IE862851L - Cloned superoxide dismutase - Google Patents
Cloned superoxide dismutaseInfo
- Publication number
- IE862851L IE862851L IE862851A IE285186A IE862851L IE 862851 L IE862851 L IE 862851L IE 862851 A IE862851 A IE 862851A IE 285186 A IE285186 A IE 285186A IE 862851 L IE862851 L IE 862851L
- Authority
- IE
- Ireland
- Prior art keywords
- superoxide dismutase
- dismutase
- medium
- human
- human manganese
- Prior art date
Links
- 102000019197 Superoxide Dismutase Human genes 0.000 title abstract 7
- 108010012715 Superoxide dismutase Proteins 0.000 title abstract 7
- 230000001580 bacterial effect Effects 0.000 abstract 3
- 108020004414 DNA Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000013587 production medium Substances 0.000 abstract 2
- 102000053602 DNA Human genes 0.000 abstract 1
- 101000868115 Homo sapiens Superoxide dismutase [Mn], mitochondrial Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A double-stranded cDNA molecule which includes DNA encoding human manganese super oxide dismutase has been created. The sequence of one strand of a double- stranded DNA molecule which encodes human manganese superoxide dismutase has been discovered. Such mole- cules may be introduced in procaryotic, e.g., bacteri- al, or eukaryotic, e.g. , yeast or mammalian, cells and the resulting cells cultured or grown under suitable conditions sa as to produce human manganese superoxide dismutase or analogs thereof which may then be recov- ered. Human MnSOD or analogs thereof may be used to catalyze the reduction of superoxide radicals, reduce reperfusion injury, prolong the survival time of iso- lated organs, or treat inflammations. The invention also concerns a method of producing enzy- matically active human manganese superoxide dismutase or an analog thereof in a bacterial cell which contains and is capable of expressing a DNA sequence encoding the superoxide dismutase by maintaining the bacterial cell under suitable conditions and in a suitable pro- duction medium. The production medium is supplemented with an amount of Mn++ so that the concentration of Mn++ in the medium is greater than about 2 ppm. This invention also concerns a method of recovering purified enzymatically active manganese super oxide dismutase from bacterial cells.
[CA1341362C]
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/912,213 US5270195A (en) | 1985-11-22 | 1992-07-10 | Plasmids for expression and method of producing a human manganese superoxide dimutase analog |
| US08/299,047 US6610520B1 (en) | 1985-11-22 | 1994-08-31 | Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby |
| US08/370,461 US5540911A (en) | 1985-11-22 | 1995-01-09 | Methods of use of human manganese superoxide dismutase |
| US08/686,466 US6361772B1 (en) | 1985-11-22 | 1996-07-25 | Human manganese superoxide dismutase DNA, its expression and method of recovering human manganese superoxide dismutase |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80109085A | 1985-11-22 | 1985-11-22 | |
| US90705186A | 1986-09-12 | 1986-09-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE862851L true IE862851L (en) | 1987-05-22 |
| IE59498B1 IE59498B1 (en) | 1994-03-09 |
Family
ID=27122291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE285186A IE59498B1 (en) | 1985-11-22 | 1986-10-29 | Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form |
Country Status (21)
| Country | Link |
|---|---|
| JP (2) | JP2609449B2 (en) |
| AT (1) | AT400443B (en) |
| AU (1) | AU607897B2 (en) |
| BE (1) | BE905796A (en) |
| CA (1) | CA1341362C (en) |
| CH (1) | CH676990A5 (en) |
| DE (1) | DE3639725C2 (en) |
| DK (1) | DK534686A (en) |
| ES (1) | ES2003518A6 (en) |
| FI (1) | FI90353C (en) |
| FR (1) | FR2590591B1 (en) |
| GB (1) | GB2183658B (en) |
| GR (1) | GR862713B (en) |
| HK (1) | HK75195A (en) |
| IE (1) | IE59498B1 (en) |
| IL (2) | IL106449A (en) |
| IT (1) | IT1205418B (en) |
| LU (1) | LU86676A1 (en) |
| NL (1) | NL8602960A (en) |
| PT (1) | PT83792B (en) |
| SE (1) | SE8604884L (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610520B1 (en) | 1985-11-22 | 2003-08-26 | Bio-Technology General Corp. | Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby |
| JPS62215532A (en) * | 1986-03-18 | 1987-09-22 | Ube Ind Ltd | anti-inflammatory agent |
| JPH0643341B2 (en) * | 1986-03-27 | 1994-06-08 | 宇部興産株式会社 | Organ function improving agent |
| JPH0643340B2 (en) * | 1986-09-03 | 1994-06-08 | 宇部興産株式会社 | Ischemic heart disease drug |
| JPS6377822A (en) * | 1986-09-18 | 1988-04-08 | Ube Ind Ltd | Organ function improver |
| US6326003B1 (en) | 1986-10-14 | 2001-12-04 | Chiron Corporation | Manganese superoxide dismutase cloning and expression in microorganisms |
| ES2083357T3 (en) * | 1987-03-14 | 1996-04-16 | Boehringer Ingelheim Int | HUMAN MANGANESE-SUPEROXIDE-DISMUTASE (HMN-SOD). |
| US5260204A (en) * | 1987-03-14 | 1993-11-09 | Boehringer Ingelheim International Gmbh | Human manganese superoxide dismutase (hMn-SOD) |
| DE3854678T2 (en) * | 1987-03-27 | 1996-06-13 | Bio Technology General Corp | Human manganese superoxide dismutase and treatment procedure. |
| JPH01233228A (en) * | 1988-03-11 | 1989-09-19 | Toyo Jozo Co Ltd | Metastasis preventive of malignant tumor cells |
| US5772996A (en) * | 1990-08-03 | 1998-06-30 | Public Health Laboratory Service Board | Pharmaceutical compositions containing superoxide dismutase from Bacillus Stearothermophilus and Bacillus Caldotenax |
| DE4038563A1 (en) * | 1990-12-04 | 1992-06-11 | Gruenenthal Gmbh | USE OF SUPEROXIDE DISMUTASES FOR PROPHYLAXIS AND / OR TREATMENT OF ORGAN FAILURE IN RISK PATIENTS WITH POLYTRAUMA |
| DE59310242D1 (en) * | 1992-09-09 | 2002-01-17 | Bio Technology General Corp | Use of manganese superoxide dismutase (Mn-SOD) for the manufacture of medicaments for the treatment of diseases in low doses |
| DE4239877C1 (en) * | 1992-11-27 | 1994-03-17 | Boehringer Ingelheim Int | Stabilized superoxide dismutase (SOD) composition |
| WO2025178510A1 (en) * | 2024-02-21 | 2025-08-28 | Евгений Владимирович ГРИГОРЬЕВ | Method of using superoxide dismutase 2 as an antioxidant in ultra-low doses |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56102787A (en) * | 1980-01-18 | 1981-08-17 | Mamoru Sugiura | Preparation of human placenta superoxide dismutase |
| BG49718A3 (en) * | 1983-07-15 | 1992-01-15 | Bio- Technology General Corp | METHOD FOR OBTAINING A POLYPEPTIDE WITH SUPEROXIDE DISMUTASE ACTIVITY |
| DE3486452T2 (en) * | 1983-10-03 | 1997-11-06 | Chiron Corp., Emeryville, Calif. | Superoxide dismutase and its expression in microorganisms |
-
1986
- 1986-10-29 IE IE285186A patent/IE59498B1/en not_active IP Right Cessation
- 1986-11-07 DK DK534686A patent/DK534686A/en not_active Application Discontinuation
- 1986-11-10 AU AU64975/86A patent/AU607897B2/en not_active Ceased
- 1986-11-13 GR GR862713A patent/GR862713B/en unknown
- 1986-11-14 GB GB8627294A patent/GB2183658B/en not_active Expired - Fee Related
- 1986-11-14 SE SE8604884A patent/SE8604884L/en not_active Application Discontinuation
- 1986-11-18 ES ES8603083A patent/ES2003518A6/en not_active Expired
- 1986-11-19 AT AT0308986A patent/AT400443B/en not_active IP Right Cessation
- 1986-11-20 IL IL10644986A patent/IL106449A/en active IP Right Grant
- 1986-11-20 IL IL80702A patent/IL80702A0/en unknown
- 1986-11-20 LU LU86676A patent/LU86676A1/en unknown
- 1986-11-20 BE BE0/217445A patent/BE905796A/en not_active IP Right Cessation
- 1986-11-21 DE DE3639725A patent/DE3639725C2/en not_active Expired - Fee Related
- 1986-11-21 FR FR868616238A patent/FR2590591B1/en not_active Expired
- 1986-11-21 NL NL8602960A patent/NL8602960A/en active Search and Examination
- 1986-11-21 PT PT83792A patent/PT83792B/en not_active IP Right Cessation
- 1986-11-21 CH CH4680/86A patent/CH676990A5/de not_active IP Right Cessation
- 1986-11-21 CA CA000523536A patent/CA1341362C/en not_active Expired - Lifetime
- 1986-11-21 JP JP61278528A patent/JP2609449B2/en not_active Expired - Lifetime
- 1986-11-21 IT IT67865/86A patent/IT1205418B/en active
- 1986-11-21 FI FI864756A patent/FI90353C/en not_active IP Right Cessation
-
1995
- 1995-05-18 HK HK75195A patent/HK75195A/en not_active IP Right Cessation
-
1996
- 1996-01-22 JP JP8008627A patent/JP2967557B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |