IE41386B1 - Aromatic ketones having cardiovascular activity - Google Patents

Aromatic ketones having cardiovascular activity

Info

Publication number: IE41386B1
Authority: IE; Ireland
Prior art keywords: give; compound; june; alkyl; treating
Prior art date: 1974-06-28

Application number

IE1395/75A

Other languages

English (en)

Other versions

IE41386L (en

Original Assignee

Clin Midy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-06-28

Filing date

1975-06-24

Publication date

1979-12-19

1975-06-24 Application filed by Clin Midy filed Critical Clin Midy

1975-06-24 Priority to IE676/78A priority Critical patent/IE41387B1/xx

1975-12-28 Publication of IE41386L publication Critical patent/IE41386L/xx

1979-12-19 Publication of IE41386B1 publication Critical patent/IE41386B1/xx

Links

230000005792 cardiovascular activity Effects 0.000 title abstract 2
150000008365 aromatic ketones Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
239000002253 acid Substances 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
MUQVVWKGBBDOEF-UHFFFAOYSA-N 4,4-dimethyl-1-phenoxypentan-2-ol Chemical class CC(C)(C)CC(O)COC1=CC=CC=C1 MUQVVWKGBBDOEF-UHFFFAOYSA-N 0.000 abstract 1
239000007818 Grignard reagent Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
125000001033 ether group Chemical group 0.000 abstract 1
NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 abstract 1
150000004795 grignard reagents Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IE1395/75A 1974-06-28 1975-06-24 Aromatic ketones having cardiovascular activity IE41386B1 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IE676/78A IE41387B1 (en)	1974-06-28	1975-06-24	8-aza-4,9-dioxa-2,3-benzobicyclo- (4.2.1)- octanes and method for preparation thereof

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB28925/74A GB1501632A (en)	1974-06-28	1974-06-28	Aromatic ketones having cardiovascular activity

Publications (2)

Publication Number	Publication Date
IE41386L IE41386L (en)	1975-12-28
IE41386B1 true IE41386B1 (en)	1979-12-19

Family

ID=10283421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE1395/75A IE41386B1 (en)	1974-06-28	1975-06-24	Aromatic ketones having cardiovascular activity

Country Status (17)

Country	Link
US (2)	US4252825A (2)
JP (2)	JPS5826743B2 (2)
AR (1)	AR205388A1 (2)
AT (1)	AT343098B (2)
BE (1)	BE830766A (2)
CA (1)	CA1052820A (2)
CS (1)	CS197248B2 (2)
DE (1)	DE2528147A1 (2)
DK (1)	DK143555C (2)
ES (1)	ES438931A1 (2)
FR (1)	FR2276032A1 (2)
GB (1)	GB1501632A (2)
IE (1)	IE41386B1 (2)
NL (1)	NL7507703A (2)
SE (2)	SE416546B (2)
YU (1)	YU165775A (2)
ZA (1)	ZA754141B (2)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1501632A (en) *	1974-06-28	1978-02-22	Cm Ind	Aromatic ketones having cardiovascular activity
JPH0516363Y2 (2) *	1986-08-01	1993-04-28
AU2003250483A1 (en)	2002-08-19	2004-03-11	Pfizer Products Inc.	Combination therapy for hyperproliferative diseases
EA009646B1 (ru) *	2003-05-30	2008-02-28	Рэнбакси Лабораториз Лтд.	Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa
US20050037063A1 (en) *	2003-07-21	2005-02-17	Bolton Anthony E.	Combined therapies
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
JP2009514851A (ja) *	2005-11-08	2009-04-09	ランバクシーラボラトリーズリミテッド	（３ｒ，５ｒ）−７−［２−（４−フルオロフェニル）−５−イソプロピル−３−フェニル−４−［（４−ヒドロキシメチルフェニルアミノ）カルボニル］−ピロール−１−イル］−３，５−ジヒドロキシ−ヘプタン酸ヘミカルシウム塩の製法
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
TW200744583A (en) *	2006-03-14	2007-12-16	Ranbaxy Lab Ltd	Statin stabilizing dosage formulations
BRPI0714361A2 (pt) *	2006-07-14	2013-03-26	Ranbaxy Lab Ltd	polimorfo cristalino, composiÇço farmacÊutica contendo o mesmo, mÉtodo para sua preparaÇço e mÉtodo de tratamento
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
EP2986599A1 (en)	2013-04-17	2016-02-24	Pfizer Inc.	N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
BR112021013807A2 (pt)	2019-01-18	2021-11-30	Astrazeneca Ab	Inibidores de pcsk9 e seus métodos de uso

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL301580A (2) *	1962-12-11
US3637852A (en) *	1963-08-26	1972-01-25	Boehringer Sohn Ingelheim	1-phenoxy-2-hydroxy-3-isopropylamino-propanes and salts thereof
DE1493454C3 (de) *	1963-08-26	1980-04-30	C.H. Boehringer Sohn, 6507 Ingelheim	1 -Aryloxy^-hydroxy-S-isopropylaminopropane und deren Salze sowie deren Herstellung und darauf basierende Arzneimittel
GB1231783A (en) *	1967-05-16	1971-05-12	May & Baker Ltd	Benzene derivatives
JPS512115B2 (2) *	1971-09-28	1976-01-23
JPS4911847A (2) *	1972-05-20	1974-02-01
GB1501632A (en) *	1974-06-28	1978-02-22	Cm Ind	Aromatic ketones having cardiovascular activity

1974
- 1974-06-28 GB GB28925/74A patent/GB1501632A/en not_active Expired
1975
- 1975-01-01 AR AR259407A patent/AR205388A1/es active
- 1975-06-20 FR FR7519386A patent/FR2276032A1/fr active Granted
- 1975-06-24 IE IE1395/75A patent/IE41386B1/xx unknown
- 1975-06-24 CS CS754483A patent/CS197248B2/cs unknown
- 1975-06-24 DE DE19752528147 patent/DE2528147A1/de not_active Withdrawn
- 1975-06-26 SE SE7507359A patent/SE416546B/xx unknown
- 1975-06-27 DK DK292475A patent/DK143555C/da not_active IP Right Cessation
- 1975-06-27 CA CA230,291A patent/CA1052820A/en not_active Expired
- 1975-06-27 NL NL7507703A patent/NL7507703A/xx not_active Application Discontinuation
- 1975-06-27 AT AT497275A patent/AT343098B/de not_active IP Right Cessation
- 1975-06-27 YU YU01657/75A patent/YU165775A/xx unknown
- 1975-06-27 ES ES438931A patent/ES438931A1/es not_active Expired
- 1975-06-27 BE BE157788A patent/BE830766A/xx not_active IP Right Cessation
- 1975-06-27 ZA ZA00754141A patent/ZA754141B/xx unknown
- 1975-06-28 JP JP50080469A patent/JPS5826743B2/ja not_active Expired
1978
- 1978-12-08 SE SE7812646A patent/SE417087B/sv unknown
1979
- 1979-01-05 US US06/001,314 patent/US4252825A/en not_active Expired - Lifetime
1980
- 1980-03-12 US US06/129,730 patent/US4302601A/en not_active Expired - Lifetime
1983
- 1983-01-07 JP JP58001033A patent/JPS5929574B2/ja not_active Expired

Also Published As

Publication number	Publication date
DK292475A (da)	1975-12-29
JPS5123233A (en)	1976-02-24
US4302601A (en)	1981-11-24
CA1052820A (en)	1979-04-17
FR2276032A1 (fr)	1976-01-23
ES438931A1 (es)	1977-05-16
SE416546B (sv)	1981-01-19
ATA497275A (de)	1977-09-15
BE830766A (fr)	1975-12-29
AU8256675A (en)	1977-01-06
FR2276032B1 (2)	1979-08-10
GB1501632A (en)	1978-02-22
YU165775A (en)	1982-02-28
CS197248B2 (en)	1980-04-30
ZA754141B (en)	1976-06-30
JPS5826743B2 (ja)	1983-06-04
JPS58140050A (ja)	1983-08-19
DK143555C (da)	1982-02-01
NL7507703A (nl)	1975-12-30
US4252825A (en)	1981-02-24
JPS5929574B2 (ja)	1984-07-21
DK143555B (da)	1981-09-07
SE417087B (sv)	1981-02-23
IE41386L (en)	1975-12-28
AT343098B (de)	1978-05-10
SE7507359L (sv)	1975-12-29
SE7812646L (sv)	1978-12-08
AR205388A1 (es)	1976-04-30
DE2528147A1 (de)	1976-01-15

Publication	Publication Date	Title
IE41386L (en)	1975-12-28	Aromatic ketones having cardiovascular activity
IE44055L (en)	1977-07-14	Phthalanes
GB1356087A (en)	1974-06-12	Alpha-cyanobenzyl cyclopropanecarboxylates
JPS568365A (en)	1981-01-28	Nitrogen-containing heterocyclic compounds bearing acetal groups and its production
DK153782C (da)	1989-01-16	Fremgangsmaade til fremstilling af beta-hydroxysmoersyre.
GB1423330A (en)	1976-02-04	Preparation of diketone derivatives
GB1288436A (2)	1972-09-06
JPS5735597A (en)	1982-02-26	25,26-epoxy-3beta,24-dihydroxycholest-5-ene or its hydroxyl- protected derivative and their preparation
ATE47709T1 (de)	1989-11-15	Verfahren zur herstellung von aldehyden.
GB1474260A (en)	1977-05-18	Perfluorinated amino compounds process for their manufacture and their use
GB1350883A (en)	1974-04-24	Bis-stilbene compounds
GB1499480A (en)	1978-02-01	Process for the manufacture of pure substituted 2,5-diarylaminoterephthalates and the corresponding free acids
GB1304141A (2)	1973-01-24
GB1394619A (en)	1975-05-21	Imides
IE41342L (en)	1975-01-09	2,3-methylene prostaglandins and their preparation
DK129969B (da)	1974-12-09	Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin.
GB1450969A (en)	1976-09-29	Hexamethyltetracosane-diol derivatives and process for preparing them
GB1297402A (2)	1972-11-22
ES446187A1 (es)	1977-10-01	Un metodo de preparar nuevos compuestos de oxima-eter.
GB1419141A (en)	1975-12-24	Halocyanoalkyl eopoxy ehters and polymers thereof
GB1416943A (en)	1975-12-10	Alkyl-alkenyl ketones and their use in pest control
IE34367L (en)	1971-01-16	P-biphenylylacetic acid esters
GB1447659A (en)	1976-08-25	1,4-bis-5-nitro-imidazolyl-2-methylene-imino- piperazines process for their manufacture and preparations comprising them
GB1474954A (en)	1977-05-25	6,8-dihalo-1,3-benzodioxanes and the use of 6,8-dihalo-1,3- benzodioxanes for the control of plant bacteria
ATE35672T1 (de)	1988-07-15	Verfahren zur herstellung von substituierten benzotrichloriden.