IL105883A - Tissue plasminogen activator glycosylation variants, glycosylated at any one of positions 103 to 105 and devoid of glycosylation at position 117, with improved therapeutic properties, method of preparing and compositions comprising them - Google Patents

Tissue plasminogen activator glycosylation variants, glycosylated at any one of positions 103 to 105 and devoid of glycosylation at position 117, with improved therapeutic properties, method of preparing and compositions comprising them

Info

Publication number
IL105883A
IL105883A IL10588393A IL10588393A IL105883A IL 105883 A IL105883 A IL 105883A IL 10588393 A IL10588393 A IL 10588393A IL 10588393 A IL10588393 A IL 10588393A IL 105883 A IL105883 A IL 105883A
Authority
IL
Israel
Prior art keywords
glycosylation
glycosylated
devoid
positions
plasminogen activator
Prior art date
Application number
IL10588393A
Other languages
English (en)
Other versions
IL105883A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL105883A0 publication Critical patent/IL105883A0/xx
Publication of IL105883A publication Critical patent/IL105883A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL10588393A 1992-06-03 1993-06-02 Tissue plasminogen activator glycosylation variants, glycosylated at any one of positions 103 to 105 and devoid of glycosylation at position 117, with improved therapeutic properties, method of preparing and compositions comprising them IL105883A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89421392A 1992-06-03 1992-06-03

Publications (2)

Publication Number Publication Date
IL105883A0 IL105883A0 (en) 1993-10-20
IL105883A true IL105883A (en) 2003-04-10

Family

ID=25402765

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10588393A IL105883A (en) 1992-06-03 1993-06-02 Tissue plasminogen activator glycosylation variants, glycosylated at any one of positions 103 to 105 and devoid of glycosylation at position 117, with improved therapeutic properties, method of preparing and compositions comprising them

Country Status (20)

Country Link
US (1) US5612029A (fr)
EP (2) EP0643772B1 (fr)
JP (1) JP3559559B2 (fr)
AT (2) ATE155816T1 (fr)
AU (1) AU664469B2 (fr)
CA (1) CA2129660C (fr)
DE (3) DE10199044I2 (fr)
DK (2) DK0786257T3 (fr)
EE (1) EE03128B1 (fr)
ES (2) ES2107041T3 (fr)
FI (1) FI117940B (fr)
GE (1) GEP20012448B (fr)
GR (1) GR3024806T3 (fr)
HK (1) HK1001190A1 (fr)
IL (1) IL105883A (fr)
LU (1) LU90800I2 (fr)
NL (1) NL300050I2 (fr)
NZ (1) NZ253556A (fr)
PT (1) PT786257E (fr)
WO (1) WO1993024635A1 (fr)

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US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
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US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
WO2006023530A2 (fr) * 2004-08-16 2006-03-02 Massachusetts Institute Of Technology Compositions et procedes permettant d'ameliorer le systeme structurel et fonctionnel de la reorganisation et de la recuperation du systeme nerveux
BRPI0610958A2 (pt) * 2005-06-02 2010-08-03 Avestha Gengraine Tech Pvt Ltd método para produzir uma forma obtida por bioengenharia do ativador de plasminogênio tecidual
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AU2007238608A1 (en) * 2006-04-14 2007-10-25 Massachusetts Institute Of Technology Identifying and modulating molecular pathways that mediate nervous system plasticity
BRPI0716143A2 (pt) 2006-08-29 2013-11-26 Genentech Inc Uso de tenecteplase para tratar derrame isquêmico agudo
JP2010505849A (ja) * 2006-10-06 2010-02-25 ユニバーシティ オブ バージニア パテント ファウンデーション 糖尿病性創傷治癒に有用な方法および組成物
CA2668347C (fr) 2006-11-07 2017-06-20 Genentech, Inc. Utilisations de variant d'activateur du plasminogene tissulaire
KR100834561B1 (ko) 2006-12-08 2008-06-02 가톨릭대학교 산학협력단 크링글 도메인 1 및 2로 이루어진 비-글리코실화 재조합단백질, 그 제조 방법 및 이를 포함하는 조성물
EP2289541A1 (fr) 2009-08-31 2011-03-02 PAION Deutschland GmbH Traitement des troubles neurologiques ou neuro-dégénératifs
EP2289542A1 (fr) 2009-08-31 2011-03-02 PAION Deutschland GmbH Traitement des troubles neurologiques ou neuro-dégénératifs
US20130122076A1 (en) * 2011-11-11 2013-05-16 Mathew Gelfand Transdermal Patch Having Ultrasound Transducer for Administering Thrombolytic Reagents to Patients Having a Protein Misfolding Disease
CN104602701B (zh) * 2012-07-05 2019-04-16 哈达斯特医疗研究服务和开发有限公司 作为抗纤维蛋白溶解剂的纤维蛋白溶酶原活化剂的突变体
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CN103623396B (zh) * 2013-04-07 2016-03-02 安源生物科技(上海)有限公司 包含重组组织型纤溶酶原激活剂的药物组合物
WO2015023830A1 (fr) 2013-08-14 2015-02-19 Stc.Unm Traitement et prévention d'un accident vasculaire cérébral et d'autres troubles neurologiques
EP3708226A1 (fr) * 2014-11-03 2020-09-16 Thrombolytic Science, LLC Procédés et compositions pour une thrombolyse sûre et efficace
TWI866194B (zh) 2017-02-03 2024-12-11 法商艾提寇生物技術公司 使用抗人類ｇｐｖｉ抗體抑制血小板凝集
EP3624832B1 (fr) 2017-05-16 2025-08-20 Institut National de la Santé et de la Recherche Médicale Procédés et compositions pharmaceutiques pour le traitement d'un accident vasculaire cérébral ischémique aigu
WO2018232305A1 (fr) 2017-06-16 2018-12-20 Thrombolytic Science, Llc Procédés et compositions pour la thrombolyse
EP3806833A1 (fr) 2018-06-15 2021-04-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Utilisation d'inhibiteurs de pi3kc2b pour la préservation de l'intégrité d'une barrière cellulaire de l'endothélium vasculaire
WO2021148439A1 (fr) 2020-01-21 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de stimulation de la fonction cérébrovasculaire
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WO2025064654A1 (fr) * 2023-09-19 2025-03-27 The Research Foundation For The State University Of New York Protéines de l'activateur tissulaire du plasminogène tronqué et utilisation associée
CN117327682A (zh) * 2023-10-07 2024-01-02 福州大学 一种兼顾高效性与安全性的新型溶栓剂的设计及其应用
EP4556492A1 (fr) 2023-11-14 2025-05-21 Acticor Biotech Traitement de maladies cardiovasculaires à l'aide d'anticorps anti-gpvi humain dans des sous-populations de sujets

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Also Published As

Publication number Publication date
FI117940B (fi) 2007-04-30
DE69333127T2 (de) 2004-05-06
DE10199044I2 (de) 2006-02-09
IL105883A0 (en) 1993-10-20
DK0786257T3 (da) 2003-10-06
ES2107041T3 (es) 1997-11-16
US5612029A (en) 1997-03-18
EP0643772A1 (fr) 1995-03-22
FI943632L (fi) 1994-10-04
NZ253556A (en) 1995-11-27
JPH07507448A (ja) 1995-08-24
NL300050I1 (nl) 2001-10-01
CA2129660C (fr) 2005-06-28
AU664469B2 (en) 1995-11-16
LU90800I2 (fr) 2001-10-08
DK0643772T3 (da) 1998-02-02
DE69312493D1 (de) 1997-09-04
GEP20012448B (en) 2001-05-25
EP0643772B1 (fr) 1997-07-23
JP3559559B2 (ja) 2004-09-02
EP0786257A1 (fr) 1997-07-30
PT786257E (pt) 2003-12-31
CA2129660A1 (fr) 1993-12-09
HK1001190A1 (en) 1998-05-29
EE03128B1 (et) 1998-10-15
ATE246000T1 (de) 2003-08-15
DE69312493T2 (de) 1998-01-15
FI943632A0 (fi) 1994-08-04
ES2203668T3 (es) 2004-04-16
WO1993024635A1 (fr) 1993-12-09
HK1000449A1 (en) 2004-03-05
ATE155816T1 (de) 1997-08-15
EP0786257B1 (fr) 2003-07-30
NL300050I2 (nl) 2001-11-01
GR3024806T3 (en) 1998-01-30
AU4397393A (en) 1993-12-30
DE69333127D1 (de) 2003-09-04
DE10199044I1 (de) 2002-02-21

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