13
JP3264289B2 (ja)	2002-03-11
AU2975292A (en)	1993-06-10
NO924691D0 (no)	1992-12-04
NO305207B1 (no)	1999-04-19
GR3034586T3 (en)	2001-01-31
FI925520L (fi)	1993-06-07
DK0545413T3 (da)	2000-10-09
HU217077B (hu)	1999-11-29
JPH0656835A (ja)	1994-03-01
KR100251996B1 (ko)	2000-09-01
CA2084222A1 (en)	1993-06-07
ATE194618T1 (de)	2000-07-15
NZ245342A (en)	1995-10-26
HU9203858D0 (en)	1993-03-29
PT545413E (pt)	2000-10-31
EP0545413A1 (en)	1993-06-09
ES2149163T3 (es)	2000-11-01
FI109026B (fi)	2002-05-15
FI925520A0 (fi)	1992-12-04
HUT62896A (en)	1993-06-28
EP0545413B1 (en)	2000-07-12

Legal Events

Date	Code	Title	Description
2005-09-12	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
FI102965B1 (fi)	1999-03-31	Kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö
DE60232065D1 (de)	2009-06-04	Indol-, azaindol- und verwandte heterozyklische amidopiperazin-derivate
FI931370A0 (fi)	1993-03-26	Kvaeve innehaollande analoger av icke-aromatiska heterocykliska foereningar med en fusionerad ring
DK0471236T3 (da)	1995-07-24	Imidazopyridinderivater og deres anvendelse
MXPA04001240A (es)	2004-06-03	Analogos antitumorales.
SE7907812L (sv)	1979-09-20	Forfarande for framstellning av cefemforeningar
MY100574A (en)	1990-12-15	5-substituted-2-cyclopropyl-6, 8-difluoroquinoline derivatives and processes for preparation thereof
FR2389623A1 (no)	1978-12-01
FR2593504B1 (fr)	1988-12-09	Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
CA2051012A1 (en)	1992-03-15	Carbocyclic adenosine analogs useful as immunosupressants
NO924691D0 (no)	1992-12-04	Nye trans-cyklopentanylpurinanaloger som er anvendbare som immunoundertrykkende midler
FR2434167A1 (fr)	1980-03-21	Derives de l'hexahydro-1,2,3,3a,8,8a pyrrolo indole (2,3,-b)
FI925191A0 (fi)	1992-11-16	Nya oxazolderivat, deras framstaellning och farmaceutiska kompositionerinnehaollande dem
ES468127A1 (es)	1979-09-16	Un procedimiento para la preparacion de nuevos derivados de pirido (2,1-b) quinazolina
DK0475413T3 (da)	1996-07-15	Carbocycliske nukleosidanaloge, der kan anvendes som immunsuppressorer
BG60248B2 (en)	1994-03-24	Process for the preparation of phenoxyethylamine derivatives
DE3675431D1 (de)	1990-12-13	1,3-oxathianderivate.
FI943360L (fi)	1994-07-14	Propoksibentseenijohdannaisia