ES8801517A1 - Un metodo para producir proteina tensioactiva alveolar - Google Patents

Un metodo para producir proteina tensioactiva alveolar

Info

Publication number
ES8801517A1
ES8801517A1 ES549817A ES549817A ES8801517A1 ES 8801517 A1 ES8801517 A1 ES 8801517A1 ES 549817 A ES549817 A ES 549817A ES 549817 A ES549817 A ES 549817A ES 8801517 A1 ES8801517 A1 ES 8801517A1
Authority
ES
Spain
Prior art keywords
proteins
alveolar surfactant
recombinant
surfactant protein
asp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549817A
Other languages
English (en)
Other versions
ES549817A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scios LLC
Original Assignee
California Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Biotechnology Inc filed Critical California Biotechnology Inc
Publication of ES8801517A1 publication Critical patent/ES8801517A1/es
Publication of ES549817A0 publication Critical patent/ES549817A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/30—Signal or leader sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

METODO PARA LA PRODUCCION DE PROTEINAS TENSIOACTIVAS ALVEOLARES. CONSISTE EN CULTIVAR CELULAS RECOMBINANTES TRANSFECTADAS CON UNA SECUENCIA DE ADN CODIFICADOR DE LA PROTEINA TENSIOACTIVA ALVEOLAR, DE MODO QUE PERMITE LA EXPRESION DE DICHO ADN EN CONDICIONES COMPATIBLES CON TALES CELULAS, EN PRESENCIA DE NUTRIENTES ADECUADOS, A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y 40JC, A PH APROXIMADAMENTE NEUTRO, EN CONDICIONES AEROBICAS; Y RECUPERAR LA PRTEINA A PARTIR DEL CULTIVO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE CIERTAS ENFERMEDADES RESPIRATORIAS.
ES549817A 1984-12-11 1985-12-11 Un metodo para producir proteina tensioactiva alveolar Expired ES8801517A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/680,358 US4659805A (en) 1984-12-11 1984-12-11 Recombinant alveolar surfactant protein

Publications (2)

Publication Number Publication Date
ES8801517A1 true ES8801517A1 (es) 1988-01-16
ES549817A0 ES549817A0 (es) 1988-01-16

Family

ID=24730771

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549817A Expired ES8801517A1 (es) 1984-12-11 1985-12-11 Un metodo para producir proteina tensioactiva alveolar

Country Status (14)

Country Link
US (1) US4659805A (es)
EP (1) EP0210189B1 (es)
JP (3) JPH07108917B2 (es)
KR (1) KR900004798B1 (es)
AT (1) ATE115147T1 (es)
AU (1) AU585579B2 (es)
DE (2) DE3590648T1 (es)
DK (1) DK172227B1 (es)
ES (1) ES8801517A1 (es)
GB (1) GB2181138B (es)
HK (1) HK1005883A1 (es)
IE (1) IE67067B1 (es)
NO (1) NO177678C (es)
WO (1) WO1986003408A1 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US5430020A (en) * 1984-12-11 1995-07-04 Scios Nova Inc. Recombinant alveolar surfactant protein
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
US5840527A (en) * 1984-12-11 1998-11-24 Byk Gulden Lomberg Chemische Fabrik Gmbh Recombinant alveolar surfactant protein
US5169761A (en) * 1984-12-11 1992-12-08 California Biotechnology Inc. Dna encoding and expression systems for alveolar surfactant proteins
MX169643B (es) * 1985-04-12 1993-07-16 Oronzio De Nora Impianti Electrodo para procesos electroquimicos, procedimiento para su produccion y cuba de electrolisis conteniendo dicho electrodo
US4918161A (en) * 1985-09-26 1990-04-17 Genetics Institute, Inc. Low molecular weight pulmonary surfactant proteins
US4882422A (en) * 1985-10-24 1989-11-21 Genetics Institute, Inc. Pulmonary surfactant proteins
US5055553A (en) * 1985-09-26 1991-10-08 Genetics Institute Inc. Low molecular weight pulmonary surfactant proteins
EP0240550A4 (en) * 1985-09-26 1989-09-19 Genetics Inst TENSIO-ACTIVE PULMONARY PROTEINS.
US5013720A (en) * 1986-05-06 1991-05-07 Abbott Laboratories SAP-6-Val proteins and methods
WO1987006943A1 (en) * 1986-05-06 1987-11-19 Children's Hospital Medical Center Pulmonary hydrophobic surfactant-associated protein of 6,000 daltons molecular weight and multimers thereof
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
WO1988005820A1 (en) * 1987-01-29 1988-08-11 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US6613734B2 (en) 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
DE69125750D1 (de) * 1990-05-21 1997-05-28 Abbott Lab Fettsäure-Oberflächenaktives-Lungenprotein Konjate
GB9120005D0 (en) * 1991-09-19 1991-11-06 Wellcome Found Method of administering phospholipid dispersions
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
DE4418936A1 (de) * 1994-05-31 1996-02-08 Byk Gulden Lomberg Chem Fab Polypeptid
ES2223478T3 (es) * 1999-01-19 2005-03-01 Altana Pharma Ag Sp-a recombinante para el tratamiento o la prevencion de infecciones e inflamaciones pulmonares.
US7053176B1 (en) 1999-09-16 2006-05-30 Altana Pharma Ag Combination of C1-INH and lung surfactant for the treatment of respiratory disorders
JP2001137349A (ja) 1999-11-16 2001-05-22 Asahi Optical Co Ltd 内視鏡用噴霧具
WO2002006301A2 (en) * 2000-06-30 2002-01-24 University Of Cincinnati Peptides with antioxidant and antimicrobial properties
AU2002338882B2 (en) 2001-10-11 2008-04-03 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Novel use of pulmonary surfactant
SE0203591D0 (sv) 2002-12-04 2002-12-04 Siemens Elema Ab Förfarande för beredning av ett mediakament och en medicinsk anordning
CA2575513C (en) 2004-08-06 2014-09-16 Altana Pharma Ag Composition comprising a pulmonary surfactant and a tnf-derived peptide
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
SI1841458T1 (sl) 2005-01-06 2012-04-30 Discovery Lab Inc Zdravljenje s predpisanim odmerjanjem surfaktanta za zdravljenje ali preprečevanje bronhopulmonalne displazije
EP2063903A1 (en) 2006-09-19 2009-06-03 Discovery Laboratories, Inc. Pulmonary surfactant formulations and methods for promoting mucus clearance
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
WO2010068754A2 (en) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
US4312860A (en) * 1980-10-24 1982-01-26 Regents Of The University Of California Lung surfactant compositions
US4562003A (en) * 1984-10-26 1985-12-31 California Biotechnology, Inc. Monoclonal antibodies against alveolar surfactant protein
AU580145B2 (en) * 1985-02-13 1989-01-05 Scios Nova Inc. Human metallothionein-ii promoter in mammalian expression system

Also Published As

Publication number Publication date
JPH08224091A (ja) 1996-09-03
GB8619801D0 (en) 1986-09-24
US4659805A (en) 1987-04-21
IE67067B1 (en) 1996-02-21
JPH07108917B2 (ja) 1995-11-22
JPS62501122A (ja) 1987-05-07
IE853133L (en) 1986-06-11
DE3587958D1 (de) 1995-01-19
JP2500197B2 (ja) 1996-05-29
DE3587958T2 (de) 1995-05-04
GB2181138A (en) 1987-04-15
ATE115147T1 (de) 1994-12-15
JPH0751066A (ja) 1995-02-28
NO177678C (no) 1995-11-01
AU585579B2 (en) 1989-06-22
DK382786D0 (da) 1986-08-11
EP0210189A1 (en) 1987-02-04
DE3590648T1 (es) 1987-02-19
KR900004798B1 (ko) 1990-07-06
EP0210189A4 (en) 1988-11-09
NO863197D0 (no) 1986-08-07
NO177678B (no) 1995-07-24
NO863197L (no) 1986-08-07
AU5308986A (en) 1986-07-01
GB2181138B (en) 1989-01-25
DK382786A (da) 1986-10-13
EP0210189B1 (en) 1994-12-07
ES549817A0 (es) 1988-01-16
WO1986003408A1 (en) 1986-06-19
KR870700019A (ko) 1987-02-28
DK172227B1 (da) 1998-01-12
HK1005883A1 (en) 1999-01-29

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20061202