IE36231L - Triazolo diazepines - Google Patents
Triazolo diazepinesInfo
- Publication number
- IE36231L IE36231L IE720404A IE40472A IE36231L IE 36231 L IE36231 L IE 36231L IE 720404 A IE720404 A IE 720404A IE 40472 A IE40472 A IE 40472A IE 36231 L IE36231 L IE 36231L
- Authority
- IE
- Ireland
- Prior art keywords
- oxides
- alkyl
- cpds
- opt
- diazepines
- Prior art date
Links
- 150000004908 diazepines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000003556 anti-epileptic effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Title cpds. of formula (I): (where R1 is H or 1-3C alkyl; R2 is 1-4C alkyl or R2--R2 is a satd. divalent 2-5C aliphatic hydrocarbon residue, and rings A and B can be substd. by F, Cl, Br, CF3, NO2 or 1-6C alkyl or alkoxy) and their 5-oxides and acid addn. salts, can be used as tranquillisers, sedatives, muscle relaxants and anti-epileptics; the 5-oxides are also of use as inters. for further pharmacologically active cpds. Cpds. (I) are e.g. prepd. by (a) reacting a 2-X-3-R1-5-phenyl-3H-1,4-benzodiazepine (where X is SH, lower alkoxy or alkylthio opt. activated by a substituent, or opt. mono- or disubstd. amino) with (R2O)2CHCONHNH2. The 5-oxides are obtd. by oxidn.
[CH545302A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH523371 | 1971-04-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36231L true IE36231L (en) | 1972-10-08 |
| IE36231B1 IE36231B1 (en) | 1976-09-15 |
Family
ID=4290168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE404/72A IE36231B1 (en) | 1971-04-08 | 1972-03-28 | Triazolo diazepine derivatives and processes for the production thereof |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US3867536A (en) |
| JP (1) | JPS5614671B1 (en) |
| AR (3) | AR193382A1 (en) |
| AT (2) | AT317222B (en) |
| AU (1) | AU472767B2 (en) |
| BE (1) | BE781816A (en) |
| CA (1) | CA991639A (en) |
| CH (1) | CH545302A (en) |
| CS (3) | CS178406B2 (en) |
| DD (1) | DD97655A5 (en) |
| DE (1) | DE2215939A1 (en) |
| DK (1) | DK141965B (en) |
| FI (1) | FI52583C (en) |
| FR (1) | FR2132767B1 (en) |
| GB (1) | GB1392327A (en) |
| HU (1) | HU165318B (en) |
| IE (1) | IE36231B1 (en) |
| IL (1) | IL39051A (en) |
| NL (1) | NL7204700A (en) |
| NO (1) | NO134839C (en) |
| PL (1) | PL83566B1 (en) |
| SE (1) | SE413408B (en) |
| SU (3) | SU499808A3 (en) |
| ZA (1) | ZA721896B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH572056A5 (en) * | 1972-11-28 | 1976-01-30 | Ciba Geigy Ag |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987052A (en) * | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
| BE759099A (en) * | 1969-11-18 | 1971-04-30 | Takeda Chemical Industries Ltd | PROCESS FOR MANUFACTURING HETEROCYCLIC COMPOUNDS |
| US3681343A (en) * | 1971-05-11 | 1972-08-01 | Upjohn Co | 6-phenyl-s-triazolo{8 4,3-a{9 {8 1,4{9 {0 benzodiazepines |
-
1971
- 1971-04-08 CH CH1212973A patent/CH545302A/en not_active IP Right Cessation
-
1972
- 1972-03-20 ZA ZA721896A patent/ZA721896B/en unknown
- 1972-03-21 IL IL39051A patent/IL39051A/en unknown
- 1972-03-27 SE SE7203938A patent/SE413408B/en unknown
- 1972-03-28 IE IE404/72A patent/IE36231B1/en unknown
- 1972-03-29 FI FI720882A patent/FI52583C/en active
- 1972-03-30 US US239780A patent/US3867536A/en not_active Expired - Lifetime
- 1972-03-30 CA CA138,606A patent/CA991639A/en not_active Expired
- 1972-04-01 DE DE19722215939 patent/DE2215939A1/en not_active Withdrawn
- 1972-04-05 GB GB1570272A patent/GB1392327A/en not_active Expired
- 1972-04-06 HU HUCI1223A patent/HU165318B/hu unknown
- 1972-04-06 AU AU40820/72A patent/AU472767B2/en not_active Expired
- 1972-04-06 NO NO1163/72A patent/NO134839C/no unknown
- 1972-04-06 DD DD162097A patent/DD97655A5/xx unknown
- 1972-04-07 BE BE781816A patent/BE781816A/en unknown
- 1972-04-07 AT AT302172A patent/AT317222B/en not_active IP Right Cessation
- 1972-04-07 SU SU1771052A patent/SU499808A3/en active
- 1972-04-07 AT AT781173A patent/AT317230B/en not_active IP Right Cessation
- 1972-04-07 NL NL7204700A patent/NL7204700A/xx not_active Application Discontinuation
- 1972-04-07 PL PL1972154657A patent/PL83566B1/en unknown
- 1972-04-07 CS CS2330A patent/CS178406B2/cs unknown
- 1972-04-07 FR FR7212299A patent/FR2132767B1/fr not_active Expired
- 1972-04-07 DK DK169972AA patent/DK141965B/en unknown
- 1972-04-07 AR AR241356A patent/AR193382A1/en active
- 1972-04-07 CS CS435A patent/CS178449B2/cs unknown
- 1972-04-07 CS CS434A patent/CS178448B2/cs unknown
- 1972-04-08 JP JP3486172A patent/JPS5614671B1/ja active Pending
-
1973
- 1973-03-26 AR AR247235A patent/AR194991A1/en active
- 1973-03-26 AR AR247234A patent/AR193942A1/en active
- 1973-10-23 SU SU1964147A patent/SU482045A3/en active
- 1973-10-23 SU SU1964148A patent/SU489332A3/en active
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