IL104201A0 - 26,27-dimethylene-1 alpha-25-dihydroxyvitamin d2 and its 24-epimer and pharmaceutical compositions containing them - Google Patents

26,27-dimethylene-1 alpha-25-dihydroxyvitamin d2 and its 24-epimer and pharmaceutical compositions containing them

Info

Publication number: IL104201A0
Authority: IL; Israel
Prior art keywords: dihydroxyvitamin; alpha; epimer; dimethylene; pharmaceutical compositions
Prior art date: 1991-12-26

Application number

IL104201A

Other languages

English (en)

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-26

Filing date

1992-12-22

Publication date

1993-05-13

1992-12-22 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1993-05-13 Publication of IL104201A0 publication Critical patent/IL104201A0/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
229910052791 calcium Inorganic materials 0.000 abstract 2
239000011575 calcium Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 abstract 1
ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
230000000125 calcaemic effect Effects 0.000 abstract 1
235000020964 calcitriol Nutrition 0.000 abstract 1
239000011612 calcitriol Substances 0.000 abstract 1
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
230000011164 ossification Effects 0.000 abstract 1
150000003703 vitamin D2 derivatives Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Obesity (AREA)
Endocrinology (AREA)
Hematology (AREA)
Dermatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL104201A 1991-12-26 1992-12-22 26,27-dimethylene-1 alpha-25-dihydroxyvitamin d2 and its 24-epimer and pharmaceutical compositions containing them IL104201A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US81385291A	1991-12-26	1991-12-26

Publications (1)

Publication Number	Publication Date
IL104201A0 true IL104201A0 (en)	1993-05-13

Family

ID=25213574

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL104201A IL104201A0 (en)	1991-12-26	1992-12-22	26,27-dimethylene-1 alpha-25-dihydroxyvitamin d2 and its 24-epimer and pharmaceutical compositions containing them

Country Status (8)

Country	Link
US (3)	US5397775A (de)
EP (1)	EP0549318B1 (de)
JP (1)	JP3195452B2 (de)
KR (1)	KR100202434B1 (de)
AT (1)	ATE144250T1 (de)
AU (1)	AU656829B2 (de)
DE (1)	DE69214617T2 (de)
IL (1)	IL104201A0 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU656829B2 (en) *	1991-12-26	1995-02-16	Wisconsin Alumni Research Foundation	26, 27-dimethylene-1 alpha, 25-dihydroxyvitamin D2 and 26,27-dihydroxyvitamin D2 and methods for preparing same
DE4328217C2 (de) *	1993-08-21	1996-01-11	Lohmann Therapie Syst Lts	Therapeutisches System zur Behandlung der Psoriasis
US5373004A (en) *	1993-11-24	1994-12-13	Wisconsin Alumni Research Foundation	26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds
US5716946A (en) *	1996-02-13	1998-02-10	Wisconsin Alumni Research Foundation	Multiple sclerosis treatment
DE19619036A1 (de)	1996-04-30	1997-11-13	Schering Ag	Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
ATE290526T1 (de) *	1997-06-25	2005-03-15	Teijin Ltd	Vitamin-d3?-derivate und aus diesen hergestellte heilmittel gegen entzündliche erkrankungen der atemwege
IT1311923B1 (it)	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1311922B1 (it)	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
US6479474B2 (en)	1999-07-08	2002-11-12	Wisconsin Alumni Research Foundation	Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
EP1482926A4 (de) *	2002-03-08	2006-04-12	Paratek Pharm Innc	Amino-methyl-substituierte tetracyclin-verbindungen
AU2010208323B2 (en)	2009-01-27	2016-03-10	Berg Llc	Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (de)	2009-08-14	2019-05-22	Berg LLC	Vitamin d3 und analoge davon zur behandlung von alopezie
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4769181A (en) *	1983-11-07	1988-09-06	Wisconsin Alumni Research Foundation	1,25-dihydroxyvitamin D2 compounds
US4588716A (en) *	1984-05-04	1986-05-13	Wisconsin Alumni Research Foundation	Method for treating metabolic bone disease in mammals
EP0412110B1 (de) *	1988-04-21	1993-07-07	Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab)	Vitamin d analoge
US4851401A (en) *	1988-07-14	1989-07-25	Wisconsin Alumni Research Foundation	Novel cyclopentano-vitamin D analogs
US4973584A (en) *	1989-03-09	1990-11-27	Deluca Hector F	Novel 1α-hydroxyvitamin D2 epimer and derivatives
US5030772A (en) *	1990-02-14	1991-07-09	Deluca Hector F	Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
AU656829B2 (en) *	1991-12-26	1995-02-16	Wisconsin Alumni Research Foundation	26, 27-dimethylene-1 alpha, 25-dihydroxyvitamin D2 and 26,27-dihydroxyvitamin D2 and methods for preparing same

1992
- 1992-12-22 AU AU30362/92A patent/AU656829B2/en not_active Ceased
- 1992-12-22 EP EP92311681A patent/EP0549318B1/de not_active Expired - Lifetime
- 1992-12-22 AT AT92311681T patent/ATE144250T1/de not_active IP Right Cessation
- 1992-12-22 DE DE69214617T patent/DE69214617T2/de not_active Expired - Fee Related
- 1992-12-22 IL IL104201A patent/IL104201A0/xx unknown
- 1992-12-24 KR KR1019920025501A patent/KR100202434B1/ko not_active Expired - Fee Related
- 1992-12-28 JP JP35879092A patent/JP3195452B2/ja not_active Expired - Fee Related
1993
- 1993-06-02 US US08/070,500 patent/US5397775A/en not_active Expired - Lifetime
1994
- 1994-11-10 US US08/337,110 patent/US5478955A/en not_active Expired - Lifetime
1995
- 1995-05-05 US US08/435,649 patent/US5494906A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69214617D1 (de)	1996-11-21
US5397775A (en)	1995-03-14
JP3195452B2 (ja)	2001-08-06
US5494906A (en)	1996-02-27
ATE144250T1 (de)	1996-11-15
US5478955A (en)	1995-12-26
AU3036292A (en)	1993-07-01
JPH05271183A (ja)	1993-10-19
KR100202434B1 (ko)	1999-06-15
EP0549318A2 (de)	1993-06-30
EP0549318A3 (en)	1993-10-06
DE69214617T2 (de)	1997-05-28
EP0549318B1 (de)	1996-10-16
AU656829B2 (en)	1995-02-16

Publication	Publication Date	Title
IL106167A0 (en)	1993-10-20	24-cyclopropane vitamin d derivatives and pharmaceutical compositions containing the same
AU8086494A (en)	1995-06-13	26,28-methylene-1alpha,25-dihydroxyvitamin d2 compounds
EP0549318A3 (en)	1993-10-06	26,27-dimethylene-1 alpha, 25-dihydroxyvitamin d2 and 26,27-dihydroxyvitamin d2 and methods for preparing same
Boris et al.	1977	Relative activities of some metabolites and analogs of cholecalciferol in stimulation of tibia ash weight in chicks otherwise deprived of vitamin D
IL78342A (en)	1991-06-10	Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
EP0550702A4 (en)	1994-06-08	Methods for preparation and use of 1-g(a),24-dihydroxy vitamin d 2?
BR9509739A (pt)	1997-10-21	Compostos 18,19-dinor-vitamina d
GB9004544D0 (en)	1990-04-25	Novel treatment ii
HU902288D0 (en)	1991-07-29	Process for producing new epimers of 1-alpha-hydroxy-d vitamin and their derivatives as well as pharmaceutical preparatives containing these compounds
IL57801A (en)	1984-03-30	Fluorovitamin d compounds and their preparation
IL91949A (en)	1993-08-18	Dispersible formulation containing the free acid form of diclofenac
ATE238986T1 (de)	2003-05-15	1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga
EP0444000A3 (en)	1991-10-23	Storage-stable glucosamine sulphate oral dosage forms and methods for their manufacture
EP0231003A3 (en)	1990-04-04	Basic substituted phenylacetonitriles, their preparation and medicaments containing them
IL105276A (en)	1997-06-10	(S)-a-PHENYL- 2-PYRIDINEETHANAMINE, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
MX9703720A (es)	1997-09-30	Compuestos de 18-nor-vitamina d.
HU913248D0 (en)	1992-02-28	Process for preparing vitamin d compounds and the corresponding 1 alphahydroxylated derivatives
GR3024253T3 (en)	1997-10-31	High dose vitamin a compositions.