ID26697A - Pemurnian neurotrofin - Google Patents

Pemurnian neurotrofin

Info

Publication number
ID26697A
ID26697A IDW990339D ID990339D ID26697A ID 26697 A ID26697 A ID 26697A ID W990339 D IDW990339 D ID W990339D ID 990339 D ID990339 D ID 990339D ID 26697 A ID26697 A ID 26697A
Authority
ID
Indonesia
Prior art keywords
neurotrophins
purification
neurotrofin
including mature
mature ngf
Prior art date
Application number
IDW990339D
Other languages
English (en)
Inventor
Louis E Burton
Charles H Schmelzer
Joanne T Beck
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ID26697A publication Critical patent/ID26697A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
IDW990339D 1996-11-15 1997-11-14 Pemurnian neurotrofin ID26697A (id)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3083896P 1996-11-15 1996-11-15
US4785597P 1997-05-29 1997-05-29

Publications (1)

Publication Number Publication Date
ID26697A true ID26697A (id) 2001-02-01

Family

ID=26706516

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW990339D ID26697A (id) 1996-11-15 1997-11-14 Pemurnian neurotrofin

Country Status (21)

Country Link
US (5) US6005081A (id)
EP (1) EP0942930B1 (id)
JP (3) JP4671372B2 (id)
KR (1) KR100554332B1 (id)
CN (1) CN1268639C (id)
AT (1) ATE371670T1 (id)
AU (1) AU729459B2 (id)
BR (1) BR9713055A (id)
CA (1) CA2268747A1 (id)
CZ (1) CZ300296B6 (id)
DE (1) DE69738074T2 (id)
EA (1) EA002349B1 (id)
ES (1) ES2293662T3 (id)
HU (1) HU222666B1 (id)
ID (1) ID26697A (id)
IL (2) IL129851A0 (id)
NO (1) NO327149B1 (id)
NZ (1) NZ335207A (id)
PL (1) PL191400B1 (id)
TR (1) TR199901734T2 (id)
WO (1) WO1998021234A2 (id)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ335207A (en) * 1996-11-15 2000-09-29 Genentech Inc Process to isolate recombinant human neurotrophin using hydrophobic chromatography resin
EP1032830A1 (en) * 1997-11-20 2000-09-06 ESA, Inc. Electrochemical analysis system
BRPI9910332B8 (pt) * 1998-05-06 2021-05-25 Genentech Inc método para purificação de um polipeptídio a partir de uma composição
ES2343023T3 (es) 2000-03-27 2010-07-21 Genetics Institute, Llc Procedimientos para purificar proteinas altamente anionicas.
ES2266535T3 (es) * 2001-06-05 2007-03-01 Genetics Institute, Llc Procedimientos relativos a la purificacion de proteinas altamente anionicas.
WO2002102844A1 (en) * 2001-06-15 2002-12-27 Queensland Bioprocessing Technology Pty Ltd Haemocyanin from abalone and process of purification thereof
CA2490409A1 (en) 2002-06-28 2004-01-08 Centocor, Inc. Mammalian ch1 deleted mimetibodies, compositions, methods and uses
US7998705B2 (en) * 2002-08-06 2011-08-16 FUJIFILM Diosynth Biotechnologies U.S.A., Inc Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol
AU2003902066A0 (en) * 2003-05-01 2003-05-15 Norika Holdings Extraction process for a pharmaceutical product
EP1538201A1 (en) * 2003-12-02 2005-06-08 F.Hoffmann-La Roche Ag Method for the recombinant production and purification of protein kinases
CA2487673C (en) * 2003-12-02 2010-11-02 F. Hoffmann-La Roche Ag Improved method for the recombinant production and purification of protein kinases
BRPI0506793A (pt) * 2004-02-20 2007-05-22 Rinat Neuroscience Corp métodos de tratamento de obesidade ou diabetes com o uso de nt-4/5
CA2564031A1 (en) * 2004-04-23 2005-11-03 Conjuchem Biotechnologies Inc. Method for the purification of albumin conjugates
WO2006125763A1 (en) 2005-05-25 2006-11-30 Novo Nordisk A/S Stabilized polypeptide formulations
US20090060861A1 (en) * 2005-05-25 2009-03-05 Novo Nordisk A/S Stabilized Polypeptide Formulations
DK1917276T3 (en) 2005-08-26 2018-05-07 Ares Trading Sa Process for Preparation of Glycosylated Interferon Beta
AU2006323925B2 (en) * 2005-12-09 2012-08-02 Ares Trading S.A. Method for purifying FSH or a FSH mutant
CN100419422C (zh) * 2005-12-12 2008-09-17 北京三诺佳邑生物技术有限责任公司 测定神经生长因子含量的方法
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
PL2253644T3 (pl) 2005-12-20 2014-04-30 Bristol Myers Squibb Co Kompozycje i sposoby wytwarzania kompozycji
CA2637707A1 (en) * 2006-02-02 2007-08-09 Rinat Neuroscience Corporation Methods for treating obesity by administering a trkb antagonist
CN101400367A (zh) 2006-02-02 2009-04-01 瑞纳神经科学公司 施用trkb激动剂治疗不希望的重量减轻或进食障碍的方法
US10741034B2 (en) 2006-05-19 2020-08-11 Apdn (B.V.I.) Inc. Security system and method of marking an inventory item and/or person in the vicinity
US9790538B2 (en) * 2013-03-07 2017-10-17 Apdn (B.V.I.) Inc. Alkaline activation for immobilization of DNA taggants
KR20090091181A (ko) * 2006-12-20 2009-08-26 리나트 뉴로사이언스 코퍼레이션 자가면역 장애의 치료를 위한 티로신 수용체 키나아제 ｂ 작용제
HUE037162T2 (hu) 2007-07-09 2018-08-28 Genentech Inc Diszulfidkötés redukciójának megelõzése polipeptidek rekombináns elõállítása során
CN105315323A (zh) * 2007-10-30 2016-02-10 健泰科生物技术公司 通过阳离子交换层析进行的抗体纯化
US8447409B2 (en) * 2008-10-15 2013-05-21 Cochlear Limited Electroneural interface for a medical implant
WO2010075535A1 (en) * 2008-12-23 2010-07-01 Regents Of The University Of Minnesota Neurotrophins and uses thereof
JP5695384B2 (ja) 2009-10-05 2015-04-01 花王株式会社 毛髪形状感受性遺伝子
JP5699429B2 (ja) * 2009-12-18 2015-04-08 東ソー株式会社 Ｆｃレセプターの精製方法
EP3715356B1 (en) 2009-12-18 2023-10-11 CSL Limited Method of purifying polypeptides
TWI504894B (zh) * 2010-06-25 2015-10-21 Nippon Zoki Pharmaceutical Co 被檢物質的判定或評價方法
CN102898514B (zh) * 2011-07-28 2015-04-29 中国人民解放军军事医学科学院生物工程研究所 重组人神经生长因子缺失突变体及其制备方法和用途
EP2594295A1 (en) 2011-11-16 2013-05-22 Servicio Andaluz De Salud Nerve implants based on a compacted biomaterial containing cells
US9266370B2 (en) 2012-10-10 2016-02-23 Apdn (B.V.I) Inc. DNA marking of previously undistinguished items for traceability
US9297032B2 (en) 2012-10-10 2016-03-29 Apdn (B.V.I.) Inc. Use of perturbants to facilitate incorporation and recovery of taggants from polymerized coatings
US9963740B2 (en) 2013-03-07 2018-05-08 APDN (B.V.I.), Inc. Method and device for marking articles
WO2015054188A1 (en) 2013-10-07 2015-04-16 Apdn (B.V.I), Inc. Multimode image and spectral reader
CN103880943A (zh) * 2014-01-20 2014-06-25 厦门北大之路生物工程有限公司 一种rhNGF成熟肽的制备方法
US10745825B2 (en) 2014-03-18 2020-08-18 Apdn (B.V.I.) Inc. Encrypted optical markers for security applications
ES2978925T3 (es) 2014-03-18 2024-09-23 Apdn Bvi Inc Marcadores ópticos cifrados para aplicaciones de seguridad
CN104195160A (zh) * 2014-08-08 2014-12-10 厦门北大之路生物工程有限公司 一种以Pro-BDNF的形式制备人脑源性神经营养因子的方法
US10760182B2 (en) 2014-12-16 2020-09-01 Apdn (B.V.I.) Inc. Method and device for marking fibrous materials
CN106279397A (zh) * 2015-06-09 2017-01-04 舒泰神（北京）生物制药股份有限公司 一种神经生长因子的提取方法
US10519605B2 (en) 2016-04-11 2019-12-31 APDN (B.V.I.), Inc. Method of marking cellulosic products
CN106478801A (zh) * 2016-10-10 2017-03-08 未名生物医药有限公司 一种从哺乳动物细胞培养物中分离重组人神经生长因子的方法
US10995371B2 (en) 2016-10-13 2021-05-04 Apdn (B.V.I.) Inc. Composition and method of DNA marking elastomeric material
US10920274B2 (en) 2017-02-21 2021-02-16 Apdn (B.V.I.) Inc. Nucleic acid coated submicron particles for authentication
GB201705955D0 (en) * 2017-04-13 2017-05-31 Cell Guidance Systems Ltd Delivery method
CN107973848B (zh) * 2017-12-28 2020-10-16 未名生物医药有限公司 一种从混合物中分离天然序列神经生长因子的方法
CN108467428A (zh) * 2018-03-26 2018-08-31 江苏中新医药有限公司 一种清除rhNGF中N端截短及异常变异体的方法
CN108239146A (zh) * 2018-03-26 2018-07-03 江苏中新医药有限公司 一种高纯度rhNGF的制备方法
CN108467429A (zh) 2018-03-26 2018-08-31 江苏中新医药有限公司 疏水层析动态清除重组人神经生长因子前体的方法
MA52351B1 (fr) * 2018-04-27 2026-04-30 Chiesi Farmaceutici S.P.A. Production de facteur de croissance nerveuse (ngf) et de ses mutéines
CN114252519B (zh) * 2020-09-23 2023-11-24 舒泰神（北京）生物制药股份有限公司 一种测定神经生长因子纯度的方法
CN114380901A (zh) * 2021-12-31 2022-04-22 华东理工大学 蛋白纳米粒子的制备方法、所得蛋白纳米粒子及其应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4407744A (en) * 1977-11-23 1983-10-04 Young David M Process for obtaining nerve growth factor
US4565785A (en) * 1978-06-08 1986-01-21 The President And Fellows Of Harvard College Recombinant DNA molecule
US4673641A (en) * 1982-12-16 1987-06-16 Molecular Genetics Research And Development Limited Partnership Co-aggregate purification of proteins
US5169762A (en) * 1983-03-03 1992-12-08 Genentech, Inc. Human nerve growth factor by recombinant technology
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4710473A (en) * 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
US4738921A (en) * 1984-09-27 1988-04-19 Eli Lilly And Company Derivative of the tryptophan operon for expression of fused gene products
US4795706A (en) * 1985-01-31 1989-01-03 Eli Lilly And Company Novel expression control sequences
IT1219874B (it) * 1988-03-18 1990-05-24 Fidia Farmaceutici Utilizzazione del fattore di crescita nervoso umano e sue composizioni farmaceutiche
US5082774A (en) * 1988-08-30 1992-01-21 The General Hospital Corporation Recombinant human nerve growth factor
US5272063A (en) * 1988-11-22 1993-12-21 Syntex (U.S.A.) Inc. Process of making human nerve growth factor
CA2005600A1 (en) * 1988-12-20 1990-06-20 Cal-Henrik Heldin Endothelial cell growth factor
ATE119938T1 (de) * 1989-08-21 1995-04-15 Takeda Chemical Industries Ltd Produktion von menschlichen nervenwachstumsfaktoren.
JPH04128300A (ja) * 1989-08-21 1992-04-28 Takeda Chem Ind Ltd ヒト神経成長因子蛋白質およびその製造法
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
US5606031A (en) * 1990-04-06 1997-02-25 Lile; Jack Production and purification of biologically active recombinant neurotrophic protein in bacteria
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
US5169764A (en) * 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
EP0550665B1 (en) * 1990-09-25 1996-07-31 Genentech, Inc. Novel neurothrophic factor
US5364769A (en) * 1990-09-25 1994-11-15 Genentech, Inc. Nucleic acid encoding neurotrophic factor four (NT-4), vectors, host cells and methods of production
US6506728B2 (en) * 1990-09-25 2003-01-14 Genentech, Inc. Methods using a novel neurotrophic factor, NT-4
EP0499993B1 (en) * 1991-02-18 1997-06-11 Takeda Chemical Industries, Ltd. Method for producing human nerve growth factor-2
PT100580A (pt) * 1991-06-12 1993-09-30 Regeneron Pharma Producao e recuperacao de neurotrofinas recombinantes
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
DE4133707A1 (de) * 1991-10-11 1993-04-15 Behringwerke Ag Verfahren zur reinigung von streptolysin o, intaktes streptolysin o erhaeltlich nach diesem verfahren und seine verwendung
JPH05211887A (ja) * 1992-01-31 1993-08-24 Hitachi Ltd 神経成長因子の生産方法
US5488099A (en) * 1992-03-06 1996-01-30 Persson, Deceased; Hakan B. Multifunctional chimeric neurotrophic factors
US5349055A (en) * 1992-03-06 1994-09-20 Persson Hakan B Nerve growth factor having altered receptor binding specificities
US5451660A (en) * 1993-12-13 1995-09-19 Genentech, Inc. Method for purifying polypeptides
US5728803A (en) * 1994-06-03 1998-03-17 Genentech, Inc. Pantropic neurotrophic factors
US5759775A (en) * 1994-10-27 1998-06-02 Genetech, Inc. Methods for detecting nucleic acids encoding AL--1 neurotrophic factor
US5733875A (en) * 1994-11-15 1998-03-31 Amgen Inc. Methods of using GDNF as a neuroprotective agent
US5650496A (en) * 1995-04-14 1997-07-22 Cephalon, Inc. IGF-I purification process
IL118201A (en) * 1995-05-11 2004-12-15 Roche Diagnostics Gmbh Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof
US5739307A (en) * 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
NZ335207A (en) * 1996-11-15 2000-09-29 Genentech Inc Process to isolate recombinant human neurotrophin using hydrophobic chromatography resin

Also Published As

Publication number Publication date
WO1998021234A2 (en) 1998-05-22
WO1998021234A3 (en) 1998-07-23
CZ300296B6 (cs) 2009-04-15
EP0942930B1 (en) 2007-08-29
KR20000053297A (ko) 2000-08-25
JP2009040786A (ja) 2009-02-26
DE69738074D1 (de) 2007-10-11
CA2268747A1 (en) 1998-05-22
HU222666B1 (hu) 2003-09-29
EP0942930A2 (en) 1999-09-22
HUP9903947A3 (en) 2001-03-28
NZ335207A (en) 2000-09-29
US6423831B1 (en) 2002-07-23
JP2001503779A (ja) 2001-03-21
KR100554332B1 (ko) 2006-02-24
NO992353L (no) 1999-07-09
PL333460A1 (en) 1999-12-20
NO327149B1 (no) 2009-05-04
JP4881234B2 (ja) 2012-02-22
JP4671372B2 (ja) 2011-04-13
EA002349B1 (ru) 2002-04-25
CN1237184A (zh) 1999-12-01
BR9713055A (pt) 2000-04-04
CN1268639C (zh) 2006-08-09
AU729459B2 (en) 2001-02-01
US6812330B2 (en) 2004-11-02
ATE371670T1 (de) 2007-09-15
AU5444898A (en) 1998-06-03
JP2007302679A (ja) 2007-11-22
TR199901734T2 (xx) 2000-01-21
US6005081A (en) 1999-12-21
IL129851A (en) 2006-12-10
IL129851A0 (en) 2000-02-29
HUP9903947A2 (hu) 2000-03-28
US20040138431A1 (en) 2004-07-15
ES2293662T3 (es) 2008-03-16
EA199900436A1 (ru) 2000-02-28
PL191400B1 (pl) 2006-05-31
CZ166699A3 (cs) 1999-10-13
US6953844B2 (en) 2005-10-11
US6184360B1 (en) 2001-02-06
US20020137893A1 (en) 2002-09-26
DE69738074T2 (de) 2008-05-21
NO992353D0 (no) 1999-05-14

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