IE44858L - HYPOLIPIDEMIC p-AMINOBENZOIC ACIDS - Google Patents
HYPOLIPIDEMIC p-AMINOBENZOIC ACIDSInfo
- Publication number
- IE44858L IE44858L IE770104A IE10477A IE44858L IE 44858 L IE44858 L IE 44858L IE 770104 A IE770104 A IE 770104A IE 10477 A IE10477 A IE 10477A IE 44858 L IE44858 L IE 44858L
- Authority
- IE
- Ireland
- Prior art keywords
- ylmethylamino
- benzodioxol
- formula
- hypolipidemic
- aminobenzoic
- Prior art date
Links
- 230000000055 hyoplipidemic effect Effects 0.000 title 1
- DXMXVBCFPHMKGZ-UHFFFAOYSA-N 4-(1,3-benzodioxol-5-ylmethylamino)benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1NCC1=CC=C(OCO2)C2=C1 DXMXVBCFPHMKGZ-UHFFFAOYSA-N 0.000 abstract 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- SATCULPHIDQDRE-UHFFFAOYSA-N piperonal Chemical compound O=CC1=CC=C2OCOC2=C1 SATCULPHIDQDRE-UHFFFAOYSA-N 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 229960004050 aminobenzoic acid Drugs 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 229940081310 piperonal Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Schiff's bases of the formula I <IMAGE> in which R is hydrogen or lower alkyl are obtained by reacting piperonal with p-aminobenzoic acid or with a p-aminobenzoic ester. 4-(1,3-Benzodioxol-5-ylmethylamino)benzoic acid and 4-(1,3-benzodioxol-5-ylmethylamino)benzoic esters of the formula II <IMAGE> in which R is hydrogen or lower alkyl are obtained by reducing Schiff's bases of the formula I. The compound 4-(1,3-benzodioxol-5-ylmethylamino)benzoic acid which can be prepared according to the invention can be used, for example, for the reduction of the lipid level in the plasma of animals.
[GB1521458A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65009076A | 1976-01-19 | 1976-01-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44858L true IE44858L (en) | 1977-07-19 |
| IE44858B1 IE44858B1 (en) | 1982-04-21 |
Family
ID=24607411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE104/77A IE44858B1 (en) | 1976-01-19 | 1977-01-19 | Hypolipidemic p-aminobenzoic acids |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5289660A (en) |
| AT (1) | AT347923B (en) |
| AU (1) | AU500881B2 (en) |
| BE (1) | BE850516A (en) |
| CA (1) | CA1072969A (en) |
| CH (1) | CH628340A5 (en) |
| DE (1) | DE2702058C2 (en) |
| DK (1) | DK153471C (en) |
| FR (1) | FR2338040A1 (en) |
| GB (2) | GB1521458A (en) |
| IE (1) | IE44858B1 (en) |
| NL (1) | NL7700480A (en) |
| NO (1) | NO145839C (en) |
| SE (1) | SE435175B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE716668C (en) * | 1938-02-15 | 1942-01-27 | Dr Aladar Skita | Process for the preparation of derivatives of substituted aminobenzoic acids |
| FR2080069A5 (en) * | 1970-02-23 | 1971-11-12 | Commissariat Energie Atomique | |
| US3868416A (en) * | 1973-10-01 | 1975-02-25 | American Cyanamid Co | Hypolipidemic 4-(monoalkylamino)benzoic acid derivatives |
-
1977
- 1977-01-07 AU AU21140/77A patent/AU500881B2/en not_active Expired
- 1977-01-10 DK DK008177A patent/DK153471C/en not_active IP Right Cessation
- 1977-01-11 CA CA269,483A patent/CA1072969A/en not_active Expired
- 1977-01-17 GB GB1803/77A patent/GB1521458A/en not_active Expired
- 1977-01-17 GB GB52242/77A patent/GB1521459A/en not_active Expired
- 1977-01-17 JP JP384477A patent/JPS5289660A/en active Granted
- 1977-01-18 FR FR7701296A patent/FR2338040A1/en active Granted
- 1977-01-18 SE SE7700490A patent/SE435175B/en not_active IP Right Cessation
- 1977-01-18 NO NO770151A patent/NO145839C/en unknown
- 1977-01-18 NL NL7700480A patent/NL7700480A/en active Search and Examination
- 1977-01-19 IE IE104/77A patent/IE44858B1/en not_active IP Right Cessation
- 1977-01-19 AT AT31277A patent/AT347923B/en not_active IP Right Cessation
- 1977-01-19 BE BE174188A patent/BE850516A/en not_active IP Right Cessation
- 1977-01-19 DE DE2702058A patent/DE2702058C2/en not_active Expired
- 1977-01-19 CH CH65877A patent/CH628340A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATA31277A (en) | 1978-06-15 |
| JPS6233230B2 (en) | 1987-07-20 |
| CH628340A5 (en) | 1982-02-26 |
| CA1072969A (en) | 1980-03-04 |
| GB1521459A (en) | 1978-08-16 |
| NO145839C (en) | 1982-06-09 |
| AT347923B (en) | 1979-01-25 |
| DK153471C (en) | 1988-11-21 |
| DE2702058A1 (en) | 1977-07-28 |
| GB1521458A (en) | 1978-08-16 |
| NO145839B (en) | 1982-03-01 |
| BE850516A (en) | 1977-07-19 |
| DE2702058C2 (en) | 1985-09-19 |
| NO770151L (en) | 1977-07-20 |
| AU500881B2 (en) | 1979-06-07 |
| SE435175B (en) | 1984-09-10 |
| FR2338040B1 (en) | 1980-04-30 |
| IE44858B1 (en) | 1982-04-21 |
| DK153471B (en) | 1988-07-18 |
| DK8177A (en) | 1977-07-20 |
| JPS5289660A (en) | 1977-07-27 |
| FR2338040A1 (en) | 1977-08-12 |
| AU2114077A (en) | 1978-07-13 |
| SE7700490L (en) | 1977-07-20 |
| NL7700480A (en) | 1977-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |