IE41823L - Methylcobalamine - Google Patents
MethylcobalamineInfo
- Publication number
- IE41823L IE41823L IE741654A IE165474A IE41823L IE 41823 L IE41823 L IE 41823L IE 741654 A IE741654 A IE 741654A IE 165474 A IE165474 A IE 165474A IE 41823 L IE41823 L IE 41823L
- Authority
- IE
- Ireland
- Prior art keywords
- methylcobalamine
- cyanocobalamine
- aug
- mono
- added
- Prior art date
Links
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 abstract 3
- 235000000639 cyanocobalamin Nutrition 0.000 abstract 3
- 239000011666 cyanocobalamin Substances 0.000 abstract 3
- CPKISUMKCULUNR-UHFFFAOYSA-N 2-methoxy-2-oxoacetic acid Chemical compound COC(=O)C(O)=O CPKISUMKCULUNR-UHFFFAOYSA-N 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001868 cobalt Chemical class 0.000 abstract 1
- GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical compound [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1419933 Methylcobalamine L'OPOCHIMIE 1 Aug 1974 [8 Aug 1973] 34008/74 Addition to 1355899 Heading C2V Methylcobalamine is prepared by the simultaneous reduction and methylation of cyanocobalamine in an aqueous methanolic solution containing at least 40 grams of cyanocobalamine per litre, through the action of mono-methyl oxalate and a metal powder. A cobalt salt may be added to the reaction mixture. In examples cyanocobalamine dissolved in aqueous methanol is converted to methylcobalamine by reaction with mono-methyl oxalate and zinc powder, cobalt chloride also being added to the reaction mixture.
[GB1419933A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7328998A FR2240232A1 (en) | 1973-08-08 | 1973-08-08 | Methylcobalamine prepn from cyanocobalamine - by reduction and methylation using methyl acid oxalate and a metal |
| FR7346829A FR2256174A2 (en) | 1973-12-28 | 1973-12-28 | Methylcobalamine prepn from cyanocobalamine - by reduction and methylation using methyl acid oxalate and a metal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41823L true IE41823L (en) | 1975-02-08 |
| IE41823B1 IE41823B1 (en) | 1980-04-09 |
Family
ID=26217885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1654/74A IE41823B1 (en) | 1973-08-08 | 1974-08-06 | Preparation of methylcobalamine |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5727119B2 (en) |
| AR (1) | AR199756A1 (en) |
| CA (1) | CA1019726A (en) |
| CH (1) | CH583744A5 (en) |
| DE (1) | DE2434967A1 (en) |
| DK (1) | DK136775B (en) |
| ES (1) | ES428798A1 (en) |
| GB (1) | GB1419933A (en) |
| IE (1) | IE41823B1 (en) |
| IL (1) | IL45384A (en) |
| IN (1) | IN139935B (en) |
| LU (1) | LU70582A1 (en) |
| NL (1) | NL7410061A (en) |
| NO (1) | NO742545L (en) |
| OA (1) | OA04753A (en) |
| SE (1) | SE412589B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2151773C1 (en) * | 1999-03-10 | 2000-06-27 | Казанский государственный университет им. В.И. Ульянова-Ленина | TETRAKIS-(L-HISTIDINATO)-μ-PEROXYDICOBALT)III HEPTAHYDRATE HAVING ANTIANEMIC, RADIOPROTECTIVE AND ANTIARRHYTHMIC ACTIVITIES |
| JP4358615B2 (en) | 2001-06-05 | 2009-11-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Method for producing methylcobalamin |
| CN102391340A (en) * | 2011-10-31 | 2012-03-28 | 河北玉星生物工程有限公司 | Preparation method of mecobalamin |
| WO2018007035A1 (en) * | 2016-07-08 | 2018-01-11 | Interquim, S.A. | Process for the purification of methylcobalamin |
| CN114874276B (en) * | 2022-04-21 | 2024-06-21 | 南京工业大学 | Improved method for synthesizing mecobalamin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE789252A (en) * | 1971-11-10 | 1973-03-26 | Boige Jean | METHOD FOR MANUFACTURING METHYLCOBALAMINE |
-
1974
- 1974-07-12 NO NO742545A patent/NO742545L/no unknown
- 1974-07-17 DK DK386274AA patent/DK136775B/en unknown
- 1974-07-19 DE DE2434967A patent/DE2434967A1/en active Pending
- 1974-07-22 LU LU70582A patent/LU70582A1/xx unknown
- 1974-07-23 CA CA205,451A patent/CA1019726A/en not_active Expired
- 1974-07-24 IN IN1642/CAL/74A patent/IN139935B/en unknown
- 1974-07-25 NL NL7410061A patent/NL7410061A/en unknown
- 1974-07-26 OA OA55258A patent/OA04753A/en unknown
- 1974-07-26 AR AR254903A patent/AR199756A1/en active
- 1974-07-29 CH CH1040374A patent/CH583744A5/xx not_active IP Right Cessation
- 1974-07-31 ES ES428798A patent/ES428798A1/en not_active Expired
- 1974-08-01 GB GB3400874A patent/GB1419933A/en not_active Expired
- 1974-08-02 SE SE7410005A patent/SE412589B/en unknown
- 1974-08-02 IL IL45384A patent/IL45384A/en unknown
- 1974-08-06 IE IE1654/74A patent/IE41823B1/en unknown
- 1974-08-07 JP JP8995074A patent/JPS5727119B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK136775B (en) | 1977-11-21 |
| OA04753A (en) | 1980-08-31 |
| IE41823B1 (en) | 1980-04-09 |
| NO742545L (en) | 1975-03-10 |
| JPS5041900A (en) | 1975-04-16 |
| DK386274A (en) | 1975-04-01 |
| GB1419933A (en) | 1975-12-31 |
| DK136775C (en) | 1978-05-08 |
| SE412589B (en) | 1980-03-10 |
| CA1019726A (en) | 1977-10-25 |
| JPS5727119B2 (en) | 1982-06-08 |
| DE2434967A1 (en) | 1975-02-20 |
| AU7188674A (en) | 1976-02-05 |
| SE7410005L (en) | 1975-02-10 |
| LU70582A1 (en) | 1976-05-31 |
| NL7410061A (en) | 1975-02-11 |
| IN139935B (en) | 1976-08-21 |
| CH583744A5 (en) | 1977-01-14 |
| IL45384A (en) | 1976-09-30 |
| ES428798A1 (en) | 1976-09-16 |
| IL45384A0 (en) | 1974-11-29 |
| AR199756A1 (en) | 1974-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1519511A (en) | Heavy duty aqueous wood preservative | |
| GB1495692A (en) | Zinc sulphadiazine as a medicament | |
| IE43653L (en) | Sequestration of oxygen dissolved in water | |
| GB1419933A (en) | Preparation of methylcobalamine | |
| GB1299648A (en) | Aminooxazoline and products thereof and processes for synthesizing same | |
| GB1425669A (en) | Electrolytic process for the preparation of dimethyl sebacate | |
| GB1500408A (en) | Process for the preparation of catalysts and supported catalysts | |
| GB1261474A (en) | Phenylacetic acid | |
| GB1441085A (en) | Production of glycidyl methacrylate | |
| JPS5322530A (en) | Preparation of inorganic powder | |
| GB1492718A (en) | Benzothiazine 1,1-dioxide derivatives | |
| GB1346544A (en) | Silver allantoinate-containing compositions | |
| GB1338994A (en) | Preparation of 1,4-dithiol-2,3-butane-diol | |
| GB1355899A (en) | Process for the preparation of methylcobalamine | |
| GB1427882A (en) | Oxytetracycline solutions | |
| GB1372019A (en) | Preparation of pyrosulphates | |
| GB1360354A (en) | Chenodeoxycholic acid | |
| GB1458775A (en) | Method of preparing 1-methyl-3-phenyl-indane | |
| GB8514315D0 (en) | Preparation of aqueous solution | |
| JPS5420090A (en) | Separation of acrylic acid hydrazide high polymer | |
| GB1359372A (en) | Preparation of 1,1,2-trimethoxyethane and o-acetic acid methyl ester | |
| GB1125811A (en) | Catalysts | |
| GB1272829A (en) | Nickel alkoxide compound | |
| GB1448295A (en) | Thiosemicarbazones | |
| GB1302679A (en) |