ID18747A - Senyawa-senyawa ester hidroksi-2-indolidinilbutirat yang tersubstitusi pada posisi-2, jenis s, dan proses pembuatannya - Google Patents

Senyawa-senyawa ester hidroksi-2-indolidinilbutirat yang tersubstitusi pada posisi-2, jenis s, dan proses pembuatannya

Info

Publication number: ID18747A
Authority: ID; Indonesia
Prior art keywords: compounds; type; indolidinylbutir; making; substituted hydroxy
Prior art date: 1996-10-30

Application number

IDP973523A

Other languages

English (en)

Indonesian (id)

Inventor

Takayuki Kawaguchim

Sumihiro Nomura

Kenhi Tsujihara

Original Assignee

Tanabe Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-30

Filing date

1997-10-24

Publication date

1998-05-07

1997-10-24 Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co

1998-05-07 Publication of ID18747A publication Critical patent/ID18747A/id

Links

150000001875 compounds Chemical class 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
-1 heterocyclic carboxylic acid Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000003402 intramolecular cyclocondensation reaction Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
230000009935 nitrosation Effects 0.000 abstract 1
238000007034 nitrosation reaction Methods 0.000 abstract 1
230000008707 rearrangement Effects 0.000 abstract 1
238000006462 rearrangement reaction Methods 0.000 abstract 1
230000009467 reduction Effects 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- G—PHYSICS
- G02—OPTICS
- G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
- G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
- G02F1/01—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour
- G02F1/13—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells
- G02F1/133—Constructional arrangements; Operation of liquid crystal cells; Circuit arrangements
- G02F1/1333—Constructional arrangements; Manufacturing methods
- G02F1/1345—Conductors connecting electrodes to cell terminals
- G02F1/13452—Conductors connecting driver circuitry and terminals of panels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- G—PHYSICS
- G02—OPTICS
- G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
- G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
- G02F1/01—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour
- G02F1/13—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells
- G02F1/1303—Apparatus specially adapted to the manufacture of LCDs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Physics & Mathematics (AREA)
Nonlinear Science (AREA)
Crystallography & Structural Chemistry (AREA)
General Physics & Mathematics (AREA)
Optics & Photonics (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Mathematical Physics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Manufacturing & Machinery (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

IDP973523A 1996-10-30 1997-10-24 Senyawa-senyawa ester hidroksi-2-indolidinilbutirat yang tersubstitusi pada posisi-2, jenis s, dan proses pembuatannya ID18747A (id)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP28807496		1996-10-30

Publications (1)

Publication Number	Publication Date
ID18747A true ID18747A (id)	1998-05-07

Family

ID=17725479

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDP973523A ID18747A (id)	1996-10-30	1997-10-24	Senyawa-senyawa ester hidroksi-2-indolidinilbutirat yang tersubstitusi pada posisi-2, jenis s, dan proses pembuatannya

Country Status (14)

Country	Link
US (7)	US5932732A (de)
EP (3)	EP0845464B1 (de)
KR (5)	KR100474496B1 (de)
CN (3)	CN100473654C (de)
AT (2)	ATE332303T1 (de)
CA (2)	CA2533685C (de)
DE (2)	DE69724081T2 (de)
DK (2)	DK1236728T3 (de)
ES (2)	ES2205134T3 (de)
HK (1)	HK1050356B (de)
ID (1)	ID18747A (de)
PT (2)	PT845464E (de)
SG (4)	SG104284A1 (de)
TW (1)	TW464652B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG104284A1 (en) *	1996-10-30	2004-06-21	Tanabe Seiyaku Co	S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
CN1531424A (zh)	2000-11-09	2004-09-22	��˹��ҩ�﹫˾	Sn-38类脂络合物和应用的方法
US20090137816A1 (en) *	2000-12-15	2009-05-28	Kurt Baum	Process for the manufacture of diaminofurazan
US6350756B1 (en)	2001-01-18	2002-02-26	California Pacific Medical Center	Camptothecin derivatives
CN101337900B (zh) *	2001-02-21	2013-12-18	株式会社雅库路特本社	喜树碱相关化合物的合成方法
TWI245768B (en) *	2001-02-21	2005-12-21	Yakult Honsha Kk	Process for synthesizing camptothecin related compound(s)
US6855720B2 (en)	2001-03-01	2005-02-15	California Pacific Medical Center	Nitrogen-based camptothecin derivatives
US6403604B1 (en)	2001-03-01	2002-06-11	California Pacific Medical Center	Nitrogen-based camptothecin derivatives
WO2003030864A1 (en) *	2001-05-29	2003-04-17	Neopharm, Inc.	Liposomal formulation of irinotecan
US20040034050A1 (en) *	2002-06-03	2004-02-19	Yang Li-Xi	Homo-camptothecin derivatives
WO2003101998A1 (en) *	2002-06-03	2003-12-11	California Pacific Medical Center	Nitrogen-based homo-camptothecin derivatives
US20060030578A1 (en) *	2002-08-20	2006-02-09	Neopharm, Inc.	Pharmaceutically active lipid based formulation of irinotecan
AU2003296897A1 (en) *	2002-08-20	2004-05-04	Neopharm, Inc.	Pharmaceutical formulations of camptothecine derivatives
JP4433918B2 (ja) *	2004-07-15	2010-03-17	コニカミノルタエムジー株式会社	画像形成方法
KR100651728B1 (ko) *	2004-11-10	2006-12-06	한국전자통신연구원	정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법
CN100390177C (zh) *	2004-11-25	2008-05-28	复旦大学	6-氰基-7-甲基-1,1-(2,2-二甲基-1,3-亚丙二氧基)-5-氧-1,2,3,5-四氢吲哚哩啶(i)的制备方法
WO2007015259A2 (en) *	2005-08-03	2007-02-08	Avra Laboratories Pvt. Ltd.	Method of synthesizing key intermediates for the production of camptothecin derivatives
US7875602B2 (en) *	2005-10-21	2011-01-25	Sutter West Bay Hospitals	Camptothecin derivatives as chemoradiosensitizing agents
CN104341429B (zh) *	2013-07-29	2016-08-10	北大方正集团有限公司	(s)-喜树碱中间体的制备方法及(s)-喜树碱的制备方法
IL277748B2 (en) *	2018-04-06	2024-07-01	Seagen Inc	Camptothecin peptide conjugates
TW202519270A (zh)	2018-06-07	2025-05-16	美商思進公司	喜樹鹼結合物
CN113041841B (zh) *	2021-03-22	2022-07-12	万华化学集团股份有限公司	一种抗污染浓水隔网的制备方法及应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4399282A (en) *	1979-07-10	1983-08-16	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives
JPS5711607A (en) *	1980-06-25	1982-01-21	Tokyo Shibaura Electric Co	Movable shelf control apparatus
JPS57116074A (en)	1981-01-09	1982-07-19	Yakult Honsha Co Ltd	Novel camptothecin derivative and its preparation
US4473692A (en) *	1981-09-04	1984-09-25	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives and process for preparing same
DE3682874D1 (de) *	1985-10-21	1992-01-23	Daiichi Seiyaku Co	Pyranoindolizinderivate und verfahren zu ihrer herstellung.
US4981968A (en) *	1987-03-31	1991-01-01	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
US5053512A (en) *	1987-04-14	1991-10-01	Research Triangle Institute	Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5244903A (en) *	1987-03-31	1993-09-14	Research Triangle Institute	Camptothecin analogs as potent inhibitors of topoisomerase I
US5122606A (en) *	1987-04-14	1992-06-16	Research Triangle Institute	10,11-methylenedioxy camptothecins
US4939255A (en) *	1987-06-24	1990-07-03	Daiichi Pharmaceutical Co., Ltd.	Hexa-cyclic camptothecin derivatives
US4943579A (en)	1987-10-06	1990-07-24	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Water soluble prodrugs of camptothecin
JPH0615547B2 (ja) *	1988-01-20	1994-03-02	株式会社ヤクルト本社	新規なカンプトテシン誘導体
JP2524803B2 (ja) *	1988-03-29	1996-08-14	株式会社ヤクルト本社	新規なカンプトテシン誘導体およびその製造法
DK0418099T3 (da) *	1989-09-15	2002-04-02	Res Triangle Inst	Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger
TW201303B (de)	1990-07-05	1993-03-01	Hoffmann La Roche
HU213136B (en) *	1990-08-14	1997-02-28	Kyorin Seiyaku Kk	Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
JP2887524B2 (ja) *	1990-11-30	1999-04-26	第一製薬株式会社	微生物による光学分割法
JP2923692B2 (ja) *	1990-11-30	1999-07-26	第一製薬株式会社	酵素による光学分割法
JPH04210675A (ja) *	1990-12-13	1992-07-31	Otsuka Pharmaceut Co Ltd	ベンゼン誘導体
ATE136898T1 (de) *	1991-10-29	1996-05-15	Glaxo Wellcome Inc	Wasserlösliche camptothecinderivate
CA2087898A1 (en) *	1992-01-24	1993-07-25	Hiroshi Akimoto	Condensed heterocyclic compounds, their production and use
AU3611093A (en) *	1992-02-21	1993-09-13	Smithkline Beecham Corporation	Substituted furo(3',4':6,7)indolizino(1,2-b)quinolinones
JP3126799B2 (ja) *	1992-03-31	2001-01-22	第一製薬株式会社	光学活性カンプトテシン誘導体及びその製法
JP3126798B2 (ja) *	1992-03-31	2001-01-22	第一製薬株式会社	光学活性インドリジン誘導体及びその製法
JP3359955B2 (ja) *	1992-07-16	2002-12-24	第一製薬株式会社	抗腫瘍剤
IS4152A (is) *	1993-04-29	1994-10-30	Glaxo Inc.	Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra
JPH07101956A (ja) *	1993-10-05	1995-04-18	Tanabe Seiyaku Co Ltd	ヒドロキシカンプトテシン化合物の製法
KR960029336A (ko) *	1995-01-09	1996-08-17	김충환	캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
TW438775B (en) *	1995-04-07	2001-06-07	Pharmacia & Upjohn Co Llc	Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds
WO1996036611A1 (en) *	1995-05-19	1996-11-21	Chiroscience Limited	3,4-disubstituted-phenylsulphonamides and their therapeutic use
SG50747A1 (en) *	1995-08-02	1998-07-20	Tanabe Seiyaku Co	Comptothecin derivatives
KR100475206B1 (ko)	1995-11-13	2005-12-16	훽스트 악티엔게젤샤프트	사이클릭및헤테로사이클릭N-치환된α-이미노하이드록삼산및카복실산
AU7732996A (en)	1995-11-22	1997-06-11	Research Triangle Institute	Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
CA2192725C (en) *	1995-12-28	2004-04-20	Kenji Tsujihara	Camptothecin derivatives
US5731316A (en)	1996-01-30	1998-03-24	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives
SG104284A1 (en) *	1996-10-30	2004-06-21	Tanabe Seiyaku Co	S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
DE19719817A1 (de) *	1997-05-13	1998-11-19	Hoechst Ag	Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren

1997
- 1997-10-23 SG SG200107149A patent/SG104284A1/en unknown
- 1997-10-23 SG SG200107147A patent/SG116433A1/en unknown
- 1997-10-23 SG SG200107148A patent/SG103322A1/en unknown
- 1997-10-23 SG SG9703851A patent/SG88737A1/en unknown
- 1997-10-23 TW TW086115665A patent/TW464652B/zh not_active IP Right Cessation
- 1997-10-24 ID IDP973523A patent/ID18747A/id unknown
- 1997-10-27 ES ES97308549T patent/ES2205134T3/es not_active Expired - Lifetime
- 1997-10-27 DK DK02006610T patent/DK1236728T3/da active
- 1997-10-27 AT AT02006610T patent/ATE332303T1/de not_active IP Right Cessation
- 1997-10-27 EP EP97308549A patent/EP0845464B1/de not_active Expired - Lifetime
- 1997-10-27 AT AT97308549T patent/ATE247120T1/de not_active IP Right Cessation
- 1997-10-27 ES ES02006610T patent/ES2267879T3/es not_active Expired - Lifetime
- 1997-10-27 PT PT97308549T patent/PT845464E/pt unknown
- 1997-10-27 DE DE69724081T patent/DE69724081T2/de not_active Expired - Fee Related
- 1997-10-27 EP EP02006610A patent/EP1236728B1/de not_active Expired - Lifetime
- 1997-10-27 PT PT02006610T patent/PT1236728E/pt unknown
- 1997-10-27 DK DK97308549T patent/DK0845464T3/da active
- 1997-10-27 DE DE69736308T patent/DE69736308T2/de not_active Expired - Fee Related
- 1997-10-27 EP EP04005684A patent/EP1528062A3/de not_active Withdrawn
- 1997-10-28 US US08/958,979 patent/US5932732A/en not_active Expired - Fee Related
- 1997-10-30 CA CA002533685A patent/CA2533685C/en not_active Expired - Fee Related
- 1997-10-30 CN CNB011109580A patent/CN100473654C/zh not_active Expired - Fee Related
- 1997-10-30 CN CNB2006101011920A patent/CN100528879C/zh not_active Expired - Fee Related
- 1997-10-30 CA CA002219692A patent/CA2219692C/en not_active Expired - Fee Related
- 1997-10-30 CN CN97122529A patent/CN1077109C/zh not_active Expired - Fee Related
- 1997-10-30 KR KR1019970056330A patent/KR100474496B1/ko not_active Expired - Fee Related
1998
- 1998-10-15 US US09/172,666 patent/US6015901A/en not_active Expired - Fee Related
- 1998-12-03 HK HK03100780.1A patent/HK1050356B/en not_active IP Right Cessation
1999
- 1999-10-18 US US09/421,335 patent/US6114529A/en not_active Expired - Fee Related
2000
- 2000-05-12 US US09/570,172 patent/US6277992B1/en not_active Expired - Fee Related
2001
- 2001-07-05 US US09/898,007 patent/US6388078B1/en not_active Expired - Fee Related
2002
- 2002-04-10 US US10/118,920 patent/US7060832B2/en not_active Expired - Fee Related
2003
- 2003-01-08 US US10/337,476 patent/US6716983B2/en not_active Expired - Fee Related
2004
- 2004-04-27 KR KR1020040029222A patent/KR100525025B1/ko not_active Expired - Fee Related
- 2004-09-13 KR KR1020040072932A patent/KR100567957B1/ko not_active Expired - Fee Related
2005
- 2005-06-10 KR KR1020050049637A patent/KR100578779B1/ko not_active Expired - Fee Related
- 2005-10-29 KR KR1020050102674A patent/KR100653592B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0845464A2 (de)	1998-06-03
SG88737A1 (en)	2002-05-21
TW464652B (en)	2001-11-21
PT845464E (pt)	2003-12-31
CN1915995A (zh)	2007-02-21
CN100528879C (zh)	2009-08-19
DK0845464T3 (da)	2003-12-01
EP0845464A3 (de)	1999-06-23
CA2219692C (en)	2007-05-22
CA2533685C (en)	2009-05-26
KR100653592B1 (ko)	2006-12-05
DK1236728T3 (da)	2006-10-30
CN1077109C (zh)	2002-01-02
KR19980033318A (ko)	1998-07-25
US6388078B1 (en)	2002-05-14
SG103322A1 (en)	2004-04-29
HK1050356A1 (en)	2003-06-20
KR20060086818A (ko)	2006-08-01
HK1011538A1 (en)	1999-07-16
US7060832B2 (en)	2006-06-13
KR100567957B1 (ko)	2006-04-05
EP1236728B1 (de)	2006-07-05
CN1183414A (zh)	1998-06-03
US6015901A (en)	2000-01-18
SG104284A1 (en)	2004-06-21
EP0845464B1 (de)	2003-08-13
ATE332303T1 (de)	2006-07-15
DE69736308D1 (de)	2006-08-17
HK1050356B (en)	2007-01-19
US5932732A (en)	1999-08-03
US20020161231A1 (en)	2002-10-31
EP1236728A2 (de)	2002-09-04
US6277992B1 (en)	2001-08-21
ES2205134T3 (es)	2004-05-01
CN100473654C (zh)	2009-04-01
US20030135049A1 (en)	2003-07-17
KR100474496B1 (ko)	2005-09-30
PT1236728E (pt)	2006-10-31
CA2533685A1 (en)	1998-04-30
ATE247120T1 (de)	2003-08-15
CA2219692A1 (en)	1998-04-30
EP1236728A3 (de)	2002-12-18
DE69736308T2 (de)	2007-06-14
MX9708343A (es)	1998-08-30
US6114529A (en)	2000-09-05
DE69724081T2 (de)	2004-06-09
CN1313286A (zh)	2001-09-19
KR100578779B1 (ko)	2006-05-12
SG116433A1 (en)	2005-11-28
KR100525025B1 (ko)	2005-10-31
US6716983B2 (en)	2004-04-06
EP1528062A2 (de)	2005-05-04
DE69724081D1 (de)	2003-09-18
EP1528062A3 (de)	2007-02-07
ES2267879T3 (es)	2007-03-16

Publication	Publication Date	Title
ID18747A (id)	1998-05-07	Senyawa-senyawa ester hidroksi-2-indolidinilbutirat yang tersubstitusi pada posisi-2, jenis s, dan proses pembuatannya
DE59401923D1 (de)	1997-04-10	Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel
GR3023174T3 (en)	1997-07-30	Substituted heterocyclic carboxylic acid amides, their preparation, and their use as medicaments.
DE69420068D1 (de)	1999-09-23	1H-Indol-3-Acetamid-Derivate als sPLA2-Inhibitoren
DE60037766D1 (de)	2008-02-21	Verfahren zur Herstellung von 2-Alkyl-3-aminothiophen Derivate und 3-Aminothiophen Derivate
DE60116201D1 (de)	2006-02-02	Verfahren zur Herstellung von Cephalosporin-Verbindungen und Zwischenprodukte für die Synthese dieser Verbindungen
DE59401759D1 (de)	1997-03-20	Verfahren zur Herstellung von Imidazopyridinderivaten
ATE554094T1 (de)	2012-05-15	Verfahren zur herstellung von 3-cephem- verbindungen
DK0643055T3 (da)	1997-12-08	Fremgangsmåde til fremstilling af 5-amino-2,2-dialkyl-1,3-dioxaner
DE69706632D1 (de)	2001-10-18	Verfahren zur herstellung von 3-norcephem-verbindungen
DE69427100D1 (de)	2001-05-23	Herstellung von Beta-lactamverbindungen und Zwischenprodukte
DE60111834D1 (de)	2005-08-11	Verfahren zur herstellung von 3-amino-1,5-benzodiazepinderivaten
ATE226207T1 (de)	2002-11-15	Verfahren zur herstellung von beta-lactam verbindungen
DE60117581D1 (de)	2006-04-27	Verfahren zur produktion eines trizyklischen kondensierten heterozyklischen derivats