IL108524A0 - Imidazodiazepine analogs - Google Patents

Imidazodiazepine analogs

Info

Publication number: IL108524A0
Authority: IL; Israel
Prior art keywords: imidazodiazepine; analogs; compounds; adenosine; ameliorated
Prior art date: 1993-02-03

Application number

IL10852494A

Other languages

English (en)

Original Assignee

Gensia Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-03

Filing date

1994-02-02

Publication date

1994-05-30

1994-02-02 Application filed by Gensia Inc filed Critical Gensia Inc

1994-05-30 Publication of IL108524A0 publication Critical patent/IL108524A0/xx

Links

BMGXAZCDDYTVFV-UHFFFAOYSA-N imidazo[4,5-c]diazepine Chemical class C1=CN=NC2=NC=NC2=C1 BMGXAZCDDYTVFV-UHFFFAOYSA-N 0.000 title 1
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000002126 C01EB10 - Adenosine Substances 0.000 abstract 1
UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 abstract 1
229960005305 adenosine Drugs 0.000 abstract 1
UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 abstract 1
LNQVTSROQXJCDD-UHFFFAOYSA-N adenosine monophosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)C(OP(O)(O)=O)C1O LNQVTSROQXJCDD-UHFFFAOYSA-N 0.000 abstract 1
230000001668 ameliorated effect Effects 0.000 abstract 1
125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Information Transfer Systems (AREA)

IL10852494A 1993-02-03 1994-02-02 Imidazodiazepine analogs IL108524A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US1284193A	1993-02-03	1993-02-03

Publications (1)

Publication Number	Publication Date
IL108524A0 true IL108524A0 (en)	1994-05-30

Family

ID=21756974

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10852494A IL108524A0 (en)	1993-02-03	1994-02-02	Imidazodiazepine analogs

Country Status (10)

Country	Link
US (1)	US5731432A (de)
EP (1)	EP0683781B1 (de)
JP (1)	JP3940810B2 (de)
AT (1)	ATE264859T1 (de)
AU (1)	AU6134994A (de)
CA (1)	CA2154577C (de)
DE (1)	DE69433722D1 (de)
IL (1)	IL108524A0 (de)
MX (1)	MX9400874A (de)
WO (1)	WO1994018200A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL103294A0 (en) *	1991-09-30	1993-05-13	Gensia Pharma	Pharmaceutical compositions for preventing tissue damage associated with decreased blood flow
ES2182847T3 (es) *	1993-09-29	2003-03-16	Nabi	Nucleosidos y nucleotidos de anillo expandido.
EP1003469A2 (de) *	1996-02-21	2000-05-31	Givaudan-Roure (International) S.A.	Vorläufer von duftstoffen
AU8438798A (en)	1997-06-16	1999-01-04	Janssen Pharmaceutica N.V.	Use of draflazine-analogues for treating pain
DE19912636A1 (de) *	1999-03-20	2000-09-21	Aventis Cropscience Gmbh	Bicyclische Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und pharmazeutische Mittel
US6103702A (en) *	1999-05-24	2000-08-15	Board Of Trustees Of The University Of Illinois	Use of adenosine deaminase inhibitors to treat systemic inflammatory response syndrome
US6579857B1 (en)	1999-06-11	2003-06-17	Evanston Northwestern Healthcare Research Institute	Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
US6300328B1 (en)	1999-08-06	2001-10-09	Alcon Universal Ltd.	Selective inhibitors of adenosine monophosphate deaminase for the treatment of optic nerve and retinal damage
US20020086835A1 (en) *	2000-05-22	2002-07-04	Law William R.	Use of adenosine deaminase inhibitors to treat systemic inflammatory response syndrome
US6727231B1 (en)	2000-10-12	2004-04-27	Repligen Corporation	Uridine therapy for patients with elevated purine levels
GB0030424D0 (en) *	2000-12-13	2001-01-24	Pfizer Ltd	Crystal structure
WO2003051314A2 (en) *	2001-12-18	2003-06-26	Medallion Biomedical, Llc	Antibiotic compounds
US7386492B2 (en) *	2002-01-15	2008-06-10	Clear Channel Communications, Inc.	Inventory and revenue maximization method and system
MX2007012045A (es)	2005-03-28	2008-01-16	Pericor Therapeutics Inc	Composiciones y formulaciones para evitar o reducir efectos adversos a un paciente.
US20070082859A1 (en) *	2005-10-07	2007-04-12	Stover Richard R	Formulations of AICA riboside
WO2008086341A1 (en) *	2007-01-09	2008-07-17	Pericor Therapeutics, Inc.	Methods. compositions, and formulations for preventing or reducing adverse effects in a patient
DE102007005329A1 (de) *	2007-01-29	2008-07-31	Eberhard-Karls-Universität Tübingen Universitätsklinikum	Mittel zur Erythrozytenprotektion
JP5591245B2 (ja) *	2008-10-03	2014-09-17	ペリコーセラピューティクス，インコーポレイテッド	急性心不全の治療のための方法および組成物
US20100261666A1 (en) *	2009-04-14	2010-10-14	The Board Of Trustees Of The University Of Illinois	Compositions and methods for the treatment of myocardial dysfunction associated with sirs or sepsis
US8969349B2 (en) *	2010-05-26	2015-03-03	Sunovion Pharmaceuticals Inc.	Substituted quinoxalines and quinoxalinones as PDE-10 inhibitors
DE102011005232A1 (de)	2011-03-08	2012-09-13	AristoCon GmbH & Co. KG	Adenosin und seine Derivate zur Verwendung in der Schmerztherapie
CN103665043B (zh)	2012-08-30	2017-11-10	江苏豪森药业集团有限公司	一种替诺福韦前药及其在医药上的应用
US20150031712A1 (en)	2013-03-12	2015-01-29	Moshe Rogosnitzky	Therapeutic Compositions Containing Dipyridamole and Treatment Packs Including Such Compositions and Methods for Producing Same
EA201890014A1 (ru)	2015-06-08	2018-07-31	О.Д. Окьюлар Дискавери Лтд.	Терапевтические композиции, содержащие дипиридамол, наборы для лечения, содержащие эти композиции, и способы их производства

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4935505A (en) *	1983-05-03	1990-06-19	Townsend Leroy B	Novel azolo [1,3] diazepine-5-ol compounds and their uses
JPS6281387A (ja) *	1985-10-03	1987-04-14	Kitasato Inst:The	新規化合物ｏｍ−３２２３およびその製造法
WO1989008658A1 (en) *	1988-03-16	1989-09-21	Scripps Clinic And Research Foundation	Substituted adenine derivatives useful as therapeutic agents
ES2052172T3 (es) *	1989-03-23	1994-07-01	Pfizer	Agentes antialergicos basados en diazepina.
GB8911029D0 (en) *	1989-05-13	1989-06-28	Schering Agrochemicals Ltd	Herbicide
US5705491A (en) *	1992-10-27	1998-01-06	Nippon Zoki Pharmaceutical Co., Ltd.	Adenosine deaminase inhibitor
AU6297294A (en) *	1993-02-03	1994-08-29	Gensia, Inc.	Adenosine deaminase inhibitor therapies

1994
- 1994-02-02 IL IL10852494A patent/IL108524A0/xx unknown
- 1994-02-03 DE DE69433722T patent/DE69433722D1/de not_active Expired - Lifetime
- 1994-02-03 EP EP94907992A patent/EP0683781B1/de not_active Expired - Lifetime
- 1994-02-03 CA CA002154577A patent/CA2154577C/en not_active Expired - Fee Related
- 1994-02-03 WO PCT/US1994/001342 patent/WO1994018200A1/en not_active Ceased
- 1994-02-03 AU AU61349/94A patent/AU6134994A/en not_active Abandoned
- 1994-02-03 JP JP51827894A patent/JP3940810B2/ja not_active Expired - Fee Related
- 1994-02-03 AT AT94907992T patent/ATE264859T1/de not_active IP Right Cessation
- 1994-02-03 US US08/192,154 patent/US5731432A/en not_active Expired - Fee Related
- 1994-02-03 MX MX9400874A patent/MX9400874A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0683781B1 (de)	2004-04-21
WO1994018200A1 (en)	1994-08-18
CA2154577C (en)	2005-08-02
JPH08506344A (ja)	1996-07-09
JP3940810B2 (ja)	2007-07-04
CA2154577A1 (en)	1994-08-18
US5731432A (en)	1998-03-24
EP0683781A4 (de)	1997-05-28
DE69433722D1 (de)	2004-05-27
EP0683781A1 (de)	1995-11-29
MX9400874A (es)	1994-08-31
AU6134994A (en)	1994-08-29
ATE264859T1 (de)	2004-05-15

Publication	Publication Date	Title
IL108524A0 (en)	1994-05-30	Imidazodiazepine analogs
MX9200294A (es)	1993-01-01	Inhibidores de cinasa de adenosina
BG102425A (en)	1999-06-30	(methylsulphonyl)phenyl-2-(5h)-furanons as cyclooxygenase-2-inhibitors
ATE140923T1 (de)	1996-08-15	Verfahren zur herstellung von n4-acyl-5'-desoxy-5-fluorocytidinderivate
DK1115840T3 (da)	2010-04-12	Afstamningsspecifikke celler og progenitorceller
GB8916901D0 (en)	1989-09-06	Improvements in or relating to organic compounds
DE3369980D1 (en)	1987-04-09	Disubstituted proline derivatives, process for their preparation and their use
IL95327A0 (en)	1991-06-30	Method and composition for the treatment of cardiac and of vascular hypertrophy and hyperplasia
DE3567210D1 (en)	1989-02-09	Isoindolinone derivatives, production and use thereof
DE3660489D1 (en)	1988-09-15	Derivatives of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl) ethane
NZ324615A (en)	2000-08-25	Method for treating autism using olanzapine
DE3568987D1 (en)	1989-04-27	Derivatives of dihydro-1h-pyrrolo(1,2-c)imidazol-3,5-dione as cognition activators
BG105624A (en)	2002-01-31	Process for preparing n6-substituted deaza-adenosine derivatives
DE3060459D1 (en)	1982-07-15	Oxadiazolylmethylthiol phosphates, methods of their production and their use in combating pests
DE69531627D1 (de)	2003-10-02	Humane hypertrophe chrondrozyten zelllinien
HU900158D0 (en)	1990-03-28	Process for preparation of 9-hydroxy-dodec-10-enyl-1-terc-butylether
ZA9610040B (en)	1998-06-12	New amino alcohol derivatives, processes for their production and pharmaceutical agents containing these compounds.
HUT48630A (en)	1989-06-28	Process for producing thiopirano-di/pyrazol/ derivatives and pharmaceutical compositions containing them
ES2105714T3 (es)	1997-10-16	Procedimiento para la obtencion de alquil- y/o alqueniloligoglicosidos de color claro.
IE780540L (en)	1978-09-18	Pyrano triazines
IL74116A (en)	1988-06-30	Saturated tricyclic nitrogen-containing diones,their preparation and pharmaceutical compositions containing them
TW377353B (en)	1999-12-21	Purine derivatives and process for their preparation
GR1001385B (el)	1993-10-29	Παράγωγα ιμιδαζο 1,2-α (πυρρολο,?ειενο η φουρανο) 3,2-d αζεπίνης συν?έσεις και μέ?οδοι χρήσεως.