IE40893L - PYRIMIDO [1,2-a] QUINOLINES - Google Patents
PYRIMIDO [1,2-a] QUINOLINESInfo
- Publication number
- IE40893L IE40893L IE750711A IE71175A IE40893L IE 40893 L IE40893 L IE 40893L IE 750711 A IE750711 A IE 750711A IE 71175 A IE71175 A IE 71175A IE 40893 L IE40893 L IE 40893L
- Authority
- IE
- Ireland
- Prior art keywords
- hydroxy
- alkoxy
- bromine
- march
- chlorine
- Prior art date
Links
- 229940111121 antirheumatic drug quinolines Drugs 0.000 title 1
- 150000003248 quinolines Chemical class 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- -1 methylsulphinyl Chemical group 0.000 abstract 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000003266 anti-allergic effect Effects 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 235000010378 sodium ascorbate Nutrition 0.000 abstract 1
- 229960005055 sodium ascorbate Drugs 0.000 abstract 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 abstract 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 abstract 1
- 229960000278 theophylline Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1451423 Anti-allergy compositions PFIZER INC 27 March 1975 ]1 April 1974 5 Feb 1975 3 March 1975] 13055/75 Heading A5B [Also in Division C2] Pharmaceutical compositions of a compound of the formula I wherein each of R 1 ; R 2 , R 3 and R 4 is hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, carbalkoxy, methylthio or methylsulphinyl or R 2 and R 3 when taken together form a 1, 3-butadienyl, methylenedioxy or ethylenedioxy group; R 5 is hydroxy, alkoxy or hydroxyalkoxy; R 6 is chlorine, bromine, hydroxy, alkoxy, C 3-4 alkenyloxy or C 3-4 alkynyloxy, wherein alkyl and alkoxy groups have up to 5 carbon atoms, provided that when R 6 is hydroxy at least one of R 1 , R 2 , R 3 and R 4 is other than hydrogen or a pharmaceutically acceptable cationic salt of a compound wherein R 5 is hydroxy, with the usual excipients show anti-allergy activity when administered orally, parenterally or by inhalation. The composition may also contain theophylline or sodium ascorbate.
[GB1451423A]
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45679774A | 1974-04-01 | 1974-04-01 | |
| US54722775A | 1975-02-05 | 1975-02-05 | |
| US55496675A | 1975-03-03 | 1975-03-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40893L true IE40893L (en) | 1975-10-01 |
| IE40893B1 IE40893B1 (en) | 1979-09-12 |
Family
ID=27412681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE711/75A IE40893B1 (en) | 1974-04-01 | 1975-04-02 | 1-oxo-1h-6-substituted pyrimido(1,2-a)quinoline-2-carboxylic acids and derivatives thereof as antiallergy agents |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5427360B2 (en) |
| CA (1) | CA1033731A (en) |
| DD (1) | DD119425A5 (en) |
| DE (1) | DE2513930A1 (en) |
| DK (1) | DK138743B (en) |
| ES (1) | ES436155A1 (en) |
| FI (1) | FI750891A7 (en) |
| FR (1) | FR2265389B1 (en) |
| GB (1) | GB1451423A (en) |
| IE (1) | IE40893B1 (en) |
| IL (1) | IL46864A0 (en) |
| LU (1) | LU72184A1 (en) |
| NL (1) | NL7503692A (en) |
| PH (1) | PH10464A (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4075343A (en) * | 1976-09-13 | 1978-02-21 | Pfizer Inc. | Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof |
| US4127720A (en) * | 1977-09-21 | 1978-11-28 | Bristol-Myers Company | Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity |
| US4209620A (en) * | 1978-06-19 | 1980-06-24 | Bristol-Myers Company | Substituted 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives having antiallergy activity |
| US4472401A (en) * | 1981-11-27 | 1984-09-18 | Roussel Uclaf | Pyrimido-quinoxalines having antiallergic properties |
| US4510143A (en) * | 1982-02-17 | 1985-04-09 | Roussel Uclaf | Antiallergic pyrimido[1,2-a]quinoxalin-2-carboxylic acid derivatives |
| AU5533996A (en) * | 1996-04-04 | 1997-10-29 | University Of Nebraska Board Of Regents | Synthetic triple helix-forming compounds |
| US6989392B2 (en) | 2002-06-18 | 2006-01-24 | Abbott Laboratories | 2-Aminoquinolines as melanin concentrating hormone receptor antagonists |
-
1975
- 1975-03-17 CA CA222,180A patent/CA1033731A/en not_active Expired
- 1975-03-18 IL IL46864A patent/IL46864A0/en unknown
- 1975-03-24 PH PH16958A patent/PH10464A/en unknown
- 1975-03-25 FI FI750891A patent/FI750891A7/fi not_active Application Discontinuation
- 1975-03-26 DE DE19752513930 patent/DE2513930A1/en not_active Ceased
- 1975-03-26 DK DK130475AA patent/DK138743B/en not_active IP Right Cessation
- 1975-03-27 GB GB1305575A patent/GB1451423A/en not_active Expired
- 1975-03-27 NL NL7503692A patent/NL7503692A/en not_active Application Discontinuation
- 1975-03-31 ES ES436155A patent/ES436155A1/en not_active Expired
- 1975-04-01 JP JP4022375A patent/JPS5427360B2/ja not_active Expired
- 1975-04-01 FR FR7510140A patent/FR2265389B1/fr not_active Expired
- 1975-04-01 DD DD185117A patent/DD119425A5/xx unknown
- 1975-04-01 LU LU72184A patent/LU72184A1/xx unknown
- 1975-04-02 IE IE711/75A patent/IE40893B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK138743C (en) | 1979-04-02 |
| LU72184A1 (en) | 1976-03-02 |
| FR2265389B1 (en) | 1978-07-28 |
| ES436155A1 (en) | 1977-02-01 |
| FI750891A7 (en) | 1975-10-02 |
| AU7937775A (en) | 1976-09-23 |
| JPS5427360B2 (en) | 1979-09-10 |
| DD119425A5 (en) | 1976-04-20 |
| DK130475A (en) | 1975-10-02 |
| GB1451423A (en) | 1976-10-06 |
| PH10464A (en) | 1977-04-25 |
| DK138743B (en) | 1978-10-23 |
| DE2513930A1 (en) | 1975-10-02 |
| NL7503692A (en) | 1975-10-03 |
| JPS50140499A (en) | 1975-11-11 |
| CA1033731A (en) | 1978-06-27 |
| IL46864A0 (en) | 1975-05-22 |
| IE40893B1 (en) | 1979-09-12 |
| FR2265389A1 (en) | 1975-10-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY100124A (en) | Dihydropyridazinones. | |
| IE38318L (en) | Amino-quinazoline derivatives | |
| AU537028B2 (en) | Imidazole derivatives | |
| AU552908B2 (en) | 4 n-phenyl benzyl-aminomethyl-imidazole | |
| IE40893L (en) | PYRIMIDO [1,2-a] QUINOLINES | |
| IE41822L (en) | Hydroxyalkyl xanthine derivatives | |
| GB1439724A (en) | Berbine derivatives and pharmaceutical compositions containing them | |
| IE41673L (en) | Fused pyrimidines | |
| GB1457484A (en) | Acylamidocephalosporins | |
| EP0066909A3 (en) | Imidazole derivatives, pharmaceutical compositions containing them and processes for their production | |
| IE39269L (en) | Nitrocarbostyrils; pharmaceutical compositions. | |
| IE37043L (en) | Pyrimidones | |
| GB1508738A (en) | 2-chloroquinolines and their use as coccidiostats | |
| GB1481930A (en) | Dibenzo(a,g)quinolizinium compounds | |
| IE811626L (en) | Anthracycline glycosides | |
| IE43972L (en) | Piperidinoalkylindole derivatives | |
| GB1477996A (en) | Quinolizine derivatives and their preparation | |
| GB1488412A (en) | Imidazo(1,2-a)quinolines | |
| GB1509778A (en) | Pharmaceutical composition and dosage units thereof | |
| IE39587B1 (en) | Antibacterial compositions | |
| GB1417745A (en) | Chromene compounds | |
| IE37317B1 (en) | Nitrogen containing isoprenoid compounds | |
| GB1443548A (en) | 3-benzazocine compounds and their production | |
| GB1528738A (en) | Isoquinolines and their preparation | |
| GB1395518A (en) | Benzodiazocine derivatives |