IL109230A - Anti-fungal composition containing bifonazole and fluocinonide - Google Patents

Anti-fungal composition containing bifonazole and fluocinonide

Info

Publication number: IL109230A
Authority: IL; Israel
Prior art keywords: composition; bifonazole; fluocinonide; pharmaceutically acceptable; acceptable vehicle
Prior art date: 1994-04-05

Application number

IL10923094A

Other languages

English (en)

Other versions

IL109230A0 (en

Original Assignee

Agis Ind 1983 Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-05

Filing date

1994-04-05

Publication date

1998-08-16

1994-04-05 Application filed by Agis Ind 1983 Ltd filed Critical Agis Ind 1983 Ltd

1994-04-05 Priority to IL10923094A priority Critical patent/IL109230A/en

1994-07-31 Publication of IL109230A0 publication Critical patent/IL109230A0/xx

1995-03-03 Priority to ZA951799A priority patent/ZA951799B/xx

1995-03-24 Priority to DK95301981T priority patent/DK0676198T3/da

1995-03-24 Priority to DE69505174T priority patent/DE69505174T2/de

1995-03-24 Priority to EP95301981A priority patent/EP0676198B1/de

1995-03-24 Priority to ES95301981T priority patent/ES2123206T3/es

1995-03-24 Priority to AT95301981T priority patent/ATE171871T1/de

1995-04-04 Priority to JP7078697A priority patent/JPH0892097A/ja

1995-04-04 Priority to CN95103643A priority patent/CN1075722C/zh

1998-08-16 Publication of IL109230A publication Critical patent/IL109230A/en

Links

OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 title claims abstract description 41
229960002206 bifonazole Drugs 0.000 title claims abstract description 41
229960000785 fluocinonide Drugs 0.000 title claims abstract description 41
WJOHZNCJWYWUJD-IUGZLZTKSA-N Fluocinonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)C)[C@@]2(C)C[C@@H]1O WJOHZNCJWYWUJD-IUGZLZTKSA-N 0.000 title claims abstract description 37
239000012871 anti-fungal composition Substances 0.000 title description 2
239000000203 mixture Substances 0.000 claims abstract description 31
230000000699 topical effect Effects 0.000 claims abstract description 11
239000003246 corticosteroid Substances 0.000 claims abstract description 9
230000000843 anti-fungal effect Effects 0.000 claims abstract description 8
229940121375 antifungal agent Drugs 0.000 claims abstract description 8
239000002260 anti-inflammatory agent Substances 0.000 claims abstract description 4
230000000855 fungicidal effect Effects 0.000 claims abstract description 4
239000000417 fungicide Substances 0.000 claims abstract description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
239000004615 ingredient Substances 0.000 claims description 20
239000003981 vehicle Substances 0.000 claims description 13
239000000839 emulsion Substances 0.000 claims description 9
238000002360 preparation method Methods 0.000 claims description 9
239000006071 cream Substances 0.000 claims description 7
239000007788 liquid Substances 0.000 claims description 6
239000000843 powder Substances 0.000 claims description 6
239000000725 suspension Substances 0.000 claims description 6
239000006260 foam Substances 0.000 claims description 5
239000000227 bioadhesive Substances 0.000 claims description 3
239000006210 lotion Substances 0.000 claims description 3
210000004400 mucous membrane Anatomy 0.000 claims description 3
239000002453 shampoo Substances 0.000 claims description 3
239000000243 solution Substances 0.000 claims description 3
201000010099 disease Diseases 0.000 claims description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
239000007921 spray Substances 0.000 claims description 2
239000000853 adhesive Substances 0.000 claims 1
230000001070 adhesive effect Effects 0.000 claims 1
230000001050 lubricating effect Effects 0.000 claims 1
239000008177 pharmaceutical agent Substances 0.000 claims 1
239000003921 oil Substances 0.000 description 13
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 12
235000019441 ethanol Nutrition 0.000 description 11
238000002156 mixing Methods 0.000 description 11
238000009472 formulation Methods 0.000 description 8
239000012071 phase Substances 0.000 description 8
239000008213 purified water Substances 0.000 description 8
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 7
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
208000031888 Mycoses Diseases 0.000 description 6
HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 6
229940079593 drug Drugs 0.000 description 6
239000003814 drug Substances 0.000 description 6
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 6
239000004310 lactic acid Substances 0.000 description 6
235000014655 lactic acid Nutrition 0.000 description 6
206010017533 Fungal infection Diseases 0.000 description 5
BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 5
229920001214 Polysorbate 60 Polymers 0.000 description 5
-1 alcohols sulphate Chemical class 0.000 description 5
LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
229960000890 hydrocortisone Drugs 0.000 description 5
229960002509 miconazole Drugs 0.000 description 5
BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 5
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
150000001298 alcohols Chemical class 0.000 description 4
229940081733 cetearyl alcohol Drugs 0.000 description 4
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 4
238000012360 testing method Methods 0.000 description 4
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
IEQAICDLOKRSRL-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO IEQAICDLOKRSRL-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 description 3
239000000443 aerosol Substances 0.000 description 3
239000006185 dispersion Substances 0.000 description 3
239000003995 emulsifying agent Substances 0.000 description 3
239000000499 gel Substances 0.000 description 3
239000008309 hydrophilic cream Substances 0.000 description 3
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 3
229940057995 liquid paraffin Drugs 0.000 description 3
238000000034 method Methods 0.000 description 3
239000002674 ointment Substances 0.000 description 3
229920001223 polyethylene glycol Polymers 0.000 description 3
239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 3
235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 3
239000001587 sorbitan monostearate Substances 0.000 description 3
235000011076 sorbitan monostearate Nutrition 0.000 description 3
229940035048 sorbitan monostearate Drugs 0.000 description 3
229940099259 vaseline Drugs 0.000 description 3
CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 2
MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 description 2
FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 2
LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 2
241000222120 Candida <Saccharomycetales> Species 0.000 description 2
241001440269 Cutina Species 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
239000004166 Lanolin Substances 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
206010039793 Seborrhoeic dermatitis Diseases 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
201000010618 Tinea cruris Diseases 0.000 description 2
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
239000003429 antifungal agent Substances 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
235000013871 bee wax Nutrition 0.000 description 2
229940092738 beeswax Drugs 0.000 description 2
239000012166 beeswax Substances 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
235000019445 benzyl alcohol Nutrition 0.000 description 2
230000002146 bilateral effect Effects 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
235000010980 cellulose Nutrition 0.000 description 2
229940074979 cetyl palmitate Drugs 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
229960004022 clotrimazole Drugs 0.000 description 2
VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
235000014113 dietary fatty acids Nutrition 0.000 description 2
238000004945 emulsification Methods 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
239000000194 fatty acid Substances 0.000 description 2
229930195729 fatty acid Natural products 0.000 description 2
150000004665 fatty acids Chemical class 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
229940074047 glyceryl cocoate Drugs 0.000 description 2
229940075529 glyceryl stearate Drugs 0.000 description 2
PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 2
XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 2
NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
235000019388 lanolin Nutrition 0.000 description 2
229940039717 lanolin Drugs 0.000 description 2
239000000314 lubricant Substances 0.000 description 2
210000004877 mucosa Anatomy 0.000 description 2
239000007764 o/w emulsion Substances 0.000 description 2
239000012188 paraffin wax Substances 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
208000017520 skin disease Diseases 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
229960005078 sorbitan sesquioleate Drugs 0.000 description 2
229940084106 spermaceti Drugs 0.000 description 2
239000012177 spermaceti Substances 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
238000003756 stirring Methods 0.000 description 2
229910021653 sulphate ion Inorganic materials 0.000 description 2
208000024891 symptom Diseases 0.000 description 2
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 2
229940100613 topical solution Drugs 0.000 description 2
239000007762 w/o emulsion Substances 0.000 description 2
ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
AFNXATANNDIXLG-SFHVURJKSA-N 1-[(2r)-2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical compound C1=CC(Cl)=CC=C1CS[C@H](C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 AFNXATANNDIXLG-SFHVURJKSA-N 0.000 description 1
LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 description 1
WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
241001480043 Arthrodermataceae Species 0.000 description 1
241000228212 Aspergillus Species 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
241000335423 Blastomyces Species 0.000 description 1
241000222122 Candida albicans Species 0.000 description 1
206010007134 Candida infections Diseases 0.000 description 1
241001340526 Chrysoclista linneella Species 0.000 description 1
241000223203 Coccidioides Species 0.000 description 1
HHJIUUAMYGBVSD-YTFFSALGSA-N Diflucortolone valerate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@H](C(=O)COC(=O)CCCC)[C@@]2(C)C[C@@H]1O HHJIUUAMYGBVSD-YTFFSALGSA-N 0.000 description 1
241001480036 Epidermophyton floccosum Species 0.000 description 1
241000192125 Firmicutes Species 0.000 description 1
241000233866 Fungi Species 0.000 description 1
241000228402 Histoplasma Species 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
241001480037 Microsporum Species 0.000 description 1
241000893980 Microsporum canis Species 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
206010030113 Oedema Diseases 0.000 description 1
208000010195 Onychomycosis Diseases 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
229920000148 Polycarbophil calcium Polymers 0.000 description 1
229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
201000004681 Psoriasis Diseases 0.000 description 1
241001303601 Rosacea Species 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
241000295644 Staphylococcaceae Species 0.000 description 1
REVZBRXEBPWDRA-UHFFFAOYSA-N Stearyl citrate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CC(O)(C(O)=O)CC(O)=O REVZBRXEBPWDRA-UHFFFAOYSA-N 0.000 description 1
239000004138 Stearyl citrate Substances 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
208000007712 Tinea Versicolor Diseases 0.000 description 1
206010067197 Tinea manuum Diseases 0.000 description 1
206010056131 Tinea versicolour Diseases 0.000 description 1
206010066901 Treatment failure Diseases 0.000 description 1
241000223238 Trichophyton Species 0.000 description 1
241001045770 Trichophyton mentagrophytes Species 0.000 description 1
241000223229 Trichophyton rubrum Species 0.000 description 1
241000222126 [Candida] glabrata Species 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
229940063655 aluminum stearate Drugs 0.000 description 1
229940124599 anti-inflammatory drug Drugs 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000001857 anti-mycotic effect Effects 0.000 description 1
239000002543 antimycotic Substances 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
239000001273 butane Substances 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
201000003984 candidiasis Diseases 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
239000007765 cera alba Substances 0.000 description 1
229940082500 cetostearyl alcohol Drugs 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
238000011260 co-administration Methods 0.000 description 1
229940031728 cocamidopropylamine oxide Drugs 0.000 description 1
235000019868 cocoa butter Nutrition 0.000 description 1
229940110456 cocoa butter Drugs 0.000 description 1
239000013065 commercial product Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
238000012790 confirmation Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
230000002596 correlated effect Effects 0.000 description 1
ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 description 1
230000037304 dermatophytes Effects 0.000 description 1
239000003599 detergent Substances 0.000 description 1
HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 1
229960003970 diflucortolone valerate Drugs 0.000 description 1
238000007865 diluting Methods 0.000 description 1
LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
229960003913 econazole Drugs 0.000 description 1
230000008686 ergosterol biosynthesis Effects 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000007717 exclusion Effects 0.000 description 1
239000003925 fat Substances 0.000 description 1
235000019197 fats Nutrition 0.000 description 1
229960001347 fluocinolone acetonide Drugs 0.000 description 1
FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
229940075507 glyceryl monostearate Drugs 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229960001067 hydrocortisone acetate Drugs 0.000 description 1
150000002460 imidazoles Chemical class 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
239000001282 iso-butane Substances 0.000 description 1
229940093629 isopropyl isostearate Drugs 0.000 description 1
XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
229960000448 lactic acid Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
229960005040 miconazole nitrate Drugs 0.000 description 1
244000005700 microbiome Species 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
229940105132 myristate Drugs 0.000 description 1
IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
231100000957 no side effect Toxicity 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
229960003483 oxiconazole Drugs 0.000 description 1
QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 description 1
229940078498 peg-5 glyceryl stearate Drugs 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
201000000508 pityriasis versicolor Diseases 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
239000004584 polyacrylic acid Substances 0.000 description 1
229950005134 polycarbophil Drugs 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229940113124 polysorbate 60 Drugs 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
239000000047 product Substances 0.000 description 1
NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
239000001294 propane Substances 0.000 description 1
239000003380 propellant Substances 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
201000004700 rosacea Diseases 0.000 description 1
210000004761 scalp Anatomy 0.000 description 1
208000008742 seborrheic dermatitis Diseases 0.000 description 1
206010040882 skin lesion Diseases 0.000 description 1
231100000444 skin lesion Toxicity 0.000 description 1
229940057950 sodium laureth sulfate Drugs 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000000528 statistical test Methods 0.000 description 1
235000019330 stearyl citrate Nutrition 0.000 description 1
230000003637 steroidlike Effects 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
229960002607 sulconazole Drugs 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
201000004647 tinea pedis Diseases 0.000 description 1
201000005882 tinea unguium Diseases 0.000 description 1
229940100615 topical ointment Drugs 0.000 description 1
239000012049 topical pharmaceutical composition Substances 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1
210000002268 wool Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)

IL10923094A 1994-04-05 1994-04-05 Anti-fungal composition containing bifonazole and fluocinonide IL109230A (en)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
IL10923094A IL109230A (en)	1994-04-05	1994-04-05	Anti-fungal composition containing bifonazole and fluocinonide
ZA951799A ZA951799B (en)	1994-04-05	1995-03-03	Fungicidal compositions containing bifonazole
DK95301981T DK0676198T3 (da)	1994-04-05	1995-03-24	Fungicide sammensætninger indeholdende en kombination af bifonazol og fluocinonid
DE69505174T DE69505174T2 (de)	1994-04-05	1995-03-24	Fungizide Zusammensetzungen enthaltend eine Kombination von Bifonazol und Fluocinonid
EP95301981A EP0676198B1 (de)	1994-04-05	1995-03-24	Fungizide Zusammensetzungen enthaltend eine Kombination von Bifonazol und Fluocinonid
ES95301981T ES2123206T3 (es)	1994-04-05	1995-03-24	Composiciones fungicidas que contienen una combinacion de bifonazol y fluocinonida.
AT95301981T ATE171871T1 (de)	1994-04-05	1995-03-24	Fungizide zusammensetzungen enthaltend eine kombination von bifonazol und fluocinonid
JP7078697A JPH0892097A (ja)	1994-04-05	1995-04-04	ビフォナゾール含有殺真菌組成物
CN95103643A CN1075722C (zh)	1994-04-05	1995-04-04	含联苯苄唑的杀真菌组合物

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL10923094A IL109230A (en)	1994-04-05	1994-04-05	Anti-fungal composition containing bifonazole and fluocinonide

Publications (2)

Publication Number	Publication Date
IL109230A0 IL109230A0 (en)	1994-07-31
IL109230A true IL109230A (en)	1998-08-16

Family

ID=11065999

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10923094A IL109230A (en)	1994-04-05	1994-04-05	Anti-fungal composition containing bifonazole and fluocinonide

Country Status (9)

Country	Link
EP (1)	EP0676198B1 (de)
JP (1)	JPH0892097A (de)
CN (1)	CN1075722C (de)
AT (1)	ATE171871T1 (de)
DE (1)	DE69505174T2 (de)
DK (1)	DK0676198T3 (de)
ES (1)	ES2123206T3 (de)
IL (1)	IL109230A (de)
ZA (1)	ZA951799B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9618964D0 (en) *	1996-09-11	1996-10-23	Tillotts Pharma Ag	Oral composition
US6075056A (en) *	1997-10-03	2000-06-13	Penederm, Inc.	Antifungal/steroid topical compositions
US8263580B2 (en)	1998-09-11	2012-09-11	Stiefel Research Australia Pty Ltd	Vitamin formulation
US8512718B2 (en)	2000-07-03	2013-08-20	Foamix Ltd.	Pharmaceutical composition for topical application
CA2495923A1 (en) *	2002-08-20	2004-03-04	Doren M. Pinnell	Methods for treating fungal infections
IL152486A0 (en)	2002-10-25	2003-05-29	Meir Eini	Alcohol-free cosmetic and pharmaceutical foam carrier
US8119109B2 (en)	2002-10-25	2012-02-21	Foamix Ltd.	Foamable compositions, kits and methods for hyperhidrosis
US9668972B2 (en)	2002-10-25	2017-06-06	Foamix Pharmaceuticals Ltd.	Nonsteroidal immunomodulating kit and composition and uses thereof
US10117812B2 (en)	2002-10-25	2018-11-06	Foamix Pharmaceuticals Ltd.	Foamable composition combining a polar solvent and a hydrophobic carrier
US9265725B2 (en)	2002-10-25	2016-02-23	Foamix Pharmaceuticals Ltd.	Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US20080138296A1 (en)	2002-10-25	2008-06-12	Foamix Ltd.	Foam prepared from nanoemulsions and uses
ES2532906T5 (es)	2002-10-25	2022-03-23	Foamix Pharmaceuticals Ltd	Espuma cosmética y farmacéutica
US8486376B2 (en)	2002-10-25	2013-07-16	Foamix Ltd.	Moisturizing foam containing lanolin
US7700076B2 (en)	2002-10-25	2010-04-20	Foamix, Ltd.	Penetrating pharmaceutical foam
US8900554B2 (en)	2002-10-25	2014-12-02	Foamix Pharmaceuticals Ltd.	Foamable composition and uses thereof
US7704518B2 (en)	2003-08-04	2010-04-27	Foamix, Ltd.	Foamable vehicle and pharmaceutical compositions thereof
US9211259B2 (en)	2002-11-29	2015-12-15	Foamix Pharmaceuticals Ltd.	Antibiotic kit and composition and uses thereof
US7820145B2 (en)	2003-08-04	2010-10-26	Foamix Ltd.	Oleaginous pharmaceutical and cosmetic foam
US8119150B2 (en)	2002-10-25	2012-02-21	Foamix Ltd.	Non-flammable insecticide composition and uses thereof
US7575739B2 (en)	2003-04-28	2009-08-18	Foamix Ltd.	Foamable iodine composition
US8795693B2 (en)	2003-08-04	2014-08-05	Foamix Ltd.	Compositions with modulating agents
US8486374B2 (en)	2003-08-04	2013-07-16	Foamix Ltd.	Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
EP2526930B1 (de)	2005-06-01	2013-12-25	GlaxoSmithKline Intellectual Property Development Limited	Vitaminformulierung
US20080260655A1 (en)	2006-11-14	2008-10-23	Dov Tamarkin	Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8636982B2 (en)	2007-08-07	2014-01-28	Foamix Ltd.	Wax foamable vehicle and pharmaceutical compositions thereof
US9439857B2 (en)	2007-11-30	2016-09-13	Foamix Pharmaceuticals Ltd.	Foam containing benzoyl peroxide
US8518376B2 (en)	2007-12-07	2013-08-27	Foamix Ltd.	Oil-based foamable carriers and formulations
WO2009072007A2 (en)	2007-12-07	2009-06-11	Foamix Ltd.	Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
EP2242476A2 (de)	2008-01-14	2010-10-27	Foamix Ltd.	Aufschäumbare pharmazeutische poloxamer-zusammensetzungen mit wirkstoffen und/oder therapeutischen zellen und verwendungen
WO2010125470A2 (en)	2009-04-28	2010-11-04	Foamix Ltd.	Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
CA2769677A1 (en)	2009-07-29	2011-02-03	Foamix Ltd.	Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013009A2 (en)	2009-07-29	2011-02-03	Foamix Ltd.	Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011024027A1 (en) *	2009-08-24	2011-03-03	Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi	Pharmaceutical combinations of diflucortolone and terbinafine
WO2011064631A1 (en)	2009-10-02	2011-06-03	Foamix Ltd.	Surfactant-free, water-free, foamable compositions and breakable foams and their uses
US9849142B2 (en)	2009-10-02	2017-12-26	Foamix Pharmaceuticals Ltd.	Methods for accelerated return of skin integrity and for the treatment of impetigo
CN104825388A (zh) *	2015-04-20	2015-08-12	陈亚春	一种联苯苄唑溶液及其制备方法
CN105287261B (zh) *	2015-10-28	2017-11-17	广州靓美莲美容科技有限公司	一种含玫瑰花油的杜鹃花酸复方祛痘膏及其制备方法
US10398641B2 (en)	2016-09-08	2019-09-03	Foamix Pharmaceuticals Ltd.	Compositions and methods for treating rosacea and acne
CN109432089A (zh) *	2018-11-02	2019-03-08	云南康创生物医药科技孵化有限公司	用于抗真菌的含联苯苄唑的药物组合物及其制备方法

1994
- 1994-04-05 IL IL10923094A patent/IL109230A/en not_active IP Right Cessation
1995
- 1995-03-03 ZA ZA951799A patent/ZA951799B/xx unknown
- 1995-03-24 DE DE69505174T patent/DE69505174T2/de not_active Expired - Fee Related
- 1995-03-24 EP EP95301981A patent/EP0676198B1/de not_active Expired - Lifetime
- 1995-03-24 ES ES95301981T patent/ES2123206T3/es not_active Expired - Lifetime
- 1995-03-24 DK DK95301981T patent/DK0676198T3/da active
- 1995-03-24 AT AT95301981T patent/ATE171871T1/de not_active IP Right Cessation
- 1995-04-04 JP JP7078697A patent/JPH0892097A/ja active Pending
- 1995-04-04 CN CN95103643A patent/CN1075722C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0676198A1 (de)	1995-10-11
ATE171871T1 (de)	1998-10-15
ES2123206T3 (es)	1999-01-01
DK0676198T3 (da)	1999-06-21
DE69505174D1 (de)	1998-11-12
IL109230A0 (en)	1994-07-31
ZA951799B (en)	1996-01-25
DE69505174T2 (de)	1999-03-04
EP0676198B1 (de)	1998-10-07
CN1111513A (zh)	1995-11-15
JPH0892097A (ja)	1996-04-09
CN1075722C (zh)	2001-12-05

Legal Events

Date	Code	Title
1998-12-27	FF	Patent granted
1999-08-17	KB	Patent renewed
2001-06-14	RH	Patent void
2004-06-01	KB	Patent renewed
2006-03-12	HC	Change of name of proprietor(s)
2008-07-09	KB	Patent renewed
2012-04-30	KB	Patent renewed
2014-11-30	EXP	Patent expired

Publication	Publication Date	Title
EP0676198B1 (de)	1998-10-07	Fungizide Zusammensetzungen enthaltend eine Kombination von Bifonazol und Fluocinonid
US6075056A (en)	2000-06-13	Antifungal/steroid topical compositions
AU2019281888B2 (en)	2024-05-02	Method and formulation for improving roflumilast skin penetration lag time
US5869529A (en)	1999-02-09	Topical preparation for the prevention and treatment of lesions and sores associated with a herpes virus
EP1390031B1 (de)	2005-02-09	Fungizide enthaltende topische zusammensetzung
CA3162675C (en)	2023-09-26	Topical roflumilast formulation having antifungal properties
JP3240330B2 (ja)	2001-12-17	コラン酸の塩を含有する医薬調合剤および化粧品調合剤
CN114630666A (zh)	2022-06-14	减少施用磷酸二酯酶-4抑制剂的副作用的方法
CA2888853C (en)	2019-02-12	Topical steroid composition and method
JPH05262641A (ja)	1993-10-12	固体脂質粒子の懸濁液を含有する局所製剤
AU2021268977A1 (en)	2022-04-21	Treatment of skin conditions using high Krafft temperature anionic surfactants
JPH0148885B2 (de)	1989-10-20
US20160213690A1 (en)	2016-07-28	Compositions and methods for the treatment of skin diseases
Gold et al.	2023	Impact of topical vehicles and cutaneous delivery technologies on patient adherence and treatment outcomes in acne and rosacea
JPH02204413A (ja)	1990-08-14	抗真菌外用製剤
HK40041771A (en)	2021-08-20	Method and formulation for improving roflumilast skin penetration lag time
EP0787490A1 (de)	1997-08-06	Topische Zusammensetzung zur Prevention und Behandlung der mit Herpesvirus assoziierten Verletzungen und Wunde
HK1214154B (zh)	2020-01-24	局部類固醇組合物和方法
HK1063282B (en)	2005-09-09	Topical composition containing a fungicide
HK1116666B (en)	2018-04-13	Anhydrous multiphase gel system