IL101851A - 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor - Google Patents

10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor

Info

Publication number
IL101851A
IL101851A IL10185192A IL10185192A IL101851A IL 101851 A IL101851 A IL 101851A IL 10185192 A IL10185192 A IL 10185192A IL 10185192 A IL10185192 A IL 10185192A IL 101851 A IL101851 A IL 101851A
Authority
IL
Israel
Prior art keywords
formula
compound
substituted
alkyl
reaction
Prior art date
Application number
IL10185192A
Other languages
English (en)
Other versions
IL101851A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL101851A0 publication Critical patent/IL101851A0/xx
Publication of IL101851A publication Critical patent/IL101851A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Paper (AREA)
  • Detergent Compositions (AREA)
IL10185192A 1991-06-13 1992-05-13 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor IL101851A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71448791A 1991-06-13 1991-06-13

Publications (2)

Publication Number Publication Date
IL101851A0 IL101851A0 (en) 1992-12-30
IL101851A true IL101851A (en) 1996-05-14

Family

ID=24870247

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10185192A IL101851A (en) 1991-06-13 1992-05-13 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor

Country Status (26)

Country Link
US (1) US5461050A (pl)
EP (2) EP0588859B1 (pl)
JP (1) JP3182421B2 (pl)
KR (1) KR100247504B1 (pl)
CN (1) CN1033587C (pl)
AT (1) ATE247118T1 (pl)
AU (1) AU652841B2 (pl)
CA (1) CA2102889C (pl)
DE (1) DE69233161T2 (pl)
ES (1) ES2204892T3 (pl)
FI (1) FI104077B (pl)
HR (1) HRP920156A2 (pl)
HU (1) HU221013B1 (pl)
IE (1) IE921919A1 (pl)
IL (1) IL101851A (pl)
MA (1) MA22554A1 (pl)
MX (1) MX9202860A (pl)
NO (2) NO300689B1 (pl)
NZ (1) NZ242775A (pl)
PL (1) PL170376B1 (pl)
SI (1) SI9200104A (pl)
TN (1) TNSN92049A1 (pl)
TW (1) TW218382B (pl)
WO (1) WO1992022553A1 (pl)
ZA (1) ZA924327B (pl)
ZM (1) ZM2892A1 (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
GR1001385B (el) * 1992-10-12 1993-10-29 Janssen Pharmaceutica Nv Παράγωγα ιμιδαζο 1,2-α (πυρρολο,?ειενο η φουρανο) 3,2-d αζεπίνης συν?έσεις και μέ?οδοι χρήσεως.
WO1994013680A1 (en) * 1992-12-04 1994-06-23 Janssen Pharmaceutica N.V. ANTIALLERGIC IMIDAZO[1,2-a](PYRROLO, THIENO OR FURANO)[2,3-d]AZEPINE DERIVATIVES
CA2150804C (en) * 1992-12-04 2006-10-10 Frans Eduard Janssens Antiallergic triazolo(pyrrolo, thieno or furano)azepine derivatives
EP0708776B1 (en) * 1993-07-13 2001-01-03 Janssen Pharmaceutica N.V. Antiallergic imidazoazepines
TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW527186B (en) 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
JP3882224B2 (ja) * 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
AU1146099A (en) 1997-09-18 1999-04-05 Janssen Pharmaceutica N.V. Fused imidazole derivatives for improving oral bioavailability of pharmaceuticalagents
HK1043128B (zh) 1998-12-19 2007-01-19 詹森药业有限公司 抗组胺的螺环化合物
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
CN100491378C (zh) 2001-06-12 2009-05-27 詹森药业有限公司 新的取代四环咪唑衍生物,其制备方法,包含它们的药物组合物及它们作为药物的用途
CA2532798C (en) * 2003-07-23 2013-02-19 X-Ceptor Therapeutics Inc. Azepine derivatives as pharmaceutical agents
DE602006016244D1 (de) 2005-03-08 2010-09-30 Janssen Pharmaceutica Nv Diazaspiro-ä4,4ü-nonanderivate als neurokinin-(nk1)-antagonisten
TWI498115B (zh) * 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
CN103570731B (zh) * 2012-07-30 2016-05-18 中国科学院广州生物医药与健康研究院 嘧啶并三环或嘧啶并四环类化合物及其药用组合物和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148903A (en) * 1977-07-28 1979-04-10 Merck & Co., Inc. Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FI104077B1 (fi) 1999-11-15
JPH06507890A (ja) 1994-09-08
WO1992022553A1 (en) 1992-12-23
HRP920156A2 (en) 1995-12-31
NO300689B1 (no) 1997-07-07
US5461050A (en) 1995-10-24
EP0588859A1 (en) 1994-03-30
FI104077B (fi) 1999-11-15
TW218382B (pl) 1994-01-01
EP0518434A1 (en) 1992-12-16
FI935557A7 (fi) 1993-12-10
SI9200104A (en) 1992-12-31
CA2102889A1 (en) 1992-12-14
IE921919A1 (en) 1992-12-16
FI935557A0 (fi) 1993-12-10
HU9303554D0 (en) 1994-04-28
HU221013B1 (hu) 2002-07-29
ATE247118T1 (de) 2003-08-15
MA22554A1 (fr) 1992-12-31
PL170376B1 (pl) 1996-12-31
NO934493D0 (no) 1993-12-09
ES2204892T3 (es) 2004-05-01
NO934493L (no) 1994-01-04
KR100247504B1 (ko) 2000-05-01
AU1901192A (en) 1993-01-12
DE69233161T2 (de) 2004-05-27
ZM2892A1 (en) 1994-05-25
MX9202860A (es) 1992-12-01
EP0588859B1 (en) 2003-08-13
ZA924327B (en) 1993-12-13
JP3182421B2 (ja) 2001-07-03
AU652841B2 (en) 1994-09-08
CN1068116A (zh) 1993-01-20
IL101851A0 (en) 1992-12-30
DE69233161D1 (de) 2003-09-18
NZ242775A (en) 1995-03-28
CN1033587C (zh) 1996-12-18
CA2102889C (en) 2002-11-26
TNSN92049A1 (fr) 1993-06-08
HUT70428A (en) 1995-10-30

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AU676702B2 (en) Antiallergic imidazo{1,2-a}(pyrrolo, thieno or furano){2,3-d}azepine derivatives
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