IL106873A - Process for selective amplification of the production of the antibiotic substance EG 0722 Factor A - Google Patents

Process for selective amplification of the production of the antibiotic substance EG 0722 Factor A

Info

Publication number: IL106873A
Authority: IL; Israel
Prior art keywords: vitamin; antibiotic; fermentation; added; fish meal
Prior art date: 1992-09-10

Application number

IL10687393A

Other languages

English (en)

Hebrew (he)

Other versions

IL106873A0 (en

Inventor

Angelo Michele Rizzo

Luciano Gastaldo

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-10

Filing date

1993-09-02

Publication date

1998-08-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8209988&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL106873(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-09-02 Application filed by Lepetit Spa filed Critical Lepetit Spa

1993-12-28 Publication of IL106873A0 publication Critical patent/IL106873A0/xx

1998-08-16 Publication of IL106873A publication Critical patent/IL106873A/en

Links

238000000034 method Methods 0.000 title claims abstract description 25
101000655610 Planobispora rosea Thiocillin GE2270 Proteins 0.000 title claims abstract description 21
238000004519 manufacturing process Methods 0.000 title claims abstract description 18
238000000855 fermentation Methods 0.000 claims abstract description 43
230000004151 fermentation Effects 0.000 claims abstract description 43
229930003779 Vitamin B12 Natural products 0.000 claims abstract description 33
239000011715 vitamin B12 Substances 0.000 claims abstract description 33
235000019163 vitamin B12 Nutrition 0.000 claims abstract description 33
230000000694 effects Effects 0.000 claims abstract description 20
241001495389 Planobispora rosea Species 0.000 claims abstract description 7
229930003231 vitamin Natural products 0.000 claims abstract description 7
235000013343 vitamin Nutrition 0.000 claims abstract description 7
239000011782 vitamin Substances 0.000 claims abstract description 7
229940088594 vitamin Drugs 0.000 claims abstract description 7
150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 6
AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims description 32
235000019733 Fish meal Nutrition 0.000 claims description 13
239000004467 fishmeal Substances 0.000 claims description 12
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
241000766754 Agra Species 0.000 claims description 8
239000011365 complex material Substances 0.000 claims description 6
229910052757 nitrogen Inorganic materials 0.000 claims description 5
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OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
229910052799 carbon Inorganic materials 0.000 claims description 4
YOZNUFWCRFCGIH-BYFNXCQMSA-L hydroxocobalamin Chemical compound O[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O YOZNUFWCRFCGIH-BYFNXCQMSA-L 0.000 claims description 4
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 3
229910052921 ammonium sulfate Inorganic materials 0.000 claims description 3
235000011130 ammonium sulphate Nutrition 0.000 claims description 3
125000004093 cyano group Chemical group *C#N 0.000 claims description 3
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JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 claims description 3
235000007672 methylcobalamin Nutrition 0.000 claims description 3
239000011585 methylcobalamin Substances 0.000 claims description 3
OAJLVMGLJZXSGX-NDSREFPTSA-L (2r,3s,4s,5r)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12 Chemical compound [Co+3].O[C@H]1[C@H](O)[C@@H]([CH2-])O[C@H]1N1C2=NC=NC(N)=C2N=C1.C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O OAJLVMGLJZXSGX-NDSREFPTSA-L 0.000 claims description 2
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230000003115 biocidal effect Effects 0.000 abstract description 14
239000003242 anti bacterial agent Substances 0.000 abstract description 6
229940088710 antibiotic agent Drugs 0.000 abstract description 6
FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 1
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WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
229910000019 calcium carbonate Inorganic materials 0.000 description 3
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BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 3
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JMDULECOHIXMNX-MZHFYNGJSA-N chembl1766417 Chemical compound C1([C@H](O)[C@H]2C=3SC=C(N=3)C=3SC=C(N=3)C3=NC(=CC=C3C=3SC=C(N=3)C(=O)N[C@H](C3=NC(=C(S3)C)C(=O)N[C@H](C3=NC(=C(S3)COC)C(=O)NCC(=O)N2)C(C)C)CC(=O)NC)C=2SC=C(N=2)C=2OC[C@H](N=2)C(=O)N2[C@@H](CCC2)C(N)=O)=CC=CC=C1 JMDULECOHIXMNX-MZHFYNGJSA-N 0.000 description 3
239000010941 cobalt Substances 0.000 description 3
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229910052708 sodium Inorganic materials 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
239000012137 tryptone Substances 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Microbiology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Bipolar Transistors (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

IL10687393A 1992-09-10 1993-09-02 Process for selective amplification of the production of the antibiotic substance EG 0722 Factor A IL106873A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP92115451		1992-09-10

Publications (2)

Publication Number	Publication Date
IL106873A0 IL106873A0 (en)	1993-12-28
IL106873A true IL106873A (en)	1998-08-16

Family

ID=8209988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10687393A IL106873A (en)	1992-09-10	1993-09-02	Process for selective amplification of the production of the antibiotic substance EG 0722 Factor A

Country Status (13)

Country	Link
EP (1)	EP0662145B1 (de)
JP (1)	JP3458355B2 (de)
KR (1)	KR100281661B1 (de)
AT (1)	ATE147105T1 (de)
CA (1)	CA2144331C (de)
DE (1)	DE69307148T2 (de)
DK (1)	DK0662145T3 (de)
ES (1)	ES2096313T3 (de)
GR (1)	GR3022960T3 (de)
HU (1)	HU213751B (de)
IL (1)	IL106873A (de)
WO (1)	WO1994005798A1 (de)
ZA (1)	ZA936544B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2186866T3 (es) *	1996-02-14	2003-05-16	Biosearch Italia Spa	Derivados de factores del antibiotico ge2270.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8821160D0 (en) *	1988-09-09	1988-10-12	Lepetit Spa	Antibiotic ge 2270

1993
- 1993-07-20 JP JP50677894A patent/JP3458355B2/ja not_active Expired - Fee Related
- 1993-07-20 DE DE69307148T patent/DE69307148T2/de not_active Expired - Fee Related
- 1993-07-20 CA CA002144331A patent/CA2144331C/en not_active Expired - Fee Related
- 1993-07-20 KR KR1019950700942A patent/KR100281661B1/ko not_active Expired - Fee Related
- 1993-07-20 DK DK93917597.2T patent/DK0662145T3/da active
- 1993-07-20 WO PCT/EP1993/001907 patent/WO1994005798A1/en not_active Ceased
- 1993-07-20 HU HU9500715A patent/HU213751B/hu not_active IP Right Cessation
- 1993-07-20 EP EP93917597A patent/EP0662145B1/de not_active Expired - Lifetime
- 1993-07-20 ES ES93917597T patent/ES2096313T3/es not_active Expired - Lifetime
- 1993-07-20 AT AT93917597T patent/ATE147105T1/de not_active IP Right Cessation
- 1993-09-02 IL IL10687393A patent/IL106873A/en not_active IP Right Cessation
- 1993-09-06 ZA ZA936544A patent/ZA936544B/xx unknown
1997
- 1997-03-27 GR GR970400635T patent/GR3022960T3/el unknown

Also Published As

Publication number	Publication date
JP3458355B2 (ja)	2003-10-20
JPH08501215A (ja)	1996-02-13
EP0662145B1 (de)	1997-01-02
AU675076B2 (en)	1997-01-23
IL106873A0 (en)	1993-12-28
DE69307148T2 (de)	1997-05-22
DE69307148D1 (de)	1997-02-13
HU213751B (en)	1997-09-29
GR3022960T3 (en)	1997-06-30
HUT71698A (en)	1996-01-29
ATE147105T1 (de)	1997-01-15
KR950703654A (ko)	1995-09-20
DK0662145T3 (da)	1997-01-20
HU9500715D0 (en)	1995-04-28
CA2144331C (en)	2005-01-04
WO1994005798A1 (en)	1994-03-17
EP0662145A1 (de)	1995-07-12
ZA936544B (en)	1994-03-28
KR100281661B1 (ko)	2001-02-15
ES2096313T3 (es)	1997-03-01
CA2144331A1 (en)	1994-03-17
AU4700493A (en)	1994-03-29

Legal Events

Date	Code	Title
1998-12-27	FF	Patent granted
1999-06-20	KB	Patent renewed
1999-07-14	HP	Change in proprietorship
2000-01-31	KB	Patent renewed
2003-11-23	KB	Patent renewed
2008-06-05	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US2595499A (en)	1952-05-06	Process for production of vitamin b12
US5227295A (en)	1993-07-13	Process for isolating A83543 and its components
US20070191415A1 (en)	2007-08-16	Production of tacrolimus (fk-506) using new streptomyces species
EP0185456B1 (de)	1990-11-07	Antibiotika-/Antitumorverbindungen CL-1577D und CL-1577E, deren Herstellung und Verwendung
US5882900A (en)	1999-03-16	Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium
KR960016874B1 (ko)	1996-12-23	미생물에 의한 트랜스-4-히드록시-l-프롤린의 제조방법
US5223413A (en)	1993-06-29	Process for the preparation of vancomycin
JPH0491793A (ja)	1992-03-25	発酵法によるアミノ酸の製造法
CA2144331C (en)	2005-01-04	Process for the selective increase of production of antibiotic ge 2270 factor a
AU675076C (en)	1998-03-19	Process for the selective increase of production of antibiotic GE 2270 factor A
US4764602A (en)	1988-08-16	Antibiotics, and their production
EP0139465B1 (de)	1990-05-16	Antibiotika und Verfahren zu deren Herstellung
CA1152915A (en)	1983-08-30	Antibiotics c-14482 b.sub.1, b.sub.2 and b.sub.3
CA1193211A (en)	1985-09-10	Process for producing mitomycin a by fermentation
US3991183A (en)	1976-11-09	Antibiotic produced by a species of micromonospora
US4249008A (en)	1981-02-03	3,4-Dihydro-4-hydroxy-5-(3-hydroxy-2-pyridinyl)-4-methyl-2H-pyrrole-2-carboxamide
US4091093A (en)	1978-05-23	Protease inhibitors
EP0413967B1 (de)	1994-11-02	Antibiotikum
CA1113874A (en)	1981-12-08	Antibiotic bl580 zeta from streptomyces hydroscopicus
US5364623A (en)	1994-11-15	Antibiotic produced by Bacillus subtilis ATCC 55422 capable of inhibiting bacteria
US4206283A (en)	1980-06-03	Protease inhibitors
EP0206068B1 (de)	1992-10-28	Antibiotika TAN-749, deren Herstellung und Anwendung
US4298599A (en)	1981-11-03	Novel antibiotic BN-235 substance, and process for the production thereof
KR960014621B1 (ko)	1996-10-19	신 균주 스트렙토마이세스 라벤도폴리아 dk-506 및 이를 이용한 아클라시노마이신 a의 제조와 분리정제 방법
JPS5924995B2 (ja)	1984-06-13	新規抗生物質ナナオマイシンｅおよびその製造法