IL104973A - Preparation of 8-(substituted ureidocarbonyl)-ergoline derivatives - Google Patents

Preparation of 8-(substituted ureidocarbonyl)-ergoline derivatives

Info

Publication number: IL104973A
Authority: IL; Israel
Prior art keywords: group; formula; preparation; hnr5r4; carbon atoms
Prior art date: 1992-03-12

Application number

IL104973A

Other languages

English (en)

Other versions

IL104973A0 (en

Inventor

Candiani Ilaria

Cabri Walter

Bedeschi Angelo

Zarini Franco

Original Assignee

Pharmacia & Upjohn Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-12

Filing date

1993-03-08

Publication date

1997-06-10

1993-03-08 Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa

1993-07-08 Publication of IL104973A0 publication Critical patent/IL104973A0/xx

1997-06-10 Publication of IL104973A publication Critical patent/IL104973A/xx

Links

-1 8-(substituted ureidocarbonyl)-ergoline Chemical class 0.000 title abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 abstract 1
230000000648 anti-parkinson Effects 0.000 abstract 1
239000000939 antiparkinson agent Substances 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000012948 isocyanate Substances 0.000 abstract 1
150000002513 isocyanates Chemical class 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
229910052698 phosphorus Inorganic materials 0.000 abstract 1
239000011574 phosphorus Substances 0.000 abstract 1
125000003373 pyrazinyl group Chemical group 0.000 abstract 1
125000002098 pyridazinyl group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
125000001113 thiadiazolyl group Chemical group 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Psychology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Control Of Electric Motors In General (AREA)
Emergency Protection Circuit Devices (AREA)

IL104973A 1992-03-12 1993-03-08 Preparation of 8-(substituted ureidocarbonyl)-ergoline derivatives IL104973A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929205439A GB9205439D0 (en)	1992-03-12	1992-03-12	Process for the synthesis of ergoline derivatives

Publications (2)

Publication Number	Publication Date
IL104973A0 IL104973A0 (en)	1993-07-08
IL104973A true IL104973A (en)	1997-06-10

Family

ID=10712024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL104973A IL104973A (en)	1992-03-12	1993-03-08	Preparation of 8-(substituted ureidocarbonyl)-ergoline derivatives

Country Status (25)

Country	Link
US (1)	US5382669A (de)
EP (1)	EP0593692B1 (de)
JP (1)	JP3339858B2 (de)
KR (1)	KR100274102B1 (de)
CN (1)	CN1038510C (de)
AT (1)	ATE180783T1 (de)
AU (1)	AU653099B2 (de)
CA (1)	CA2106371C (de)
CZ (1)	CZ281708B6 (de)
DE (1)	DE69325138D1 (de)
FI (1)	FI113473B (de)
GB (1)	GB9205439D0 (de)
HU (1)	HU210407B (de)
IL (1)	IL104973A (de)
MX (1)	MX9301297A (de)
MY (1)	MY109152A (de)
NO (1)	NO302754B1 (de)
NZ (1)	NZ249115A (de)
PH (1)	PH30138A (de)
RU (1)	RU2118323C1 (de)
SK (1)	SK279039B6 (de)
TW (1)	TW215089B (de)
UA (1)	UA26400C2 (de)
WO (1)	WO1993018034A1 (de)
ZA (1)	ZA931720B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0007308D0 (en)	2000-03-24	2000-05-17	Pharmacia & Upjohn Spa	Process for preparing crystalline form \| of cabergoline
US6696568B2 (en)	2001-04-16	2004-02-24	Finetech Ltd.	Process and intermediates for production of cabergoline and related compounds
MXPA05010868A (es) *	2003-04-11	2005-11-25	Conseils De Rech S Et D Aplica	Analogos quimericos de somatostatina-dopamina.
IL155545A (en) *	2003-04-21	2009-12-24	Finetech Pharmaceutical Ltd	Solvate form of cabergoline
HUP0400517A3 (en) *	2004-03-04	2006-05-29	Richter Gedeon Vegyeszet	Process for producing cabergoline
GB0409785D0 (en) *	2004-04-30	2004-06-09	Resolution Chemicals Ltd	Preparation of cabergoline
FR2877945A1 (fr) *	2004-11-18	2006-05-19	Archemis Sa	Procede de la preparation de la cabergoline
EP1858894A1 (de)	2005-03-17	2007-11-28	Synthon Argentina S.A.	Verbessertes verfahren zur herstellung von cabergolin
GB0505965D0 (en) *	2005-03-23	2005-04-27	Resolution Chemicals Ltd	Preparation of cabergoline
EP1925616A1 (de) *	2006-10-26	2008-05-28	LEK Pharmaceuticals D.D.	Verfahren zur Herstellung kristalliner Formen des Cabergolins via stabile Solvate des Cabergolins
US7939665B2 (en) *	2007-05-04	2011-05-10	Apotex Pharmachem Inc.	Efficient process for the preparation of cabergoline and its intermediates
US9670199B2 (en)	2012-11-19	2017-06-06	Regents Of The University Of Minnesota	Ergoline derivatives as dopamine receptor modulators

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2074566B (en) *	1980-04-03	1983-11-02	Erba Farmitalia	Ergoline derivatives
GB2103603B (en) *	1981-08-11	1985-04-11	Erba Farmitalia	Ergoline derivatives

1992
- 1992-03-12 GB GB929205439A patent/GB9205439D0/en active Pending
1993
- 1993-02-15 RU RU93058546A patent/RU2118323C1/ru not_active IP Right Cessation
- 1993-02-15 SK SK1401-93A patent/SK279039B6/sk unknown
- 1993-02-15 KR KR1019930703386A patent/KR100274102B1/ko not_active Expired - Fee Related
- 1993-02-15 UA UA93003963A patent/UA26400C2/uk unknown
- 1993-02-15 EP EP93903972A patent/EP0593692B1/de not_active Expired - Lifetime
- 1993-02-15 AT AT93903972T patent/ATE180783T1/de active
- 1993-02-15 JP JP51527993A patent/JP3339858B2/ja not_active Expired - Fee Related
- 1993-02-15 DE DE69325138T patent/DE69325138D1/de not_active Expired - Lifetime
- 1993-02-15 AU AU34974/93A patent/AU653099B2/en not_active Ceased
- 1993-02-15 CA CA002106371A patent/CA2106371C/en not_active Expired - Fee Related
- 1993-02-15 HU HU9303541A patent/HU210407B/hu unknown
- 1993-02-15 CZ CZ932715A patent/CZ281708B6/cs not_active IP Right Cessation
- 1993-02-15 WO PCT/EP1993/000360 patent/WO1993018034A1/en not_active Ceased
- 1993-02-15 NZ NZ249115A patent/NZ249115A/en not_active IP Right Cessation
- 1993-02-16 TW TW082101067A patent/TW215089B/zh active
- 1993-03-08 IL IL104973A patent/IL104973A/xx not_active IP Right Cessation
- 1993-03-09 PH PH45839A patent/PH30138A/en unknown
- 1993-03-09 MX MX9301297A patent/MX9301297A/es not_active IP Right Cessation
- 1993-03-09 US US08/028,286 patent/US5382669A/en not_active Expired - Lifetime
- 1993-03-09 CN CN93102663A patent/CN1038510C/zh not_active Expired - Fee Related
- 1993-03-10 ZA ZA931720A patent/ZA931720B/xx unknown
- 1993-03-11 MY MYPI93000439A patent/MY109152A/en unknown
- 1993-11-08 FI FI934933A patent/FI113473B/fi active
- 1993-11-11 NO NO934077A patent/NO302754B1/no unknown

Also Published As

Publication number	Publication date
UA26400C2 (uk)	1999-08-30
EP0593692A1 (de)	1994-04-27
GB9205439D0 (en)	1992-04-22
FI934933A0 (fi)	1993-11-08
CN1076196A (zh)	1993-09-15
ZA931720B (en)	1993-11-01
HUT66712A (en)	1994-12-28
MX9301297A (es)	1993-09-01
KR100274102B1 (ko)	2000-12-15
FI934933A7 (fi)	1993-11-08
HU210407B (en)	1995-04-28
NO934077D0 (no)	1993-11-11
SK279039B6 (sk)	1998-05-06
NZ249115A (en)	1995-04-27
FI113473B (fi)	2004-04-30
WO1993018034A1 (en)	1993-09-16
IL104973A0 (en)	1993-07-08
MY109152A (en)	1996-12-31
AU3497493A (en)	1993-10-05
CZ271593A3 (en)	1994-04-13
PH30138A (en)	1997-01-21
JP3339858B2 (ja)	2002-10-28
AU653099B2 (en)	1994-09-15
JPH06507648A (ja)	1994-09-01
NO302754B1 (no)	1998-04-20
EP0593692B1 (de)	1999-06-02
US5382669A (en)	1995-01-17
DE69325138D1 (de)	1999-07-08
RU2118323C1 (ru)	1998-08-27
CZ281708B6 (cs)	1996-12-11
CN1038510C (zh)	1998-05-27
CA2106371A1 (en)	1993-09-13
NO934077L (no)	1993-11-11
TW215089B (de)	1993-10-21
SK140193A3 (en)	1994-11-09
CA2106371C (en)	2003-09-23
ATE180783T1 (de)	1999-06-15

Legal Events

Date	Code	Title
1998-01-04	FF	Patent granted
1998-03-10	KB	Patent renewed
1999-08-17	KB	Patent renewed
2003-05-29	KB	Patent renewed
2007-12-03	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
AU679859B2 (en)	1997-07-10	Novel compound, process for producing the same, and antitumor agent
KR910007926A (ko)	1991-05-30	1h-아미다조[4,5-c]퀴놀린의 제조방법
EP0432661A3 (en)	1992-03-04	2-substituted phenyl-2-oxazoline or thiazoline derivatives, process for producing the same and insecticides and acaricides containing the same
CA2184919A1 (en)	1996-07-18	New Piperazine Derivatives and Methods for the Preparation Thereof and Compositions Containing the Same
EP0945452A4 (de)	2002-06-05	Zuckerderivate, geliermittel, geliermittelzubereitungen, verfahren zu ihrer herstellung und gelzubereitungen
IL103301A0 (en)	1993-02-21	Pyrimidine nucleoside derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
HU912884D0 (en)	1992-01-28	1-methyl-carba-penem derivatives and method for producing them
PT76897B (en)	1986-01-24	Process for the preparation of a fungicidal and/or plant growth regulating composition containing substituted azolyl-ketones and azolyl-alcohols
DE69529619D1 (en)	2003-03-20	Pyrimidinylpyrazolderivate
ES2038166T3 (es)	1993-07-16	Procedimiento para preparar un derivado de indenotiazol.
MD422C2 (ro)	1997-04-30	Derivaţi ai azolului şi compuţi intermediari pentru producerea lor
GEP19981430B (en)	1998-10-30	Method for Production of -Phenylizoserin and its Derivatives
EP0347930A3 (de)	1992-01-02	Metalloxid enthaltende Mischung
AU2192683A (en)	1984-07-05	Pyrazolo(1,5-alpha)-1,3,5-triazines
GB2292379B (en)	1998-02-18	Preparation of thioamides
YU43902A (sh)	2005-03-15	Novi razgranati supstituisani amino derivati od 3-amino-1- -fenil-1h(1,2,4) triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže
MX9603616A (es)	1997-06-28	Derivados de ciclopentadienilo y procesos para su preparacion.
TW336235B (en)	1998-07-11	3'-aziridino-anthracycline derivatives, process for preparating them and pharmaceutical composition containing them
GR3005059T3 (de)	1993-05-24
ES8602712A1 (es)	1985-12-01	Un procedimiento para preparar un derivado de rodanina
GR3004979T3 (de)	1993-04-28
HUT37394A (en)	1985-12-28	Process for the production of derivatives of 6-sulfoxy-phenyl and for the production of medicines of cytoprotective effect containing these derivatives as agent
DE68926016D1 (de)	1996-04-25	Halogeno-4-Methylpyrazole und Verfahren zu ihrer Herstellung
ES2157679T3 (es)	2001-08-16	Procedimiento para preparar un compuesto de 2-cianobifenilo.
EP0308319A3 (en)	1990-07-04	4-piperidinecarboxamide derivatives