ATE144250T1 - 26,27-dimethylen-1-alpha, 25-dihydroxyvitamin-d2 und 26,27-dihydroxyvitamin-d2 und verfahren zu ihrer herstellung - Google Patents

26,27-dimethylen-1-alpha, 25-dihydroxyvitamin-d2 und 26,27-dihydroxyvitamin-d2 und verfahren zu ihrer herstellung

Info

Publication number: ATE144250T1
Authority: AT; Austria
Prior art keywords: dihydroxyvitamin; alpha; activity; dimethylene; production
Prior art date: 1991-12-26

Application number

AT92311681T

Other languages

English (en)

Inventor

Hector Floyd Deluca

Naoshi Nakagawa

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-26

Filing date

1992-12-22

Publication date

1996-11-15

1992-12-22 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1996-11-15 Application granted granted Critical

1996-11-15 Publication of ATE144250T1 publication Critical patent/ATE144250T1/de

Links

OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
229910052791 calcium Inorganic materials 0.000 abstract 2
239000011575 calcium Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 abstract 1
ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
230000000125 calcaemic effect Effects 0.000 abstract 1
235000020964 calcitriol Nutrition 0.000 abstract 1
239000011612 calcitriol Substances 0.000 abstract 1
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
230000011164 ossification Effects 0.000 abstract 1
150000003703 vitamin D2 derivatives Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Obesity (AREA)
Endocrinology (AREA)
Hematology (AREA)
Dermatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT92311681T 1991-12-26 1992-12-22 26,27-dimethylen-1-alpha, 25-dihydroxyvitamin-d2 und 26,27-dihydroxyvitamin-d2 und verfahren zu ihrer herstellung ATE144250T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US81385291A	1991-12-26	1991-12-26

Publications (1)

Publication Number	Publication Date
ATE144250T1 true ATE144250T1 (de)	1996-11-15

Family

ID=25213574

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92311681T ATE144250T1 (de)	1991-12-26	1992-12-22	26,27-dimethylen-1-alpha, 25-dihydroxyvitamin-d2 und 26,27-dihydroxyvitamin-d2 und verfahren zu ihrer herstellung

Country Status (8)

Country	Link
US (3)	US5397775A (de)
EP (1)	EP0549318B1 (de)
JP (1)	JP3195452B2 (de)
KR (1)	KR100202434B1 (de)
AT (1)	ATE144250T1 (de)
AU (1)	AU656829B2 (de)
DE (1)	DE69214617T2 (de)
IL (1)	IL104201A0 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE144250T1 (de) *	1991-12-26	1996-11-15	Wisconsin Alumni Res Found	26,27-dimethylen-1-alpha, 25-dihydroxyvitamin-d2 und 26,27-dihydroxyvitamin-d2 und verfahren zu ihrer herstellung
DE4328217C2 (de) *	1993-08-21	1996-01-11	Lohmann Therapie Syst Lts	Therapeutisches System zur Behandlung der Psoriasis
US5373004A (en) *	1993-11-24	1994-12-13	Wisconsin Alumni Research Foundation	26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds
US5716946A (en) *	1996-02-13	1998-02-10	Wisconsin Alumni Research Foundation	Multiple sclerosis treatment
DE19619036A1 (de)	1996-04-30	1997-11-13	Schering Ag	Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
CN1090180C (zh) *	1997-06-25	2002-09-04	帝人株式会社	维生素d3衍生物及其用于炎性呼吸道疾病的治疗剂
IT1311923B1 (it)	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1311922B1 (it)	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
US6479474B2 (en) *	1999-07-08	2002-11-12	Wisconsin Alumni Research Foundation	Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
JP2005526754A (ja) *	2002-03-08	2005-09-08	パラテックファーマシューティカルズインコーポレイテッド	アミノメチル置換されたテトラサイクリン化合物
CA2981549A1 (en) *	2009-01-27	2010-08-05	Berg Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN106265695B (zh)	2009-08-14	2021-05-07	博格有限责任公司	用于治疗脱发的维生素d3及其类似物
CN112156097A (zh)	2013-05-29	2021-01-01	博格有限责任公司	使用维生素d预防或减轻化疗诱发的脱发

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4769181A (en) *	1983-11-07	1988-09-06	Wisconsin Alumni Research Foundation	1,25-dihydroxyvitamin D2 compounds
US4588716A (en) *	1984-05-04	1986-05-13	Wisconsin Alumni Research Foundation	Method for treating metabolic bone disease in mammals
KR0144358B1 (ko) *	1988-04-21	1998-07-15	피. 라이달 크리스텐슨	비타민 d 동족체
US4851401A (en) *	1988-07-14	1989-07-25	Wisconsin Alumni Research Foundation	Novel cyclopentano-vitamin D analogs
US4973584A (en) *	1989-03-09	1990-11-27	Deluca Hector F	Novel 1α-hydroxyvitamin D2 epimer and derivatives
US5030772A (en) *	1990-02-14	1991-07-09	Deluca Hector F	Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
ATE144250T1 (de) *	1991-12-26	1996-11-15	Wisconsin Alumni Res Found	26,27-dimethylen-1-alpha, 25-dihydroxyvitamin-d2 und 26,27-dihydroxyvitamin-d2 und verfahren zu ihrer herstellung

1992
- 1992-12-22 AT AT92311681T patent/ATE144250T1/de not_active IP Right Cessation
- 1992-12-22 IL IL104201A patent/IL104201A0/xx unknown
- 1992-12-22 EP EP92311681A patent/EP0549318B1/de not_active Expired - Lifetime
- 1992-12-22 DE DE69214617T patent/DE69214617T2/de not_active Expired - Fee Related
- 1992-12-22 AU AU30362/92A patent/AU656829B2/en not_active Ceased
- 1992-12-24 KR KR1019920025501A patent/KR100202434B1/ko not_active Expired - Fee Related
- 1992-12-28 JP JP35879092A patent/JP3195452B2/ja not_active Expired - Fee Related
1993
- 1993-06-02 US US08/070,500 patent/US5397775A/en not_active Expired - Lifetime
1994
- 1994-11-10 US US08/337,110 patent/US5478955A/en not_active Expired - Lifetime
1995
- 1995-05-05 US US08/435,649 patent/US5494906A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP3195452B2 (ja)	2001-08-06
AU656829B2 (en)	1995-02-16
US5397775A (en)	1995-03-14
JPH05271183A (ja)	1993-10-19
IL104201A0 (en)	1993-05-13
EP0549318A3 (en)	1993-10-06
DE69214617T2 (de)	1997-05-28
AU3036292A (en)	1993-07-01
KR100202434B1 (ko)	1999-06-15
DE69214617D1 (de)	1996-11-21
EP0549318B1 (de)	1996-10-16
US5494906A (en)	1996-02-27
US5478955A (en)	1995-12-26
EP0549318A2 (de)	1993-06-30

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Legal Events

Date	Code	Title	Description
1997-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties