IE65503B1 - Pt (IV) complexes - Google Patents

Pt (IV) complexes

Info

Publication number
IE65503B1
IE65503B1 IE31989A IE31989A IE65503B1 IE 65503 B1 IE65503 B1 IE 65503B1 IE 31989 A IE31989 A IE 31989A IE 31989 A IE31989 A IE 31989A IE 65503 B1 IE65503 B1 IE 65503B1
Authority
IE
Ireland
Prior art keywords
alkyl
ptcl2
complex according
carbon atoms
complexes
Prior art date
Application number
IE31989A
Other languages
English (en)
Other versions
IE890319L (en
Inventor
Michael J Abrams
Christen M Gaindomenico
Jean F Vollano
Barry A Murrer
Original Assignee
Johnson Matthey Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson Matthey Inc filed Critical Johnson Matthey Inc
Publication of IE890319L publication Critical patent/IE890319L/en
Publication of IE65503B1 publication Critical patent/IE65503B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IE31989A 1988-02-02 1989-02-01 Pt (IV) complexes IE65503B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15167488A 1988-02-02 1988-02-02
US29677689A 1989-01-13 1989-01-13

Publications (2)

Publication Number Publication Date
IE890319L IE890319L (en) 1989-08-02
IE65503B1 true IE65503B1 (en) 1995-11-01

Family

ID=26848859

Family Applications (1)

Application Number Title Priority Date Filing Date
IE31989A IE65503B1 (en) 1988-02-02 1989-02-01 Pt (IV) complexes

Country Status (16)

Country Link
EP (1) EP0328274B1 (da)
JP (1) JP2781403B2 (da)
KR (1) KR0147270B1 (da)
AT (1) ATE113054T1 (da)
AU (1) AU618310B2 (da)
CA (1) CA1340286C (da)
DE (1) DE68918878T2 (da)
DK (1) DK175050B1 (da)
ES (1) ES2063119T3 (da)
FI (1) FI91260C (da)
HU (1) HU205767B (da)
IE (1) IE65503B1 (da)
IL (1) IL89119A (da)
NO (1) NO177569C (da)
NZ (1) NZ227839A (da)
PT (1) PT89608B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196555A (en) * 1989-10-17 1993-03-23 Bristol-Myers Squibb Company Water and solvent soluble axial hydroxy and mono- and di- carboxylic acid derivatives having high tumor activity
FI905018A7 (fi) * 1989-10-17 1991-04-18 Bristol Myers Squibb Co Veteen ja liuottimeen liukenevat aksiaaliset hydroksi- ja mono- ja di-karboksyylihappojohdannaiset, joilla on korkea kasvainaktiivisuus
GB9105037D0 (en) * 1991-03-09 1991-04-24 Johnson Matthey Plc Improvements in chemical compounds
IT1251115B (it) * 1991-07-26 1995-05-04 Mauro Esposito Complessi molecolari del platino ad attivita' antitumorale
US5624919A (en) * 1993-09-14 1997-04-29 The University Of Vermont And State Agricultural College Trans platinum (IV) complexes
EP0646589A3 (en) * 1993-10-04 1995-06-28 Tanaka Precious Metal Ind Anti-tumor platinum (IV) complexes.
GB9408218D0 (en) * 1994-04-26 1994-06-15 Johnson Matthey Plc Improvements in platinum complexes
GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
US6008395A (en) * 1995-02-28 1999-12-28 Kidani; Yoshinori Platinum (IV) complex, production process thereof and carcinostatic agent containing the same
KR100246722B1 (ko) * 1997-12-30 2000-04-01 박호군 경구용 백금 착화합물 항암제 및 그 제조방법
CZ288912B6 (cs) * 1998-05-27 2001-09-12 Lachema, A. S. Komplex platiny v oxidačním čísle IV, způsob přípravy tohoto komplexu, tento komplex jako léčivo a farmaceutická kompozice tento komplex obsahující
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
CN1296377C (zh) * 2003-06-11 2007-01-24 南京大学 含醚键羧酸根为配体的铂（ⅱ）配合物的制备
AU2004270655B2 (en) 2003-08-13 2011-03-24 University Of South Florida Methods for inhibiting tumor cell proliferation
EP1524273B1 (de) * 2003-10-13 2006-11-22 Salama, Zoser B. nat.rer.Dr. Verfahren zur Herstellung von trans- oder cis-Diammoniumdichlorodihydroxoplatin (IV)-Salzen und -Derivaten und ihre Verwendung zur Herstellung von pharmazeutischen Wirkstoffen
US20050288365A1 (en) 2004-01-06 2005-12-29 Heidi Kay Platinum complexes and methods for inhibiting tumor cell proliferation
US20060205810A1 (en) * 2004-11-24 2006-09-14 Schering Corporation Platinum therapeutic combinations
CZ300590B6 (cs) * 2006-06-20 2009-06-24 Pliva - Lachema A. S. Farmaceutická kompozice pro injekcní podání
CZ300424B6 (cs) * 2006-06-20 2009-05-13 Pliva - Lachema A. S. Farmaceutická kompozice pro perorální podání
US9771387B2 (en) 2013-07-16 2017-09-26 Placon Therapeutics Platinum compounds having a heterocycle ligand, nanoparticles, and uses thereof
JP6321291B2 (ja) 2014-09-03 2018-05-09 ブイユーエービー ファーマ エー．エス． 増加した抗腫瘍効果を有する白金（ｉｖ）錯体
CN107709286B (zh) * 2015-06-24 2021-02-19 日本化药株式会社 新型铂(ⅳ)络合物
WO2017047497A1 (ja) 2015-09-14 2017-03-23 日本化薬株式会社 ６配位白金錯体の高分子結合体
CN105713046B (zh) * 2016-02-01 2018-10-26 复旦大学 一种铂类抗肿瘤前体药物，其纳米水凝胶药物及其制备方法
CN107955042B (zh) * 2017-11-23 2020-01-21 青岛大学附属医院 具有抗癌活性的铂类配合物、制备方法及应用
US12351593B2 (en) 2019-09-05 2025-07-08 Vuab Pharma A.S. Platinum IV complexes with substantially increased antitumor efficacy
CN112961190A (zh) * 2021-02-07 2021-06-15 山东省第二人民医院(山东省耳鼻喉医院、山东省耳鼻喉研究所) 一种藜芦酸四价铂及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8101026A (nl) * 1981-03-03 1982-10-01 Tno Platinadiamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel.
JPS6087295A (ja) * 1983-10-19 1985-05-16 Nippon Kayaku Co Ltd 新規白金錯体
JPS62207283A (ja) * 1986-03-07 1987-09-11 Yoshinori Kitani 新規な白金錯体

Also Published As

Publication number Publication date
ES2063119T3 (es) 1995-01-01
ATE113054T1 (de) 1994-11-15
FI890512A0 (fi) 1989-02-02
DE68918878D1 (de) 1994-11-24
FI890512L (fi) 1989-08-03
JP2781403B2 (ja) 1998-07-30
DK49189D0 (da) 1989-02-02
FI91260C (fi) 1994-06-10
PT89608B (pt) 1994-05-31
DK49189A (da) 1989-08-03
NO890426L (no) 1989-08-03
IL89119A0 (en) 1989-08-15
EP0328274A1 (en) 1989-08-16
CA1340286C (en) 1998-12-22
JPH01294684A (ja) 1989-11-28
IE890319L (en) 1989-08-02
EP0328274B1 (en) 1994-10-19
KR0147270B1 (ko) 1998-08-17
HUT49890A (en) 1989-11-28
DE68918878T2 (de) 1995-02-23
AU618310B2 (en) 1991-12-19
FI91260B (fi) 1994-02-28
NO177569B (no) 1995-07-03
DK175050B1 (da) 2004-05-10
AU2897189A (en) 1989-08-03
IL89119A (en) 1994-04-12
PT89608A (pt) 1989-10-04
KR890013044A (ko) 1989-09-21
NO890426D0 (no) 1989-02-02
HU205767B (en) 1992-06-29
NO177569C (no) 1995-10-11
NZ227839A (en) 1991-06-25

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