IL100386A - Suitable free vaccine against virus - Google Patents
Suitable free vaccine against virusInfo
- Publication number
- IL100386A IL100386A IL10038691A IL10038691A IL100386A IL 100386 A IL100386 A IL 100386A IL 10038691 A IL10038691 A IL 10038691A IL 10038691 A IL10038691 A IL 10038691A IL 100386 A IL100386 A IL 100386A
- Authority
- IL
- Israel
- Prior art keywords
- cell
- free
- vaccine
- virus
- viruses
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 78
- 241000701047 Gallid alphaherpesvirus 2 Species 0.000 title claims abstract description 10
- 241000700605 Viruses Species 0.000 claims abstract description 109
- 208000006758 Marek Disease Diseases 0.000 claims abstract description 95
- 244000144977 poultry Species 0.000 claims abstract description 12
- 238000002360 preparation method Methods 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
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- 238000011282 treatment Methods 0.000 claims description 2
- 229940031416 bivalent vaccine Drugs 0.000 abstract description 6
- 229940031348 multivalent vaccine Drugs 0.000 abstract description 4
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
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- 241000272496 Galliformes Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000030289 Lymphoproliferative disease Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241001502481 Meleagrid alphaherpesvirus 1 Species 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 229940001007 aluminium phosphate Drugs 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
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- 238000003556 assay Methods 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
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- 229940031551 inactivated vaccine Drugs 0.000 description 1
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- 238000002347 injection Methods 0.000 description 1
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- 238000007918 intramuscular administration Methods 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 201000001268 lymphoproliferative syndrome Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
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- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
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- 238000012809 post-inoculation Methods 0.000 description 1
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- 229960000380 propiolactone Drugs 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
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- 239000008107 starch Substances 0.000 description 1
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- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 231100000588 tumorigenic Toxicity 0.000 description 1
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- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
- A61K39/255—Marek's disease virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
- C12N2710/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
- C12N2710/16361—Methods of inactivation or attenuation
- C12N2710/16364—Methods of inactivation or attenuation by serial passage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP90314297 | 1990-12-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL100386A0 IL100386A0 (en) | 1992-09-06 |
| IL100386A true IL100386A (en) | 1995-07-31 |
Family
ID=8205666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10038691A IL100386A (en) | 1990-12-24 | 1991-12-16 | Suitable free vaccine against virus |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5378467A (fr) |
| EP (1) | EP0496135B1 (fr) |
| JP (1) | JP3410744B2 (fr) |
| KR (1) | KR100187317B1 (fr) |
| CN (1) | CN1034554C (fr) |
| AT (1) | ATE109007T1 (fr) |
| CA (1) | CA2058386C (fr) |
| DE (1) | DE69103130T2 (fr) |
| DK (1) | DK0496135T3 (fr) |
| DZ (1) | DZ1550A1 (fr) |
| ES (1) | ES2061165T3 (fr) |
| HU (2) | HUT62200A (fr) |
| IL (1) | IL100386A (fr) |
| MX (1) | MX9102757A (fr) |
| NZ (1) | NZ241122A (fr) |
| SA (1) | SA92120430B1 (fr) |
| ZA (1) | ZA9110022B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993023078A1 (fr) * | 1992-05-19 | 1993-11-25 | Viktoria Alexeevna Lukina | Vaccin prophylactique contre la maladie de marek chez les oiseaux et son procede de preparation |
| FR2719056B1 (fr) * | 1994-04-20 | 1996-09-06 | Rhone Merieux | Herpesvirus transformés pour exprimer gD in vitro. |
| IL114501A (en) * | 1994-07-14 | 1999-08-17 | Akzo Nobel Nv | Marek's disease virus vaccine |
| EP0703294A1 (fr) * | 1994-07-14 | 1996-03-27 | Akzo Nobel N.V. | Vaccin viral contre la maladie de Marek |
| US5565202A (en) * | 1994-08-12 | 1996-10-15 | The United States Of America As Represented By The Secretary Of Agriculture | Low enhancement serotype 2 vaccine for marek's disease |
| FR2857671B1 (fr) * | 2003-07-18 | 2007-10-05 | Centre Nat Rech Scient | Nouveau procede de culture de keratinocytes et ses applications |
| DK2384761T3 (da) * | 2010-05-07 | 2013-12-09 | Deutsches Krebsforsch | Modificeret gnaverparvovirus, som er i stand til formering og spredning i humane gliomer |
| WO2019121888A1 (fr) | 2017-12-20 | 2019-06-27 | Intervet International B.V. | Diluant perfectionné pour vaccin contre l'alpha-herpèsvirus associé à des cellules |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4160024A (en) * | 1978-05-01 | 1979-07-03 | Cornell Research Foundation, Inc. | Marek's disease vaccine |
| US4895718A (en) * | 1987-07-10 | 1990-01-23 | The United States Of America, As Represented By The Secretary Of Agriculture | Serotype 2 Marek's disease vaccine |
| JPS62212326A (ja) * | 1987-09-14 | 1987-09-18 | Gen Corp:Kk | マレツク病2価生ワクチンとその製造方法 |
-
1991
- 1991-12-16 IL IL10038691A patent/IL100386A/en not_active IP Right Cessation
- 1991-12-19 ZA ZA9110022A patent/ZA9110022B/xx unknown
- 1991-12-20 DE DE69103130T patent/DE69103130T2/de not_active Revoked
- 1991-12-20 AT AT91203365T patent/ATE109007T1/de not_active IP Right Cessation
- 1991-12-20 EP EP91203365A patent/EP0496135B1/fr not_active Revoked
- 1991-12-20 NZ NZ241122A patent/NZ241122A/en not_active IP Right Cessation
- 1991-12-20 ES ES91203365T patent/ES2061165T3/es not_active Expired - Lifetime
- 1991-12-20 DK DK91203365.1T patent/DK0496135T3/da active
- 1991-12-23 CN CN91112829A patent/CN1034554C/zh not_active Expired - Fee Related
- 1991-12-23 HU HU914111A patent/HUT62200A/hu unknown
- 1991-12-23 KR KR1019910023956A patent/KR100187317B1/ko not_active Expired - Fee Related
- 1991-12-23 CA CA002058386A patent/CA2058386C/fr not_active Expired - Fee Related
- 1991-12-23 MX MX9102757A patent/MX9102757A/es unknown
- 1991-12-23 DZ DZ910174A patent/DZ1550A1/fr active
- 1991-12-24 JP JP34156491A patent/JP3410744B2/ja not_active Expired - Fee Related
-
1992
- 1992-03-18 SA SA92120430A patent/SA92120430B1/ar unknown
-
1993
- 1993-11-23 US US08/156,967 patent/US5378467A/en not_active Expired - Lifetime
-
1994
- 1994-12-29 HU HU94P/P00059P patent/HU210344A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0496135A2 (fr) | 1992-07-29 |
| CN1064409A (zh) | 1992-09-16 |
| CA2058386C (fr) | 2003-02-11 |
| JP3410744B2 (ja) | 2003-05-26 |
| HUT62200A (en) | 1993-04-28 |
| DZ1550A1 (fr) | 2002-02-17 |
| EP0496135B1 (fr) | 1994-07-27 |
| KR100187317B1 (ko) | 1999-05-01 |
| KR920011520A (ko) | 1992-07-24 |
| ATE109007T1 (de) | 1994-08-15 |
| MX9102757A (es) | 1992-07-01 |
| EP0496135A3 (fr) | 1992-08-05 |
| ES2061165T3 (es) | 1994-12-01 |
| CN1034554C (zh) | 1997-04-16 |
| DE69103130T2 (de) | 1994-12-01 |
| HU210344A9 (en) | 1995-04-28 |
| ZA9110022B (en) | 1992-10-28 |
| IL100386A0 (en) | 1992-09-06 |
| HU914111D0 (en) | 1992-03-30 |
| DK0496135T3 (da) | 1994-11-28 |
| CA2058386A1 (fr) | 1992-06-25 |
| NZ241122A (en) | 1992-10-28 |
| SA92120430B1 (ar) | 2004-05-31 |
| JPH04295433A (ja) | 1992-10-20 |
| DE69103130D1 (de) | 1994-09-01 |
| US5378467A (en) | 1995-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |