IE32443L - Thiazole-containing pharmaceuticals - Google Patents
Thiazole-containing pharmaceuticalsInfo
- Publication number
- IE32443L IE32443L IE121768A IE121768A IE32443L IE 32443 L IE32443 L IE 32443L IE 121768 A IE121768 A IE 121768A IE 121768 A IE121768 A IE 121768A IE 32443 L IE32443 L IE 32443L
- Authority
- IE
- Ireland
- Prior art keywords
- radical
- cooh
- amide
- salt
- formula
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- -1 cyanoethenyl Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000003557 thiazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Novel thiazoles which have an antiinflammatory effect and which can be used as pharmaceuticals and correspond to the formula (I) <IMAGE> in which R1 is an optionally substituted carbocyclic or heterocyclic aromatic radical; R2 is a radical of the formula -CH=CH-COOH or -CH2-CH2-COOH or the radical of a salt or amide of these acids; and R3 is hydrogen or an alkyl radical with 1 to 4 carbon atoms, and their acid addition salts, with the proviso that R2 is the radical of a salt or amide of the said acid groups if R1 is an unsubstituted phenyl radical or a mono- or dimethoxyphenyl radical and R3 is a hydrogen atom, are obtained by hydrolysing the corresponding cyanoethenyl or cyanoethyl derivatives.
[GB1237194A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB48640/67A GB1237194A (en) | 1967-10-26 | 1967-10-26 | Pharmaceutical compositions containing 2-arylthiazoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE32443L true IE32443L (en) | 1969-04-26 |
| IE32443B1 IE32443B1 (en) | 1973-08-08 |
Family
ID=10449369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE121768A IE32443B1 (en) | 1967-10-26 | 1968-10-11 | Pharmaceutical compositions containing 2-aryl thiazoles |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4810466B1 (en) |
| BE (1) | BE722290A (en) |
| CA (1) | CA930740A (en) |
| CH (2) | CH540280A (en) |
| DE (1) | DE1804448C3 (en) |
| FR (2) | FR1587945A (en) |
| GB (1) | GB1237194A (en) |
| IE (1) | IE32443B1 (en) |
| NL (1) | NL165932C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8725475D0 (en) * | 1987-10-30 | 1987-12-02 | Amp Holland | Modular jack |
| CN100475810C (en) * | 2002-08-30 | 2009-04-08 | 霍夫曼-拉罗奇有限公司 | Novel 2-arylthiazole compounds as pparalpha and ppargamma agonists |
| EP1939180A1 (en) | 2006-12-20 | 2008-07-02 | sanofi-aventis | Heteroarylacrylamides and their use as pharmaceuticals for the stimulation of the expression of endothelial NO synthase |
| EP1939181A1 (en) * | 2006-12-27 | 2008-07-02 | sanofi-aventis | Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL130759C (en) * | 1965-10-07 |
-
1967
- 1967-10-26 GB GB48640/67A patent/GB1237194A/en not_active Expired
-
1968
- 1968-10-05 CA CA031766A patent/CA930740A/en not_active Expired
- 1968-10-07 JP JP7251268A patent/JPS4810466B1/ja active Pending
- 1968-10-11 IE IE121768A patent/IE32443B1/en unknown
- 1968-10-14 BE BE722290D patent/BE722290A/xx not_active IP Right Cessation
- 1968-10-15 FR FR1587945D patent/FR1587945A/fr not_active Expired
- 1968-10-15 FR FR169961A patent/FR7971M/fr not_active Expired
- 1968-10-17 CH CH1556768A patent/CH540280A/en not_active IP Right Cessation
- 1968-10-17 CH CH1832872A patent/CH609051A5/en not_active IP Right Cessation
- 1968-10-22 DE DE19681804448 patent/DE1804448C3/en not_active Expired
- 1968-10-24 NL NL6815215A patent/NL165932C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA930740A (en) | 1973-07-24 |
| FR1587945A (en) | 1970-04-03 |
| IE32443B1 (en) | 1973-08-08 |
| CH609051A5 (en) | 1979-02-15 |
| FR7971M (en) | 1970-06-01 |
| DE1804448C3 (en) | 1981-04-02 |
| JPS4810466B1 (en) | 1973-04-03 |
| NL6815215A (en) | 1969-04-29 |
| NL165932C (en) | 1981-06-15 |
| CH540280A (en) | 1973-08-15 |
| NL165932B (en) | 1981-01-15 |
| BE722290A (en) | 1969-04-14 |
| DE1804448A1 (en) | 1969-08-14 |
| DE1804448B2 (en) | 1980-07-03 |
| GB1237194A (en) | 1971-06-30 |
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