IL105372A - 1, 2, 4-Oxadiazolyl- phenoxyalkyl isoxazoles and pharmaceutical compositions containing them - Google Patents

1, 2, 4-Oxadiazolyl- phenoxyalkyl isoxazoles and pharmaceutical compositions containing them

Info

Publication number
IL105372A
IL105372A IL10537293A IL10537293A IL105372A IL 105372 A IL105372 A IL 105372A IL 10537293 A IL10537293 A IL 10537293A IL 10537293 A IL10537293 A IL 10537293A IL 105372 A IL105372 A IL 105372A
Authority
IL
Israel
Prior art keywords
compound
mmol
formula
alkoxy
alkyl
Prior art date
Application number
IL10537293A
Other languages
English (en)
Other versions
IL105372A0 (en
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IL105372A0 publication Critical patent/IL105372A0/xx
Publication of IL105372A publication Critical patent/IL105372A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL10537293A 1992-04-15 1993-04-14 1, 2, 4-Oxadiazolyl- phenoxyalkyl isoxazoles and pharmaceutical compositions containing them IL105372A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/869,287 US5349068A (en) 1992-04-15 1992-04-15 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Publications (2)

Publication Number Publication Date
IL105372A0 IL105372A0 (en) 1993-08-18
IL105372A true IL105372A (en) 1998-12-27

Family

ID=25353269

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10537293A IL105372A (en) 1992-04-15 1993-04-14 1, 2, 4-Oxadiazolyl- phenoxyalkyl isoxazoles and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (3) US5349068A (fr)
EP (1) EP0566199B1 (fr)
JP (1) JP3103845B2 (fr)
KR (1) KR100314158B1 (fr)
AT (1) ATE189958T1 (fr)
AU (1) AU666528B2 (fr)
CA (1) CA2094012C (fr)
CZ (1) CZ285845B6 (fr)
DE (1) DE69327913T2 (fr)
DK (1) DK0566199T3 (fr)
ES (1) ES2143487T3 (fr)
FI (1) FI112229B (fr)
GR (1) GR3033486T3 (fr)
HU (2) HU220606B1 (fr)
IL (1) IL105372A (fr)
MX (1) MX9302169A (fr)
MY (1) MY110191A (fr)
NO (1) NO302700B1 (fr)
NZ (1) NZ247411A (fr)
PH (1) PH30454A (fr)
PT (1) PT566199E (fr)
RU (1) RU2114112C1 (fr)
SG (1) SG50663A1 (fr)
SK (1) SK279786B6 (fr)
TW (1) TW239140B (fr)
UA (1) UA35557C2 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5552420A (en) * 1994-05-13 1996-09-03 Sterling Winthrop Inc. Therapeutic phenoxyalkylazoles and phenoxyalkylazines
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
US6528652B1 (en) 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
AUPR213700A0 (en) * 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
US7041685B2 (en) * 2001-06-08 2006-05-09 Cytovia, Inc. Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
US7129359B2 (en) 2002-07-09 2006-10-31 National Health Research Institutes Imidazolidinone compounds
CA2459376A1 (fr) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions les contenant et leurs procedes d'utilisation comme agents anti-picornavirus
CA2459375A1 (fr) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions les contenant et leurs procedes d'utilisation en tant qu'agents anti-picornavirus
EP2193792B1 (fr) 2001-12-07 2011-08-31 Ana Maria Sandino Néomycine pour augmenter la survie d'animaux aquatiques qui sont exposés à IPNV
US20060167109A1 (en) * 2002-02-14 2006-07-27 Pevear Daniel C Methods of reducing rhinovirus contagion and related compositions
JP2006516250A (ja) * 2002-12-18 2006-06-29 サイトビア インコーポレイティッド カスパーゼ活性化剤およびアポトーシス誘導物質としての３，５−二置換−［１，２，４］−オキサジアゾールおよびそれらの誘導体ならびにそれらの使用
US7259174B2 (en) * 2004-05-25 2007-08-21 National Health Research Institutes Imidazolidinone compounds
WO2006017505A2 (fr) * 2004-08-04 2006-02-16 Schering Corporation Formulations pharmaceutiques
CA2641616A1 (fr) * 2006-02-09 2007-08-23 Schering Corporation Formulations pharmaceutiques
AR059359A1 (es) * 2006-02-09 2008-03-26 Schering Corp Formulaciones farmaceuticas que contienen pleconaril
JP2009526063A (ja) * 2006-02-09 2009-07-16 シェーリング コーポレイション 医薬製剤
ES2550152T3 (es) 2006-12-13 2015-11-04 F. Hoffmann-La Roche Ag Derivados de 2-(piperidin-4-il)-4-fenoxi-o fenilamino-pirimidina como inhibidores no nucleósidos de transcriptasa inversa
KR101031584B1 (ko) * 2009-04-21 2011-04-27 파인오토시스템(주) 전면부가 개폐되는 차량용 적외선 조사장치
CN103102322B (zh) * 2011-11-14 2016-02-24 上海交通大学 噁唑类化合物及其制备方法、药物组合物及其用途
TWI811428B (zh) 2018-08-21 2023-08-11 日商杏林製藥股份有限公司 雙環雜芳香環衍生物
WO2021062189A1 (fr) * 2019-09-27 2021-04-01 Collaborations Pharmaceuticals, Inc. Dérivés d'isoxazole-3-carboxamide et leur utilisation pour le traitement de maladies provoquées par une infection virale
WO2021209563A1 (fr) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Composés destinés à être utilisés dans le traitement d'infections virales par un coronavirus associé au syndrome respiratoire

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA846525B (en) * 1983-08-29 1985-04-24 Sterling Drug Inc (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
US4843087A (en) * 1983-08-29 1989-06-27 Sterling Drug Inc. Di-heterocyclic compounds and their use as antiviral agents
US4861791A (en) * 1983-08-29 1989-08-29 Sterling Drug Inc. Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents
CA1280753C (fr) * 1985-07-02 1991-02-26 Philip Michael Carabateas Methode de preparation de derives de substitution heterocycliques de phenoxyalkylisoxasoles et de phenoxyalkylfuranes
GB8619433D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Also Published As

Publication number Publication date
NZ247411A (en) 1994-06-27
MY110191A (en) 1998-02-28
PT566199E (pt) 2000-09-29
CA2094012A1 (fr) 1993-10-16
JP3103845B2 (ja) 2000-10-30
DE69327913T2 (de) 2000-10-12
TW239140B (fr) 1995-01-21
ATE189958T1 (de) 2000-03-15
GR3033486T3 (en) 2000-09-29
EP0566199A1 (fr) 1993-10-20
SG50663A1 (en) 1998-07-20
HUT65574A (en) 1994-07-28
SK35393A3 (en) 1994-06-08
HU9301084D0 (en) 1993-06-28
KR100314158B1 (ko) 2002-02-19
FI112229B (fi) 2003-11-14
US5464848A (en) 1995-11-07
CA2094012C (fr) 2001-08-21
DK0566199T3 (da) 2000-06-19
US5349068A (en) 1994-09-20
NO931366L (no) 1993-10-18
US5643929A (en) 1997-07-01
IL105372A0 (en) 1993-08-18
UA35557C2 (uk) 2001-04-16
MX9302169A (es) 1993-10-01
AU666528B2 (en) 1996-02-15
NO302700B1 (no) 1998-04-14
KR930021637A (ko) 1993-11-22
NO931366D0 (no) 1993-04-14
EP0566199B1 (fr) 2000-03-01
HU211320A9 (en) 1995-11-28
SK279786B6 (sk) 1999-03-12
RU2114112C1 (ru) 1998-06-27
HU220606B1 (hu) 2002-03-28
CZ59793A3 (en) 1994-02-16
AU3688193A (en) 1993-10-21
FI931707L (fi) 1993-10-16
ES2143487T3 (es) 2000-05-16
DE69327913D1 (de) 2000-04-06
CZ285845B6 (cs) 1999-11-17
JPH0649066A (ja) 1994-02-22
FI931707A0 (fi) 1993-04-15
PH30454A (en) 1997-05-28

Similar Documents

Publication Publication Date Title
EP0566199B1 (fr) 1,2,4-oxadiazolyl-phénoxyalkyl isoxazole et leur utilisation comme agents antiviraux
CA1299176C (fr) Procede pour preparer des derives isoxazole et furane
CA1238912A (fr) Oxazolines utilisees comme agents antiviraux
JPH0572394B2 (fr)
US4942241A (en) 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4939267A (en) Haloalkoxy phenyl 4,5 dihydro oxazoles
CA2074004C (fr) 1,2,4-oxadiazolylphenoxyalkylisoxazoles et leur utilisation comme agents antiviraux
US4945164A (en) 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US5175178A (en) 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
KR100197853B1 (ko) 옥사디아졸릴-페녹시알킬 이속사졸, 이들의 제조방법 및 이를 함유하는 항비루스제로서 유용한 조성물
CA2022425C (fr) 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles et leur utilisation comme agents antiviraux
US5002960A (en) N-haloalkyl-4-(isoxazol-5-yl)alkoxy benzamides

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
HP Change in proprietorship
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired