IL103962A - Trans 9(3-hydroxy-cyclopentan-1-yl) purine analogs their preparation and immunosuppressant pharmaceutical compositions containing them - Google Patents

Trans 9(3-hydroxy-cyclopentan-1-yl) purine analogs their preparation and immunosuppressant pharmaceutical compositions containing them

Info

Publication number: IL103962A
Authority: IL; Israel
Prior art keywords: trans; purine analogs; cyclopentan; hydroxy; preparation
Prior art date: 1991-12-06

Application number

IL10396292A

Other languages

English (en)

Other versions

IL103962A0 (en

Original Assignee

Marion Merrell Dow Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-06

Filing date

1992-12-03

Publication date

1997-01-10

1992-12-03 Application filed by Marion Merrell Dow Inc filed Critical Marion Merrell Dow Inc

1993-05-13 Publication of IL103962A0 publication Critical patent/IL103962A0/xx

1997-01-10 Publication of IL103962A publication Critical patent/IL103962A/xx

Links

229960003444 immunosuppressant agent Drugs 0.000 title abstract 2
239000003018 immunosuppressive agent Substances 0.000 title abstract 2
OBAWKSLILVXKKB-YUMQZZPRSA-N (1s,3s)-3-purin-9-ylcyclopentan-1-ol Chemical class C1[C@@H](O)CC[C@@H]1N1C2=NC=NC=C2N=C1 OBAWKSLILVXKKB-YUMQZZPRSA-N 0.000 title 1
230000001861 immunosuppressant effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
229910003204 NH2 Inorganic materials 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
CFTPMBWYBDKGSA-UHFFFAOYSA-N 2-cyclopentyl-7h-purine Chemical class C1CCCC1C1=NC=C(NC=N2)C2=N1 CFTPMBWYBDKGSA-UHFFFAOYSA-N 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
125000005251 aryl acyl group Chemical group 0.000 abstract 1
-1 cyclopentanyl ring Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Transplantation (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL10396292A 1991-12-06 1992-12-03 Trans 9(3-hydroxy-cyclopentan-1-yl) purine analogs their preparation and immunosuppressant pharmaceutical compositions containing them IL103962A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US80415391A	1991-12-06	1991-12-06
US96560192A	1992-11-02	1992-11-02

Publications (2)

Publication Number	Publication Date
IL103962A0 IL103962A0 (en)	1993-05-13
IL103962A true IL103962A (en)	1997-01-10

Family

ID=27122672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10396292A IL103962A (en)	1991-12-06	1992-12-03	Trans 9(3-hydroxy-cyclopentan-1-yl) purine analogs their preparation and immunosuppressant pharmaceutical compositions containing them

Country Status (17)

Country	Link
EP (1)	EP0545413B1 (de)
JP (1)	JP3264289B2 (de)
KR (1)	KR100251996B1 (de)
AT (1)	ATE194618T1 (de)
AU (1)	AU658698B2 (de)
CA (1)	CA2084222C (de)
DE (1)	DE69231242T2 (de)
DK (1)	DK0545413T3 (de)
ES (1)	ES2149163T3 (de)
FI (1)	FI109026B (de)
GR (1)	GR3034586T3 (de)
HU (2)	HU217077B (de)
IL (1)	IL103962A (de)
MX (1)	MX9206963A (de)
NO (1)	NO305207B1 (de)
NZ (1)	NZ245342A (de)
PT (1)	PT545413E (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0705263T3 (da)	1993-06-21	1997-05-05	Merrell Pharma Inc	Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner
ES2232871T3 (es) *	1996-07-03	2005-06-01	Sumitomo Pharmaceuticals Company, Limited	Nuevos derivados de purina.
US6413974B1 (en)	1998-02-26	2002-07-02	Aventis Pharmaceuticals Inc.	6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
US6479487B1 (en)	1998-02-26	2002-11-12	Aventis Pharmaceuticals Inc.	6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
FR2793794B1 (fr) *	1999-05-21	2001-07-27	Hoechst Marion Roussel Inc	Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
US6861524B2 (en)	2000-10-31	2005-03-01	Aventis Pharmaceuticals Inc.	Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4038479A (en) *	1969-11-17	1977-07-26	Burroughs Wellcome Co.	Amino purine derivatives
US4076711A (en) *	1976-04-05	1978-02-28	Schering Corporation	Triazolo [4,5-d]-pyrimidines
CA2001715C (en) *	1988-11-14	1999-12-28	Muzammil M. Mansuri	Carbocyclic nucleosides and nucleotides
EP0465297B1 (de) *	1990-07-04	1996-01-31	Merrell Dow Pharmaceuticals Inc.	9-Purinyl-Phosphonsäurederivate
CA2051012C (en) *	1990-09-14	2002-04-02	David R. Borcherding	Carbocyclic adenosine analogs useful as immunosupressants

1992
- 1992-12-01 AU AU29752/92A patent/AU658698B2/en not_active Ceased
- 1992-12-01 CA CA002084222A patent/CA2084222C/en not_active Expired - Fee Related
- 1992-12-02 NZ NZ245342A patent/NZ245342A/en unknown
- 1992-12-03 DK DK92120653T patent/DK0545413T3/da active
- 1992-12-03 IL IL10396292A patent/IL103962A/xx not_active IP Right Cessation
- 1992-12-03 MX MX9206963A patent/MX9206963A/es not_active IP Right Cessation
- 1992-12-03 AT AT92120653T patent/ATE194618T1/de not_active IP Right Cessation
- 1992-12-03 EP EP92120653A patent/EP0545413B1/de not_active Expired - Lifetime
- 1992-12-03 ES ES92120653T patent/ES2149163T3/es not_active Expired - Lifetime
- 1992-12-03 PT PT92120653T patent/PT545413E/pt unknown
- 1992-12-03 DE DE69231242T patent/DE69231242T2/de not_active Expired - Lifetime
- 1992-12-04 HU HU9203858A patent/HU217077B/hu not_active IP Right Cessation
- 1992-12-04 NO NO924691A patent/NO305207B1/no not_active IP Right Cessation
- 1992-12-04 JP JP35013492A patent/JP3264289B2/ja not_active Expired - Lifetime
- 1992-12-04 HU HU9203858A patent/HU9203858D0/hu unknown
- 1992-12-04 FI FI925520A patent/FI109026B/fi not_active IP Right Cessation
- 1992-12-05 KR KR1019920023426A patent/KR100251996B1/ko not_active Expired - Fee Related
2000
- 2000-10-09 GR GR20000402275T patent/GR3034586T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU9203858D0 (en)	1993-03-29
EP0545413A1 (de)	1993-06-09
NO924691L (no)	1993-06-07
PT545413E (pt)	2000-10-31
AU2975292A (en)	1993-06-10
IL103962A0 (en)	1993-05-13
FI925520A0 (fi)	1992-12-04
JPH0656835A (ja)	1994-03-01
KR100251996B1 (ko)	2000-09-01
HUT62896A (en)	1993-06-28
NZ245342A (en)	1995-10-26
FI109026B (fi)	2002-05-15
FI925520L (fi)	1993-06-07
GR3034586T3 (en)	2001-01-31
CA2084222C (en)	2004-04-06
MX9206963A (es)	1993-06-01
ES2149163T3 (es)	2000-11-01
DE69231242D1 (de)	2000-08-17
DK0545413T3 (da)	2000-10-09
HU217077B (hu)	1999-11-29
JP3264289B2 (ja)	2002-03-11
ATE194618T1 (de)	2000-07-15
DE69231242T2 (de)	2000-12-21
NO924691D0 (no)	1992-12-04
NO305207B1 (no)	1999-04-19
CA2084222A1 (en)	1993-06-07
EP0545413B1 (de)	2000-07-12
AU658698B2 (en)	1995-04-27

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Legal Events

Date	Code	Title
1997-07-13	FF	Patent granted
1998-01-04	KB	Patent renewed
1999-06-20	KB	Patent renewed
1999-09-22	HC	Change of name of proprietor(s)
2003-02-12	KB	Patent renewed
2007-07-24	MM9K	Patent not in force due to non-payment of renewal fees