IE67067B1 - Recombinant alveolar surfactant protein - Google Patents

Recombinant alveolar surfactant protein

Info

Publication number: IE67067B1
Authority: IE; Ireland
Prior art keywords: asp; protein; dna; cells; sequence
Prior art date: 1984-12-11

Application number

IE313385A

Other languages

English (en)

Other versions

IE853133L (en

Inventor

Jr James W Schilling

Robert T White

Barbara Cordell

Bradley J Benson

Original Assignee

Scios Nova Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-11

Filing date

1985-12-11

Publication date

1996-02-21

1985-12-11 Application filed by Scios Nova Inc filed Critical Scios Nova Inc

1986-06-11 Publication of IE853133L publication Critical patent/IE853133L/en

1996-02-21 Publication of IE67067B1 publication Critical patent/IE67067B1/en

Links

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230000000813 microbial effect Effects 0.000 description 1
230000003228 microsomal effect Effects 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000002703 mutagenesis Methods 0.000 description 1
231100000350 mutagenesis Toxicity 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
229940042880 natural phospholipid Drugs 0.000 description 1
238000002663 nebulization Methods 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
201000002652 newborn respiratory distress syndrome Diseases 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
239000006179 pH buffering agent Substances 0.000 description 1
238000005192 partition Methods 0.000 description 1
229950009506 penicillinase Drugs 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
125000001095 phosphatidyl group Chemical group 0.000 description 1
150000008105 phosphatidylcholines Chemical class 0.000 description 1
230000026731 phosphorylation Effects 0.000 description 1
238000006366 phosphorylation reaction Methods 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
230000007505 plaque formation Effects 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
201000003144 pneumothorax Diseases 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
230000001323 posttranslational effect Effects 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
235000011118 potassium hydroxide Nutrition 0.000 description 1
HJRIWDYVYNNCFY-UHFFFAOYSA-M potassium;dimethylarsinate Chemical compound [K+].C[As](C)([O-])=O HJRIWDYVYNNCFY-UHFFFAOYSA-M 0.000 description 1
239000002243 precursor Substances 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
230000002028 premature Effects 0.000 description 1
230000037452 priming Effects 0.000 description 1
230000008569 process Effects 0.000 description 1
235000013930 proline Nutrition 0.000 description 1
235000004252 protein component Nutrition 0.000 description 1
239000012460 protein solution Substances 0.000 description 1
210000003456 pulmonary alveoli Anatomy 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000008439 repair process Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
239000012723 sample buffer Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
239000013049 sediment Substances 0.000 description 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
238000004513 sizing Methods 0.000 description 1
238000002791 soaking Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000007787 solid Substances 0.000 description 1
229940063673 spermidine Drugs 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
239000013589 supplement Substances 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
230000005026 transcription initiation Effects 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
239000001226 triphosphate Substances 0.000 description 1
235000011178 triphosphate Nutrition 0.000 description 1
125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1
238000009423 ventilation Methods 0.000 description 1
239000011800 void material Substances 0.000 description 1
229940056904 zinc ascorbate Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pulmonology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Cosmetics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IE313385A 1984-12-11 1985-12-11 Recombinant alveolar surfactant protein IE67067B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/680,358 US4659805A (en)	1984-12-11	1984-12-11	Recombinant alveolar surfactant protein

Publications (2)

Publication Number	Publication Date
IE853133L IE853133L (en)	1986-06-11
IE67067B1 true IE67067B1 (en)	1996-02-21

Family

ID=24730771

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE313385A IE67067B1 (en)	1984-12-11	1985-12-11	Recombinant alveolar surfactant protein

Country Status (14)

Country	Link
US (1)	US4659805A (da)
EP (1)	EP0210189B1 (da)
JP (3)	JPH07108917B2 (da)
KR (1)	KR900004798B1 (da)
AT (1)	ATE115147T1 (da)
AU (1)	AU585579B2 (da)
DE (2)	DE3590648T1 (da)
DK (1)	DK172227B1 (da)
ES (1)	ES8801517A1 (da)
GB (1)	GB2181138B (da)
HK (1)	HK1005883A1 (da)
IE (1)	IE67067B1 (da)
NO (1)	NO177678C (da)
WO (1)	WO1986003408A1 (da)

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US4965199A (en) *	1984-04-20	1990-10-23	Genentech, Inc.	Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US5430020A (en) *	1984-12-11	1995-07-04	Scios Nova Inc.	Recombinant alveolar surfactant protein
US4933280A (en) *	1984-12-11	1990-06-12	California Biotechnology Inc.	Recombinant DNA sequence encoding Alveolar Surfactant Protein
US5840527A (en) *	1984-12-11	1998-11-24	Byk Gulden Lomberg Chemische Fabrik Gmbh	Recombinant alveolar surfactant protein
US5169761A (en) *	1984-12-11	1992-12-08	California Biotechnology Inc.	Dna encoding and expression systems for alveolar surfactant proteins
MX169643B (es) *	1985-04-12	1993-07-16	Oronzio De Nora Impianti	Electrodo para procesos electroquimicos, procedimiento para su produccion y cuba de electrolisis conteniendo dicho electrodo
US4918161A (en) *	1985-09-26	1990-04-17	Genetics Institute, Inc.	Low molecular weight pulmonary surfactant proteins
US4882422A (en) *	1985-10-24	1989-11-21	Genetics Institute, Inc.	Pulmonary surfactant proteins
US5055553A (en) *	1985-09-26	1991-10-08	Genetics Institute Inc.	Low molecular weight pulmonary surfactant proteins
EP0240550A4 (en) *	1985-09-26	1989-09-19	Genetics Inst	TENSIO-ACTIVE PULMONARY PROTEINS.
US5013720A (en) *	1986-05-06	1991-05-07	Abbott Laboratories	SAP-6-Val proteins and methods
WO1987006943A1 (en) *	1986-05-06	1987-11-19	Children's Hospital Medical Center	Pulmonary hydrophobic surfactant-associated protein of 6,000 daltons molecular weight and multimers thereof
WO1988003170A1 (en) *	1986-10-24	1988-05-05	Whitsett Jeffrey A	Pulmonary hydrophobic surfactant-associated proteins
JPH01501282A (ja) *	1986-12-08	1989-05-11	ホイツトセツト，ジエフリー　エイ．	肺胞疎水性界面活性物質関連タンパク質
WO1988005820A1 (en) *	1987-01-29	1988-08-11	California Biotechnology, Inc.	Recombinant alveolar surfactant protein
US6613734B2 (en)	1988-01-06	2003-09-02	The Scripps Research Institute	Peptides-containing liposomal surfactants
US5164369A (en) *	1988-01-06	1992-11-17	The Scripps Research Institute	Pulmonary surfactant protein and related polypeptide
US5260273A (en) *	1988-01-06	1993-11-09	The Scripps Research Institute	Pulmonary surfactant protein and related polypeptide
SE8803713D0 (sv) *	1988-10-18	1988-10-18	Kabigen Ab	Biologically active lipoprotein and its use
US5006343A (en) *	1988-12-29	1991-04-09	Benson Bradley J	Pulmonary administration of pharmaceutically active substances
DE69125750D1 (de) *	1990-05-21	1997-05-28	Abbott Lab	Fettsäure-Oberflächenaktives-Lungenprotein Konjate
GB9120005D0 (en) *	1991-09-19	1991-11-06	Wellcome Found	Method of administering phospholipid dispersions
US5272252A (en) *	1991-11-04	1993-12-21	Merrell Dow Pharmaceuticals Inc.	Synthetic lung surfactant having antioxidant properties
DE4418936A1 (de) *	1994-05-31	1996-02-08	Byk Gulden Lomberg Chem Fab	Polypeptid
ES2223478T3 (es) *	1999-01-19	2005-03-01	Altana Pharma Ag	Sp-a recombinante para el tratamiento o la prevencion de infecciones e inflamaciones pulmonares.
US7053176B1 (en)	1999-09-16	2006-05-30	Altana Pharma Ag	Combination of C1-INH and lung surfactant for the treatment of respiratory disorders
JP2001137349A (ja)	1999-11-16	2001-05-22	Asahi Optical Co Ltd	内視鏡用噴霧具
WO2002006301A2 (en) *	2000-06-30	2002-01-24	University Of Cincinnati	Peptides with antioxidant and antimicrobial properties
AU2002338882B2 (en)	2001-10-11	2008-04-03	Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.	Novel use of pulmonary surfactant
SE0203591D0 (sv)	2002-12-04	2002-12-04	Siemens Elema Ab	Förfarande för beredning av ett mediakament och en medicinsk anordning
CA2575513C (en)	2004-08-06	2014-09-16	Altana Pharma Ag	Composition comprising a pulmonary surfactant and a tnf-derived peptide
US7582312B2 (en)	2004-11-15	2009-09-01	Discovery Laboratories, Inc.	Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
SI1841458T1 (sl)	2005-01-06	2012-04-30	Discovery Lab Inc	Zdravljenje s predpisanim odmerjanjem surfaktanta za zdravljenje ali preprečevanje bronhopulmonalne displazije
EP2063903A1 (en)	2006-09-19	2009-06-03	Discovery Laboratories, Inc.	Pulmonary surfactant formulations and methods for promoting mucus clearance
US7951781B2 (en)	2006-11-02	2011-05-31	University Of Iowa Research Foundation	Methods and compositions related to PLUNC surfactant polypeptides
WO2010068754A2 (en)	2008-12-10	2010-06-17	Paka Pulmonary Pharmaceuticals, Inc.	Methods and compositions for delivery of medicaments to the lungs
WO2013188016A2 (en)	2012-05-04	2013-12-19	Discovery Laboratories, Inc.	Surfactant therapy for exposure to ionizing radiation

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Publication number	Priority date	Publication date	Assignee	Title
US4506013A (en) *	1980-10-03	1985-03-19	Eli Lilly And Company	Stabilizing and selecting recombinant DNA host cells
US4312860A (en) *	1980-10-24	1982-01-26	Regents Of The University Of California	Lung surfactant compositions
US4562003A (en) *	1984-10-26	1985-12-31	California Biotechnology, Inc.	Monoclonal antibodies against alveolar surfactant protein
AU580145B2 (en) *	1985-02-13	1989-01-05	Scios Nova Inc.	Human metallothionein-ii promoter in mammalian expression system

1984
- 1984-12-11 US US06/680,358 patent/US4659805A/en not_active Expired - Lifetime
1985
- 1985-12-10 GB GB08619801A patent/GB2181138B/en not_active Expired
- 1985-12-10 EP EP86900477A patent/EP0210189B1/en not_active Expired - Lifetime
- 1985-12-10 JP JP61500416A patent/JPH07108917B2/ja not_active Expired - Lifetime
- 1985-12-10 DE DE19853590648 patent/DE3590648T1/de not_active Ceased
- 1985-12-10 AT AT86900477T patent/ATE115147T1/de not_active IP Right Cessation
- 1985-12-10 HK HK98105038A patent/HK1005883A1/en not_active IP Right Cessation
- 1985-12-10 DE DE3587958T patent/DE3587958T2/de not_active Expired - Lifetime
- 1985-12-10 KR KR1019860700554A patent/KR900004798B1/ko not_active Expired
- 1985-12-10 AU AU53089/86A patent/AU585579B2/en not_active Expired
- 1985-12-10 WO PCT/US1985/002445 patent/WO1986003408A1/en not_active Ceased
- 1985-12-11 IE IE313385A patent/IE67067B1/en not_active IP Right Cessation
- 1985-12-11 ES ES549817A patent/ES8801517A1/es not_active Expired
1986
- 1986-08-07 NO NO863197A patent/NO177678C/no not_active IP Right Cessation
- 1986-08-11 DK DK382786A patent/DK172227B1/da not_active IP Right Cessation
1994
- 1994-06-14 JP JP6132329A patent/JP2500197B2/ja not_active Expired - Lifetime
1995
- 1995-11-08 JP JP7316070A patent/JPH08224091A/ja active Pending

Also Published As

Publication number	Publication date
JPH08224091A (ja)	1996-09-03
GB8619801D0 (en)	1986-09-24
US4659805A (en)	1987-04-21
JPH07108917B2 (ja)	1995-11-22
JPS62501122A (ja)	1987-05-07
IE853133L (en)	1986-06-11
ES8801517A1 (es)	1988-01-16
DE3587958D1 (de)	1995-01-19
JP2500197B2 (ja)	1996-05-29
DE3587958T2 (de)	1995-05-04
GB2181138A (en)	1987-04-15
ATE115147T1 (de)	1994-12-15
JPH0751066A (ja)	1995-02-28
NO177678C (no)	1995-11-01
AU585579B2 (en)	1989-06-22
DK382786D0 (da)	1986-08-11
EP0210189A1 (en)	1987-02-04
DE3590648T1 (da)	1987-02-19
KR900004798B1 (ko)	1990-07-06
EP0210189A4 (en)	1988-11-09
NO863197D0 (no)	1986-08-07
NO177678B (no)	1995-07-24
NO863197L (no)	1986-08-07
AU5308986A (en)	1986-07-01
GB2181138B (en)	1989-01-25
DK382786A (da)	1986-10-13
EP0210189B1 (en)	1994-12-07
ES549817A0 (es)	1988-01-16
WO1986003408A1 (en)	1986-06-19
KR870700019A (ko)	1987-02-28
DK172227B1 (da)	1998-01-12
HK1005883A1 (en)	1999-01-29

Legal Events

Date	Code	Title	Description
2006-01-25	MK9A	Patent expired

Publication	Publication Date	Title
AU585579B2 (en)	1989-06-22	Recombinant alveolar surfactant protein
US4912038A (en)	1990-03-27	Recombinant DNA sequence encoding alveolar surfactant protein
HK1005883B (en)	1999-01-29	Recombinant alveolar surfactant protein
US4933280A (en)	1990-06-12	Recombinant DNA sequence encoding Alveolar Surfactant Protein
EP0383837B1 (en)	1998-02-04	Alveolar surfactant proteins
EP0290516A1 (en)	1988-11-17	Pulmonary hydrophobic surfactant-associated proteins
JP2757987B2 (ja)	1998-05-25	ヒト抗‐炎症ホスホリパーゼ阻害蛋白
EP0307513A2 (en)	1989-03-22	Pulmonary hydrophobic surfactant-associated proteins
JP2005053929A (ja)	2005-03-03	肺胞界面活性タンパク質
US5840527A (en)	1998-11-24	Recombinant alveolar surfactant protein
CA1340580C (en)	1999-06-08	Recombinant alveolar surfactant protein
US5430020A (en)	1995-07-04	Recombinant alveolar surfactant protein
WO1988005820A1 (en)	1988-08-11	Recombinant alveolar surfactant protein
HK1005887B (en)	1999-01-29	Recombinant alveolar surfactant protein
HK1008744B (en)	1999-05-14	Alveolar surfactant proteins
HK1008744A1 (en)	1999-05-14	Alveolar surfactant proteins
NO875477L (no)	1988-02-26	Rekombinant alveolaert overflateaktivt protein.