IL105329A - Pharmacological preparation for the treatment of malignancies using history (2-lomethylidene and antineoplastic preparation specific for phase S or phase M - Google Patents

Pharmacological preparation for the treatment of malignancies using history (2-lomethylidene and antineoplastic preparation specific for phase S or phase M

Info

Publication number: IL105329A
Authority: IL; Israel
Prior art keywords: group; halogen; hydrogen; formula; phase
Prior art date: 1992-04-10

Application number

IL105329A

Other languages

English (en)

Hebrew (he)

Other versions

IL105329A0 (en

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-10

Filing date

1993-04-07

Publication date

1998-06-15

1993-04-07 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1993-08-18 Publication of IL105329A0 publication Critical patent/IL105329A0/xx

1998-06-15 Publication of IL105329A publication Critical patent/IL105329A/en

Links

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230000027311 M phase Effects 0.000 title claims abstract description 30
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239000002246 antineoplastic agent Substances 0.000 title description 7
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238000000034 method Methods 0.000 claims abstract description 5
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238000011282 treatment Methods 0.000 claims description 31
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229910052757 nitrogen Inorganic materials 0.000 claims description 22
239000000203 mixture Substances 0.000 claims description 21
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

IL105329A 1992-04-10 1993-04-07 Pharmacological preparation for the treatment of malignancies using history (2-lomethylidene and antineoplastic preparation specific for phase S or phase M IL105329A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US86639992A	1992-04-10	1992-04-10

Publications (2)

Publication Number	Publication Date
IL105329A0 IL105329A0 (en)	1993-08-18
IL105329A true IL105329A (en)	1998-06-15

Family

ID=25347526

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL105329A IL105329A (en)	1992-04-10	1993-04-07	Pharmacological preparation for the treatment of malignancies using history (2-lomethylidene and antineoplastic preparation specific for phase S or phase M

Country Status (17)

Country	Link
US (2)	US20040102461A1 (da)
EP (1)	EP0664708B1 (da)
JP (1)	JP3713668B2 (da)
KR (1)	KR100258668B1 (da)
AT (1)	ATE170077T1 (da)
AU (1)	AU667527B2 (da)
CA (1)	CA2117891C (da)
DE (1)	DE69320646T2 (da)
DK (1)	DK0664708T3 (da)
ES (1)	ES2123642T3 (da)
HU (1)	HU219476B (da)
IL (1)	IL105329A (da)
MX (1)	MX9302038A (da)
NZ (1)	NZ251211A (da)
TW (1)	TW362971B (da)
WO (1)	WO1993020825A1 (da)
ZA (1)	ZA932455B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
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AU2768295A (en) *	1994-07-11	1996-02-09	Hoechst Marion Roussel, Inc.	Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
WO1996001834A1 (en) *	1994-07-12	1996-01-25	Yamasa Corporation	2'-deoxy-2'-(substituted or unsubstituted methylidene)-4'-thionucleoside
US7220737B1 (en)	1997-09-04	2007-05-22	Novoneuron, Inc	Noribogaine in the treatment of pain and drug addiction
ES2224430T3 (es)	1997-09-04	2005-03-01	Novoneuron Inc	Noribogaina en el tratamiento del dolor y de la toxicomania.
CA2326004A1 (en)	2000-11-02	2002-05-02	Richard E. Jones	Methods for treating cellular proliferative disorders
EP1480982A4 (en) *	2002-02-14	2007-08-01	Pharmasset Inc	MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES
WO2004042081A1 (de) *	2002-11-04	2004-05-21	Charité-Universitätsme Dizin Berlin	Spezifische haplotypen des mdr1-gens und deren anwendung in der diagnose und therapie
US8362007B1 (en)	2010-05-11	2013-01-29	Demerx, Inc.	Substituted noribogaine
US9394294B2 (en)	2010-05-11	2016-07-19	Demerx, Inc.	Methods and compositions for preparing and purifying noribogaine
US8765737B1 (en)	2010-05-11	2014-07-01	Demerx, Inc.	Methods and compositions for preparing and purifying noribogaine
US8802832B2 (en)	2010-06-22	2014-08-12	Demerx, Inc.	Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9586954B2 (en)	2010-06-22	2017-03-07	Demerx, Inc.	N-substituted noribogaine prodrugs
US8637648B1 (en)	2010-06-22	2014-01-28	Demerx, Inc.	Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8741891B1 (en)	2010-06-22	2014-06-03	Demerx, Inc.	N-substituted noribogaine prodrugs
CA2806232A1 (en)	2010-07-23	2012-01-26	Demerx, Inc.	Noribogaine compositions
EP2481740B1 (en)	2011-01-26	2015-11-04	DemeRx, Inc.	Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en)	2011-08-26	2017-04-11	Demerx, Inc.	Synthetic noribogaine
WO2013085922A1 (en)	2011-12-09	2013-06-13	Demerx, Inc.	Phosphate esters of noribogaine
KR102072041B1 (ko)	2011-12-22	2020-01-31	앨리오스 바이오파마 인크.	치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체
WO2013112673A1 (en)	2012-01-25	2013-08-01	Demerx, Inc.	Synthetic voacangine
US9150584B2 (en)	2012-01-25	2015-10-06	Demerx, Inc.	Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
EP2934541A4 (en)	2012-12-20	2016-08-03	Demerx Inc	SUBSTITUTED NORIBOGAIN
US9045481B2 (en)	2012-12-20	2015-06-02	Demerx, Inc.	Substituted noribogaine
US9550789B2 (en)	2014-06-18	2017-01-24	Demerx, Inc.	Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them

1993
- 1993-03-15 JP JP51832893A patent/JP3713668B2/ja not_active Expired - Fee Related
- 1993-03-15 ES ES93907581T patent/ES2123642T3/es not_active Expired - Lifetime
- 1993-03-15 AU AU38131/93A patent/AU667527B2/en not_active Ceased
- 1993-03-15 AT AT93907581T patent/ATE170077T1/de not_active IP Right Cessation
- 1993-03-15 WO PCT/US1993/002490 patent/WO1993020825A1/en not_active Ceased
- 1993-03-15 CA CA002117891A patent/CA2117891C/en not_active Expired - Fee Related
- 1993-03-15 DE DE69320646T patent/DE69320646T2/de not_active Expired - Fee Related
- 1993-03-15 NZ NZ251211A patent/NZ251211A/en not_active IP Right Cessation
- 1993-03-15 HU HU9402914A patent/HU219476B/hu not_active IP Right Cessation
- 1993-03-15 DK DK93907581T patent/DK0664708T3/da active
- 1993-03-15 EP EP93907581A patent/EP0664708B1/en not_active Expired - Lifetime
- 1993-03-15 KR KR1019940703561A patent/KR100258668B1/ko not_active Expired - Fee Related
- 1993-04-05 ZA ZA932455A patent/ZA932455B/xx unknown
- 1993-04-07 MX MX9302038A patent/MX9302038A/es not_active IP Right Cessation
- 1993-04-07 IL IL105329A patent/IL105329A/en not_active IP Right Cessation
- 1993-04-08 TW TW082102613A patent/TW362971B/zh not_active IP Right Cessation
1998
- 1998-09-25 US US09/160,977 patent/US20040102461A1/en not_active Abandoned
2004
- 2004-09-17 US US10/943,429 patent/US20050032738A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NZ251211A (en)	1997-05-26
AU3813193A (en)	1993-11-18
JPH07505653A (ja)	1995-06-22
AU667527B2 (en)	1996-03-28
IL105329A0 (en)	1993-08-18
TW362971B (en)	1999-07-01
KR100258668B1 (ko)	2000-07-01
EP0664708B1 (en)	1998-08-26
JP3713668B2 (ja)	2005-11-09
DE69320646D1 (de)	1998-10-01
HU219476B (hu)	2001-04-28
DK0664708T3 (da)	1998-11-02
MX9302038A (es)	1993-10-01
EP0664708A4 (en)	1995-04-24
ZA932455B (en)	1993-10-20
HU9402914D0 (en)	1995-01-30
US20050032738A1 (en)	2005-02-10
WO1993020825A1 (en)	1993-10-28
KR950700749A (ko)	1995-02-20
HUT71224A (en)	1995-11-28
CA2117891C (en)	1998-07-07
US20040102461A1 (en)	2004-05-27
CA2117891A1 (en)	1993-10-28
ES2123642T3 (es)	1999-01-16
EP0664708A1 (en)	1995-08-02
ATE170077T1 (de)	1998-09-15
DE69320646T2 (de)	1999-01-14

Legal Events

Date	Code	Title
1998-11-26	FF	Patent granted
1999-06-20	KB	Patent renewed
1999-10-28	KB	Patent renewed
2003-06-24	KB	Patent renewed
2007-07-06	KB	Patent renewed
2011-12-29	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
EP0664708B1 (en)	1998-08-26	Method of treating cancer by conjunctive therapy with 2'-halomethylidene derivatives and an s-phase or m-phase specific antineoplastic agent
US5635218A (en)	1997-06-03	Method of treating cancer by conjunctive therapy with N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent
EP3171870B1 (en)	2021-10-20	Protein phosphatase 2a inhibitors for treating myelodysplastic syndromes
JP5684787B2 (ja)	2015-03-18	シチジンベースの抗新生物薬とシチジンデアミナーゼ阻害薬との組合せ、および癌の治療におけるその使用
EP3068406B1 (en)	2020-01-08	Mutual prodrug comprising short chain fatty acids and zebularine or 1'-cyano-cytarabine for cancer treatment
JP5687687B2 (ja)	2015-03-18	癌を治療するための（２’−デオキシ−リボフラノシル）−１，３，４，７−テトラヒドロ−（１，３）ジアゼピン−２−オン誘導体
US9844529B2 (en)	2017-12-19	Combination therapy for ovarian cancer
EP0490380B1 (en)	1998-02-18	Use of N,N'-bis 3-(ethylamino)propyl -1,7-heptanediamine and a cytotoxic agent
JP5581200B2 (ja)	2014-08-27	シチジン誘導体及びカルボプラチンを含有する抗腫瘍剤
WO2025166537A1 (en)	2025-08-14	Methods of treatment using an ezh2 modulator
NZ623622B2 (en)	2015-11-03	Combination therapy for ovarian cancer
HK1060066B (en)	2007-07-20	Pharmaceutical combinations based on pyridoindolone derivatives and anticancer agents
HK1060066A1 (en)	2004-07-30	Pharmaceutical combinations based on pyridoindolone derivatives and anticancer agents