IL102280A - PROCESS FOR THE PREPARATION OF 13, 14-DIHYDRO-15(R)-17- PHENYL-18, 19, 20 - TRINOR- PGF2a ESTERS AND A NEW INTERMEDIATE FOR THIS PROCESS - Google Patents

PROCESS FOR THE PREPARATION OF 13, 14-DIHYDRO-15(R)-17- PHENYL-18, 19, 20 - TRINOR- PGF2a ESTERS AND A NEW INTERMEDIATE FOR THIS PROCESS

Info

Publication number
IL102280A
IL102280A IL102280A IL10228092A IL102280A IL 102280 A IL102280 A IL 102280A IL 102280 A IL102280 A IL 102280A IL 10228092 A IL10228092 A IL 10228092A IL 102280 A IL102280 A IL 102280A
Authority
IL
Israel
Prior art keywords
formula
compound
phenyl
hydroxy
furan
Prior art date
Application number
IL102280A
Other languages
English (en)
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of IL102280A publication Critical patent/IL102280A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Emergency Lowering Means (AREA)
  • Catalysts (AREA)
IL102280A 1991-06-24 1992-06-22 PROCESS FOR THE PREPARATION OF 13, 14-DIHYDRO-15(R)-17- PHENYL-18, 19, 20 - TRINOR- PGF2a ESTERS AND A NEW INTERMEDIATE FOR THIS PROCESS IL102280A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU912092A HU212570B (en) 1991-06-24 1991-06-24 Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester

Publications (1)

Publication Number Publication Date
IL102280A true IL102280A (en) 1998-02-08

Family

ID=10957725

Family Applications (1)

Application Number Title Priority Date Filing Date
IL102280A IL102280A (en) 1991-06-24 1992-06-22 PROCESS FOR THE PREPARATION OF 13, 14-DIHYDRO-15(R)-17- PHENYL-18, 19, 20 - TRINOR- PGF2a ESTERS AND A NEW INTERMEDIATE FOR THIS PROCESS

Country Status (23)

Country Link
US (1) US5466833A (de)
EP (1) EP0544899B1 (de)
JP (1) JP2635213B2 (de)
KR (1) KR0163022B1 (de)
CN (1) CN1035764C (de)
AT (1) ATE127450T1 (de)
AU (1) AU656994B2 (de)
BG (1) BG61261B1 (de)
CZ (1) CZ287168B6 (de)
DE (1) DE69204627T2 (de)
DK (1) DK0544899T3 (de)
ES (1) ES2078055T3 (de)
FI (1) FI104895B (de)
GR (1) GR3017874T3 (de)
HU (1) HU212570B (de)
IE (1) IE71645B1 (de)
IL (1) IL102280A (de)
PL (1) PL170728B1 (de)
RO (1) RO117323B1 (de)
RU (1) RU2099325C1 (de)
TW (1) TW310321B (de)
UA (1) UA39864C2 (de)
WO (1) WO1993000329A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510383A (en) † 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
US6225348B1 (en) 1998-08-20 2001-05-01 Alfred W. Paulsen Method of treating macular degeneration with a prostaglandin derivative
IL134241A (en) * 2000-01-27 2006-06-11 Finetech Pharmaceutical Ltd Process for the preparation of latanoprost
IL143477A (en) 2001-05-31 2009-07-20 Finetech Pharmaceutical Ltd Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives
GB0112699D0 (en) * 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
US20110065129A1 (en) * 2001-07-27 2011-03-17 Lowe Derek B Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
ITRM20050231A1 (it) * 2005-05-13 2006-11-14 Technopharma Sa Procedimento per la sintesi di derivati delle prostaglandine f.
US8546114B2 (en) 2006-01-18 2013-10-01 Chirogate International Inc. Processes for the preparation of optically active cyclopentenones and cyclopentenones prepared therefrom
US7511168B2 (en) 2006-01-18 2009-03-31 Shih-Yi Wei Processes and intermediates for the preparations of prostaglandins
JP2008037782A (ja) * 2006-08-04 2008-02-21 Daiichi Fine Chemical Co Ltd プロスタグランジン誘導体の製造方法
US7642370B2 (en) 2006-08-07 2010-01-05 Daiichi Fine Chemical Co., Ltd. Method for preparing prostaglandin derivative
IT1392492B1 (it) 2008-12-24 2012-03-09 Ind Chimica Srl Processo per la purificazione del latanoprost, analogo sintetico della prostaglandina pgf2alfa.
SG182285A1 (en) * 2010-01-11 2012-08-30 Inotek Pharmaceuticals Corp Combination, kit and method of reducing intraocular pressure
EA201290958A1 (ru) 2010-03-26 2013-04-30 Инотек Фармасьютикалз Корпорейшн Способ снижения внутриглазного давления у людей с применением n6-циклопентиладенозина (cpa), производных cpa или их пролекарств
EP2495235B1 (de) 2011-03-04 2015-08-05 Newchem S.p.A. Herstellungsverfahren zur Synthese von Prostaglandinen und Zwischenprodukte davon
JP6212485B2 (ja) 2011-06-02 2017-10-11 キノイン・ゼー・エル・テー プロスタグランジンアミドの新規製造方法
HU231203B1 (hu) 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
BR112014018413A8 (pt) 2012-01-26 2017-07-11 Inotek Pharmaceuticals Corp Polimorfos anidros de nitrato de metila [(2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-diidroxitetraidrofuran-2-il)] e processos de preparação do mesmo
HU230744B1 (hu) * 2012-11-30 2018-01-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
CA2903114A1 (en) 2013-03-15 2014-09-25 Inotek Pharmaceuticals Corporation Ophthalmic formulations
HU231214B1 (hu) * 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE786251A (fr) * 1971-07-14 1973-01-15 Ici Ltd Nouveaux derives du cyclopentane
US3971826A (en) 1972-07-13 1976-07-27 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandins
WO1990002553A1 (en) * 1988-09-06 1990-03-22 Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension

Also Published As

Publication number Publication date
FI104895B (fi) 2000-04-28
AU656994B2 (en) 1995-02-23
FI930773A7 (fi) 1993-02-22
CZ287168B6 (en) 2000-10-11
US5466833A (en) 1995-11-14
DE69204627D1 (de) 1995-10-12
IE922026A1 (en) 1992-12-30
CN1035764C (zh) 1997-09-03
ATE127450T1 (de) 1995-09-15
HU212570B (en) 1996-08-29
TW310321B (de) 1997-07-11
DK0544899T3 (da) 1995-10-23
IE71645B1 (en) 1997-02-26
ES2078055T3 (es) 1995-12-01
FI930773A0 (fi) 1993-02-22
DE69204627T2 (de) 1996-05-02
RU2099325C1 (ru) 1997-12-20
EP0544899B1 (de) 1995-09-06
BG97471A (bg) 1994-03-24
EP0544899A1 (de) 1993-06-09
JP2635213B2 (ja) 1997-07-30
CN1072408A (zh) 1993-05-26
AU2262992A (en) 1993-01-25
HU912092D0 (en) 1991-12-30
CZ27193A3 (en) 1993-10-13
UA39864C2 (uk) 2001-07-16
JPH06500804A (ja) 1994-01-27
GR3017874T3 (en) 1996-01-31
PL298127A1 (en) 1994-01-24
RO117323B1 (ro) 2002-01-30
PL170728B1 (pl) 1997-01-31
KR0163022B1 (ko) 1999-01-15
HUT62561A (en) 1993-05-28
WO1993000329A1 (en) 1993-01-07
BG61261B1 (en) 1997-04-30

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