ID26697A - Pemurnian neurotrofin - Google Patents

Pemurnian neurotrofin

Info

Publication number
ID26697A
ID26697A IDW990339D ID990339D ID26697A ID 26697 A ID26697 A ID 26697A ID W990339 D IDW990339 D ID W990339D ID 990339 D ID990339 D ID 990339D ID 26697 A ID26697 A ID 26697A
Authority
ID
Indonesia
Prior art keywords
neurotrophins
purification
neurotrofin
including mature
mature ngf
Prior art date
Application number
IDW990339D
Other languages
English (en)
Inventor
Louis E Burton
Charles H Schmelzer
Joanne T Beck
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ID26697A publication Critical patent/ID26697A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
IDW990339D 1996-11-15 1997-11-14 Pemurnian neurotrofin ID26697A (id)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3083896P 1996-11-15 1996-11-15
US4785597P 1997-05-29 1997-05-29

Publications (1)

Publication Number Publication Date
ID26697A true ID26697A (id) 2001-02-01

Family

ID=26706516

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW990339D ID26697A (id) 1996-11-15 1997-11-14 Pemurnian neurotrofin

Country Status (21)

Country Link
US (5) US6005081A (id)
EP (1) EP0942930B1 (id)
JP (3) JP4671372B2 (id)
KR (1) KR100554332B1 (id)
CN (1) CN1268639C (id)
AT (1) ATE371670T1 (id)
AU (1) AU729459B2 (id)
BR (1) BR9713055A (id)
CA (1) CA2268747A1 (id)
CZ (1) CZ300296B6 (id)
DE (1) DE69738074T2 (id)
EA (1) EA002349B1 (id)
ES (1) ES2293662T3 (id)
HU (1) HU222666B1 (id)
ID (1) ID26697A (id)
IL (2) IL129851A0 (id)
NO (1) NO327149B1 (id)
NZ (1) NZ335207A (id)
PL (1) PL191400B1 (id)
TR (1) TR199901734T2 (id)
WO (1) WO1998021234A2 (id)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2268747A1 (en) * 1996-11-15 1998-05-22 Genentech, Inc. Purification of neurotrophins
JP2001524670A (ja) * 1997-11-20 2001-12-04 イーエスエー・インコーポレーテッド 電気化学的分析システム
ES2292682T3 (es) * 1998-05-06 2008-03-16 Genentech, Inc. Purificacion de anticuerpos mediante cromatografia de intercambio ionico.
CA2404155C (en) 2000-03-27 2011-08-09 Genetics Institute, Llc. Methods for purifying highly anionic proteins
WO2002098531A1 (en) * 2001-06-05 2002-12-12 Genetics Institute, Llc Methods for purifying highly anionic proteins
WO2002102844A1 (en) * 2001-06-15 2002-12-27 Queensland Bioprocessing Technology Pty Ltd Haemocyanin from abalone and process of purification thereof
AU2003280130B2 (en) 2002-06-28 2009-06-11 Centocor, Inc. Mammalian CH1 deleted mimetibodies, compositions, methods and uses
US7998705B2 (en) * 2002-08-06 2011-08-16 FUJIFILM Diosynth Biotechnologies U.S.A., Inc Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol
AU2003902066A0 (en) * 2003-05-01 2003-05-15 Norika Holdings Extraction process for a pharmaceutical product
CA2487673C (en) * 2003-12-02 2010-11-02 F. Hoffmann-La Roche Ag Improved method for the recombinant production and purification of protein kinases
EP1538201A1 (en) * 2003-12-02 2005-06-08 F.Hoffmann-La Roche Ag Method for the recombinant production and purification of protein kinases
JP2007523196A (ja) * 2004-02-20 2007-08-16 ライナット ニューロサイエンス コーポレイション Ｎｔ−４／５を用いて肥満または糖尿病を処置する方法
ES2328591T3 (es) * 2004-04-23 2009-11-16 Conjuchem Biotechnologies Inc. Procedimiento para la purificacion de conjugados de albumina.
US20090060861A1 (en) * 2005-05-25 2009-03-05 Novo Nordisk A/S Stabilized Polypeptide Formulations
EP1888118B1 (en) 2005-05-25 2016-08-17 Novo Nordisk A/S Polypeptide formulations stabilized with ethylenediamine
SG155183A1 (en) 2005-08-26 2009-09-30 Ares Trading Sa Process for the preparation of glycosylated interferon beta
US8604175B2 (en) 2005-12-09 2013-12-10 Ares Trading S.A. Method for purifying FSH or a FSH mutant
CN100419422C (zh) * 2005-12-12 2008-09-17 北京三诺佳邑生物技术有限责任公司 测定神经生长因子含量的方法
AU2006330922B2 (en) 2005-12-20 2012-07-26 Bristol-Myers Squibb Company Compositions and methods for producing a composition
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
EP1988923A1 (en) * 2006-02-02 2008-11-12 Rinat Neuroscience Corp. Methods for treating unwanted weight loss or eating disorders by administering a trkb agonist
US7935342B2 (en) * 2006-02-02 2011-05-03 Rinat Neuroscience Corp. Methods for treating obesity by administering a trkB antagonist
US10741034B2 (en) 2006-05-19 2020-08-11 Apdn (B.V.I.) Inc. Security system and method of marking an inventory item and/or person in the vicinity
US9790538B2 (en) * 2013-03-07 2017-10-17 Apdn (B.V.I.) Inc. Alkaline activation for immobilization of DNA taggants
BRPI0720473A2 (pt) * 2006-12-20 2014-01-14 Rinat Neuroscience Corp Agonistas de trkb para tratamento de distúbios autoimunes
MX354993B (es) 2007-07-09 2018-03-28 Genentech Inc Prevención de reducción de enlaces de disulfuro durante la producción recombinante de polipéptidos.
BRPI0817182A2 (pt) 2007-10-30 2015-03-17 Genentech Inc Método para purificar um anticorpo e composições
US8447409B2 (en) * 2008-10-15 2013-05-21 Cochlear Limited Electroneural interface for a medical implant
WO2010075535A1 (en) * 2008-12-23 2010-07-01 Regents Of The University Of Minnesota Neurotrophins and uses thereof
JP5695384B2 (ja) 2009-10-05 2015-04-01 花王株式会社 毛髪形状感受性遺伝子
DK2513135T3 (da) 2009-12-18 2020-05-18 Csl Ltd Fremgangsmåde til oprensning af polypeptider
JP5699429B2 (ja) * 2009-12-18 2015-04-08 東ソー株式会社 Ｆｃレセプターの精製方法
WO2011162317A1 (ja) * 2010-06-25 2011-12-29 日本臓器製薬株式会社 被検物質の判定又は評価方法
CN102898514B (zh) * 2011-07-28 2015-04-29 中国人民解放军军事医学科学院生物工程研究所 重组人神经生长因子缺失突变体及其制备方法和用途
EP2594295A1 (en) 2011-11-16 2013-05-22 Servicio Andaluz De Salud Nerve implants based on a compacted biomaterial containing cells
US9266370B2 (en) 2012-10-10 2016-02-23 Apdn (B.V.I) Inc. DNA marking of previously undistinguished items for traceability
US9297032B2 (en) 2012-10-10 2016-03-29 Apdn (B.V.I.) Inc. Use of perturbants to facilitate incorporation and recovery of taggants from polymerized coatings
US9963740B2 (en) 2013-03-07 2018-05-08 APDN (B.V.I.), Inc. Method and device for marking articles
WO2015054188A1 (en) 2013-10-07 2015-04-16 Apdn (B.V.I), Inc. Multimode image and spectral reader
CN103880943A (zh) * 2014-01-20 2014-06-25 厦门北大之路生物工程有限公司 一种rhNGF成熟肽的制备方法
CN106103121B (zh) 2014-03-18 2019-12-06 亚普蒂恩(B.V.I.)公司 用于安全应用的加密光学标记物
US10745825B2 (en) 2014-03-18 2020-08-18 Apdn (B.V.I.) Inc. Encrypted optical markers for security applications
CN104195160A (zh) * 2014-08-08 2014-12-10 厦门北大之路生物工程有限公司 一种以Pro-BDNF的形式制备人脑源性神经营养因子的方法
US10760182B2 (en) 2014-12-16 2020-09-01 Apdn (B.V.I.) Inc. Method and device for marking fibrous materials
CN106279397A (zh) * 2015-06-09 2017-01-04 舒泰神（北京）生物制药股份有限公司 一种神经生长因子的提取方法
CN109070130B (zh) 2016-04-11 2022-03-22 亚普蒂恩（B V I）公司 用于标记纤维素产品的方法
CN106478801A (zh) * 2016-10-10 2017-03-08 未名生物医药有限公司 一种从哺乳动物细胞培养物中分离重组人神经生长因子的方法
US10995371B2 (en) 2016-10-13 2021-05-04 Apdn (B.V.I.) Inc. Composition and method of DNA marking elastomeric material
WO2018156352A1 (en) 2017-02-21 2018-08-30 Apdn (B.V.I) Inc. Nucleic acid coated submicron particles for authentication
GB201705955D0 (en) * 2017-04-13 2017-05-31 Cell Guidance Systems Ltd Delivery method
CN107973848B (zh) * 2017-12-28 2020-10-16 未名生物医药有限公司 一种从混合物中分离天然序列神经生长因子的方法
CN108467429A (zh) * 2018-03-26 2018-08-31 江苏中新医药有限公司 疏水层析动态清除重组人神经生长因子前体的方法
CN108239146A (zh) * 2018-03-26 2018-07-03 江苏中新医药有限公司 一种高纯度rhNGF的制备方法
CN108467428A (zh) * 2018-03-26 2018-08-31 江苏中新医药有限公司 一种清除rhNGF中N端截短及异常变异体的方法
EP3784691B1 (en) * 2018-04-27 2026-03-25 Chiesi Farmaceutici S.p.A. Production of nerve growth factor (ngf) and of muteins thereof
CN114252519B (zh) * 2020-09-23 2023-11-24 舒泰神（北京）生物制药股份有限公司 一种测定神经生长因子纯度的方法
CN114380901A (zh) * 2021-12-31 2022-04-22 华东理工大学 蛋白纳米粒子的制备方法、所得蛋白纳米粒子及其应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4407744A (en) * 1977-11-23 1983-10-04 Young David M Process for obtaining nerve growth factor
US4565785A (en) * 1978-06-08 1986-01-21 The President And Fellows Of Harvard College Recombinant DNA molecule
US4673641A (en) * 1982-12-16 1987-06-16 Molecular Genetics Research And Development Limited Partnership Co-aggregate purification of proteins
US5169762A (en) * 1983-03-03 1992-12-08 Genentech, Inc. Human nerve growth factor by recombinant technology
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4710473A (en) * 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
US4738921A (en) * 1984-09-27 1988-04-19 Eli Lilly And Company Derivative of the tryptophan operon for expression of fused gene products
US4795706A (en) * 1985-01-31 1989-01-03 Eli Lilly And Company Novel expression control sequences
IT1219874B (it) * 1988-03-18 1990-05-24 Fidia Farmaceutici Utilizzazione del fattore di crescita nervoso umano e sue composizioni farmaceutiche
US5082774A (en) * 1988-08-30 1992-01-21 The General Hospital Corporation Recombinant human nerve growth factor
US5272063A (en) * 1988-11-22 1993-12-21 Syntex (U.S.A.) Inc. Process of making human nerve growth factor
CA2005600A1 (en) * 1988-12-20 1990-06-20 Cal-Henrik Heldin Endothelial cell growth factor
DK0414151T3 (da) * 1989-08-21 1995-05-22 Takeda Chemical Industries Ltd Humane nervevæskstfaktorproteiner og fremstilling deraf
JPH04128300A (ja) * 1989-08-21 1992-04-28 Takeda Chem Ind Ltd ヒト神経成長因子蛋白質およびその製造法
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US5606031A (en) * 1990-04-06 1997-02-25 Lile; Jack Production and purification of biologically active recombinant neurotrophic protein in bacteria
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
US5169764A (en) * 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
US5702906A (en) * 1990-09-25 1997-12-30 Genentech, Inc. Antibodies to neurotrophic factor-4 (NT-4)
DK0550665T3 (da) * 1990-09-25 1996-12-02 Genentech Inc Ny neurotrofisk faktor
US5364769A (en) * 1990-09-25 1994-11-15 Genentech, Inc. Nucleic acid encoding neurotrophic factor four (NT-4), vectors, host cells and methods of production
DE69220259T2 (de) * 1991-02-18 1997-11-13 Takeda Chemical Industries Ltd Verfahren zur Herstellung von menschlichem NGF-2
PT100580A (pt) * 1991-06-12 1993-09-30 Regeneron Pharma Producao e recuperacao de neurotrofinas recombinantes
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
DE4133707A1 (de) * 1991-10-11 1993-04-15 Behringwerke Ag Verfahren zur reinigung von streptolysin o, intaktes streptolysin o erhaeltlich nach diesem verfahren und seine verwendung
JPH05211887A (ja) * 1992-01-31 1993-08-24 Hitachi Ltd 神経成長因子の生産方法
US5488099A (en) * 1992-03-06 1996-01-30 Persson, Deceased; Hakan B. Multifunctional chimeric neurotrophic factors
US5349055A (en) * 1992-03-06 1994-09-20 Persson Hakan B Nerve growth factor having altered receptor binding specificities
US5451660A (en) * 1993-12-13 1995-09-19 Genentech, Inc. Method for purifying polypeptides
US5728803A (en) * 1994-06-03 1998-03-17 Genentech, Inc. Pantropic neurotrophic factors
US5798448A (en) * 1994-10-27 1998-08-25 Genentech, Inc. AL-1 neurotrophic factor antibodies
US5733875A (en) * 1994-11-15 1998-03-31 Amgen Inc. Methods of using GDNF as a neuroprotective agent
US5650496A (en) * 1995-04-14 1997-07-22 Cephalon, Inc. IGF-I purification process
IL118201A (en) * 1995-05-11 2004-12-15 Roche Diagnostics Gmbh Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof
US5739307A (en) * 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
CA2268747A1 (en) * 1996-11-15 1998-05-22 Genentech, Inc. Purification of neurotrophins

Also Published As

Publication number Publication date
IL129851A (en) 2006-12-10
JP4671372B2 (ja) 2011-04-13
JP2007302679A (ja) 2007-11-22
ES2293662T3 (es) 2008-03-16
US6423831B1 (en) 2002-07-23
DE69738074D1 (de) 2007-10-11
JP2001503779A (ja) 2001-03-21
US6953844B2 (en) 2005-10-11
US20020137893A1 (en) 2002-09-26
CN1237184A (zh) 1999-12-01
AU729459B2 (en) 2001-02-01
US6005081A (en) 1999-12-21
CZ166699A3 (cs) 1999-10-13
US6812330B2 (en) 2004-11-02
PL191400B1 (pl) 2006-05-31
CA2268747A1 (en) 1998-05-22
US20040138431A1 (en) 2004-07-15
WO1998021234A3 (en) 1998-07-23
TR199901734T2 (xx) 2000-01-21
EP0942930B1 (en) 2007-08-29
JP4881234B2 (ja) 2012-02-22
NO992353L (no) 1999-07-09
EA002349B1 (ru) 2002-04-25
WO1998021234A2 (en) 1998-05-22
NO992353D0 (no) 1999-05-14
ATE371670T1 (de) 2007-09-15
AU5444898A (en) 1998-06-03
JP2009040786A (ja) 2009-02-26
HUP9903947A2 (hu) 2000-03-28
NZ335207A (en) 2000-09-29
NO327149B1 (no) 2009-05-04
DE69738074T2 (de) 2008-05-21
PL333460A1 (en) 1999-12-20
KR100554332B1 (ko) 2006-02-24
HUP9903947A3 (en) 2001-03-28
US6184360B1 (en) 2001-02-06
HU222666B1 (hu) 2003-09-29
EP0942930A2 (en) 1999-09-22
BR9713055A (pt) 2000-04-04
IL129851A0 (en) 2000-02-29
CN1268639C (zh) 2006-08-09
EA199900436A1 (ru) 2000-02-28
KR20000053297A (ko) 2000-08-25
CZ300296B6 (cs) 2009-04-15

Similar Documents

Publication Publication Date Title
ID26697A (id) Pemurnian neurotrofin
NO963239L (no) Klorpyrimid-mellomprodukter
TR199901174T2 (xx) Yeni heterosiklilmetil-ikameli pirazol t�revleri.
DK0923386T3 (da) Dispenser-anordning med to kamre til luftopfriskning
ID21235A (id) Produksi para-xylen terselektif oleh metilasi toluen
TR200102800T2 (tr) Yeni bileşikler.
DE69531682D1 (de) Sterolderivate für die regulierung der meiose
PT1017659E (pt) Tetra-hidronaftalenos substituidos e compostos analogos
PT915819E (pt) Analogos de iludina uteis como agentes anti-tumorais
FI931332A0 (fi) Uusia alkyleenidiammoniumdiklavulanaattijohdannaisia, menetelmä niidenvalmistamiseksi samoin kuin niiden käyttö kalvulaanihapon puhdistamiseksi
MX9702666A (es) Nuevos peptidos con efectos inmunoreguladores.
ATE202483T1 (de) Immuntolerante prothrombinkomplex-präparation
YU63696A (sh) Novi fenilamidin-derivati, postupci za njihovo pripremanje i njihova primena kao lekova
SE9604582D0 (sv) Novel compounds
IT1278034B1 (it) Apaprecchio per il controllo del peso di sigarette.
ID17163A (id) Proses penyisihan bingkai untuk menyesuaikan mode film
FI903680A0 (fi) Bilhjul med gott faeste.
IL128186A0 (en) Intermediates for the preparation of 2-imidazoline-5-ones
PT851856E (pt) Derivados de indolo como analogos melatoninergicos
ATE265418T1 (de) Neue substituierte 3-phenoxy- und 3- phenylalkyloxy-2-phenyl-propylamine
MX9704836A (es) Proceso para la fabricaciom de acetonilbenzamidas.
IT1302971B1 (it) Procedimento di produzione per prosciutti, e mezzi relativi alprocedimento
NO962850D0 (no) Apparat for innretning av to deler
IT1294932B1 (it) Uso di 2-amminotetraline-6,7 sostituite per la preparazione di composizioni farmaceutiche atte al trattamento di patologie
NO960849D0 (no) Difluorstaton-antivirale analoger