PH30454A - 1,2,4-Oxadiazolyl-phenoxy-alkyl-isoxazoles and their use as antiviral agents - Google Patents

1,2,4-Oxadiazolyl-phenoxy-alkyl-isoxazoles and their use as antiviral agents

Info

Publication number: PH30454A
Authority: PH; Philippines
Prior art keywords: alkyl; alkoxy; antiviral agents; isoxazoles; oxadiazolyl
Prior art date: 1992-04-15

Application number

PH46044A

Other languages

English (en)

Inventor

Diana Guy Dominic

Theodore John Nitz

Original Assignee

Sterling Winthrop Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-15

Filing date

1993-04-14

Publication date

1997-05-28

1993-04-14 Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc

1997-05-28 Publication of PH30454A publication Critical patent/PH30454A/en

Links

239000003443 antiviral agent Substances 0.000 title abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
-1 cyano, 2,2,2-trifluoroethyl Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000006371 dihalo methyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000004970 halomethyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
125000004953 trihalomethyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PH46044A 1992-04-15 1993-04-14 1,2,4-Oxadiazolyl-phenoxy-alkyl-isoxazoles and their use as antiviral agents PH30454A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/869,287 US5349068A (en)	1992-04-15	1992-04-15	1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Publications (1)

Publication Number	Publication Date
PH30454A true PH30454A (en)	1997-05-28

Family

ID=25353269

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH46044A PH30454A (en)	1992-04-15	1993-04-14	1,2,4-Oxadiazolyl-phenoxy-alkyl-isoxazoles and their use as antiviral agents

Country Status (26)

Country	Link
US (3)	US5349068A (fr)
EP (1)	EP0566199B1 (fr)
JP (1)	JP3103845B2 (fr)
KR (1)	KR100314158B1 (fr)
AT (1)	ATE189958T1 (fr)
AU (1)	AU666528B2 (fr)
CA (1)	CA2094012C (fr)
CZ (1)	CZ285845B6 (fr)
DE (1)	DE69327913T2 (fr)
DK (1)	DK0566199T3 (fr)
ES (1)	ES2143487T3 (fr)
FI (1)	FI112229B (fr)
GR (1)	GR3033486T3 (fr)
HU (2)	HU220606B1 (fr)
IL (1)	IL105372A (fr)
MX (1)	MX9302169A (fr)
MY (1)	MY110191A (fr)
NO (1)	NO302700B1 (fr)
NZ (1)	NZ247411A (fr)
PH (1)	PH30454A (fr)
PT (1)	PT566199E (fr)
RU (1)	RU2114112C1 (fr)
SG (1)	SG50663A1 (fr)
SK (1)	SK279786B6 (fr)
TW (1)	TW239140B (fr)
UA (1)	UA35557C2 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5349068A (en) *	1992-04-15	1994-09-20	Sterling Winthrop Inc.	1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5552420A (en) *	1994-05-13	1996-09-03	Sterling Winthrop Inc.	Therapeutic phenoxyalkylazoles and phenoxyalkylazines
IL118657A0 (en) *	1996-06-14	1996-10-16	Arad Dorit	Inhibitors for picornavirus proteases
IL122591A0 (en)	1997-12-14	1998-06-15	Arad Dorit	Pharmaceutical compositions comprising cystein protease inhibitors
US6528652B1 (en)	1999-01-21	2003-03-04	Chronimed	Composition and device for detecting leukocytes in urine
US6348324B1 (en)	1999-01-21	2002-02-19	Hypoguard America Limited	Composition and device for detecting leukocytes in urine
AUPQ105499A0 (en)	1999-06-18	1999-07-08	Biota Scientific Management Pty Ltd	Antiviral agents
AUPR213700A0 (en) *	2000-12-18	2001-01-25	Biota Scientific Management Pty Ltd	Antiviral agents
US7041685B2 (en) *	2001-06-08	2006-05-09	Cytovia, Inc.	Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
US7129359B2 (en)	2002-07-09	2006-10-31	National Health Research Institutes	Imidazolidinone compounds
CA2459376A1 (fr) *	2001-08-29	2003-03-13	Viropharma Incorporated	Oxadiazolyl-phenoxyalkylisoxazoles, compositions les contenant et leurs procedes d'utilisation comme agents anti-picornavirus
CA2459375A1 (fr) *	2001-08-29	2003-03-13	Viropharma Incorporated	Oxadiazolyl-phenoxyalkylisoxazoles, compositions les contenant et leurs procedes d'utilisation en tant qu'agents anti-picornavirus
EP2193792B1 (fr)	2001-12-07	2011-08-31	Ana Maria Sandino	Néomycine pour augmenter la survie d'animaux aquatiques qui sont exposés à IPNV
US20060167109A1 (en) *	2002-02-14	2006-07-27	Pevear Daniel C	Methods of reducing rhinovirus contagion and related compositions
JP2006516250A (ja) *	2002-12-18	2006-06-29	サイトビアインコーポレイティッド	カスパーゼ活性化剤およびアポトーシス誘導物質としての３，５−二置換−［１，２，４］−オキサジアゾールおよびそれらの誘導体ならびにそれらの使用
US7259174B2 (en) *	2004-05-25	2007-08-21	National Health Research Institutes	Imidazolidinone compounds
WO2006017505A2 (fr) *	2004-08-04	2006-02-16	Schering Corporation	Formulations pharmaceutiques
CA2641616A1 (fr) *	2006-02-09	2007-08-23	Schering Corporation	Formulations pharmaceutiques
AR059359A1 (es) *	2006-02-09	2008-03-26	Schering Corp	Formulaciones farmaceuticas que contienen pleconaril
JP2009526063A (ja) *	2006-02-09	2009-07-16	シェーリングコーポレイション	医薬製剤
ES2550152T3 (es)	2006-12-13	2015-11-04	F. Hoffmann-La Roche Ag	Derivados de 2-(piperidin-4-il)-4-fenoxi-o fenilamino-pirimidina como inhibidores no nucleósidos de transcriptasa inversa
KR101031584B1 (ko) *	2009-04-21	2011-04-27	파인오토시스템(주)	전면부가 개폐되는 차량용 적외선 조사장치
CN103102322B (zh) *	2011-11-14	2016-02-24	上海交通大学	噁唑类化合物及其制备方法、药物组合物及其用途
TWI811428B (zh)	2018-08-21	2023-08-11	日商杏林製藥股份有限公司	雙環雜芳香環衍生物
WO2021062189A1 (fr) *	2019-09-27	2021-04-01	Collaborations Pharmaceuticals, Inc.	Dérivés d'isoxazole-3-carboxamide et leur utilisation pour le traitement de maladies provoquées par une infection virale
WO2021209563A1 (fr)	2020-04-16	2021-10-21	Som Innovation Biotech, S.A.	Composés destinés à être utilisés dans le traitement d'infections virales par un coronavirus associé au syndrome respiratoire

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA846525B (en) *	1983-08-29	1985-04-24	Sterling Drug Inc	(substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
US4843087A (en) *	1983-08-29	1989-06-27	Sterling Drug Inc.	Di-heterocyclic compounds and their use as antiviral agents
US4861791A (en) *	1983-08-29	1989-08-29	Sterling Drug Inc.	Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents
CA1280753C (fr) *	1985-07-02	1991-02-26	Philip Michael Carabateas	Methode de preparation de derives de substitution heterocycliques de phenoxyalkylisoxasoles et de phenoxyalkylfuranes
GB8619433D0 (en) *	1986-08-08	1986-09-17	Lilly Industries Ltd	Pharmaceutical compounds
NZ234760A (en) *	1989-08-18	1991-09-25	Sterling Drug Inc	Antiviral oxazole compounds and compositions
US4942241A (en) *	1989-08-21	1990-07-17	Sterling Drug Inc.	1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) *	1989-08-18	1990-07-31	Sterling Drug Inc.	1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US5175178A (en) *	1989-08-21	1992-12-29	Sterling Drug Inc.	1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5175177A (en) *	1991-07-17	1992-12-29	Sterling Drug Inc.	1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) *	1992-04-15	1994-09-20	Sterling Winthrop Inc.	1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

1992
- 1992-04-15 US US07/869,287 patent/US5349068A/en not_active Expired - Lifetime
1993
- 1993-03-31 TW TW082102383A patent/TW239140B/zh not_active IP Right Cessation
- 1993-04-07 CZ CZ93597A patent/CZ285845B6/cs not_active IP Right Cessation
- 1993-04-10 MY MYPI93000665A patent/MY110191A/en unknown
- 1993-04-13 SG SG1996008085A patent/SG50663A1/en unknown
- 1993-04-13 PT PT93201058T patent/PT566199E/pt unknown
- 1993-04-13 ES ES93201058T patent/ES2143487T3/es not_active Expired - Lifetime
- 1993-04-13 AT AT93201058T patent/ATE189958T1/de active
- 1993-04-13 EP EP93201058A patent/EP0566199B1/fr not_active Expired - Lifetime
- 1993-04-13 DE DE69327913T patent/DE69327913T2/de not_active Expired - Lifetime
- 1993-04-13 DK DK93201058T patent/DK0566199T3/da active
- 1993-04-14 RU RU93004675A patent/RU2114112C1/ru active
- 1993-04-14 CA CA002094012A patent/CA2094012C/fr not_active Expired - Lifetime
- 1993-04-14 HU HU9301084A patent/HU220606B1/hu unknown
- 1993-04-14 AU AU36881/93A patent/AU666528B2/en not_active Expired
- 1993-04-14 PH PH46044A patent/PH30454A/en unknown
- 1993-04-14 KR KR1019930006244A patent/KR100314158B1/ko not_active Expired - Lifetime
- 1993-04-14 NO NO19931366A patent/NO302700B1/no not_active IP Right Cessation
- 1993-04-14 IL IL10537293A patent/IL105372A/en not_active IP Right Cessation
- 1993-04-14 MX MX9302169A patent/MX9302169A/es unknown
- 1993-04-15 JP JP05088647A patent/JP3103845B2/ja not_active Expired - Lifetime
- 1993-04-15 FI FI931707A patent/FI112229B/fi not_active IP Right Cessation
- 1993-04-15 NZ NZ247411A patent/NZ247411A/en not_active IP Right Cessation
- 1993-04-15 SK SK353-93A patent/SK279786B6/sk not_active IP Right Cessation
- 1993-06-15 UA UA93003099A patent/UA35557C2/uk unknown
- 1993-10-01 US US08/131,050 patent/US5464848A/en not_active Expired - Lifetime
1995
- 1995-05-19 US US08/444,795 patent/US5643929A/en not_active Expired - Lifetime
- 1995-06-30 HU HU95P/P00642P patent/HU211320A9/hu unknown
2000
- 2000-05-24 GR GR20000401183T patent/GR3033486T3/el unknown

Also Published As

Publication number	Publication date
NZ247411A (en)	1994-06-27
MY110191A (en)	1998-02-28
PT566199E (pt)	2000-09-29
CA2094012A1 (fr)	1993-10-16
JP3103845B2 (ja)	2000-10-30
DE69327913T2 (de)	2000-10-12
TW239140B (fr)	1995-01-21
ATE189958T1 (de)	2000-03-15
GR3033486T3 (en)	2000-09-29
EP0566199A1 (fr)	1993-10-20
SG50663A1 (en)	1998-07-20
HUT65574A (en)	1994-07-28
SK35393A3 (en)	1994-06-08
HU9301084D0 (en)	1993-06-28
KR100314158B1 (ko)	2002-02-19
FI112229B (fi)	2003-11-14
US5464848A (en)	1995-11-07
CA2094012C (fr)	2001-08-21
DK0566199T3 (da)	2000-06-19
US5349068A (en)	1994-09-20
NO931366L (no)	1993-10-18
US5643929A (en)	1997-07-01
IL105372A0 (en)	1993-08-18
UA35557C2 (uk)	2001-04-16
IL105372A (en)	1998-12-27
MX9302169A (es)	1993-10-01
AU666528B2 (en)	1996-02-15
NO302700B1 (no)	1998-04-14
KR930021637A (ko)	1993-11-22
NO931366D0 (no)	1993-04-14
EP0566199B1 (fr)	2000-03-01
HU211320A9 (en)	1995-11-28
SK279786B6 (sk)	1999-03-12
RU2114112C1 (ru)	1998-06-27
HU220606B1 (hu)	2002-03-28
CZ59793A3 (en)	1994-02-16
AU3688193A (en)	1993-10-21
FI931707L (fi)	1993-10-16
ES2143487T3 (es)	2000-05-16
DE69327913D1 (de)	2000-04-06
CZ285845B6 (cs)	1999-11-17
JPH0649066A (ja)	1994-02-22
FI931707A0 (fi)	1993-04-15

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TW239140B (fr)	1995-01-21
MY118904A (en)	2005-02-28	4-oxo-1, 4-dihydro-3-quinolinecarboxamides as antiviral agents
IL91417A0 (en)	1990-04-29	Antidepressant n-substituted nicotinamide compounds
NZ337529A (en)	2000-10-27	Pyrrolo[2,3-d]pyrimidine derivatives useful as tyrosine kinase inhibitors
IL104024A (en)	1997-04-15	4-pyrimidinyl and pyridinyl derivatives of indol-3-yl- alkyl piperazines and antimigraine pharmaceutical compositions containing them
HU9401221D0 (en)	1994-08-29	New heterocyclic compounds
ES8604128A1 (es)	1986-01-16	Un procedimiento para la preparacion de nuevos derivados de bencenosulfonamida
MY117092A (en)	2004-05-31	Chemotherapeutic pyrrolocarbazole derivatives
PL341514A1 (en)	2001-04-23	Substituted compounds of 2-benzylamino-2-phenyl acetamide
CS743389A3 (en)	1992-03-18	Amino(methyl)phenyl derivatives, process for their preparation and use
ES2010089A6 (es)	1989-10-16	Procedimiento para la obtencion de n-oxidos de gamma-carbolina antipsicoticos.
AU606701B2 (en)	1991-02-14	Antipsychotic compositions containing dioxopiperidine derivatives
MX9204194A (es)	1993-08-01	Los compuestos de 1,2,4-oxadiazolil-fenoxialquilisoxazolas y su uso como agentes antivirales
EP0785193A4 (fr)	2000-04-19	Derive d'arylthiadiazole et agent antiviral le contenant
AU2212692A (en)	1993-03-11	N,n',n'-trisubstituted-5-bis-aminomethylene-13-dioxane-4, 6-dione inhibitors of acyl-coa:cholesterol-acyl transferase
EP0443474A3 (en)	1992-04-22	1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents
EP0651747A1 (fr)	1995-05-10	Derives de carbostyryle.