ID27290A - Penggunaan senyawa 1,5-dideoksi-1,5-imino-d-glusitol tersubstitusi-n pada pengobatan infeksi virus hepatitis - Google Patents
Penggunaan senyawa 1,5-dideoksi-1,5-imino-d-glusitol tersubstitusi-n pada pengobatan infeksi virus hepatitisInfo
- Publication number
- ID27290A ID27290A IDW20001493A ID20001493A ID27290A ID 27290 A ID27290 A ID 27290A ID W20001493 A IDW20001493 A ID W20001493A ID 20001493 A ID20001493 A ID 20001493A ID 27290 A ID27290 A ID 27290A
- Authority
- ID
- Indonesia
- Prior art keywords
- imino
- substituted
- glusitol
- dideoksi
- hepatitic
- Prior art date
Links
- 230000009385 viral infection Effects 0.000 title abstract 2
- 239000003443 antiviral agent Substances 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- -1 N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds Chemical class 0.000 abstract 2
- 230000002519 immonomodulatory effect Effects 0.000 abstract 2
- 239000002955 immunomodulating agent Substances 0.000 abstract 2
- 239000003022 immunostimulating agent Substances 0.000 abstract 2
- 239000002777 nucleoside Substances 0.000 abstract 2
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7450898P | 1998-02-12 | 1998-02-12 | |
| US09/023,401 US20030100532A1 (en) | 1997-02-14 | 1998-02-12 | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID27290A true ID27290A (id) | 2001-03-22 |
Family
ID=26697090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDW20001493A ID27290A (id) | 1998-02-12 | 1999-02-12 | Penggunaan senyawa 1,5-dideoksi-1,5-imino-d-glusitol tersubstitusi-n pada pengobatan infeksi virus hepatitis |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6809083B1 (de) |
| EP (1) | EP1061922B9 (de) |
| JP (1) | JP2002502875A (de) |
| KR (1) | KR20010040937A (de) |
| AT (1) | ATE331515T1 (de) |
| AU (2) | AU762125B2 (de) |
| BR (1) | BR9907882A (de) |
| CA (1) | CA2319713C (de) |
| DE (1) | DE69932154T2 (de) |
| EA (1) | EA004705B1 (de) |
| ES (1) | ES2272054T3 (de) |
| ID (1) | ID27290A (de) |
| MY (1) | MY122185A (de) |
| TR (1) | TR200002323T2 (de) |
| TW (1) | TWI222867B (de) |
| WO (1) | WO1999040916A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030100532A1 (en) * | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
| US6689759B1 (en) | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
| EA004705B1 (ru) | 1998-02-12 | 2004-06-24 | Дж.Д.Серл Энд Ко. | Применение n-замещенных 1,5-дидезокси-1,5-имино-d-глюцитных производных для лечения инфекций, вызываемых вирусами гепатита |
| WO2001008672A2 (en) * | 1999-02-12 | 2001-02-08 | G.D. Searle & Co. | Glucamine compounds for treating hepatitis virus infections |
| ES2311921T3 (es) * | 1999-02-12 | 2009-02-16 | United Therapeutics Corporation | N-(8,8,8-trifluorooctil)1-5,-didesoxi-1,5-imino-d-glucitol para tratar infecciones por el virus de la hepatitis. |
| DE60037664T2 (de) | 1999-08-10 | 2008-12-24 | The Chancellor, Masters And Scholars Of The University Of Oxford | Langkettige n-alkyl verbindungen und deren oxa-derivate zur verwendung als anitvirale mittel |
| WO2001060366A1 (en) * | 2000-02-14 | 2001-08-23 | Pharmacia Corporation | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections |
| AU2013203966B2 (en) * | 2000-05-23 | 2016-05-19 | Idenix Pharmaceuticals, Inc. | Methods and compositions for treating hepatitis C virus |
| PL359169A1 (en) | 2000-05-26 | 2004-08-23 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses |
| AU2002359327A1 (en) * | 2001-10-30 | 2003-05-12 | Thomas Jefferson University | Method of treating viral infections |
| WO2006085141A2 (en) * | 2004-08-13 | 2006-08-17 | Migenix Inc. | Compositions and methods for treating or preventing hepadnaviridae infection |
| PL2027137T3 (pl) * | 2005-06-08 | 2015-08-31 | Amicus Therapeutics Inc | Oczyszczanie imino- i aminocukrów |
| US20060293250A1 (en) * | 2005-06-08 | 2006-12-28 | Michael Major | Crystalline sugar compositions and method of making |
| JP2008545800A (ja) * | 2005-06-08 | 2008-12-18 | アミカス セラピューティックス インコーポレイテッド | トリフラート化化合物の安定化 |
| US7473683B2 (en) | 2005-09-14 | 2009-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Nonpolar thymidine analogs |
| CN101489554A (zh) * | 2006-05-24 | 2009-07-22 | 联合治疗公司 | 脱氧吉瑞霉素和d-阿拉伯胶素醇类似物及使用方法 |
| CN102727437A (zh) | 2006-08-02 | 2012-10-17 | 牛津大学院长校长专家委员会 | 病毒感染的脂质体治疗 |
| US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
| KR20100127842A (ko) * | 2008-03-26 | 2010-12-06 | 유니버시티 오브 옥스퍼드 | 소포체 표적화 리포좀 |
| ES2579628T3 (es) | 2009-02-23 | 2016-08-12 | Emergent Virology Llc | Iminoazúcares y métodos de tratamiento de enfermedades virales |
| EP2410989A2 (de) * | 2009-03-27 | 2012-02-01 | The Chancellor, Masters and Scholars of the University of Oxford | Liposome zur senkung des cholesterinspiegels |
| WO2010144759A1 (en) | 2009-06-12 | 2010-12-16 | United Therapeutics Corporation | Iminosugars and methods of treating bunyaviral and togaviral diseases |
| JP5575246B2 (ja) * | 2009-09-04 | 2014-08-20 | ユナイテッド セラピューティクス コーポレイション | ポックスウイルス感染の治療方法 |
| CA2875975A1 (en) | 2012-06-06 | 2013-12-12 | Unither Virology, Llc | Novel iminosugars and their applications |
| CA2966893C (en) | 2014-11-05 | 2023-10-24 | Emergent Virology Llc | Iminosugars |
| HK1255835A1 (zh) * | 2016-01-08 | 2019-08-30 | Arbutus Biopharma Corporation | 用於治疗乙型肝炎的治疗组合物及方法 |
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| YU33730B (en) | 1967-04-18 | 1978-02-28 | Farmaceutici Italia | Process for preparing a novel antibiotic substance and salts thereof |
| GB1555654A (en) | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| US4065562A (en) | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
| US4012448A (en) | 1976-01-15 | 1977-03-15 | Stanford Research Institute | Synthesis of adriamycin and 7,9-epiadriamycin |
| NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| GB2020278B (en) | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
| JPS5562004A (en) | 1978-11-02 | 1980-05-10 | Kureha Chem Ind Co Ltd | Control agent against plant viral disease |
| US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| DE3049446A1 (de) | 1980-12-30 | 1982-07-29 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 1,5-didesoxy-1,5-imino-d-glucitol und dessen n-derivaten |
| ZA822995B (en) | 1981-05-21 | 1983-12-28 | Wyeth John & Brother Ltd | Slow release pharmaceutical composition |
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| JPH01203326A (ja) | 1987-12-21 | 1989-08-16 | Monsanto Co | ヒト免疫不全ウイルス抑制剤 |
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| FI101344B (fi) | 1988-03-31 | 1998-06-15 | Tanabe Seiyaku Co | Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseut tisesti aktiivista ainetta |
| US5041441A (en) | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
| EP0350012A3 (de) * | 1988-07-08 | 1990-09-05 | Meiji Seika Kaisha Ltd. | Antivirale Zusammensetzung |
| US5310745A (en) | 1988-11-03 | 1994-05-10 | G. D. Searle & Co. | Antiviral compounds |
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| US5003072A (en) | 1988-11-03 | 1991-03-26 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
| US5144037A (en) | 1988-11-03 | 1992-09-01 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-d-glucitol derivatives |
| US4957926A (en) | 1988-12-22 | 1990-09-18 | Monsanto Company | Method of treating herpesviruses |
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| DE4009561A1 (de) | 1990-03-24 | 1991-09-26 | Bayer Ag | Neue desoxynojirimycinderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
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| DK0477160T3 (da) | 1990-09-20 | 1996-05-20 | Monsanto Co | Fremgangsmåde til fremstilling af N-substitueret 1-deoxynojirimycin |
| US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
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| WO1994004546A1 (fr) | 1992-08-14 | 1994-03-03 | Nippon Shinyaku Co., Ltd. | Derive de moranoline |
| FR2700267B1 (fr) | 1993-01-13 | 1995-03-17 | Oreal | N-acyl amino déoxy alditols, et leur utilisation dans des compositions cosmétiques ou dermopharmaceutiques. |
| DE69419601T2 (de) | 1993-03-17 | 1999-12-02 | Kao Corp., Tokio/Tokyo | Aminderivate und sie enthaltende dermatologische zubereitungen |
| US5399567A (en) | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
| AU7518694A (en) | 1993-08-20 | 1995-03-21 | G.D. Searle & Co. | Retroviral protease inhibitors and combinations thereof |
| US6093702A (en) * | 1993-12-20 | 2000-07-25 | The United States Of America As Represented By The Department Of Health And Human Services | Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread |
| DK0739205T3 (da) * | 1994-01-13 | 2000-05-01 | Searle & Co | Anvendelse af N-alkylderivater af 1,5-didesoxy-1,5-imino-D-glucitol til behandling af hepatitis-B-virusinfektioner |
| AU1876095A (en) * | 1994-02-25 | 1995-09-11 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
| US5451679A (en) | 1994-03-08 | 1995-09-19 | G. D. Searle & Co. | 2-chloro and 2-bromo derivatives of 1,5-iminosugars |
| US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
| FR2731150B1 (fr) | 1995-03-03 | 1997-04-18 | Oreal | Utilisation de composes amphiphiles en tant qu'agent epaississant de milieux non aqueux |
| US5763470A (en) | 1995-06-07 | 1998-06-09 | Sugen Inc. | Benzopyran compounds and methods for their use |
| WO1997000881A1 (fr) | 1995-06-22 | 1997-01-09 | Nippon Shinyaku Co., Ltd. | Derives de la moranoline |
| ES2244048T3 (es) * | 1997-02-14 | 2005-12-01 | G.D. Searle Llc. | Uso de compuestos (n)-sustituidos-1,5-didesoxi-1,5-imino-d-glucitol en terapia de combinacion para el tratamiento de infecciones con virus de hepatitis. |
| AU761748B2 (en) | 1997-12-11 | 2003-06-12 | Chancellor, Masters And Scholars Of The University Of Oxford, The | Inhibition of membrane-associated viral replication |
| EA004705B1 (ru) | 1998-02-12 | 2004-06-24 | Дж.Д.Серл Энд Ко. | Применение n-замещенных 1,5-дидезокси-1,5-имино-d-глюцитных производных для лечения инфекций, вызываемых вирусами гепатита |
-
1999
- 1999-02-12 EA EA200000836A patent/EA004705B1/ru not_active IP Right Cessation
- 1999-02-12 ID IDW20001493A patent/ID27290A/id unknown
- 1999-02-12 ES ES99908079T patent/ES2272054T3/es not_active Expired - Lifetime
- 1999-02-12 MY MYPI99000516A patent/MY122185A/en unknown
- 1999-02-12 KR KR1020007008852A patent/KR20010040937A/ko not_active Ceased
- 1999-02-12 TR TR2000/02323T patent/TR200002323T2/xx unknown
- 1999-02-12 EP EP99908079A patent/EP1061922B9/de not_active Expired - Lifetime
- 1999-02-12 US US09/249,220 patent/US6809083B1/en not_active Expired - Lifetime
- 1999-02-12 AU AU27595/99A patent/AU762125B2/en not_active Ceased
- 1999-02-12 DE DE69932154T patent/DE69932154T2/de not_active Expired - Lifetime
- 1999-02-12 JP JP2000531168A patent/JP2002502875A/ja active Pending
- 1999-02-12 AT AT99908079T patent/ATE331515T1/de not_active IP Right Cessation
- 1999-02-12 WO PCT/US1999/001874 patent/WO1999040916A1/en not_active Ceased
- 1999-02-12 BR BR9907882-1A patent/BR9907882A/pt not_active Application Discontinuation
- 1999-02-12 CA CA2319713A patent/CA2319713C/en not_active Expired - Fee Related
- 1999-04-07 TW TW088102296A patent/TWI222867B/zh not_active IP Right Cessation
-
2003
- 2003-09-18 AU AU2003248024A patent/AU2003248024A1/en not_active Abandoned
-
2004
- 2004-08-03 US US10/910,197 patent/US20050267153A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050267153A1 (en) | 2005-12-01 |
| WO1999040916A1 (en) | 1999-08-19 |
| US6809083B1 (en) | 2004-10-26 |
| BR9907882A (pt) | 2000-10-17 |
| EA004705B1 (ru) | 2004-06-24 |
| AU2003248024A1 (en) | 2003-10-30 |
| TWI222867B (en) | 2004-11-01 |
| KR20010040937A (ko) | 2001-05-15 |
| TR200002323T2 (tr) | 2000-12-21 |
| MY122185A (en) | 2006-03-31 |
| DE69932154D1 (de) | 2006-08-10 |
| DE69932154T2 (de) | 2007-05-31 |
| AU762125B2 (en) | 2003-06-19 |
| EP1061922B9 (de) | 2007-03-07 |
| CA2319713C (en) | 2012-06-26 |
| ES2272054T3 (es) | 2007-04-16 |
| JP2002502875A (ja) | 2002-01-29 |
| EP1061922A1 (de) | 2000-12-27 |
| AU2759599A (en) | 1999-08-30 |
| EA200000836A1 (ru) | 2001-04-23 |
| EP1061922B1 (de) | 2006-06-28 |
| ATE331515T1 (de) | 2006-07-15 |
| CA2319713A1 (en) | 1999-08-19 |
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